BR112021024787A2 - Métodos para ativar uma via de sinalização wnt, para intensificar a regeneração de tecido e para facilitar a interação de um receptor fzd2 ou fzd7 e um correceptor wnt, molécula de ligação multivalente, e, composição farmacêutica - Google Patents

Métodos para ativar uma via de sinalização wnt, para intensificar a regeneração de tecido e para facilitar a interação de um receptor fzd2 ou fzd7 e um correceptor wnt, molécula de ligação multivalente, e, composição farmacêutica

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Publication number
BR112021024787A2
BR112021024787A2 BR112021024787A BR112021024787A BR112021024787A2 BR 112021024787 A2 BR112021024787 A2 BR 112021024787A2 BR 112021024787 A BR112021024787 A BR 112021024787A BR 112021024787 A BR112021024787 A BR 112021024787A BR 112021024787 A2 BR112021024787 A2 BR 112021024787A2
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BR
Brazil
Prior art keywords
receptor
wnt
methods
signaling pathway
binding molecule
Prior art date
Application number
BR112021024787A
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English (en)
Inventor
Sachdev Sidhu
Stephane Angers
Yuyong Tao
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Antlera Therapeutics Inc
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Publication date
Application filed by Antlera Therapeutics Inc filed Critical Antlera Therapeutics Inc
Publication of BR112021024787A2 publication Critical patent/BR112021024787A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35—Valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

métodos para ativar uma via de sinalização wnt, para intensificar a regeneração de tecido e para facilitar a interação de um receptor fzd2 ou fzd7 e um correceptor wnt, molécula de ligação multivalente, e, composição farmacêutica. são descritos neste documento métodos para afetar a ligação de uma molécula de ligação multivalente a um receptor fzd e um correceptor wnt em uma célula, em que a ligação da molécula de ligação multivalente ao receptor fzd e ao correceptor na célula ativa uma via de sinalização wnt. também são descritas aqui moléculas de ligação multivalentes compreendendo um domínio de ligação ao receptor fzd e um domínio de ligação do correceptor wnt em qualquer uma das extremidades de um domínio fc que ativam uma via de sinalização wnt e métodos para seu uso.
BR112021024787A 2019-06-11 2020-06-10 Métodos para ativar uma via de sinalização wnt, para intensificar a regeneração de tecido e para facilitar a interação de um receptor fzd2 ou fzd7 e um correceptor wnt, molécula de ligação multivalente, e, composição farmacêutica BR112021024787A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962860161P 2019-06-11 2019-06-11
PCT/IB2020/055463 WO2020250156A1 (en) 2019-06-11 2020-06-10 Multivalent fzd and wnt binding molecules and uses thereof

Publications (1)

Publication Number Publication Date
BR112021024787A2 true BR112021024787A2 (pt) 2022-05-03

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BR112021024787A BR112021024787A2 (pt) 2019-06-11 2020-06-10 Métodos para ativar uma via de sinalização wnt, para intensificar a regeneração de tecido e para facilitar a interação de um receptor fzd2 ou fzd7 e um correceptor wnt, molécula de ligação multivalente, e, composição farmacêutica

Country Status (11)

Country Link
US (1) US20220315659A1 (pt)
EP (1) EP3983443A4 (pt)
JP (1) JP7377288B2 (pt)
KR (1) KR20220024460A (pt)
CN (1) CN114423784A (pt)
AU (1) AU2020291208A1 (pt)
BR (1) BR112021024787A2 (pt)
CA (1) CA3140580A1 (pt)
IL (1) IL288730A (pt)
MX (1) MX2021015439A (pt)
WO (1) WO2020250156A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11993645B2 (en) 2017-01-11 2024-05-28 The Board Of Trustees Of The Leland Stanford Junior University Compositions comprising R-Spondin (RSPO) surrogate molecules
JP7305543B2 (ja) 2017-01-26 2023-07-10 スロゼン オペレーティング， インコーポレイテッド 組織特異的Ｗｎｔシグナル増強分子およびその使用
JP2023554500A (ja) * 2020-12-18 2023-12-27 アントラーエイ セラピューティクス インコーポレイテッド 四価ＦＺＤ及びＷＮＴコレセプター（ｃｏ－ｒｅｃｅｐｔｏｒ）結合抗体分子並びにその使用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2424567B1 (en) * 2009-04-27 2018-11-21 OncoMed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
EP2739651B1 (en) * 2011-08-05 2019-02-20 Genentech, Inc. Anti-polyubiquitin antibodies and methods of use
EP3033356B1 (en) * 2013-08-14 2020-01-15 Sachdev Sidhu Antibodies against frizzled proteins and methods of use thereof
US11142577B2 (en) * 2014-09-12 2021-10-12 The Board Of Trustees Of The Leland Stanford Junior University WNT signaling agonist molecules
JP7305543B2 (ja) * 2017-01-26 2023-07-10 スロゼン オペレーティング， インコーポレイテッド 組織特異的Ｗｎｔシグナル増強分子およびその使用
US11773171B2 (en) 2017-12-19 2023-10-03 Surrozen Operating, Inc. WNT surrogate molecules and uses thereof
CA3129736A1 (en) * 2018-02-14 2019-08-22 Antlera Therapeutics Inc. Multivalent binding molecules activating wnt signaling and uses thereof

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CA3140580A1 (en) 2020-12-17
MX2021015439A (es) 2022-03-11
EP3983443A1 (en) 2022-04-20
IL288730A (en) 2022-02-01
AU2020291208A1 (en) 2022-01-06
KR20220024460A (ko) 2022-03-03
WO2020250156A1 (en) 2020-12-17
JP7377288B2 (ja) 2023-11-09
EP3983443A4 (en) 2023-06-07
JP2022536142A (ja) 2022-08-12
US20220315659A1 (en) 2022-10-06
CN114423784A (zh) 2022-04-29

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