AR068997A1 - Anticuerpos contra el vegf completamente humano y sus metodos de uso - Google Patents
Anticuerpos contra el vegf completamente humano y sus metodos de usoInfo
- Publication number
- AR068997A1 AR068997A1 ARP080104609A ARP080104609A AR068997A1 AR 068997 A1 AR068997 A1 AR 068997A1 AR P080104609 A ARP080104609 A AR P080104609A AR P080104609 A ARP080104609 A AR P080104609A AR 068997 A1 AR068997 A1 AR 068997A1
- Authority
- AR
- Argentina
- Prior art keywords
- vegf
- human vegf
- methods
- antibodies against
- completely human
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
Abstract
Se presentan anticuerpos completamente humanos y fragmentos de unión al antígeno de estos que se unen específicamente al VEGF (factor de crecimiento endotelial vascular) humano e inhiben la unión del VEGF a los receptores VEGF-R1 y VEGF-R2, y en consecuencia inhiben la señalización del VEGF. Los anticuerpos y fragmentos de unión al antígeno revelados pueden utilizarse, por ejemplo, para tratar la angiogénesis y condiciones asociadas con la angiogénesis tanto in vivo como in vitro. Composición farmacéutica y complejo que comprende el anticuerpo antedicho, y VEGF humano.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US98180807P | 2007-10-22 | 2007-10-22 | |
US4637008P | 2008-04-18 | 2008-04-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR068997A1 true AR068997A1 (es) | 2009-12-23 |
Family
ID=40580334
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP080104609A AR068997A1 (es) | 2007-10-22 | 2008-10-22 | Anticuerpos contra el vegf completamente humano y sus metodos de uso |
Country Status (10)
Country | Link |
---|---|
US (1) | US8216571B2 (es) |
EP (1) | EP2212432A4 (es) |
JP (1) | JP2011500086A (es) |
CN (1) | CN101918579A (es) |
AR (1) | AR068997A1 (es) |
CA (1) | CA2702637A1 (es) |
MX (1) | MX2010004327A (es) |
PE (1) | PE20091196A1 (es) |
RU (1) | RU2010120674A (es) |
WO (1) | WO2009055343A2 (es) |
Families Citing this family (72)
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DE602006021142D1 (de) | 2005-02-03 | 2011-05-19 | Gen Hospital Corp | Verfahren zur behandlung von gefitinib-resistentem krebs |
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SMP200800060B (it) | 2006-04-07 | 2009-07-14 | Procter & Gamble | Anticorpi che legano la proteina umana tirosina fosfatasi beta (hptbeta) e loro usi |
BRPI0717431A2 (pt) * | 2006-09-29 | 2013-11-12 | Oncomed Pharm Inc | Composições e métodos de diagnóstico e tratamento do câncer |
JP2010507594A (ja) * | 2006-10-20 | 2010-03-11 | シェーリング コーポレイション | 完全ヒト抗vegf抗体および使用方法 |
US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
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PT2310011E (pt) | 2008-06-17 | 2013-10-07 | Wyeth Llc | Combinações antineoplásicas contendo hki-272 e vinorelbina |
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PT2326329T (pt) | 2008-08-04 | 2017-02-14 | Wyeth Llc | Combinações antineoplásicas de 4-anilino-3-cianoquinolinas e capecitabina |
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-
2008
- 2008-10-20 WO PCT/US2008/080531 patent/WO2009055343A2/en active Application Filing
- 2008-10-20 MX MX2010004327A patent/MX2010004327A/es not_active Application Discontinuation
- 2008-10-20 EP EP08841610A patent/EP2212432A4/en not_active Withdrawn
- 2008-10-20 JP JP2010531152A patent/JP2011500086A/ja not_active Withdrawn
- 2008-10-20 US US12/739,383 patent/US8216571B2/en not_active Expired - Fee Related
- 2008-10-20 RU RU2010120674/10A patent/RU2010120674A/ru not_active Application Discontinuation
- 2008-10-20 CN CN2008801222083A patent/CN101918579A/zh active Pending
- 2008-10-20 CA CA2702637A patent/CA2702637A1/en not_active Abandoned
- 2008-10-22 PE PE2008001814A patent/PE20091196A1/es not_active Application Discontinuation
- 2008-10-22 AR ARP080104609A patent/AR068997A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
US8216571B2 (en) | 2012-07-10 |
WO2009055343A2 (en) | 2009-04-30 |
US20110097340A1 (en) | 2011-04-28 |
WO2009055343A3 (en) | 2009-09-24 |
CA2702637A1 (en) | 2009-04-30 |
CN101918579A (zh) | 2010-12-15 |
EP2212432A2 (en) | 2010-08-04 |
RU2010120674A (ru) | 2011-11-27 |
PE20091196A1 (es) | 2009-08-10 |
JP2011500086A (ja) | 2011-01-06 |
MX2010004327A (es) | 2010-05-13 |
EP2212432A4 (en) | 2011-10-19 |
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