BR112022008685A2 - Compostos moduladores de gpr52 - Google Patents

Compostos moduladores de gpr52

Info

Publication number
BR112022008685A2
BR112022008685A2 BR112022008685A BR112022008685A BR112022008685A2 BR 112022008685 A2 BR112022008685 A2 BR 112022008685A2 BR 112022008685 A BR112022008685 A BR 112022008685A BR 112022008685 A BR112022008685 A BR 112022008685A BR 112022008685 A2 BR112022008685 A2 BR 112022008685A2
Authority
BR
Brazil
Prior art keywords
gpr52
modulating compounds
compounds
modulating
amelioration
Prior art date
Application number
BR112022008685A
Other languages
English (en)
Inventor
Joanne Bucknell Sarah
Paul Watson Stephen
Alistair O'brien Michael
De Graaf Chris
Alan Swain Nigel
Original Assignee
Heptares Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1916298.1A external-priority patent/GB201916298D0/en
Priority claimed from GBGB1918992.7A external-priority patent/GB201918992D0/en
Priority claimed from GBGB1918974.5A external-priority patent/GB201918974D0/en
Application filed by Heptares Therapeutics Ltd filed Critical Heptares Therapeutics Ltd
Publication of BR112022008685A2 publication Critical patent/BR112022008685A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

COMPOSTOS MODULADORES DE GPR52. A presente invenção refere-se a novos compostos de Fórmula (1) e seus sais, em que R1, Q, X, Y e Z são definidos neste documento, e a seu uso no tratamento, na prevenção, na melhora, no controle ou na redução do risco de distúrbios associados aos receptores GPR52.
BR112022008685A 2019-11-08 2020-11-09 Compostos moduladores de gpr52 BR112022008685A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1916298.1A GB201916298D0 (en) 2019-11-08 2019-11-08 GPR52 modulator compounds
GBGB1918992.7A GB201918992D0 (en) 2019-12-20 2019-12-20 GPR52 modulator compounds
GBGB1918974.5A GB201918974D0 (en) 2019-12-20 2019-12-20 Gpr52 modulator compounds
PCT/GB2020/052832 WO2021090030A1 (en) 2019-11-08 2020-11-09 Gpr52 modulator compounds

Publications (1)

Publication Number Publication Date
BR112022008685A2 true BR112022008685A2 (pt) 2022-07-26

Family

ID=73344101

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022008685A BR112022008685A2 (pt) 2019-11-08 2020-11-09 Compostos moduladores de gpr52

Country Status (10)

Country Link
US (1) US20230002374A1 (pt)
EP (1) EP4055016A1 (pt)
JP (1) JP2023501984A (pt)
KR (1) KR20220098156A (pt)
CN (1) CN114650992A (pt)
AU (1) AU2020381168A1 (pt)
BR (1) BR112022008685A2 (pt)
CA (1) CA3156474A1 (pt)
MX (1) MX2022005111A (pt)
WO (1) WO2021090030A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202013558D0 (en) * 2020-08-28 2020-10-14 Heptares Therapeutics Ltd GRP52 Modularor compounds
CN117940420A (zh) 2021-09-14 2024-04-26 勃林格殷格翰国际有限公司 3-苯氧基氮杂环丁烷-1-基-杂芳基吡咯烷衍生物及其作为药物的用途
GB202113186D0 (en) * 2021-09-15 2021-10-27 Heptares Therapeutics Ltd GPR52 Modulator compounds
EP4289427A1 (en) 2022-06-10 2023-12-13 Anagenesis Biotechnologies Dihydro[1,8]naphthyridin-7-one and pyrido[3,2-b][1,4]oxazin-3-one for use in treating cancer, and metastases in particular.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20100097077A (ko) * 2009-02-25 2010-09-02 주식회사 중외제약 Hsp90에 대한 억제 효능을 갖는 피리디논 유도체
ES2784316T3 (es) 2015-04-29 2020-09-24 Arena Pharm Inc 1-Heteroaril-indolin-4-carboxamidas como moduladores de GPR52 útiles para el tratamiento o la prevención de trastornos relacionados con el mismo
JP2019536820A (ja) * 2016-12-01 2019-12-19 アプトセ バイオサイエンシーズ インコーポレイテッド Brad4およびjak2の二重阻害剤としての縮合環式ピリミジン化合物、ならびにその使用に関する方法
AU2018350989A1 (en) * 2017-10-17 2020-05-28 Epizyme, Inc. Amine-substituted heterocyclic compounds as EHMT2 inhibitors and derivatives thereof

