BR112021018788A2 - Células, tecidos e órgãos personalizados para transplante de um doador (não humano) humanizado, indivi-dualizado, designado livre de patógenos e métodos e produtos relacionados aos mesmos - Google Patents

Células, tecidos e órgãos personalizados para transplante de um doador (não humano) humanizado, indivi-dualizado, designado livre de patógenos e métodos e produtos relacionados aos mesmos

Info

Publication number
BR112021018788A2
BR112021018788A2 BR112021018788A BR112021018788A BR112021018788A2 BR 112021018788 A2 BR112021018788 A2 BR 112021018788A2 BR 112021018788 A BR112021018788 A BR 112021018788A BR 112021018788 A BR112021018788 A BR 112021018788A BR 112021018788 A2 BR112021018788 A2 BR 112021018788A2
Authority
BR
Brazil
Prior art keywords
human
transplantation
organs
tissues
humanized
Prior art date
Application number
BR112021018788A
Other languages
English (en)
Portuguese (pt)
Inventor
J Chang Elizabeth
Jon Adkins
W Holzer Paul
L Mon Roy Rodney
Original Assignee
Xenotherapeutics Corp
Xenotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/054833 external-priority patent/WO2020072982A1/en
Application filed by Xenotherapeutics Corp, Xenotherapeutics Inc filed Critical Xenotherapeutics Corp
Publication of BR112021018788A2 publication Critical patent/BR112021018788A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/108—Swine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/02—Animal zootechnically ameliorated
    • A01K2267/025—Animal producing cells or organs for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
BR112021018788A 2019-03-25 2020-03-25 Células, tecidos e órgãos personalizados para transplante de um doador (não humano) humanizado, indivi-dualizado, designado livre de patógenos e métodos e produtos relacionados aos mesmos BR112021018788A2 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962823455P 2019-03-25 2019-03-25
US201962848272P 2019-05-15 2019-05-15
PCT/US2019/054833 WO2020072982A1 (en) 2018-10-05 2019-10-04 Xenotransplantation products and methods
US202062964397P 2020-01-22 2020-01-22
US202062975611P 2020-02-12 2020-02-12
PCT/US2020/024780 WO2020198397A1 (en) 2019-03-25 2020-03-25 Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same

Publications (1)

Publication Number Publication Date
BR112021018788A2 true BR112021018788A2 (pt) 2021-11-23

Family

ID=72609069

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021018788A BR112021018788A2 (pt) 2019-03-25 2020-03-25 Células, tecidos e órgãos personalizados para transplante de um doador (não humano) humanizado, indivi-dualizado, designado livre de patógenos e métodos e produtos relacionados aos mesmos

Country Status (10)

Country Link
EP (1) EP3945799A1 (de)
JP (1) JP2022527061A (de)
KR (1) KR20220004029A (de)
CN (1) CN113784615A (de)
AU (1) AU2020244827A1 (de)
BR (1) BR112021018788A2 (de)
CA (1) CA3133638A1 (de)
IL (1) IL286538A (de)
MX (1) MX2021011709A (de)
WO (1) WO2020198397A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3189986A1 (en) * 2020-08-24 2022-03-03 Xenotherapeutics, Inc. Immunologically compatible cells, tissues, organs, and methods for transplantation for silencing, humanization, and personalization with minimized collateral genomic disruptions
WO2022133155A1 (en) * 2020-12-16 2022-06-23 Xenotherapeutics, Inc. Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs
EP4347035A1 (de) * 2021-06-01 2024-04-10 University of Massachusetts Cas9-nickase-vermittelte geneditierung
WO2022256401A1 (en) * 2021-06-01 2022-12-08 Xenotherapeutics, Inc. Xenogeneic nerve transplants and methods
CN114574557B (zh) * 2022-05-09 2022-09-09 上海美迪西生物医药股份有限公司 Nk细胞治疗产品通用型临床前生物分布检测试剂盒
CN115236078A (zh) * 2022-07-12 2022-10-25 黑龙江省农业科学院食品加工研究所 一种加工稻米留皮度的测定方法

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
IL120909A0 (en) 1997-05-26 1997-09-30 Lrr & D Ltd Compositions and means for the treatment of burns and other cutaneous traumas
AU5575899A (en) 1998-08-20 2000-03-14 Biotransplant Incorporated Inbred mhc-homozygous miniature swine and uses thereof
IL137689A0 (en) 2000-08-03 2001-10-31 L R Res & Dev Ltd System for enhanced chemical debridement
JP2005514016A (ja) 2001-12-21 2005-05-19 ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ ノックアウトブタ及びその製造方法
WO2003090598A2 (en) 2002-04-23 2003-11-06 Mediwound, Ltd. Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome
AU2003265415A1 (en) 2002-08-14 2004-03-03 Immerge Biotherapeutics, Inc. Alpha(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND Alpha(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
US8106251B2 (en) 2002-08-21 2012-01-31 Revivicor, Inc. Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
EP1534819B1 (de) 2002-08-21 2009-12-09 Revivicor, Inc. Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferase
EP2292257A3 (de) 2004-07-13 2011-06-22 Mediwound, Ltd. Zusammensetzungen und verfahren zur heilung von hautwunden
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
MX2011003557A (es) 2008-10-02 2011-09-01 Lrr & D Ltd Vendas para heridas con capa de interfaz.
WO2013169929A1 (en) 2012-05-08 2013-11-14 The General Hospital Corporation Reducing immunogenicity of xenogeneic transplant tissues
KR102380245B1 (ko) 2013-11-07 2022-03-30 에디타스 메디신, 인코포레이티드 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
CN107106607A (zh) 2014-10-22 2017-08-29 印第安纳大学研究与技术公司 适用于异种移植的三重转基因猪
US11284607B2 (en) 2015-03-24 2022-03-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
EP3313176A4 (de) * 2015-06-26 2019-06-26 Indiana University Research&technology Corporation Transgene schweine mit genetischen modifikationen von sla
WO2017044864A1 (en) * 2015-09-09 2017-03-16 Revivicor, Inc Multi-transgenic pig for xenotransplantation
WO2019006330A1 (en) * 2017-06-30 2019-01-03 Indiana University Research And Technology Corporation COMPOSITIONS AND METHODS FOR DETECTING REACTIVITY TO ALS

Also Published As

Publication number Publication date
CN113784615A (zh) 2021-12-10
WO2020198397A1 (en) 2020-10-01
CA3133638A1 (en) 2020-10-01
IL286538A (en) 2021-12-01
EP3945799A1 (de) 2022-02-09
KR20220004029A (ko) 2022-01-11
JP2022527061A (ja) 2022-05-30
MX2021011709A (es) 2022-01-06
AU2020244827A1 (en) 2021-09-30

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: XENOTHERAPEUTICS INC. (US) ; ALEXIS BIO, INC. (US)

B25G Requested change of headquarter approved

Owner name: XENOTHERAPEUTICS INC. (US) ; ALEXIS BIO, INC. (US)