BR112021001012A2 - compostos de sulfonilureia como inibidores da atividade de interleucina-1 - Google Patents

compostos de sulfonilureia como inibidores da atividade de interleucina-1 Download PDF

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Publication number
BR112021001012A2
BR112021001012A2 BR112021001012-2A BR112021001012A BR112021001012A2 BR 112021001012 A2 BR112021001012 A2 BR 112021001012A2 BR 112021001012 A BR112021001012 A BR 112021001012A BR 112021001012 A2 BR112021001012 A2 BR 112021001012A2
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BR
Brazil
Prior art keywords
c6alkyl
pharmaceutically acceptable
dihydro
pyrazolo
oxazine
Prior art date
Application number
BR112021001012-2A
Other languages
English (en)
Portuguese (pt)
Inventor
Jeffrey A. Stafford
James M. Veal
Lynnie Lin TRZOSS
Christopher McBride
Richard M. Pastor
Steven Thomas Staben
Craig Stivala
Matthew Volgraf
Original Assignee
F. Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by F. Hoffmann-La Roche Ag filed Critical F. Hoffmann-La Roche Ag
Publication of BR112021001012A2 publication Critical patent/BR112021001012A2/pt

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BR112021001012-2A 2018-07-20 2019-07-19 compostos de sulfonilureia como inibidores da atividade de interleucina-1 BR112021001012A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862701358P 2018-07-20 2018-07-20
US62/701,358 2018-07-20
PCT/US2019/042703 WO2020018970A1 (en) 2018-07-20 2019-07-19 Sulfonylurea compounds as inhibitors of interleukin-1 activity

Publications (1)

Publication Number Publication Date
BR112021001012A2 true BR112021001012A2 (pt) 2021-04-20

Family

ID=67515207

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021001012-2A BR112021001012A2 (pt) 2018-07-20 2019-07-19 compostos de sulfonilureia como inibidores da atividade de interleucina-1

Country Status (20)

Country Link
US (1) US11560391B2 (https=)
EP (1) EP3823726A1 (https=)
JP (1) JP7411631B2 (https=)
KR (1) KR20210034588A (https=)
CN (1) CN112437683A (https=)
AR (1) AR117617A1 (https=)
AU (1) AU2019305095A1 (https=)
BR (1) BR112021001012A2 (https=)
CA (1) CA3104199A1 (https=)
CL (1) CL2021000152A1 (https=)
CO (1) CO2021000817A2 (https=)
CR (1) CR20210024A (https=)
IL (1) IL280139A (https=)
MA (1) MA53170A (https=)
MX (1) MX2021000660A (https=)
PE (1) PE20211049A1 (https=)
PH (1) PH12020552155A1 (https=)
SG (1) SG11202012159TA (https=)
TW (1) TW202019937A (https=)
WO (1) WO2020018970A1 (https=)

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Also Published As

Publication number Publication date
US20210261568A1 (en) 2021-08-26
AR117617A1 (es) 2021-08-18
WO2020018970A1 (en) 2020-01-23
MA53170A (fr) 2021-05-26
MX2021000660A (es) 2021-03-25
EP3823726A1 (en) 2021-05-26
JP7411631B2 (ja) 2024-01-11
CR20210024A (es) 2021-02-22
PH12020552155A1 (en) 2021-07-05
CN112437683A (zh) 2021-03-02
TW202019937A (zh) 2020-06-01
CO2021000817A2 (es) 2021-02-17
KR20210034588A (ko) 2021-03-30
CA3104199A1 (en) 2020-01-23
PE20211049A1 (es) 2021-06-04
CL2021000152A1 (es) 2021-07-09
IL280139A (en) 2021-03-01
SG11202012159TA (en) 2021-01-28
US11560391B2 (en) 2023-01-24
AU2019305095A1 (en) 2020-12-17
JP2021530536A (ja) 2021-11-11

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]