BR112020024018A2 - compostos inibidores de vmat2, composições e métodos relacionados a eles - Google Patents

compostos inibidores de vmat2, composições e métodos relacionados a eles Download PDF

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Publication number
BR112020024018A2
BR112020024018A2 BR112020024018-4A BR112020024018A BR112020024018A2 BR 112020024018 A2 BR112020024018 A2 BR 112020024018A2 BR 112020024018 A BR112020024018 A BR 112020024018A BR 112020024018 A2 BR112020024018 A2 BR 112020024018A2
Authority
BR
Brazil
Prior art keywords
individual
vmat2 inhibitor
alkyl
psychiatric disorder
treatment
Prior art date
Application number
BR112020024018-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Christopher F. O'Brien
Nicole HARRIOTT
Original Assignee
Neurocrine Biosciences Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurocrine Biosciences Inc. filed Critical Neurocrine Biosciences Inc.
Publication of BR112020024018A2 publication Critical patent/BR112020024018A2/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
BR112020024018-4A 2018-06-14 2019-06-13 compostos inibidores de vmat2, composições e métodos relacionados a eles BR112020024018A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862684935P 2018-06-14 2018-06-14
US62/684,935 2018-06-14
PCT/US2019/037046 WO2019241555A1 (en) 2018-06-14 2019-06-13 Vmat2 inhibitor compounds, compositions, and methods relating thereto

Publications (1)

Publication Number Publication Date
BR112020024018A2 true BR112020024018A2 (pt) 2021-02-23

Family

ID=67263041

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020024018-4A BR112020024018A2 (pt) 2018-06-14 2019-06-13 compostos inibidores de vmat2, composições e métodos relacionados a eles

Country Status (16)

Country Link
EP (2) EP4691560A3 (https=)
JP (2) JP2021528386A (https=)
KR (1) KR20210021006A (https=)
CN (1) CN112638387A (https=)
AU (1) AU2019287524A1 (https=)
BR (1) BR112020024018A2 (https=)
CA (1) CA3100694A1 (https=)
EA (1) EA202092750A1 (https=)
IL (1) IL278758A (https=)
JO (1) JOP20200298A1 (https=)
MA (1) MA52896A (https=)
MX (1) MX2020013004A (https=)
PH (1) PH12020552088A1 (https=)
SG (1) SG11202011544UA (https=)
TW (1) TW202011963A (https=)
WO (1) WO2019241555A1 (https=)

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* Cited by examiner, † Cited by third party
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RS61645B1 (sr) 2015-10-30 2021-04-29 Neurocrine Biosciences Inc Valbenazin ditozilat i njihovi polimorfi
JP6869988B2 (ja) 2015-12-23 2021-05-12 ニューロクライン バイオサイエンシーズ，インコーポレイテッド （Ｓ）−（２Ｒ，３Ｒ，１１ｂＲ）−３−イソブチル−９，１０−ジメトキシ−２，３，４，６，７，１１ｂ−ヘキサヒドロ−１Ｈ−ピリド［２，１−ａ］イソキノリン−２−イル２−アミノ−３−メチルブタノエートジ（４−メチルベンゼンスルホネート）の調製のための合成方法
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CA3076000A1 (en) 2017-09-21 2019-03-28 Neurocrine Biosciences, Inc. High dosage valbenazine formulation and compositions, methods, and kits related thereto
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
JP2021502959A (ja) 2017-10-10 2021-02-04 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
CA3097189A1 (en) 2018-04-25 2019-10-31 Shinkei Therapeutics Llc Tetrabenazine transdermal delivery device
MA53239A (fr) 2018-08-15 2022-05-04 Neurocrine Biosciences Inc Procédés d'administration de certains inhibiteurs de vmat2
US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
WO2023076568A1 (en) * 2021-10-29 2023-05-04 Neurocrine Biosciences, Inc. Valbenazine compositions

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Also Published As

Publication number Publication date
EP4691560A2 (en) 2026-02-11
PH12020552088A1 (en) 2021-08-02
CN112638387A (zh) 2021-04-09
JP2024114905A (ja) 2024-08-23
JP2021528386A (ja) 2021-10-21
TW202011963A (zh) 2020-04-01
AU2019287524A1 (en) 2020-12-24
EP3806856A1 (en) 2021-04-21
MX2020013004A (es) 2021-02-17
MA52896A (fr) 2021-04-21
IL278758A (en) 2021-01-31
EP4691560A3 (en) 2026-04-15
KR20210021006A (ko) 2021-02-24
CA3100694A1 (en) 2019-12-19
WO2019241555A1 (en) 2019-12-19
JOP20200298A1 (ar) 2020-11-22
EA202092750A1 (ru) 2021-05-13
SG11202011544UA (en) 2020-12-30

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B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements