BR112022004125A2 - Compostos 5,6-heteroaromáticos contendo benzilamina úteis contra infecção micobacteriana - Google Patents
Compostos 5,6-heteroaromáticos contendo benzilamina úteis contra infecção micobacterianaInfo
- Publication number
- BR112022004125A2 BR112022004125A2 BR112022004125A BR112022004125A BR112022004125A2 BR 112022004125 A2 BR112022004125 A2 BR 112022004125A2 BR 112022004125 A BR112022004125 A BR 112022004125A BR 112022004125 A BR112022004125 A BR 112022004125A BR 112022004125 A2 BR112022004125 A2 BR 112022004125A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds containing
- halogen
- independently
- heteroaromatic compounds
- mycobacterial infection
- Prior art date
Links
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title abstract 4
- 206010062207 Mycobacterial infection Diseases 0.000 title abstract 2
- 208000027531 mycobacterial infectious disease Diseases 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
compostos 5,6-heteroaromáticos contendo benzilamina úteis contra infecção micobacteriana. a presente invenção refere-se ao composto representado pela fórmula (i) ou um sal farmaceuticamente aceitável do mesmo, em que um grupo representado pela fórmula (ii) é um grupo representado pela fórmula (iii) ou (iv); r1 é cada um independentemente halogênio, hidroxila, ciano ou semelhantes; m é 0, 1, 2, 3 ou 4; r2 é um átomo de hidrogênio, halogênio, ciano, alquila substituída ou não substituída ou semelhantes; r3a, r3b, r3c, e r3d são cada um independentemente um átomo de hidrogênio, halogênio ou semelhantes, com a condição de que r3a, r3b, r3c e r3d não sejam simultaneamente átomos de hidrogênio; o anel c é representado como a seguir: (v), (vi), (vii), (viii), (ix) ou (x). x é ch ou n; y é ch ou n; r4 é cada um independentemente halogênio, hidroxila, ciano ou semelhantes; p é 0 ou 1; q é 0, 1, 2, 3 ou 4; r5 é cr5c ou n; r6 é cr6c ou n; r7 é cr7c ou n; r8 é cr8c ou n; r9 é cr9c ou n; com a condição de que r5, r6, r7, r8 e r9 não sejam simultaneamente n; r5c, r6c, r7c, r8c e r9c sejam cada um independentemente um átomo de hidrogênio ou semelhantes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962898066P | 2019-09-10 | 2019-09-10 | |
| PCT/US2020/050173 WO2021050708A1 (en) | 2019-09-10 | 2020-09-10 | Benzyl amine-containing 5,6-heteroaromatic compounds useful against mycobacterial infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112022004125A2 true BR112022004125A2 (pt) | 2022-05-31 |
Family
ID=74866045
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112022004125A BR112022004125A2 (pt) | 2019-09-10 | 2020-09-10 | Compostos 5,6-heteroaromáticos contendo benzilamina úteis contra infecção micobacteriana |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20220340566A1 (pt) |
| EP (1) | EP4028130A4 (pt) |
| JP (1) | JP2022547228A (pt) |
| KR (1) | KR20220062021A (pt) |
| CN (2) | CN115093408A (pt) |
| AU (1) | AU2020344572A1 (pt) |
| BR (1) | BR112022004125A2 (pt) |
| CA (1) | CA3153724A1 (pt) |
| IL (1) | IL291187A (pt) |
| MX (1) | MX2022002878A (pt) |
| TW (1) | TW202124379A (pt) |
