CN111108208A - 包含愈合子的组合物及其用途 - Google Patents
包含愈合子的组合物及其用途 Download PDFInfo
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- CN111108208A CN111108208A CN201880051296.6A CN201880051296A CN111108208A CN 111108208 A CN111108208 A CN 111108208A CN 201880051296 A CN201880051296 A CN 201880051296A CN 111108208 A CN111108208 A CN 111108208A
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/00041—Use of virus, viral particle or viral elements as a vector
- C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
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- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762518898P | 2017-06-13 | 2017-06-13 | |
| US62/518,898 | 2017-06-13 | ||
| US201762597387P | 2017-12-11 | 2017-12-11 | |
| US62/597,387 | 2017-12-11 | ||
| US201862676730P | 2018-05-25 | 2018-05-25 | |
| US62/676,730 | 2018-05-25 | ||
| PCT/US2018/037379 WO2018232017A1 (en) | 2017-06-13 | 2018-06-13 | Compositions comprising curons and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111108208A true CN111108208A (zh) | 2020-05-05 |
Family
ID=62846247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201880051296.6A Pending CN111108208A (zh) | 2017-06-13 | 2018-06-13 | 包含愈合子的组合物及其用途 |
Country Status (11)
| Country | Link |
|---|---|
| US (4) | US20200123203A1 (enExample) |
| EP (1) | EP3638797A1 (enExample) |
| JP (3) | JP2020524993A (enExample) |
| KR (2) | KR20200038236A (enExample) |
| CN (1) | CN111108208A (enExample) |
| AU (2) | AU2018285860A1 (enExample) |
| BR (1) | BR112019026226A2 (enExample) |
| CA (1) | CA3066750A1 (enExample) |
| IL (1) | IL271275A (enExample) |
| MX (2) | MX2019015018A (enExample) |
| WO (1) | WO2018232017A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3100035A1 (en) | 2018-08-27 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Use of raman spectroscopy in downstream purification |
| CA3119339A1 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering intracellular therapeutic modalities |
| US11166996B2 (en) | 2018-12-12 | 2021-11-09 | Flagship Pioneering Innovations V, Inc. | Anellovirus compositions and methods of use |
| BR112021009379A2 (pt) * | 2018-12-12 | 2021-08-17 | Flagship Pioneering Innovations V, Inc | anelossomos para entrega de modalidades terapêuticas secretadas |
| WO2020123795A2 (en) * | 2018-12-12 | 2020-06-18 | Flagship Pioneering Innovations V, Inc. | Anellosomes for delivering protein replacement therapeutic modalities |
| MX2021006977A (es) * | 2018-12-12 | 2021-10-13 | Flagship Pioneering Innovations V Inc | Anellosomas y metodos de uso. |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| JP7759311B2 (ja) | 2019-07-19 | 2025-10-23 | フラッグシップ パイオニアリング イノベーションズ シックス,エルエルシー | リコンビナーゼ組成物及び使用方法 |
| WO2021252955A1 (en) * | 2020-06-12 | 2021-12-16 | Flagship Pioneering Innovations V, Inc. | Tandem anellovirus constructs |
| CN116034160A (zh) * | 2020-06-12 | 2023-04-28 | 旗舰先锋创新V股份有限公司 | 杆状病毒表达系统 |
| MX2022016475A (es) * | 2020-06-17 | 2023-04-11 | Flagship Pioneering Innovations V Inc | Metodos de identificacion y caracterizacion de anellovirus y usos de los mismos. |
| CN116670154A (zh) | 2020-07-24 | 2023-08-29 | 总医院公司 | 增强的病毒样颗粒及使用其递送至细胞的方法 |
| EP4189084A1 (en) * | 2020-07-27 | 2023-06-07 | Wisconsin Alumni Research Foundation | Methods of making unbiased phage libraries |
| CA3206361A1 (en) * | 2020-12-23 | 2022-06-30 | Flagship Pioneering Innovations V, Inc. | In vitro assembly of anellovirus capsids enclosing rna |
| EP4288115A4 (en) * | 2021-02-08 | 2025-06-18 | Flagship Pioneering Innovations V, Inc. | Hybrid aav-anellovectors |
| US20250027107A1 (en) * | 2021-10-18 | 2025-01-23 | Flagship Pioneering Innovations Vii, Llc | Dna compositions and related methods |
