BR112021004553A2 - anticorpos anti-klrg1 - Google Patents
anticorpos anti-klrg1 Download PDFInfo
- Publication number
- BR112021004553A2 BR112021004553A2 BR112021004553-8A BR112021004553A BR112021004553A2 BR 112021004553 A2 BR112021004553 A2 BR 112021004553A2 BR 112021004553 A BR112021004553 A BR 112021004553A BR 112021004553 A2 BR112021004553 A2 BR 112021004553A2
- Authority
- BR
- Brazil
- Prior art keywords
- seq
- antibody
- abc
- klrg1
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862732329P | 2018-09-17 | 2018-09-17 | |
| US62/732,329 | 2018-09-17 | ||
| PCT/US2019/050110 WO2020060781A1 (en) | 2018-09-17 | 2019-09-06 | Anti-klrg1 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112021004553A2 true BR112021004553A2 (pt) | 2021-06-08 |
Family
ID=69887899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112021004553-8A BR112021004553A2 (pt) | 2018-09-17 | 2019-09-06 | anticorpos anti-klrg1 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12365735B2 (https=) |
| EP (1) | EP3852779A4 (https=) |
| JP (2) | JP7654548B2 (https=) |
| KR (1) | KR102934267B1 (https=) |
| CN (2) | CN112752580B (https=) |
| AU (1) | AU2019344524A1 (https=) |
| BR (1) | BR112021004553A2 (https=) |
| CA (1) | CA3113069A1 (https=) |
| EA (1) | EA202190647A1 (https=) |
| IL (2) | IL281594B2 (https=) |
| MX (2) | MX2021003119A (https=) |
| SG (1) | SG11202102114UA (https=) |
| WO (1) | WO2020060781A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112021004553A2 (pt) | 2018-09-17 | 2021-06-08 | Abcuro, Inc. | anticorpos anti-klrg1 |
| WO2022056289A1 (en) * | 2020-09-11 | 2022-03-17 | National Jewish Health | Methods and compositions for treating respiratory diseases or conditions related to innate lymphoid cells |
| WO2022204529A1 (en) | 2021-03-26 | 2022-09-29 | Abcuro, Inc. | Anti-klrg1 antibodies |
| CA3212311A1 (en) * | 2021-03-26 | 2022-09-29 | Abcuro, Inc. | Anti-klrg1 antibodies |
| WO2024072872A2 (en) * | 2022-09-27 | 2024-04-04 | The Brigham And Women's Hospital, Inc. | Klrg1 signalling therapy for infectious disease |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| TWI380996B (zh) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | 抗ｏｘ４０ｌ抗體 |
| WO2006047350A2 (en) | 2004-10-21 | 2006-05-04 | Xencor, Inc. | IgG IMMUNOGLOBULIN VARIANTS WITH OPTIMIZED EFFECTOR FUNCTION |
| AU2005335714B2 (en) | 2004-11-10 | 2012-07-26 | Macrogenics, Inc. | Engineering Fc antibody regions to confer effector function |
| AU2005304624B2 (en) | 2004-11-12 | 2010-10-07 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| EP1858925A2 (en) | 2005-01-12 | 2007-11-28 | Xencor, Inc. | Antibodies and fc fusion proteins with altered immunogenicity |
| KR101523391B1 (ko) | 2006-12-27 | 2015-05-27 | 에모리 유니버시티 | 감염 및 종양 치료를 위한 조성물 및 방법 |
| KR20160070165A (ko) | 2008-02-08 | 2016-06-17 | 메디뮨 엘엘씨 | Ｆｃ 리간드 친화성이 감소된 항-ＩＦＮＡＲ１ 항체 |
| WO2011016238A1 (en) | 2009-08-06 | 2011-02-10 | Immunas Pharma, Inc. | Antibodies that specifically bind to a beta oligomers and use thereof |
| US10053513B2 (en) | 2009-11-30 | 2018-08-21 | Janssen Biotech, Inc. | Antibody Fc mutants with ablated effector functions |
