BR112020024551A2 - métodos para usar moduladores de splicing - Google Patents

métodos para usar moduladores de splicing Download PDF

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Publication number
BR112020024551A2
BR112020024551A2 BR112020024551-8A BR112020024551A BR112020024551A2 BR 112020024551 A2 BR112020024551 A2 BR 112020024551A2 BR 112020024551 A BR112020024551 A BR 112020024551A BR 112020024551 A2 BR112020024551 A2 BR 112020024551A2
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BR
Brazil
Prior art keywords
pharmaceutically acceptable
neoantigen
compound
acceptable salt
fact
Prior art date
Application number
BR112020024551-8A
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English (en)
Portuguese (pt)
Inventor
Ermira Pazolli
Silvia Buonamici
James Palacino
Michael Seiler
Ping Zhu
Evan Barry
Lihua Yu
Original Assignee
Eisai R&D Management Co., Ltd.
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Application filed by Eisai R&D Management Co., Ltd. filed Critical Eisai R&D Management Co., Ltd.
Publication of BR112020024551A2 publication Critical patent/BR112020024551A2/pt

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
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  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
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  • Endocrinology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Flanged Joints, Insulating Joints, And Other Joints (AREA)
BR112020024551-8A 2018-06-01 2019-05-31 métodos para usar moduladores de splicing BR112020024551A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862679699P 2018-06-01 2018-06-01
US201862679696P 2018-06-01 2018-06-01
US62/679.699 2018-06-01
US62/679.696 2018-06-01
PCT/US2019/034992 WO2019232433A2 (en) 2018-06-01 2019-05-31 Methods of using splicing modulators

Publications (1)

Publication Number Publication Date
BR112020024551A2 true BR112020024551A2 (pt) 2021-03-02

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Application Number Title Priority Date Filing Date
BR112020024551-8A BR112020024551A2 (pt) 2018-06-01 2019-05-31 métodos para usar moduladores de splicing

Country Status (11)

Country Link
US (2) US11998544B2 (https=)
EP (1) EP3801523B1 (https=)
JP (1) JP7346466B2 (https=)
KR (1) KR20210016406A (https=)
CN (1) CN112367996B (https=)
AU (1) AU2019279012A1 (https=)
BR (1) BR112020024551A2 (https=)
CA (1) CA3101205A1 (https=)
IL (2) IL278740B2 (https=)
MX (1) MX2020012940A (https=)
WO (1) WO2019232433A2 (https=)

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