Also Published As

Publication number Publication date
CA3156474A1 (en) 2021-05-14
JP2023501984A (ja) 2023-01-20
EP4055016A1 (en) 2022-09-14
CN114650992A (zh) 2022-06-21
MX2022005111A (es) 2022-05-30
AU2020381168A1 (en) 2022-04-14
US20230002374A1 (en) 2023-01-05
KR20220098156A (ko) 2022-07-11
WO2021090030A1 (en) 2021-05-14

Similar Documents

Publication Publication Date Title
BR112022008685A2 (pt) Compostos moduladores de gpr52
BR112018000687A2 (pt) composto, composição e mistura herbicida e métodos para o controle do crescimento da vegetação indesejada
BR112017021859A2 (pt) ?composto, composição e mistura herbicida e método para o controle do crescimento de vegetação indesejada?
BR112017019995A2 (pt) composto, composição, mistura herbicida e método de controle do crescimento de vegetação
BR112016012584A2 (pt) Composto, composições herbicidas, misturas herbicidas e método para o controle do crescimento da vegetação indesejada
BR112022003375A2 (pt) Compostos de pirazina-amida pesticidamente ativos
BR112016015983A2 (pt) Compostos de indazol como inibidores de irak4, seus usos, e composição farmacêutica
BR112015004161B8 (pt) Derivado bicíclico fusionado de sulfamoíla e seu uso no tratamento e prevenção de infecção por vírus da hepatite b, bem como composição farmacêutica e produto que o compreende
BR112021019987A2 (pt) Compostos de diazina-amida pesticidamente ativos
BR112018001964A2 (pt) composto, composição herbicida, mistura herbicida e método para o controle do crescimento de vegetação
BR112016016443B8 (pt) composto, composição herbicida, misturas herbicidas,método para o controle do crescimento de vegetação indesejada e método para o controle do crescimento de vegetação indesejada na colheita de vegetais geneticamente modificados
BR112021017604A2 (pt) Compostos úteis na terapia para hiv
BR112017009601A2 (pt) derivados de aminoácidos e seus usos
BR112017001439A2 (pt) ?composto, composição e mistura herbicida e métodos de controle do crescimento de vegetação?
BR112022000713A2 (pt) Imidazopirimidinas como inibidores de eed e o uso das mesmas
BR112018077223A2 (pt) compostos de pirimidina, uso de compostos de pirimidina, composições herbicidas, método para controlar vegetação indesejada e uso das composições herbicidas
BR112017000821A2 (pt) novos compostos de pirimidina substituída.
BR112016007757A8 (pt) Derivados antibacterianos de 2h-indazol
BR112019000290A2 (pt) pró-fármacos de fósforo dos estimuladores da scg
BR112017015093A2 (pt) derivados de hidroxialquil-piperazina como moduladores do receptor cxcr3
BR112022004917A2 (pt) Compostos de amina cíclica pesticidamente ativos
BR112022001390A2 (pt) Inibidores de enzima
BR112022001054A2 (pt) Inibidores enzimáticos
BR112022004348A2 (pt) Aperfeiçoamentos em ou relacionados a compostos orgânicos
MX2021004280A (es) Derivados de pirazol como compuestos antagonistas de receptor de histamina h4.

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]