KR20220004029A - 인간화된, 맞춤형, 지정된-병원체 유리, (비-인간) 공여체로부터 이식을 위한 개인화된 세포, 조직 및 장기 및 이와 관련된 방법 및 생성물 - Google Patents

인간화된, 맞춤형, 지정된-병원체 유리, (비-인간) 공여체로부터 이식을 위한 개인화된 세포, 조직 및 장기 및 이와 관련된 방법 및 생성물 Download PDF

Info

Publication number
KR20220004029A
KR20220004029A KR1020217033604A KR20217033604A KR20220004029A KR 20220004029 A KR20220004029 A KR 20220004029A KR 1020217033604 A KR1020217033604 A KR 1020217033604A KR 20217033604 A KR20217033604 A KR 20217033604A KR 20220004029 A KR20220004029 A KR 20220004029A
Authority
KR
South Korea
Prior art keywords
sla
reprogrammed
human
wild
porcine
Prior art date
Application number
KR1020217033604A
Other languages
English (en)
Korean (ko)
Inventor
폴 더블유. 홀저
존 애드킨스
로드니 엘. 몬 로이
엘리자베스 제이. 창
Original Assignee
제노세라퓨틱스, 인코포레이티드
제노세라퓨틱스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2019/054833 external-priority patent/WO2020072982A1/en
Application filed by 제노세라퓨틱스, 인코포레이티드, 제노세라퓨틱스 코포레이션 filed Critical 제노세라퓨틱스, 인코포레이티드
Publication of KR20220004029A publication Critical patent/KR20220004029A/ko

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0271Chimeric vertebrates, e.g. comprising exogenous cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004Oxidoreductases (1.)
    • C12N9/0071Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1048Glycosyltransferases (2.4)
    • C12N9/1051Hexosyltransferases (2.4.1)
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00Animals characterised by species
    • A01K2227/10Mammal
    • A01K2227/108Swine
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/02Animal zootechnically ameliorated
    • A01K2267/025Animal producing cells or organs for transplantation

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Animal Husbandry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
KR1020217033604A 2019-03-25 2020-03-25 인간화된, 맞춤형, 지정된-병원체 유리, (비-인간) 공여체로부터 이식을 위한 개인화된 세포, 조직 및 장기 및 이와 관련된 방법 및 생성물 KR20220004029A (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201962823455P 2019-03-25 2019-03-25
US62/823,455 2019-03-25
US201962848272P 2019-05-15 2019-05-15
US62/848,272 2019-05-15
PCT/US2019/054833 WO2020072982A1 (en) 2018-10-05 2019-10-04 Xenotransplantation products and methods
USPCT/US2019/054833 2019-10-04
US202062964397P 2020-01-22 2020-01-22
US62/964,397 2020-01-22
US202062975611P 2020-02-12 2020-02-12
US62/975,611 2020-02-12
PCT/US2020/024780 WO2020198397A1 (en) 2019-03-25 2020-03-25 Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non- human) donor and methods and products relating to same

Publications (1)

Publication Number Publication Date
KR20220004029A true KR20220004029A (ko) 2022-01-11

Family

ID=72609069

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020217033604A KR20220004029A (ko) 2019-03-25 2020-03-25 인간화된, 맞춤형, 지정된-병원체 유리, (비-인간) 공여체로부터 이식을 위한 개인화된 세포, 조직 및 장기 및 이와 관련된 방법 및 생성물

Country Status (10)

