BR112020006669A2 - formas cristalinas de 1,2,4-oxadiazol 3-substituído - Google Patents

formas cristalinas de 1,2,4-oxadiazol 3-substituído Download PDF

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Publication number
BR112020006669A2
BR112020006669A2 BR112020006669-9A BR112020006669A BR112020006669A2 BR 112020006669 A2 BR112020006669 A2 BR 112020006669A2 BR 112020006669 A BR112020006669 A BR 112020006669A BR 112020006669 A2 BR112020006669 A2 BR 112020006669A2
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BR
Brazil
Prior art keywords
compound
fact
formula
weight
crystalline
Prior art date
Application number
BR112020006669-9A
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English (en)
Portuguese (pt)
Inventor
Pottayil Govindan Nair Sasikumar
Seetharamaiah Setty Sudarshan Naremaddepalli
Original Assignee
Aurigene Discovery Technologies Limited
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Application filed by Aurigene Discovery Technologies Limited filed Critical Aurigene Discovery Technologies Limited
Publication of BR112020006669A2 publication Critical patent/BR112020006669A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112020006669-9A 2017-10-11 2018-10-10 formas cristalinas de 1,2,4-oxadiazol 3-substituído BR112020006669A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201741036169 2017-10-11
IN201741036169 2017-10-11
PCT/IB2018/057840 WO2019073399A1 (en) 2017-10-11 2018-10-10 CRYSTALLINE FORMS OF 1,2,4-OXADIAZOLE SUBSTITUTED IN POSITION 3

Publications (1)

Publication Number Publication Date
BR112020006669A2 true BR112020006669A2 (pt) 2020-09-24

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020006669-9A BR112020006669A2 (pt) 2017-10-11 2018-10-10 formas cristalinas de 1,2,4-oxadiazol 3-substituído

Country Status (14)

Country Link
US (4) US11136300B2 (enExample)
EP (1) EP3694841A1 (enExample)
JP (2) JP7618445B2 (enExample)
KR (2) KR20240151258A (enExample)
CN (2) CN117417308A (enExample)
AU (2) AU2018348350B2 (enExample)
BR (1) BR112020006669A2 (enExample)
CA (1) CA3078872A1 (enExample)
EA (1) EA202090536A1 (enExample)
IL (2) IL273896B2 (enExample)
MY (1) MY201777A (enExample)
PH (1) PH12020550125A1 (enExample)
SG (1) SG11202003081WA (enExample)
WO (1) WO2019073399A1 (enExample)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030155B1 (ru) 2013-09-06 2018-06-29 Ауриген Дискавери Текнолоджиз Лимитед Производные 1,2,4-оксадиазола в качестве иммуномодуляторов
KR102708045B1 (ko) 2015-03-10 2024-09-23 오리진 온콜로지 리미티드 면역조절제로서의 1,2,4-옥사다이아졸 및 티아다이아졸 화합물
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
JP7618445B2 (ja) 2017-10-11 2025-01-21 オーリジーン オンコロジー リミテッド ３－置換１，２，４－オキサジアゾールの結晶形態
CN111372584A (zh) 2017-11-03 2020-07-03 奥瑞基尼探索技术有限公司 Tim-3和pd-1途径的双重抑制剂
EA202090749A1 (ru) 2017-11-06 2020-08-19 Ориджен Дискавери Текнолоджис Лимитед Способы совместной терапии для иммуномодуляции

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Also Published As

Publication number Publication date
CN117417308A (zh) 2024-01-19
JP2020536872A (ja) 2020-12-17
CA3078872A1 (en) 2019-04-18
US20200239422A1 (en) 2020-07-30
US20220048875A1 (en) 2022-02-17
KR20240151258A (ko) 2024-10-17
IL273896A (en) 2020-05-31
SG11202003081WA (en) 2020-05-28
US11680051B2 (en) 2023-06-20
IL273896B2 (en) 2025-08-01
JP2023109937A (ja) 2023-08-08
WO2019073399A1 (en) 2019-04-18
EP3694841A1 (en) 2020-08-19
AU2018348350A1 (en) 2020-04-02
PH12020550125A1 (en) 2021-01-25
MY201777A (en) 2024-03-17
US12187689B2 (en) 2025-01-07
US20250136562A1 (en) 2025-05-01
AU2018348350B2 (en) 2024-05-02
IL273896B1 (en) 2025-04-01
AU2024202522A1 (en) 2024-05-09
EA202090536A1 (ru) 2020-07-22
US20230278970A1 (en) 2023-09-07
KR20200068659A (ko) 2020-06-15
IL318981A (en) 2025-04-01
JP7618445B2 (ja) 2025-01-21
KR102838640B1 (ko) 2025-07-24
CN111194308A (zh) 2020-05-22
US11136300B2 (en) 2021-10-05

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Owner name: AURIGENE ONCOLOGY LIMITED (IN)