KR20210035094A - 결장직장암 및 진행성 선종을 스크리닝하기 위한 키트 및 그의 적용 - Google Patents

결장직장암 및 진행성 선종을 스크리닝하기 위한 키트 및 그의 적용 Download PDF

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KR20210035094A
KR20210035094A KR1020207037127A KR20207037127A KR20210035094A KR 20210035094 A KR20210035094 A KR 20210035094A KR 1020207037127 A KR1020207037127 A KR 1020207037127A KR 20207037127 A KR20207037127 A KR 20207037127A KR 20210035094 A KR20210035094 A KR 20210035094A
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seq
gene
probe
detecting
patient
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Korean (ko)
Inventor
쿤야오 리
후이 리
웨이시안 젱
지아오 양
강 리우
닝 루
이요우 첸
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항저우 뉴 호리즌 헬스 테크놀로지 코. 엘티디.
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Priority claimed from CN201810502359.7A external-priority patent/CN108660209B/zh
Priority claimed from CN201810502387.9A external-priority patent/CN108676878B/zh
Application filed by 항저우 뉴 호리즌 헬스 테크놀로지 코. 엘티디. filed Critical 항저우 뉴 호리즌 헬스 테크놀로지 코. 엘티디.
Publication of KR20210035094A publication Critical patent/KR20210035094A/ko
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/72—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood pigments, e.g. haemoglobin, bilirubin or other porphyrins; involving occult blood
    • G01N33/721—Haemoglobin
    • C—CHEMISTRY; METALLURGY
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    • C12Q2561/00—Nucleic acid detection characterised by assay method
    • C12Q2561/113—Real time assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020207037127A 2018-05-23 2019-05-23 결장직장암 및 진행성 선종을 스크리닝하기 위한 키트 및 그의 적용 Pending KR20210035094A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201810502359.7A CN108660209B (zh) 2018-05-23 2018-05-23 基于bmp3基因甲基化制备结直肠癌早期检测的产品
CN201810502387.9 2018-05-23
CN201810502387.9A CN108676878B (zh) 2018-05-23 2018-05-23 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途
CN201810502359.7 2018-05-23
PCT/US2019/033831 WO2019226942A1 (en) 2018-05-23 2019-05-23 The kit for screening colorectal cancer and advanced adenoma and its application

Publications (1)

Publication Number Publication Date
KR20210035094A true KR20210035094A (ko) 2021-03-31

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KR1020207037127A Pending KR20210035094A (ko) 2018-05-23 2019-05-23 결장직장암 및 진행성 선종을 스크리닝하기 위한 키트 및 그의 적용

Country Status (10)

Country Link
US (1) US20210207221A1 (https=)
EP (1) EP3797112A4 (https=)
JP (1) JP7637509B2 (https=)
KR (1) KR20210035094A (https=)
CN (1) CN112752763B (https=)
AU (1) AU2019275073A1 (https=)
BR (1) BR112020023274A2 (https=)
CA (1) CA3098028A1 (https=)
SG (1) SG11202010208YA (https=)
WO (1) WO2019226942A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113699237A (zh) * 2020-07-29 2021-11-26 上海吉凯医学检验所有限公司 一种检测早期结直肠癌和腺瘤的dna甲基化标志物的试剂盒

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541308A (en) * 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
EP1942197A1 (de) * 2000-09-01 2008-07-09 Epigenomics AG Verfahren zur Bestimmung des Methylierungsgrades von bestimmten Cytosinen in genomischer DNA im Sequenzkontext 5'-CpG-3'
DE10112515B4 (de) * 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
CN103649298A (zh) * 2011-05-12 2014-03-19 精密科学公司 核酸的分离
WO2013142545A1 (en) * 2012-03-20 2013-09-26 Exact Sciences Corporation Marker panel for detecting cancer
EP4234722A3 (en) * 2014-03-31 2023-09-20 Mayo Foundation for Medical Education and Research Detecting colorectal neoplasm
WO2016094839A2 (en) * 2014-12-12 2016-06-16 Exact Sciences Corporation Compositions and methods for performing methylation detection assays
ES2879964T3 (es) * 2014-12-12 2021-11-23 Exact Sciences Dev Co Llc Composiciones y métodos para realizar ensayos de detección de metilación
CN104975110A (zh) * 2015-06-02 2015-10-14 浙江诺辉生物技术有限公司 用于检测生物样本中bmp3和ndrg4甲基化水平的引物和探针
AU2016343937B2 (en) * 2015-10-30 2023-01-19 Exact Sciences Corporation Multiplex amplification detection assay and isolation and detection of DNA from plasma
WO2018087129A1 (en) * 2016-11-08 2018-05-17 Region Nordjylland, Aalborg University Hospital Colorectal cancer methylation markers
CN106399570A (zh) 2016-11-30 2017-02-15 杭州诺辉健康科技有限公司 用于早期结直肠癌辅助诊断的试剂盒及其使用方法和检测系统

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Publication number Publication date
WO2019226942A1 (en) 2019-11-28
EP3797112A1 (en) 2021-03-31
US20210207221A1 (en) 2021-07-08
AU2019275073A8 (en) 2020-12-10
JP2021526370A (ja) 2021-10-07
BR112020023274A2 (pt) 2021-02-23
CN112752763B (zh) 2025-01-03
SG11202010208YA (en) 2020-11-27
CA3098028A1 (en) 2019-11-28
EP3797112A4 (en) 2022-03-23
JP7637509B2 (ja) 2025-02-28
CN112752763A (zh) 2021-05-04
AU2019275073A1 (en) 2020-11-26

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