BR112018077128A2 - composição e uso - Google Patents
composição e usoInfo
- Publication number
- BR112018077128A2 BR112018077128A2 BR112018077128-7A BR112018077128A BR112018077128A2 BR 112018077128 A2 BR112018077128 A2 BR 112018077128A2 BR 112018077128 A BR112018077128 A BR 112018077128A BR 112018077128 A2 BR112018077128 A2 BR 112018077128A2
- Authority
- BR
- Brazil
- Prior art keywords
- extract
- lipophilic
- spp
- oleracea
- acetylglycosamine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
a presente invenção refere-se a composições que compreendem: a) um extrato de vitis vinifera, em forma livre ou na forma de um complexo com fosfolipídios, ou um extrato de punica granatum; e b) um extrato lipofílico de zingiber officinale; e c) um extrato lipofílico, obtido de plantas contendo isobutilamidas de ácidos graxos poli-insaturados, selecionado a partir do grupo constituído por extrato de echinacea spp., extrato de zanthoxylum spp. ou extrato de acmella oleracea (ou spilanthes oleracea); e d) uma fração insaponificável de óleo de oliva e/ou óleo de milho; ou e) n-acetilglicosamina; ou f) diacereína; e o seu uso na prevenção e/ou no tratamento de inflamação e dor osteoarticular e lesão da cartilagem.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUA2016A004757A ITUA20164757A1 (it) | 2016-06-29 | 2016-06-29 | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore osteoarticolare e del danno cartilagineo |
IT102016000067621 | 2016-06-29 | ||
PCT/EP2017/066002 WO2018002144A1 (en) | 2016-06-29 | 2017-06-28 | Compositions useful in the prevention and/or treatment of osteoarticular inflammation and pain and cartilage damage |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018077128A2 true BR112018077128A2 (pt) | 2019-04-30 |
Family
ID=57750452
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018077128-7A BR112018077128A2 (pt) | 2016-06-29 | 2017-06-28 | composição e uso |
Country Status (19)
Country | Link |
---|---|
US (1) | US10583162B2 (pt) |
EP (1) | EP3478310B1 (pt) |
JP (1) | JP7100593B2 (pt) |
KR (1) | KR102398013B1 (pt) |
CN (1) | CN109475591A (pt) |
AU (1) | AU2017288470A1 (pt) |
BR (1) | BR112018077128A2 (pt) |
CA (1) | CA3026476A1 (pt) |
DK (1) | DK3478310T3 (pt) |
ES (1) | ES2912123T3 (pt) |
HU (1) | HUE058969T2 (pt) |
IL (1) | IL263988B (pt) |
IT (1) | ITUA20164757A1 (pt) |
MX (1) | MX2019000161A (pt) |
PL (1) | PL3478310T3 (pt) |
RU (1) | RU2750993C2 (pt) |
SG (1) | SG11201811680VA (pt) |
SI (1) | SI3478310T1 (pt) |
WO (1) | WO2018002144A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITUB20161030A1 (it) * | 2016-02-24 | 2017-08-24 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore |
WO2020255913A1 (ja) * | 2019-06-17 | 2020-12-24 | 田中貴金属工業株式会社 | 有機マンガン化合物からなる化学蒸着用原料及び該化学蒸着用原料を用いた化学蒸着法 |
EP4100034A1 (en) * | 2020-02-06 | 2022-12-14 | Unigen, Inc. | Compositions comprising extracts of aplinia and other plants for improving joint health and treating arthritis |
IT202100004682A1 (it) * | 2021-03-01 | 2022-09-01 | Farmad Laboratori Firenze S R L | Integratore alimentare utile come adiuvante nel trattamento del dolore cronico |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1541469A (en) | 1976-12-01 | 1979-02-28 | Inverni Della Beffa Spa | Method of obtaining flavonolic oligomers |
IT1201151B (it) * | 1987-01-14 | 1989-01-27 | Indena Spa | Complessi fosfolipidici con estratti da vitis vinifera,procedimento per la loro preparazione e composizioni che li cntengono |
DE69020341T2 (de) | 1990-07-05 | 1995-11-02 | Indena Spa | Echinacea-Extrakte, Verfahren zur Herstellung und Zubereitungen, die sie enthalten. |
ITMI981542A1 (it) | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