| SG188285A1 (en) * | 2010-09-02 | 2013-04-30 | Vaccinex Inc | Anti-cxcl13 antibodies and methods of using the same |
| ES2692268T5 (en) | 2011-03-29 | 2025-02-26 | Roche Glycart Ag | Antibody fc variants |
| JP6152090B2 (ja) | 2011-04-21 | 2017-06-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 視神経脊髄炎を処置するための組成物および方法 |
| DK3424953T3 (en) | 2011-06-06 | 2020-11-02 | Novo Nordisk As | Terapeutiske antistoffer |
| JPWO2012176765A1 (ja) | 2011-06-24 | 2015-02-23 | 株式会社ペルセウスプロテオミクス | 抗ヒトｐ−カドへリン（ｃｄｈ３）遺伝子組み換え抗体 |
| WO2014177459A2 (en) | 2013-04-29 | 2014-11-06 | F. Hoffmann-La Roche Ag | Fc-receptor binding modified asymmetric antibodies and methods of use |
| JP2017518958A (ja) | 2014-03-19 | 2017-07-13 | マッカイ メディカル ファウンデイション ザ プレスビテリアン チャーチ イン タイワン マッカイ メモリアル ホスピタルＭａｃｋａｙ Ｍｅｄｉｃａｌ Ｆｏｕｎｄａｔｉｏｎ Ｔｈｅ Ｐｒｅｓｂｙｔｅｒｉａｎ Ｃｈｕｒｃｈ Ｉｎ Ｔａｉｗａｎ Ｍａｃｋａｙ Ｍｅｍｏｒｉａｌ Ｈｏｓｐｉｔａｌ | 免疫原性グリコペプチドに対する抗体、それを含む組成物、及びそれらの使用 |
| WO2016009487A1 (ja) | 2014-07-14 | 2016-01-21 | 三菱電機株式会社 | 空気調和装置 |
| HUE068868T2 (hu) | 2015-07-30 | 2025-02-28 | Macrogenics Inc | PD-1-hez kötõdõ molekulák és alkalmazásukra szolgáló eljárások |
| WO2017053469A2 (en) | 2015-09-21 | 2017-03-30 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
| AU2016334623A1 (en) | 2015-10-07 | 2018-02-15 | F. Hoffmann-La Roche Ag | Bispecific antibodies with tetravalency for a costimulatory TNF receptor |
| KR20250057128A (ko) | 2015-12-30 | 2025-04-28 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
| WO2017152102A2 (en) | 2016-03-04 | 2017-09-08 | Alector Llc | Anti-trem1 antibodies and methods of use thereof |
| JP2019518791A (ja) | 2016-06-03 | 2019-07-04 | ザ・ブリガム・アンド・ウィメンズ・ホスピタルＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ | Ｋｌｒｇ１シグナリングセラピー |
| AU2017326003A1 (en) | 2016-09-16 | 2019-04-11 | Children's Medical Center Corporation | KLRG1 depletion therapy |
| US20190336615A1 (en) | 2017-01-27 | 2019-11-07 | Silverback Therapeutics, Inc. | Tumor targeting conjugates and methods of use thereof |
| CA3059938A1 (en) | 2017-04-14 | 2018-10-18 | Kodiak Sciences Inc. | Complement factor d antagonist antibodies and conjugates thereof |
| CN111093702A (zh) | 2017-06-22 | 2020-05-01 | 财团法人生物技术开发中心 | 靶细胞依赖性T细胞的接合和活化型不对称异二聚Fc-ScFv融合抗体形式用于癌症治疗 |
| WO2019169229A1 (en) | 2018-03-01 | 2019-09-06 | Nextcure, Inc. | Klrg1 binding compositions and methods of use thereof |
| BR112021004553A2 (pt) | 2018-09-17 | 2021-06-08 | Abcuro, Inc. | anticorpos anti-klrg1 |
| AU2020272939A1 (en) | 2019-04-09 | 2021-11-11 | Abcuro, Inc. | Killer cell lectin-like receptor subfamily G member 1 (KLRG1) depleting antibodies |
| CA3212311A1 (en) | 2021-03-26 | 2022-09-29 | Abcuro, Inc. | Anti-klrg1 antibodies |
-
2019
- 2019-09-06 BR BR112021004553-8A patent/BR112021004553A2/pt unknown
- 2019-09-06 CN CN201980060735.4A patent/CN112752580B/zh active Active
- 2019-09-06 CA CA3113069A patent/CA3113069A1/en active Pending
- 2019-09-06 EP EP19862063.5A patent/EP3852779A4/en active Pending
- 2019-09-06 US US17/285,793 patent/US12365735B2/en active Active
- 2019-09-06 EA EA202190647A patent/EA202190647A1/ru unknown
- 2019-09-06 IL IL281594A patent/IL281594B2/en unknown