| TW202430215A (zh) | 2022-12-14 | 2024-08-01 | 美商旗艦先鋒創新有限責任(Vii)公司 | 用於將治療劑遞送至骨之組成物和方法 |
| WO2025194138A1 (en) | 2024-03-14 | 2025-09-18 | Tessera Therapeutics, Inc. | St1cas9 compositions and methods for modulating a genome |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395472B1 (en) * | 1999-02-05 | 2002-05-28 | Abbott Laboratories | Methods of utilizing the TT virus |
| CN103596974A (zh) * | 2011-04-15 | 2014-02-19 | 卡姆普根有限公司 | 多肽和多核苷酸及其用于治疗免疫相关失调和癌症的用途 |
| CN106536729A (zh) * | 2013-12-12 | 2017-03-22 | 布罗德研究所有限公司 | 使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
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| FR751473A (fr) * | 1932-06-01 | 1933-09-04 | Poste d'incendie | |
| WO1998010088A1 (en) | 1996-09-06 | 1998-03-12 | Trustees Of The University Of Pennsylvania | An inducible method for production of recombinant adeno-associated viruses utilizing t7 polymerase |
| US6693086B1 (en) | 1998-06-25 | 2004-02-17 | National Jewish Medical And Research Center | Systemic immune activation method using nucleic acid-lipid complexes |
| ATE485031T1 (de) | 2002-06-28 | 2010-11-15 | Protiva Biotherapeutics Inc | Verfahren und vorrichtung zur herstellung von liposomen |
| ES2559828T3 (es) | 2003-07-16 | 2016-02-16 | Protiva Biotherapeutics Inc. | ARN de interferencia encapsulado en lípidos |
| AU2004272646B2 (en) | 2003-09-15 | 2011-11-24 | Arbutus Biopharma Corporation | Polyethyleneglycol-modified lipid compounds and uses thereof |
| US8084599B2 (en) | 2004-03-15 | 2011-12-27 | City Of Hope | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA |
| EP1781593B1 (en) | 2004-06-07 | 2011-12-14 | Protiva Biotherapeutics Inc. | Cationic lipids and methods of use |
| EP1766035B1 (en) | 2004-06-07 | 2011-12-07 | Protiva Biotherapeutics Inc. | Lipid encapsulated interfering rna |
| EP1768692B8 (en) | 2004-07-01 | 2015-06-17 | Yale University | Targeted and high density drug loaded polymeric materials |
| WO2007048046A2 (en) | 2005-10-20 | 2007-04-26 | Protiva Biotherapeutics, Inc. | Sirna silencing of filovirus gene expression |
| CA2628300C (en) | 2005-11-02 | 2018-04-17 | Protiva Biotherapeutics, Inc. | Modified sirna molecules and uses thereof |
| US7915399B2 (en) | 2006-06-09 | 2011-03-29 | Protiva Biotherapeutics, Inc. | Modified siRNA molecules and uses thereof |
| ES2638448T3 (es) | 2008-04-15 | 2017-10-20 | Protiva Biotherapeutics Inc. | Novedosas formulaciones de lípidos para la administración de ácidos nucleicos |
| US8513207B2 (en) | 2008-12-18 | 2013-08-20 | Dicerna Pharmaceuticals, Inc. | Extended dicer substrate agents and methods for the specific inhibition of gene expression |
| WO2010093788A2 (en) | 2009-02-11 | 2010-08-19 | Dicerna Pharmaceuticals, Inc. | Multiplex dicer substrate rna interference molecules having joining sequences |
| WO2010099510A2 (en) | 2009-02-27 | 2010-09-02 | The Administrators Of The Tulane Educational Fund | Amino acid-based compounds, their methods of use, and methods of screening |
| JP5766188B2 (ja) | 2009-07-01 | 2015-08-19 | プロチバ バイオセラピューティクス インコーポレイティッド | 固形腫瘍に治療剤を送達するための脂質製剤 |
| CA2767129C (en) | 2009-07-01 | 2015-01-06 | Protiva Biotherapeutics, Inc. | Compositions and methods for silencing apolipoprotein b |
| US9676828B2 (en) * | 2010-06-23 | 2017-06-13 | Deutsches Krebsforschungszentrum | Rearranged TT virus molecules for use in diagnosis, prevention and treatment of cancer and autoimmunity |
