KR20220119454A - T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물 - Google Patents

T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물 Download PDF

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Publication number
KR20220119454A
KR20220119454A KR1020227025284A KR20227025284A KR20220119454A KR 20220119454 A KR20220119454 A KR 20220119454A KR 1020227025284 A KR1020227025284 A KR 1020227025284A KR 20227025284 A KR20227025284 A KR 20227025284A KR 20220119454 A KR20220119454 A KR 20220119454A
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cys
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ala
thr
alkyl
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Korean (ko)
Inventor
유펜더 벨라파르티
리차드 이. 올슨
자야쿠마르 산카라 와리에르
하시부르 라하만
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브리스톨-마이어스 스큅 컴퍼니
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Publication of KR20220119454A publication Critical patent/KR20220119454A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227025284A 2019-12-23 2020-12-22 T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물 Pending KR20220119454A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201911053553 2019-12-23
IN201911053553 2019-12-23
PCT/US2020/066508 WO2021133751A1 (en) 2019-12-23 2020-12-22 Substituted quinazolinyl compounds useful as t cell activators

Publications (1)

Publication Number Publication Date
KR20220119454A true KR20220119454A (ko) 2022-08-29

Family

ID=74195154

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227025284A Pending KR20220119454A (ko) 2019-12-23 2020-12-22 T 세포 활성화제로서 유용한 치환된 퀴나졸리닐 화합물

Country Status (12)

Country Link
US (1) US12492172B2 (https=)
EP (1) EP4081516B1 (https=)
JP (1) JP2023507847A (https=)
KR (1) KR20220119454A (https=)
CN (1) CN114846007B (https=)
AU (1) AU2020415377A1 (https=)
BR (1) BR112022012179A2 (https=)
CA (1) CA3162985A1 (https=)
ES (1) ES3038401T3 (https=)
IL (1) IL294148A (https=)
MX (1) MX2022006958A (https=)
WO (1) WO2021133751A1 (https=)

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WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
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KR20240156394A (ko) 2022-03-01 2024-10-29 인실리코 메디신 아이피 리미티드 디아실글리세롤 키나아제 (dgk) 알파 억제제 및 이의 용도
CN118829642A (zh) * 2022-03-01 2024-10-22 英矽智能科技知识产权有限公司 二酰基甘油激酶(DGK)α抑制剂及其用途
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Publication number Publication date
CA3162985A1 (en) 2021-07-01
CN114846007A (zh) 2022-08-02
IL294148A (en) 2022-08-01
JP2023507847A (ja) 2023-02-27
US12492172B2 (en) 2025-12-09
BR112022012179A2 (pt) 2022-09-06
EP4081516A1 (en) 2022-11-02
MX2022006958A (es) 2022-07-12
CN114846007B (zh) 2024-11-22
EP4081516B1 (en) 2025-07-30
WO2021133751A1 (en) 2021-07-01
US20230094758A1 (en) 2023-03-30
AU2020415377A1 (en) 2022-08-18
ES3038401T3 (en) 2025-10-13

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