BR112019026226A2 - composições compreendendo curóns e usos dos mesmos - Google Patents
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| EA202092684A1 (ru) | 2018-08-27 | 2021-03-11 | Ридженерон Фармасьютикалз, Инк. | Применение рамановской спектроскопии для последующей очистки |
| EP3894568A2 (en) * | 2018-12-12 | 2021-10-20 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering secreted therapeutic modalities |
| US11166996B2 (en) | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
| BR112021009282A2 (pt) * | 2018-12-12 | 2021-08-17 | Flagship Pioneering Innovations V, Inc | anelossomos para entrega de modalidades terapêuticas intracelulares |
| CN113631716A (zh) * | 2018-12-12 | 2021-11-09 | 旗舰先锋创新V股份有限公司 | 指环体和使用方法 |
| CN114127303A (zh) * | 2018-12-12 | 2022-03-01 | 旗舰先锋创新V股份有限公司 | 用于递送蛋白质替代治疗方式的指环体 |
| JP2022536364A (ja) | 2019-06-13 | 2022-08-15 | ザ ジェネラル ホスピタル コーポレイション | 操作されたヒト内在性ウイルス様粒子および細胞への送達のためのその使用方法 |
| CA3147875A1 (en) | 2019-07-19 | 2021-01-28 | Flagship Pioneering Innovations Vi, Llc | Recombinase compositions and methods of use |
| CN116034160A (zh) * | 2020-06-12 | 2023-04-28 | 旗舰先锋创新V股份有限公司 | 杆状病毒表达系统 |
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| CA3187036A1 (en) * | 2020-06-17 | 2021-12-23 | Flagship Pioneering Innovations V, Inc. | Methods of identifying and characterizing anelloviruses and uses thereof |
| WO2022020800A2 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
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| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 用於將治療劑遞送至骨之組成物和方法 |
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| JP5243789B2 (ja) | 2004-03-15 | 2013-07-24 | シティ・オブ・ホープ | 二本鎖ｒｎａによる遺伝子発現の特異的阻害のための方法及び組成物 |
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| PL2279254T3 (pl) | 2008-04-15 | 2017-11-30 | Protiva Biotherapeutics Inc. | Nowe preparaty lipidowe do dostarczania kwasów nukleinowych |
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| WO2010099510A2 (en) | 2009-02-27 | 2010-09-02 | The Administrators Of The Tulane Educational Fund | Amino acid-based compounds, their methods of use, and methods of screening |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| WO2011000108A1 (en) | 2009-07-01 | 2011-01-06 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein b |
| US9676828B2 (en) * | 2010-06-23 | 2017-06-13 | Deutsches Krebsforschungszentrum | Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity |
| US9409987B2 (en) * | 2011-04-15 | 2016-08-09 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| RS59199B1 (sr) | 2012-05-25 | 2019-10-31 | Univ California | Metode i jedinjenja za rnk-upravljanu ciljanu dnk modifikaciju i za rnk- upravljanu modulaciju transkripta |
| JP6517143B2 (ja) | 2012-10-23 | 2019-05-22 | ツールゲン インコーポレイテッド | 標的ｄｎａに特異的なガイドｒｎａおよびｃａｓタンパク質コード核酸またはｃａｓタンパク質を含む、標的ｄｎａを切断するための組成物、ならびにその使用 |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| WO2014093655A2 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| EP2898075B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| JP2016505256A (ja) | 2012-12-12 | 2016-02-25 | ザ・ブロード・インスティテュート・インコーポレイテッ | 配列操作のためのＣＲＩＳＰＲ−Ｃａｓ成分系、方法および組成物 |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| IL239344B2 (en) | 2012-12-12 | 2024-06-01 | Broad Inst Inc | Systems engineering, methods and optimal guiding components for sequence manipulation |
| SG10201804977UA (en) * | 2013-12-12 | 2018-07-30 | Broad Inst Inc | Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for Targeting Disorders and Diseases Using Particle Delivery Components |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
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2019
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2020
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2022
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2024
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2025
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| US20200123203A1 (en) | 2020-04-23 |
| US20230279423A1 (en) | 2023-09-07 |
| JP2024087003A (ja) | 2024-06-28 |
| US20190211361A1 (en) | 2019-07-11 |
| IL271275A (en) | 2020-01-30 |
| CN111108208A (zh) | 2020-05-05 |
| MX2019015018A (es) | 2020-09-10 |
| EP3638797A1 (en) | 2020-04-22 |
| JP2023010961A (ja) | 2023-01-20 |
| KR20200038236A (ko) | 2020-04-10 |
| KR20250028508A (ko) | 2025-02-28 |
| US20200385757A1 (en) | 2020-12-10 |
| AU2025200497A1 (en) | 2025-04-10 |
| RU2020100074A3 (enExample) | 2022-02-08 |
| RU2020100074A (ru) | 2021-08-03 |
| MX2023011657A (es) | 2023-10-11 |
| WO2018232017A1 (en) | 2018-12-20 |
| AU2018285860A1 (en) | 2020-01-02 |
| CA3066750A1 (en) | 2018-12-20 |
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