BR112022006272A2 - Formulação de transporte ou armazenamento de células-tronco mesenquimais e métodos de preparação e uso da mesma - Google Patents

Formulação de transporte ou armazenamento de células-tronco mesenquimais e métodos de preparação e uso da mesma

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Publication number
BR112022006272A2
BR112022006272A2 BR112022006272A BR112022006272A BR112022006272A2 BR 112022006272 A2 BR112022006272 A2 BR 112022006272A2 BR 112022006272 A BR112022006272 A BR 112022006272A BR 112022006272 A BR112022006272 A BR 112022006272A BR 112022006272 A2 BR112022006272 A2 BR 112022006272A2
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BR
Brazil
Prior art keywords
mesenchymal stem
storage
formulation
stem cells
methods
Prior art date
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BR112022006272A
Other languages
English (en)
Inventor
Thang Phan Toan
M Freed Brian
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Cellresearch Corp Pte Ltd
Univ Colorado Regents
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Publication date
Application filed by Cellresearch Corp Pte Ltd, Univ Colorado Regents filed Critical Cellresearch Corp Pte Ltd
Publication of BR112022006272A2 publication Critical patent/BR112022006272A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C—CHEMISTRY; METALLURGY
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0668—Mesenchymal stem cells from other natural sources
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/0231—Chemically defined matrices, e.g. alginate gels, for immobilising, holding or storing cells, tissue or organs for preservation purposes; Chemically altering or fixing cells, tissue or organs, e.g. by cross-linking, for preservation purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/14—Calcium; Ca chelators; Calcitonin
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
    • C12N2500/16—Magnesium; Mg chelators
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    • C12N2500/38—Vitamins
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    • C12N2500/00—Specific components of cell culture medium
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/44—Thiols, e.g. mercaptoethanol
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure

Abstract

oFORMULAÇÃO DE TRANSPORTE OU ARMAZENAMENTO DE CÉLULAS-TRONCO MESENQUIMAIS E MÉTODOS DE PREPARAÇÃO E USO DA MESMA. A presente invenção refere-se a uma formulação de transpor-te ou armazenamento de células-tronco mesenquimais, um método de preparação formulação de transporte ou armazenamento de células-tronco mesenquimais, bem como aos métodos de uso da formulação de transporte ou armazenamento de células-tronco mesenquimais. Tais métodos incluem um método de transporte de células-tronco mesenquimais nesta formulação de armazenamento ou transporte, bem como um método de tratamento de um indivíduo com uma doença, o método compreendendo a administração tópica de células-tronco mesenquimais que foram armazenadas ou transportadas nesta formulação de armazenamento ou transporte. Também refere-se a uma dosagem unitária das células-tronco mesenquimais.
BR112022006272A 2019-10-08 2020-10-08 Formulação de transporte ou armazenamento de células-tronco mesenquimais e métodos de preparação e uso da mesma BR112022006272A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962912368P 2019-10-08 2019-10-08
PCT/SG2020/050572 WO2021071430A1 (en) 2019-10-08 2020-10-08 A mesenchymal stem cell storing or transport formulation and methods of making and using the same

Publications (1)

Publication Number Publication Date
BR112022006272A2 true BR112022006272A2 (pt) 2022-08-30

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Country Status (9)

Country Link
US (1) US20210102171A1 (pt)
EP (1) EP4040957A4 (pt)
JP (1) JP2022552230A (pt)
KR (1) KR20220108763A (pt)
CN (1) CN114867347B (pt)
AU (1) AU2020364930A1 (pt)
BR (1) BR112022006272A2 (pt)
CA (1) CA3152751A1 (pt)
WO (1) WO2021071430A1 (pt)

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Publication number Priority date Publication date Assignee Title
BR112019005652A2 (pt) * 2016-10-05 2019-06-04 Cellresearch Corp Pte Ltd método de isolamento de células-tronco mesenquimais da membrana amniótica do cordão umbilical utilizando um meio de cultura de células
CN113498779B (zh) * 2021-04-22 2022-05-31 重庆医科大学附属儿童医院 一种运输细胞的试剂及方法
WO2023192484A2 (en) * 2022-04-01 2023-10-05 Bright Cell, Inc. A mesenchymal stem cells formulation for cosmetic use
CN115843782A (zh) * 2022-12-27 2023-03-28 南京三生生物技术股份有限公司 一种细胞保存液及其在细胞贮藏中的应用以及一种冷藏细胞转入冷冻保存的方法

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WO2007046775A1 (en) * 2005-10-21 2007-04-26 Cellresearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
WO2012092420A2 (en) * 2010-12-30 2012-07-05 Anthrogenesis Corporation Methods for cryopreserving and encapsulating cells
US20160184364A1 (en) * 2013-08-14 2016-06-30 Stempeutics Research Pvt. Ltd. Management of osteoarthritis using pooled allogeneic mesenchymal stem cells
ES2880948T3 (es) * 2014-05-12 2021-11-26 Roosterbio Inc Células listas para imprimir y dispositivos integrados
US20160095307A1 (en) * 2014-10-07 2016-04-07 NuTech Medical, Inc. Method and composition for hypothermic storage of placental tissue
CZ306800B6 (cs) * 2016-05-13 2017-07-12 Ústav experimentální medicíny AV ČR, v. v. i. Prostředek pro uchování, transport a aplikaci kmenových buněk
BR112019005652A2 (pt) * 2016-10-05 2019-06-04 Cellresearch Corp Pte Ltd método de isolamento de células-tronco mesenquimais da membrana amniótica do cordão umbilical utilizando um meio de cultura de células
CN110191702A (zh) * 2016-10-19 2019-08-30 哈比尔·F·赫拉基瓦拉 用于治疗受损皮肤组织的局部敷料组合物
EP3772936A4 (en) * 2018-04-09 2022-01-05 CellResearch Corporation Pte. Ltd. METHOD FOR TRANSPORTING MESENCHYMAL STEM CELLS BY A TRANSPORT SOLUTION AND METHOD FOR ADMINISTERING STEM CELLS TO WOUNDS
CA3112505C (en) * 2018-09-20 2023-06-20 Citospin, S.L. Method for obtaining an enriched population of functional mesenchymal stem cells, cells obtained thereof and compositions comprising the same

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Publication number Publication date
AU2020364930A1 (en) 2022-04-14
KR20220108763A (ko) 2022-08-03
JP2022552230A (ja) 2022-12-15
CN114867347B (zh) 2024-03-05
CN114867347A (zh) 2022-08-05
CA3152751A1 (en) 2021-04-15
EP4040957A4 (en) 2023-11-01
EP4040957A1 (en) 2022-08-17
US20210102171A1 (en) 2021-04-08
WO2021071430A1 (en) 2021-04-15

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