| MY189533A (en) | 2012-05-25 | 2022-02-16 | Univ California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| WO2014065596A1 (en) | 2012-10-23 | 2014-05-01 | Toolgen Incorporated | Composition for cleaving a target dna comprising a guide rna specific for the target dna and cas protein-encoding nucleic acid or cas protein, and use thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| CN119752887A (zh) | 2012-12-12 | 2025-04-04 | 布罗德研究所有限公司 | 用于序列操纵的系统、方法和优化的指导组合物的工程化 |
| CA2894668A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas systems and methods for altering expression of gene products in eukaryotic cells |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| US9790490B2 (en) | 2015-06-18 | 2017-10-17 | The Broad Institute Inc. | CRISPR enzymes and systems |
-
2018
- 2018-06-13 KR KR1020207000972A patent/KR20200038236A/ko not_active Ceased
- 2018-06-13 BR BR112019026226-1A patent/BR112019026226A2/pt unknown
- 2018-06-13 MX MX2019015018A patent/MX2019015018A/es unknown
- 2018-06-13 CN CN201880051296.6A patent/CN111108208A/zh active Pending
- 2018-06-13 KR KR1020257004957A patent/KR20250028508A/ko active Pending
- 2018-06-13 JP JP2019568601A patent/JP2020524993A/ja not_active Withdrawn
- 2018-06-13 EP EP18738411.0A patent/EP3638797A1/en active Pending
- 2018-06-13 US US16/622,146 patent/US20200123203A1/en not_active Abandoned
- 2018-06-13 CA CA3066750A patent/CA3066750A1/en active Pending
- 2018-06-13 AU AU2018285860A patent/AU2018285860A1/en not_active Abandoned
- 2018-06-13 WO PCT/US2018/037379 patent/WO2018232017A1/en not_active Ceased
-
2019
- 2019-03-27 US US16/366,571 patent/US20190211361A1/en not_active Abandoned
- 2019-12-09 IL IL271275A patent/IL271275A/en unknown
- 2019-12-11 MX MX2023011657A patent/MX2023011657A/es unknown
-
2020
- 2020-01-16 US US16/744,363 patent/US20200385757A1/en not_active Abandoned
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2022
- 2022-07-15 US US17/812,896 patent/US20230279423A1/en not_active Abandoned
- 2022-11-24 JP JP2022187239A patent/JP2023010961A/ja not_active Withdrawn
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2024
- 2024-04-23 JP JP2024069618A patent/JP2024087003A/ja active Pending
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2025
- 2025-01-24 AU AU2025200497A patent/AU2025200497A1/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6395472B1 (en) * | 1999-02-05 | 2002-05-28 | Abbott Laboratories | Methods of utilizing the TT virus |
| CN103596974A (zh) * | 2011-04-15 | 2014-02-19 | 卡姆普根有限公司 | 多肽和多核苷酸及其用于治疗免疫相关失调和癌症的用途 |
| CN106536729A (zh) * | 2013-12-12 | 2017-03-22 | 布罗德研究所有限公司 | 使用粒子递送组分靶向障碍和疾病的crispr‑cas系统和组合物的递送、用途和治疗应用 |
Non-Patent Citations (3)
| Title |
|---|
| GALMES等: "TTV-like mini virus isolate TTMA_LY2", pages 1 * |
| RODNEY P. KINCAID等: "A Human Torque Teno Virus Encodes a MicroRNA That Inhibits Interferon Signaling", vol. 9, no. 12, pages 1003818 * |
| 阿荣: "TTMV_ORF1基因的克...接ELISA检测方法的建立", 中国优秀硕士学位论文全文数据库农业科学辑, 15 December 2011 (2011-12-15), pages 050 - 98 * |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20250028508A (ko) | 2025-02-28 |
| CA3066750A1 (en) | 2018-12-20 |
| US20200123203A1 (en) | 2020-04-23 |
| EP3638797A1 (en) | 2020-04-22 |
| WO2018232017A1 (en) | 2018-12-20 |
| JP2023010961A (ja) | 2023-01-20 |
| BR112019026226A2 (pt) | 2020-06-30 |
| MX2023011657A (es) | 2023-10-11 |
| KR20200038236A (ko) | 2020-04-10 |
| JP2024087003A (ja) | 2024-06-28 |
| US20200385757A1 (en) | 2020-12-10 |
| AU2025200497A1 (en) | 2025-04-10 |
| JP2020524993A (ja) | 2020-08-27 |
| IL271275A (en) | 2020-01-30 |
| US20230279423A1 (en) | 2023-09-07 |
| RU2020100074A3 (enExample) | 2022-02-08 |
| US20190211361A1 (en) | 2019-07-11 |
| MX2019015018A (es) | 2020-09-10 |
| RU2020100074A (ru) | 2021-08-03 |
| AU2018285860A1 (en) | 2020-01-02 |
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