CA3078872A1 - Crystalline forms of 3-substituted 1,2,4-oxadiazole - Google Patents

Crystalline forms of 3-substituted 1,2,4-oxadiazole Download PDF

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Publication number
CA3078872A1
CA3078872A1 CA3078872A CA3078872A CA3078872A1 CA 3078872 A1 CA3078872 A1 CA 3078872A1 CA 3078872 A CA3078872 A CA 3078872A CA 3078872 A CA3078872 A CA 3078872A CA 3078872 A1 CA3078872 A1 CA 3078872A1
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Canada
Prior art keywords
compound
formula
crystalline
solvent
mixture
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Pending
Application number
CA3078872A
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English (en)
French (fr)
Inventor
Pottayil Govindan Nair Sasikumar
Seetharamaiah Setty Sudarshan Naremaddepalli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aurigene Oncology Ltd
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Aurigene Discovery Technologies Ltd
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Publication date
Application filed by Aurigene Discovery Technologies Ltd filed Critical Aurigene Discovery Technologies Ltd
Publication of CA3078872A1 publication Critical patent/CA3078872A1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245Oxadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3078872A 2017-10-11 2018-10-10 Crystalline forms of 3-substituted 1,2,4-oxadiazole Pending CA3078872A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201741036169 2017-10-11
IN201741036169 2017-10-11
PCT/IB2018/057840 WO2019073399A1 (en) 2017-10-11 2018-10-10 CRYSTALLINE FORMS OF 1,2,4-OXADIAZOLE SUBSTITUTED IN POSITION 3

Publications (1)

Publication Number Publication Date
CA3078872A1 true CA3078872A1 (en) 2019-04-18

Family

ID=64664328

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3078872A Pending CA3078872A1 (en) 2017-10-11 2018-10-10 Crystalline forms of 3-substituted 1,2,4-oxadiazole

Country Status (14)

Country Link
US (4) US11136300B2 (enExample)
EP (1) EP3694841A1 (enExample)
JP (2) JP7618445B2 (enExample)
KR (2) KR20240151258A (enExample)
CN (2) CN111194308A (enExample)
AU (2) AU2018348350B2 (enExample)
BR (1) BR112020006669A2 (enExample)
CA (1) CA3078872A1 (enExample)
EA (1) EA202090536A1 (enExample)
IL (2) IL273896B2 (enExample)
MY (1) MY201777A (enExample)
PH (1) PH12020550125A1 (enExample)
SG (1) SG11202003081WA (enExample)
WO (1) WO2019073399A1 (enExample)

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HUE048874T2 (hu) * 2013-09-06 2020-08-28 Aurigene Discovery Tech Ltd 1,2,4-oxadiazol-származékok, mint immunmodulátorok
AU2016230793B2 (en) 2015-03-10 2021-03-25 Aurigene Discovery Technologies Limited 1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
WO2019061324A1 (en) 2017-09-29 2019-04-04 Curis Inc. CRYSTALLINE FORMS OF IMMUNOMODULATORS
EP3694841A1 (en) 2017-10-11 2020-08-19 Aurigene Discovery Technologies Limited Crystalline forms of 3-substituted 1,2,4-oxadiazole
MX2020004531A (es) 2017-11-03 2020-08-03 Aurigene Discovery Tech Ltd Inhibidores dobles de tim-3 y las vias de pd-1.
EP3706798A1 (en) 2017-11-06 2020-09-16 Aurigene Discovery Technologies Limited Conjoint therapies for immunomodulation

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Also Published As

Publication number Publication date
US20220048875A1 (en) 2022-02-17
CN111194308A (zh) 2020-05-22
JP2023109937A (ja) 2023-08-08
MY201777A (en) 2024-03-17
US12187689B2 (en) 2025-01-07
KR102838640B1 (ko) 2025-07-24
BR112020006669A2 (pt) 2020-09-24
US11136300B2 (en) 2021-10-05
AU2018348350A1 (en) 2020-04-02
IL273896A (en) 2020-05-31
AU2018348350B2 (en) 2024-05-02
JP2020536872A (ja) 2020-12-17
US11680051B2 (en) 2023-06-20
EP3694841A1 (en) 2020-08-19
EA202090536A1 (ru) 2020-07-22
CN117417308A (zh) 2024-01-19
IL273896B1 (en) 2025-04-01
AU2024202522A1 (en) 2024-05-09
US20200239422A1 (en) 2020-07-30
SG11202003081WA (en) 2020-05-28
KR20240151258A (ko) 2024-10-17
JP7618445B2 (ja) 2025-01-21
IL318981A (en) 2025-04-01
IL273896B2 (en) 2025-08-01
WO2019073399A1 (en) 2019-04-18
KR20200068659A (ko) 2020-06-15
US20230278970A1 (en) 2023-09-07
US20250136562A1 (en) 2025-05-01
PH12020550125A1 (en) 2021-01-25

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