BR112021006940A2 - compostos - Google Patents

compostos Download PDF

Info

Publication number
BR112021006940A2
BR112021006940A2 BR112021006940-2A BR112021006940A BR112021006940A2 BR 112021006940 A2 BR112021006940 A2 BR 112021006940A2 BR 112021006940 A BR112021006940 A BR 112021006940A BR 112021006940 A2 BR112021006940 A2 BR 112021006940A2
Authority
BR
Brazil
Prior art keywords
disorders
benzofuran
dione
imidazolidine
cyclopropane
Prior art date
Application number
BR112021006940-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Giuseppe Alvaro
Agostino Marasco
Original Assignee
Autifony Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autifony Therapeutics Limited filed Critical Autifony Therapeutics Limited
Publication of BR112021006940A2 publication Critical patent/BR112021006940A2/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR112021006940-2A 2018-10-16 2019-10-16 compostos BR112021006940A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP18200626 2018-10-16
EP18200626.2 2018-10-16
PCT/GB2019/052937 WO2020079422A1 (en) 2018-10-16 2019-10-16 Novel compounds

Publications (1)

Publication Number Publication Date
BR112021006940A2 true BR112021006940A2 (pt) 2021-07-13

Family

ID=63878368

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021006940-2A BR112021006940A2 (pt) 2018-10-16 2019-10-16 compostos

Country Status (20)

Country Link
EP (1) EP3867247B1 (https=)
JP (1) JP7465868B2 (https=)
KR (1) KR102854594B1 (https=)
AR (1) AR116713A1 (https=)
AU (1) AU2019360017B9 (https=)
BR (1) BR112021006940A2 (https=)
DK (1) DK3867247T3 (https=)
ES (1) ES2988842T3 (https=)
FI (1) FI3867247T3 (https=)
HR (1) HRP20241318T1 (https=)
HU (1) HUE068686T2 (https=)
IL (1) IL282096B2 (https=)
LT (1) LT3867247T (https=)
MX (1) MX2021004386A (https=)
PL (1) PL3867247T3 (https=)
PT (1) PT3867247T (https=)
SI (1) SI3867247T1 (https=)
TW (1) TWI827706B (https=)
WO (1) WO2020079422A1 (https=)
ZA (1) ZA202101487B (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12358901B2 (en) 2018-10-16 2025-07-15 Autifony Therapeutics Limited KV3 modulators
JP7522203B2 (ja) * 2020-02-06 2024-07-24 アウトイフオンイ トヘラペウトイクス リミテッド Kv3モジュレーター
CA3228446A1 (en) 2021-08-09 2023-02-16 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators for use in autism spectrum disorders
US20240327406A1 (en) 2021-08-10 2024-10-03 Autifony Therapeutics Limited Potassium channel modulators
EP4630117A1 (en) 2022-12-06 2025-10-15 Autifony Therapeutics Limited Compounds for the treatment of centra nervous system disorders

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5788404B2 (ja) 2009-12-11 2015-09-30 アウトイフオンイ トヘラペウトイクス リミテッド イミダゾリジンジオン誘導体
EP2649066B1 (en) 2010-12-06 2015-10-21 Autifony Therapeutics Limited Hydantoin derivatives useful as kv3 inhibitors
US9193704B2 (en) 2011-06-07 2015-11-24 Autifony Therapeutics Limited Hydantoin derivatives as KV3 inhibitors
GB201209986D0 (en) 2012-06-06 2012-07-18 Autifony Therapeutics Ltd Novel compounds
AU2012349847B2 (en) 2011-12-06 2017-02-16 Autifony Therapeutics Limited Hydantoin derivatives useful as Kv3 inhibitors
EP2852588B8 (en) 2012-05-22 2018-01-10 Autifony Therapeutics Limited Hydantoin derivatives as kv3 inhibitors
US9422252B2 (en) 2012-05-22 2016-08-23 Autifony Therapeutics Limited Triazoles as Kv3 inhibitors
WO2013182851A1 (en) 2012-06-06 2013-12-12 Autifony Therapeutics Limited Prophylaxis or treatment of diseases where a modulator of kv3.3 channels is required
GB201521751D0 (en) 2015-12-10 2016-01-27 Autifony Therapeutics Ltd Novel uses
GB201522179D0 (en) 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
GB201613163D0 (en) 2016-07-29 2016-09-14 Autifony Therapeutics Ltd Novel compounds
WO2018109484A1 (en) 2016-12-16 2018-06-21 Autifony Therapeutics Limited Hydantoin modulators of kv3 channels

Also Published As

Publication number Publication date
DK3867247T3 (da) 2024-09-16
AU2019360017A1 (en) 2021-04-01
ZA202101487B (en) 2024-05-30
PT3867247T (pt) 2024-09-17
AR116713A1 (es) 2021-06-02
JP7465868B2 (ja) 2024-04-11
KR20210076081A (ko) 2021-06-23
EP3867247B1 (en) 2024-07-24
FI3867247T3 (fi) 2024-10-30
IL282096B2 (en) 2024-07-01
TW202035394A (zh) 2020-10-01
HRP20241318T1 (hr) 2024-12-20
AU2019360017B9 (en) 2025-03-27
IL282096A (en) 2021-05-31
PL3867247T3 (pl) 2024-12-09
JP2022505143A (ja) 2022-01-14
IL282096B1 (en) 2024-03-01
HUE068686T2 (hu) 2025-01-28
AU2019360017B2 (en) 2025-03-06
EP3867247A1 (en) 2021-08-25
SI3867247T1 (sl) 2024-11-29
TWI827706B (zh) 2024-01-01
MX2021004386A (es) 2021-06-04
ES2988842T3 (es) 2024-11-21
KR102854594B1 (ko) 2025-09-02
WO2020079422A1 (en) 2020-04-23
LT3867247T (lt) 2024-11-11

Similar Documents

Publication Publication Date Title
BR112021006940A2 (pt) compostos
CN103596943B (zh) 用作kv3抑制剂的乙内酰脲衍生物
CA2856654C (en) Hydantoin derivatives useful as kv3 inhibitors
JP2019502696A (ja) Kv3チャネルのヒダントインモジュレーター
EP3555073A1 (en) Hydantoin modulators of kv3 channels
JP7522203B2 (ja) Kv3モジュレーター
WO2023017263A1 (en) Potassium channel modulators
RU2830279C2 (ru) Новые соединения
US12358901B2 (en) KV3 modulators
HK40059039A (en) Novel compounds
HK40059039B (en) Novel compounds
CA3169057C (en) Kv3 modulators
EA049235B1 (ru) Модуляторы kv3
HK40081003A (en) Kv3 modulators
HK40081003B (zh) Kv3调节剂
BR112014013400B1 (pt) Compostos derivados de hidantoína úteis como inibidores de kv3 e seus usos na profilaxia ou tratamento de distúrbios auditivos e esquizofrenia ou no tratamento de síndrome do x frágil

Legal Events

Date Code Title Description
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]