- 2019-09-06 AU AU2019344524A patent/AU2019344524A1/en active Pending
- 2019-09-06 JP JP2021539334A patent/JP7654548B2/ja active Active
- 2019-09-06 MX MX2021003119A patent/MX2021003119A/es unknown
- 2019-09-06 KR KR1020217008068A patent/KR102934267B1/ko active Active
- 2019-09-06 WO PCT/US2019/050110 patent/WO2020060781A1/en not_active Ceased
- 2019-09-06 SG SG11202102114UA patent/SG11202102114UA/en unknown
- 2019-09-06 CN CN202411978380.6A patent/CN119638835A/zh active Pending
-
2021
- 2021-03-16 MX MX2025008993A patent/MX2025008993A/es unknown
-
2024
- 2024-08-02 JP JP2024127876A patent/JP2024156878A/ja active Pending
-
2025
- 2025-09-04 IL IL323170A patent/IL323170A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL281594B2 (en) | 2026-02-01 |
| MX2025008993A (es) | 2025-09-02 |
| JP2022501065A (ja) | 2022-01-06 |
| AU2019344524A1 (en) | 2021-03-25 |
| CN119638835A (zh) | 2025-03-18 |
| MX2021003119A (es) | 2021-05-14 |
| IL281594A (en) | 2021-05-31 |
| KR20210060477A (ko) | 2021-05-26 |
| SG11202102114UA (en) | 2021-04-29 |
| EP3852779A1 (en) | 2021-07-28 |
| US20210347899A1 (en) | 2021-11-11 |
| JP2024156878A (ja) | 2024-11-06 |
| CN112752580B (zh) | 2024-12-13 |
| US12365735B2 (en) | 2025-07-22 |
| IL323170A (en) | 2025-11-01 |
| EA202190647A1 (ru) | 2021-09-09 |
| CA3113069A1 (en) | 2020-03-26 |
| EP3852779A4 (en) | 2022-06-08 |
| WO2020060781A1 (en) | 2020-03-26 |
| CN112752580A (zh) | 2021-05-04 |
| JP7654548B2 (ja) | 2025-04-01 |
| IL281594B1 (en) | 2025-10-01 |
| KR102934267B1 (ko) | 2026-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4511943B2 (ja) | Ｐｄ−１に対する抗体およびその使用 | |
| CN113474362B (zh) | 对cd44特异性的抗体 | |
| US12365735B2 (en) | Anti-KLRG1 antibodies | |
| TW202132347A (zh) | 針對cd3和bcma的抗體和自其製備的雙特異性結合蛋白 | |
| CN113423736A (zh) | 对muc18特异性的抗体 | |
| BR112020022371A2 (pt) | anticorpos de alta afinidade para pd-1 e lag-3 e proteínas de ligação biespecífica produzidas a partir dos mesmos | |
| WO2015166105A2 (en) | Ion channel modulators and uses thereof | |
| CN113423830A (zh) | 对muc18特异性的抗体 | |
| TW202337908A (zh) | 抗b7-h7抗體或其抗原結合片段及製備方法與應用 | |
| CN114456259B (zh) | 一种抗新冠病毒的抗体及其制备方法和应用 | |
| US20260125479A1 (en) | Anti-klrg1 antibodies | |
| EA049153B1 (ru) | Антитела к klrg1 | |
| TWI843182B (zh) | 一種抗b7-h4抗體及其製備方法和應用 | |
| HK40125826A (zh) | 抗l1cam抗体及其用途 | |
| HK40067877A (en) | Antibodies to cd3 and bcma, and bispecific binding proteins made therefrom | |
| BR122025002178A2 (pt) | Anticorpos para cd3 e bcma, e proteínas de ligação biespecíficas feitas a partir dos mesmos | |
| HK40060753A (en) | Antibodies specific to muc18 | |
| HK40061374A (en) | Antibodies specific to cd44 | |
| CN115724969A (zh) | Lag-3结合分子及其应用 | |
| HK40060752A (en) | Antibodies specific to muc18 | |
| HK40061374B (zh) | 对cd44特异性的抗体 | |
| HK40060752B (en) | Antibodies specific to muc18 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25G | Requested change of headquarter approved |
Owner name: ABCURO, INC. (US) |
|
| B25A | Requested transfer of rights approved |
Owner name: THE BRIGHAM AND WOMEN S HOSPITAL, INC. (US) |
|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] |