BR112020023274A2 - kit para rastreamento de câncer colorretal e adenoma avançado e sua aplicação - Google Patents
kit para rastreamento de câncer colorretal e adenoma avançado e sua aplicação Download PDFInfo
- Publication number
- BR112020023274A2 BR112020023274A2 BR112020023274-2A BR112020023274A BR112020023274A2 BR 112020023274 A2 BR112020023274 A2 BR 112020023274A2 BR 112020023274 A BR112020023274 A BR 112020023274A BR 112020023274 A2 BR112020023274 A2 BR 112020023274A2
- Authority
- BR
- Brazil
- Prior art keywords
- seq
- probe
- gene
- patient
- bmp3
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
- G01N33/721—Haemoglobin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2561/00—Nucleic acid detection characterised by assay method
- C12Q2561/113—Real time assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/112—Disease subtyping, staging or classification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810502359.7A CN108660209B (zh) | 2018-05-23 | 2018-05-23 | 基于bmp3基因甲基化制备结直肠癌早期检测的产品 |
| CN201810502387.9 | 2018-05-23 | ||
| CN201810502387.9A CN108676878B (zh) | 2018-05-23 | 2018-05-23 | 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途 |
| CN201810502359.7 | 2018-05-23 | ||
| PCT/US2019/033831 WO2019226942A1 (en) | 2018-05-23 | 2019-05-23 | The kit for screening colorectal cancer and advanced adenoma and its application |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112020023274A2 true BR112020023274A2 (pt) | 2021-02-23 |
Family
ID=68617194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112020023274-2A BR112020023274A2 (pt) | 2018-05-23 | 2019-05-23 | kit para rastreamento de câncer colorretal e adenoma avançado e sua aplicação |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20210207221A1 (https=) |
| EP (1) | EP3797112A4 (https=) |
| JP (1) | JP7637509B2 (https=) |
| KR (1) | KR20210035094A (https=) |
| CN (1) | CN112752763B (https=) |
| AU (1) | AU2019275073A1 (https=) |
| BR (1) | BR112020023274A2 (https=) |
| CA (1) | CA3098028A1 (https=) |
| SG (1) | SG11202010208YA (https=) |
| WO (1) | WO2019226942A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113699237A (zh) * | 2020-07-29 | 2021-11-26 | 上海吉凯医学检验所有限公司 | 一种检测早期结直肠癌和腺瘤的dna甲基化标志物的试剂盒 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| EP1942197A1 (de) * | 2000-09-01 | 2008-07-09 | Epigenomics AG | Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3' |
| DE10112515B4 (de) * | 2001-03-09 | 2004-02-12 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität |
| CN103649298A (zh) * | 2011-05-12 | 2014-03-19 | 精密科学公司 | 核酸的分离 |
| WO2013142545A1 (en) * | 2012-03-20 | 2013-09-26 | Exact Sciences Corporation | Marker panel for detecting cancer |
| EP4234722A3 (en) * | 2014-03-31 | 2023-09-20 | Mayo Foundation for Medical Education and Research | Detecting colorectal neoplasm |
| WO2016094839A2 (en) * | 2014-12-12 | 2016-06-16 | Exact Sciences Corporation | Compositions and methods for performing methylation detection assays |
| ES2879964T3 (es) * | 2014-12-12 | 2021-11-23 | Exact Sciences Dev Co Llc | Composiciones y métodos para realizar ensayos de detección de metilación |
| CN104975110A (zh) * | 2015-06-02 | 2015-10-14 | 浙江诺辉生物技术有限公司 | 用于检测生物样本中bmp3和ndrg4甲基化水平的引物和探针 |
| AU2016343937B2 (en) * | 2015-10-30 | 2023-01-19 | Exact Sciences Corporation | Multiplex amplification detection assay and isolation and detection of DNA from plasma |
| WO2018087129A1 (en) * | 2016-11-08 | 2018-05-17 | Region Nordjylland, Aalborg University Hospital | Colorectal cancer methylation markers |
| CN106399570A (zh) | 2016-11-30 | 2017-02-15 | 杭州诺辉健康科技有限公司 | 用于早期结直肠癌辅助诊断的试剂盒及其使用方法和检测系统 |
-
2019
- 2019-05-23 EP EP19806858.7A patent/EP3797112A4/en not_active Withdrawn
- 2019-05-23 CN CN201980033966.6A patent/CN112752763B/zh active Active
- 2019-05-23 BR BR112020023274-2A patent/BR112020023274A2/pt unknown
- 2019-05-23 JP JP2020564893A patent/JP7637509B2/ja active Active
- 2019-05-23 SG SG11202010208YA patent/SG11202010208YA/en unknown
- 2019-05-23 AU AU2019275073A patent/AU2019275073A1/en not_active Abandoned
- 2019-05-23 US US17/057,227 patent/US20210207221A1/en not_active Abandoned
- 2019-05-23 WO PCT/US2019/033831 patent/WO2019226942A1/en not_active Ceased
- 2019-05-23 KR KR1020207037127A patent/KR20210035094A/ko active Pending
- 2019-05-23 CA CA3098028A patent/CA3098028A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019226942A1 (en) | 2019-11-28 |
| EP3797112A1 (en) | 2021-03-31 |
| US20210207221A1 (en) | 2021-07-08 |
| KR20210035094A (ko) | 2021-03-31 |
| AU2019275073A8 (en) | 2020-12-10 |
| JP2021526370A (ja) | 2021-10-07 |
| CN112752763B (zh) | 2025-01-03 |
| SG11202010208YA (en) | 2020-11-27 |
| CA3098028A1 (en) | 2019-11-28 |
| EP3797112A4 (en) | 2022-03-23 |
| JP7637509B2 (ja) | 2025-02-28 |
| CN112752763A (zh) | 2021-05-04 |
| AU2019275073A1 (en) | 2020-11-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
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