JP2021528386A - Ｖｍａｔ２インヒビター化合物、上記化合物に関する組成物および方法 - Google Patents

Ｖｍａｔ２インヒビター化合物、上記化合物に関する組成物および方法 Download PDF

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JP2021528386A
JP2021528386A JP2020568772A JP2020568772A JP2021528386A JP 2021528386 A JP2021528386 A JP 2021528386A JP 2020568772 A JP2020568772 A JP 2020568772A JP 2020568772 A JP2020568772 A JP 2020568772A JP 2021528386 A JP2021528386 A JP 2021528386A
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alkyl
vmat2 inhibitor
pharmaceutically acceptable
heterocyclyl
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JPWO2019241555A5 (https=
JP2021528386A5 (https=
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クリストファー エフ． オブライエン，
ニコル ハリオット，
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ニューロクライン バイオサイエンシーズ，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2020568772A 2018-06-14 2019-06-13 Ｖｍａｔ２インヒビター化合物、上記化合物に関する組成物および方法 Withdrawn JP2021528386A (ja)

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JP2024104749A JP2024114905A (ja) 2018-06-14 2024-06-28 Ｖｍａｔ２インヒビター化合物、上記化合物に関する組成物および方法

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US201862684935P 2018-06-14 2018-06-14
US62/684,935 2018-06-14
PCT/US2019/037046 WO2019241555A1 (en) 2018-06-14 2019-06-13 Vmat2 inhibitor compounds, compositions, and methods relating thereto

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JP2021528386A true JP2021528386A (ja) 2021-10-21
JPWO2019241555A5 JPWO2019241555A5 (https=) 2022-06-16
JP2021528386A5 JP2021528386A5 (https=) 2022-06-16

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JP2024104749A Pending JP2024114905A (ja) 2018-06-14 2024-06-28 Ｖｍａｔ２インヒビター化合物、上記化合物に関する組成物および方法

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EP (2) EP4691560A3 (https=)
JP (2) JP2021528386A (https=)
KR (1) KR20210021006A (https=)
CN (1) CN112638387A (https=)
AU (1) AU2019287524A1 (https=)
BR (1) BR112020024018A2 (https=)
CA (1) CA3100694A1 (https=)
EA (1) EA202092750A1 (https=)
IL (1) IL278758A (https=)
JO (1) JOP20200298A1 (https=)
MA (1) MA52896A (https=)
MX (1) MX2020013004A (https=)
PH (1) PH12020552088A1 (https=)
SG (1) SG11202011544UA (https=)
TW (1) TW202011963A (https=)
WO (1) WO2019241555A1 (https=)

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MY193767A (en) 2015-10-30 2022-10-27 Neurocrine Biosciences Inc Valbenazine salts and polymorphs thereof
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ES3024958T3 (en) 2017-09-21 2025-06-05 Neurocrine Biosciences Inc High dosage valbenazine formulation and compositions, methods, and kits related thereto
KR20250070134A (ko) 2017-10-10 2025-05-20 뉴로크린 바이오사이언시즈 인코퍼레이티드 특정 vmat2 억제제의 투여 방법
JP2021502959A (ja) 2017-10-10 2021-02-04 ニューロクライン バイオサイエンシーズ，インコーポレイテッド 特定のｖｍａｔ２インヒビターを投与するための方法
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US10940141B1 (en) 2019-08-23 2021-03-09 Neurocrine Biosciences, Inc. Methods for the administration of certain VMAT2 inhibitors
US20250000805A1 (en) * 2021-10-29 2025-01-02 Neurocrine Biosciences, Inc. Valbenazine compositions

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JP2024114905A (ja) 2024-08-23
EP4691560A2 (en) 2026-02-11
MX2020013004A (es) 2021-02-17
EA202092750A1 (ru) 2021-05-13
TW202011963A (zh) 2020-04-01
CA3100694A1 (en) 2019-12-19
JOP20200298A1 (ar) 2020-11-22
IL278758A (en) 2021-01-31
MA52896A (fr) 2021-04-21
AU2019287524A1 (en) 2020-12-24
CN112638387A (zh) 2021-04-09
EP4691560A3 (en) 2026-04-15
BR112020024018A2 (pt) 2021-02-23
KR20210021006A (ko) 2021-02-24
EP3806856A1 (en) 2021-04-21
SG11202011544UA (en) 2020-12-30
WO2019241555A1 (en) 2019-12-19
PH12020552088A1 (en) 2021-08-02

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