GB2403405A (en) * | 2003-06-02 | 2005-01-05 | Health Perception | Topical composition for the treatment of joint damage or pain |
ITMI20051485A1 (it) | 2005-07-29 | 2007-01-30 | Indena Spa | Estratto da semi d'uva ottenibile per frazionamento su resina |
ES2431338T3 (es) | 2008-11-25 | 2013-11-26 | Indena S.P.A. | Extractos vegetales para su uso como fitoquímicos |
KR101099021B1 (ko) * | 2009-04-24 | 2011-12-28 | 에이치 엘 지노믹스(주) | 유럽종 포도의 씨 추출물을 함유하는 골관절염 예방 또는 치료용 약학 조성물 |
DE102009050407A1 (de) * | 2009-10-22 | 2011-06-22 | Bionorica SE, 92318 | Entzündungshemmendes Mittel enthaltend Hydrolysate aus Pflanzenextrakten |
CA2780324A1 (en) * | 2009-12-04 | 2011-06-09 | Colgate-Palmolive Company | Oral compositions containing a combination of natural extracts and related methods |
IT1401141B1 (it) * | 2010-07-26 | 2013-07-12 | Indena Spa | Formulazioni contenenti estratti di echinacea angustifolia e di zingiber officinale utili nella riduzione dell'infiammazione e del dolore periferico |
WO2012060884A1 (en) * | 2010-11-04 | 2012-05-10 | Nestec S.A. | Methods and compositions for preventing and treating osteoarthritis |
US9038725B2 (en) * | 2012-07-10 | 2015-05-26 | Halliburton Energy Services, Inc. | Method and system for servicing a wellbore |
EP3107555B1 (en) * | 2014-02-20 | 2020-06-03 | Indena S.p.A. | Compositions containing extracts of curcuma longa and echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
-
2016
- 2016-06-29 IT ITUA2016A004757A patent/ITUA20164757A1/it unknown
-
2017
- 2017-06-28 AU AU2017288470A patent/AU2017288470A1/en not_active Abandoned
- 2017-06-28 DK DK17739500.1T patent/DK3478310T3/da active
- 2017-06-28 HU HUE17739500A patent/HUE058969T2/hu unknown
- 2017-06-28 BR BR112018077128-7A patent/BR112018077128A2/pt active Search and Examination
- 2017-06-28 MX MX2019000161A patent/MX2019000161A/es unknown
- 2017-06-28 JP JP2018568667A patent/JP7100593B2/ja active Active
- 2017-06-28 RU RU2019100779A patent/RU2750993C2/ru active
- 2017-06-28 KR KR1020197001401A patent/KR102398013B1/ko active IP Right Grant
- 2017-06-28 CA CA3026476A patent/CA3026476A1/en active Pending
- 2017-06-28 SI SI201731141T patent/SI3478310T1/sl unknown
- 2017-06-28 SG SG11201811680VA patent/SG11201811680VA/en unknown
- 2017-06-28 US US16/313,202 patent/US10583162B2/en not_active Expired - Fee Related
- 2017-06-28 EP EP17739500.1A patent/EP3478310B1/en active Active
- 2017-06-28 ES ES17739500T patent/ES2912123T3/es active Active
- 2017-06-28 PL PL17739500T patent/PL3478310T3/pl unknown
- 2017-06-28 CN CN201780038357.0A patent/CN109475591A/zh active Pending
- 2017-06-28 WO PCT/EP2017/066002 patent/WO2018002144A1/en unknown
-
2018
- 2018-12-27 IL IL263988A patent/IL263988B/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
JP2019520368A (ja) | 2019-07-18 |
RU2019100779A (ru) | 2020-07-29 |
SG11201811680VA (en) | 2019-01-30 |
US20190151396A1 (en) | 2019-05-23 |
JP7100593B2 (ja) | 2022-07-13 |
KR20190021333A (ko) | 2019-03-05 |
IL263988B (en) | 2021-05-31 |
KR102398013B1 (ko) | 2022-05-13 |
US10583162B2 (en) | 2020-03-10 |
ITUA20164757A1 (it) | 2017-12-29 |
DK3478310T3 (da) | 2022-04-11 |
RU2019100779A3 (pt) | 2020-09-14 |
HUE058969T2 (hu) | 2022-09-28 |
CN109475591A (zh) | 2019-03-15 |
PL3478310T3 (pl) | 2022-06-20 |
WO2018002144A1 (en) | 2018-01-04 |
CA3026476A1 (en) | 2018-01-04 |
SI3478310T1 (sl) | 2022-06-30 |
EP3478310B1 (en) | 2022-03-30 |
MX2019000161A (es) | 2019-05-30 |
RU2750993C2 (ru) | 2021-07-07 |
ES2912123T3 (es) | 2022-05-24 |
EP3478310A1 (en) | 2019-05-08 |
AU2017288470A1 (en) | 2019-01-24 |
IL263988A (en) | 2019-01-31 |
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