BR112022003089A2 - Métodos de produção de células progenitoras hemogênicas a partir de células-tronco pluripotentes - Google Patents

Métodos de produção de células progenitoras hemogênicas a partir de células-tronco pluripotentes

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Publication number
BR112022003089A2
BR112022003089A2 BR112022003089A BR112022003089A BR112022003089A2 BR 112022003089 A2 BR112022003089 A2 BR 112022003089A2 BR 112022003089 A BR112022003089 A BR 112022003089A BR 112022003089 A BR112022003089 A BR 112022003089A BR 112022003089 A2 BR112022003089 A2 BR 112022003089A2
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Brazil
Prior art keywords
cells
hemogenic
methods
pluripotent stem
producing
Prior art date
Application number
BR112022003089A
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English (en)
Portuguese (pt)
Inventor
Tao Yang Cheng
Lee Carpenter
Original Assignee
Adaptimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Adaptimmune Ltd filed Critical Adaptimmune Ltd
Publication of BR112022003089A2 publication Critical patent/BR112022003089A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/32—T-cell receptors [TCR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
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    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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    • C12N5/0636—T lymphocytes
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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BR112022003089A 2019-08-20 2020-08-20 Métodos de produção de células progenitoras hemogênicas a partir de células-tronco pluripotentes BR112022003089A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1911957.7A GB201911957D0 (en) 2019-08-20 2019-08-20 Methods of producing haemogenic progenitor cells from pluripotent stem cells
PCT/EP2020/073396 WO2021032851A1 (en) 2019-08-20 2020-08-20 Methods of producing haemogenic progenitor cells from pluripotent stem cells

Publications (1)

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BR112022003089A2 true BR112022003089A2 (pt) 2022-05-17

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BR112022003089A BR112022003089A2 (pt) 2019-08-20 2020-08-20 Métodos de produção de células progenitoras hemogênicas a partir de células-tronco pluripotentes

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Country Link
US (1) US20220267733A1 (https=)
EP (1) EP4017967A1 (https=)
JP (1) JP2022545782A (https=)
KR (1) KR20220049032A (https=)
CN (1) CN114269906A (https=)
AU (1) AU2020332863A1 (https=)
BR (1) BR112022003089A2 (https=)
CA (1) CA3150427A1 (https=)
GB (1) GB201911957D0 (https=)
IL (1) IL290605A (https=)
MX (1) MX2022001960A (https=)
WO (1) WO2021032851A1 (https=)

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US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
GB202102297D0 (en) * 2021-02-18 2021-04-07 Adaptimmune Ltd Methods of Producing Haemogenic Endothelial Cells from Pluripotent Stem Cells
CN113046318B (zh) * 2021-04-13 2023-04-18 中国科学院深圳先进技术研究院 一种诱导多能干细胞向造血前体细胞分化的培养基以及方法
EP4326852A4 (en) * 2021-04-22 2025-04-23 Artec Biotech, Inc. Method for producing hematopoietic cells from stem cells using vascular organoids
CN113265377B (zh) * 2021-06-11 2023-01-24 中国医学科学院血液病医院(中国医学科学院血液学研究所) 一种动脉内皮促进功能性t细胞再生的方法
WO2023038436A1 (ko) * 2021-09-10 2023-03-16 의료법인 성광의료재단 전분화능 줄기세포 유래 조혈모세포 제조방법 및 상기 제조된 조혈모세포를 이용한 인간화 마우스 모델 제작방법
CN116410927A (zh) * 2021-12-31 2023-07-11 士泽生物医药（苏州）有限公司 干细胞诱导分化为造血祖细胞的方法
CN116376822A (zh) * 2021-12-31 2023-07-04 北京大学 利用人多潜能干细胞体外制备t淋巴细胞
TW202340453A (zh) * 2022-01-28 2023-10-16 中國大陸商杭州啟函生物科技有限公司 用於基於細胞的免疫療法的方法和組合物
GB202205572D0 (en) 2022-04-14 2022-06-01 Adaptimmune Ltd Engineered T cells
GB202208545D0 (en) 2022-06-10 2022-07-27 Adaptimmune Ltd Production of immune cells
CN114958771B (zh) * 2022-06-27 2023-12-05 广东康盾创新产业集团股份公司 一种ipsc-car-nk细胞的制备方法
CN115247151B (zh) * 2022-09-21 2022-12-27 呈诺再生医学科技(北京)有限公司 制备造血内皮细胞的方法及制备造血干细胞或造血干祖细胞的方法
KR20240054468A (ko) * 2022-10-18 2024-04-26 의료법인 성광의료재단 줄기세포에서 대식세포로의 분화 유도용 배지 조성물 및 이를 이용한 분화 방법
AU2022489613A1 (en) * 2022-12-02 2025-07-10 Nuwacell Biotechnologies Co., Ltd. Methods and compositions for differentiation of pluripotent stem cells and derived natural killer cells
CN117264888A (zh) * 2023-10-11 2023-12-22 苏州艾凯利元生物科技有限公司 一种制备造血干细胞和祖细胞的方法
GB202318950D0 (en) 2023-12-12 2024-01-24 Adaptimmune Ltd Production of immune cells

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US8652845B2 (en) * 2010-03-18 2014-02-18 Kyoto University Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium
HUE043785T2 (hu) * 2013-03-13 2019-09-30 Wisconsin Alumni Res Found Módszerek és anyagok humán pluripotens õssejtek hematoendothelialis differenciálására meghatározott körülmények között
US10385313B2 (en) * 2013-10-01 2019-08-20 The Usa, As Represented By The Secretary, Department Of Health And Human Services Human IPSC-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings
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US11261430B2 (en) * 2016-05-03 2022-03-01 The Children's Medical Center Corporation Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells
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CN112041428B (zh) * 2018-01-18 2024-05-24 新加坡科技研究局 用于在悬浮培养物中分化人多能干细胞系的方法
GB202006903D0 (en) * 2020-05-11 2020-06-24 Adaptimmune Ltd Modified iPSCs

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KR20220049032A (ko) 2022-04-20
US20220267733A1 (en) 2022-08-25
IL290605A (en) 2022-04-01
CN114269906A (zh) 2022-04-01
WO2021032851A1 (en) 2021-02-25
JP2022545782A (ja) 2022-10-31
GB201911957D0 (en) 2019-10-02
AU2020332863A1 (en) 2022-03-24
MX2022001960A (es) 2022-03-11
EP4017967A1 (en) 2022-06-29
CA3150427A1 (en) 2021-02-25

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