| WO (1) | WO2021050708A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022119899A1 (en) * | 2020-12-02 | 2022-06-09 | Shionogi & Co., Ltd. | A medicament for treating mycobacterial infection characterized by combining a cytochrome bc1 inhibitor with clarithromycin or azithromycin |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110483499A (zh) | 2009-11-05 | 2019-11-22 | 圣母大学 | 咪唑并[1,2-a]吡啶类化合物及其合成及使用方法 |
| SG10201502109VA (en) * | 2010-03-18 | 2015-05-28 | Pasteur Institut Korea | Anti-infective compounds |
| BR112015001201B1 (pt) | 2012-07-18 | 2022-02-22 | University Of Notre Dame Du Lac | Compostos anti-infecciosos 5,5-heteroaromáticos e composição |
| HUE056198T2 (hu) * | 2013-08-02 | 2022-02-28 | Pasteur Institut Korea | Fertõzés elleni vegyületek |
| CN105524058B (zh) * | 2014-10-21 | 2018-03-27 | 广州艾格生物科技有限公司 | 吡唑并[1,5‑a]吡啶类化合物及其应用 |
| EP4074378A1 (en) | 2015-07-02 | 2022-10-19 | Janssen Sciences Ireland Unlimited Company | Antibacterial compounds |
| PE20181352A1 (es) | 2015-09-17 | 2018-08-22 | Marvin J Miller | Compuestos heterociclicos que contienen bencilamina y composiciones utiles contra infeccion por micobacterias |
| AU2017286370B2 (en) | 2016-06-16 | 2021-09-09 | Janssen Sciences Ireland Uc | Heterocyclic compounds as antibacte rials |
| CN109476657A (zh) | 2016-06-16 | 2019-03-15 | 爱尔兰詹森科学公司 | 作为抗细菌剂的杂环化合物 |
| BR112019017901A2 (pt) | 2017-03-01 | 2020-05-12 | Janssen Sciences Ireland Unlimited Company | Terapia de combinação |
| CN107243008B (zh) * | 2017-04-13 | 2021-03-30 | 中国科学院广州生物医药与健康研究院 | 吡唑并[1,5-a]吡啶类化合物的新应用及一种治疗脓肿分枝杆菌感染的组合物 |
| CN108159049B (zh) * | 2018-02-01 | 2021-01-05 | 中国科学院广州生物医药与健康研究院 | 一种吡啶类化合物的新用途 |
| US20210009583A1 (en) | 2018-03-12 | 2021-01-14 | University Of Notre Dame Du Lac | Deuterated imidazopyridines |
-
2020
- 2020-09-08 TW TW109130764A patent/TW202124379A/zh unknown
- 2020-09-10 CA CA3153724A patent/CA3153724A1/en active Pending
- 2020-09-10 EP EP20863977.3A patent/EP4028130A4/en active Pending
- 2020-09-10 BR BR112022004125A patent/BR112022004125A2/pt unknown
- 2020-09-10 KR KR1020227011314A patent/KR20220062021A/ko active Search and Examination
- 2020-09-10 JP JP2022515760A patent/JP2022547228A/ja active Pending
- 2020-09-10 CN CN202210604012.XA patent/CN115093408A/zh active Pending
- 2020-09-10 US US17/641,668 patent/US20220340566A1/en active Pending
- 2020-09-10 WO PCT/US2020/050173 patent/WO2021050708A1/en unknown
- 2020-09-10 MX MX2022002878A patent/MX2022002878A/es unknown
- 2020-09-10 AU AU2020344572A patent/AU2020344572A1/en active Pending
- 2020-09-10 CN CN202080062740.1A patent/CN114401965A/zh active Pending
-
2022
- 2022-03-08 IL IL291187A patent/IL291187A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220062021A (ko) | 2022-05-13 |
| IL291187A (en) | 2022-05-01 |
| JP2022547228A (ja) | 2022-11-10 |
| EP4028130A4 (en) | 2023-08-30 |
| EP4028130A1 (en) | 2022-07-20 |
| MX2022002878A (es) | 2022-05-06 |
| US20220340566A1 (en) | 2022-10-27 |
| CN115093408A (zh) | 2022-09-23 |
| TW202124379A (zh) | 2021-07-01 |
| AU2020344572A1 (en) | 2022-04-21 |
| WO2021050708A1 (en) | 2021-03-18 |
| CA3153724A1 (en) | 2021-03-18 |
| CN114401965A (zh) | 2022-04-26 |
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