Country Link
EP (1) EP3945799A1 (de)
JP (1) JP2022527061A (de)
KR (1) KR20220004029A (de)
CN (1) CN113784615A (de)
AU (1) AU2020244827A1 (de)
BR (1) BR112021018788A2 (de)
CA (1) CA3133638A1 (de)
IL (1) IL286538A (de)
MX (1) MX2021011709A (de)
WO (1) WO2020198397A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3189986A1 (en) * 2020-08-24 2022-03-03 Xenotherapeutics, Inc. Immunologically compatible cells, tissues, organs, and methods for transplantation for silencing, humanization, and personalization with minimized collateral genomic disruptions
WO2022133155A1 (en) * 2020-12-16 2022-06-23 Xenotherapeutics, Inc. Humanization of beta2-microglobulin in porcine genome resulting in functional expression of human βeta2-microglobulin within donor cells, tissues, or organs
EP4347035A1 (de) * 2021-06-01 2024-04-10 University of Massachusetts Cas9-nickase-vermittelte geneditierung
WO2022256401A1 (en) * 2021-06-01 2022-12-08 Xenotherapeutics, Inc. Xenogeneic nerve transplants and methods
CN114574557B (zh) * 2022-05-09 2022-09-09 上海美迪西生物医药股份有限公司 Nk细胞治疗产品通用型临床前生物分布检测试剂盒
CN115236078A (zh) * 2022-07-12 2022-10-25 黑龙江省农业科学院食品加工研究所 一种加工稻米留皮度的测定方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL120909A0 (en) 1997-05-26 1997-09-30 Lrr & D Ltd Compositions and means for the treatment of burns and other cutaneous traumas
AU5575899A (en) 1998-08-20 2000-03-14 Biotransplant Incorporated Inbred mhc-homozygous miniature swine and uses thereof
IL137689A0 (en) 2000-08-03 2001-10-31 L R Res & Dev Ltd System for enhanced chemical debridement
JP2005514016A (ja) 2001-12-21 2005-05-19 ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ ノックアウトブタ及びその製造方法
WO2003090598A2 (en) 2002-04-23 2003-11-06 Mediwound, Ltd. Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome
AU2003265415A1 (en) 2002-08-14 2004-03-03 Immerge Biotherapeutics, Inc. Alpha(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND Alpha(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
US8106251B2 (en) 2002-08-21 2012-01-31 Revivicor, Inc. Tissue products derived from porcine animals lacking any expression of functional alpha 1,3 galactosyltransferase
EP1534819B1 (de) 2002-08-21 2009-12-09 Revivicor, Inc. Schweine ohne jegliche expression funktioneller alpha-1,3-galactosyltransferase
EP2292257A3 (de) 2004-07-13 2011-06-22 Mediwound, Ltd. Zusammensetzungen und verfahren zur heilung von hautwunden
IL165334A0 (en) 2004-11-22 2006-01-15 Mediwound Ltd Debriding composition from bromelain and methods of producing same
MX2011003557A (es) 2008-10-02 2011-09-01 Lrr & D Ltd Vendas para heridas con capa de interfaz.
WO2013169929A1 (en) 2012-05-08 2013-11-14 The General Hospital Corporation Reducing immunogenicity of xenogeneic transplant tissues
KR102380245B1 (ko) 2013-11-07 2022-03-30 에디타스 메디신, 인코포레이티드 지배적인 gRNA를 이용하는 CRISPR-관련 방법 및 조성물
CN107106607A (zh) 2014-10-22 2017-08-29 印第安纳大学研究与技术公司 适用于异种移植的三重转基因猪
US11284607B2 (en) 2015-03-24 2022-03-29 The Trustees Of Columbia University In The City Of New York Genetic modification of pigs for xenotransplantation
EP3313176A4 (de) * 2015-06-26 2019-06-26 Indiana University Research&technology Corporation Transgene schweine mit genetischen modifikationen von sla
WO2017044864A1 (en) * 2015-09-09 2017-03-16 Revivicor, Inc Multi-transgenic pig for xenotransplantation
WO2019006330A1 (en) * 2017-06-30 2019-01-03 Indiana University Research And Technology Corporation COMPOSITIONS AND METHODS FOR DETECTING REACTIVITY TO ALS

Also Published As

Publication number Publication date
CN113784615A (zh) 2021-12-10
WO2020198397A1 (en) 2020-10-01
CA3133638A1 (en) 2020-10-01
IL286538A (en) 2021-12-01
EP3945799A1 (de) 2022-02-09
JP2022527061A (ja) 2022-05-30
BR112021018788A2 (pt) 2021-11-23
MX2021011709A (es) 2022-01-06
AU2020244827A1 (en) 2021-09-30

Similar Documents

Publication Publication Date Title
KR20220004029A (ko) 인간화된, 맞춤형, 지정된-병원체 유리, (비-인간) 공여체로부터 이식을 위한 개인화된 세포, 조직 및 장기 및 이와 관련된 방법 및 생성물
JP7431837B2 (ja) 異種移植製品及び異種移植方法
US20220406409A1 (en) Selection and Monitoring Methods for Xenotransplantation
US20230078894A1 (en) Personalized cells, tissues, and organs for transplantation from a humanized, bespoke, designated-pathogen free, (non-human) donor and methods and products relating to same
US20240075186A1 (en) Xenotransplantation products and methods
US20230323400A1 (en) Immunologically compatible cells, tissues, organs, and methods for transplantation for silencing, humanization, and personalization with minimized collateral genomic disruptions