BR112018077122A2 - métodos para a determinação da adequação de um neo-epítopo, para a determinação da adequação de uma combinação para fornecer uma vacina, para proporcionar uma célula imune recombinante, para fornecer uma resposta imune e para tratar um mamífero com uma doença, vacina e célula imune recombinante - Google Patents

métodos para a determinação da adequação de um neo-epítopo, para a determinação da adequação de uma combinação para fornecer uma vacina, para proporcionar uma célula imune recombinante, para fornecer uma resposta imune e para tratar um mamífero com uma doença, vacina e célula imune recombinante

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Publication number
BR112018077122A2
BR112018077122A2 BR112018077122-8A BR112018077122A BR112018077122A2 BR 112018077122 A2 BR112018077122 A2 BR 112018077122A2 BR 112018077122 A BR112018077122 A BR 112018077122A BR 112018077122 A2 BR112018077122 A2 BR 112018077122A2
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Brazil
Prior art keywords
providing
vaccine
suitability
determining
recombinant
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BR112018077122-8A
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English (en)
Other versions
BR112018077122A8 (pt
Inventor
D. Tadmor Arbel
Sahin Ugur
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Biontech Rna Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Biontech Rna Pharmaceuticals Gmbh filed Critical Biontech Rna Pharmaceuticals Gmbh
Publication of BR112018077122A2 publication Critical patent/BR112018077122A2/pt
Publication of BR112018077122A8 publication Critical patent/BR112018077122A8/pt

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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
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    • C12Q2600/00—Oligonucleotides characterized by their use
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Abstract

a presente invenção refere-se a métodos para determinar se neo-epítopos que são apenas expressos em ou sobre células doentes são adequados alvos específicos de doença, de forma que a célula doente é menos provável de escapar da vigilância imune, e o uso dos neo-epítopos em proporcionar uma resposta imune contra células doentes que expressa os neo-epítopos.
BR112018077122A 2016-07-20 2017-07-19 Métodos para a determinação da adequação de um neo-epítopo, para a determinação da adequação de uma combinação para fornecer uma vacina, para proporcionar uma célula imune recombinante, para fornecer uma resposta imune e para tratar um mamífero com uma doença, vacina e célula imune recombinante BR112018077122A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP2016067348 2016-07-20
EPPCT/EP2016/067348 2016-07-20
PCT/EP2017/068226 WO2018015433A2 (en) 2016-07-20 2017-07-19 Selecting neoepitopes as disease-specific targets for therapy with enhanced efficacy

Publications (2)

Publication Number Publication Date
BR112018077122A2 true BR112018077122A2 (pt) 2019-04-30
BR112018077122A8 BR112018077122A8 (pt) 2023-01-31

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BR112018077122A BR112018077122A8 (pt) 2016-07-20 2017-07-19 Métodos para a determinação da adequação de um neo-epítopo, para a determinação da adequação de uma combinação para fornecer uma vacina, para proporcionar uma célula imune recombinante, para fornecer uma resposta imune e para tratar um mamífero com uma doença, vacina e célula imune recombinante

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US (1) US20190189241A1 (pt)
EP (2) EP3967324A1 (pt)
JP (2) JP7171543B2 (pt)
KR (2) KR102516166B1 (pt)
CN (2) CN109477149A (pt)
AU (1) AU2017299162A1 (pt)
BR (1) BR112018077122A8 (pt)
CA (1) CA3031003A1 (pt)
CY (1) CY1124551T1 (pt)
DK (1) DK3488443T3 (pt)
ES (1) ES2890424T3 (pt)
HR (1) HRP20211443T1 (pt)
HU (1) HUE056660T2 (pt)
IL (2) IL264203B1 (pt)
LT (1) LT3488443T (pt)
MX (4) MX2019000733A (pt)
PL (1) PL3488443T3 (pt)
PT (1) PT3488443T (pt)
RS (1) RS62390B1 (pt)
SG (2) SG10201912678QA (pt)
SI (1) SI3488443T1 (pt)
WO (1) WO2018015433A2 (pt)

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CN109294983A (zh) * 2018-09-30 2019-02-01 北京鼎成肽源生物技术有限公司 一种lff2细胞
CN111402954B (zh) * 2019-01-02 2023-07-21 中国人民解放军军事科学院军事医学研究院 一种辨识与预测空间辐射损伤防护药靶相关人类基因的方法

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Publication number Publication date
ES2890424T3 (es) 2022-01-19
KR102516166B1 (ko) 2023-03-31
MX2023009369A (es) 2023-08-16
WO2018015433A3 (en) 2018-03-01
DK3488443T3 (da) 2021-09-27
SI3488443T1 (sl) 2021-11-30
IL264203A (en) 2019-02-28
MX2023009371A (es) 2023-08-16
HRP20211443T1 (hr) 2021-12-24
CN109477149A (zh) 2019-03-15
EP3488443B1 (en) 2021-08-18
US20190189241A1 (en) 2019-06-20
PL3488443T3 (pl) 2021-12-20
AU2017299162A1 (en) 2019-02-07
PT3488443T (pt) 2021-09-24
HUE056660T2 (hu) 2022-03-28
JP2023009120A (ja) 2023-01-19
MX2019000733A (es) 2019-05-02
KR20190027832A (ko) 2019-03-15
EP3488443A2 (en) 2019-05-29
JP7171543B2 (ja) 2022-11-15
CN117757931A (zh) 2024-03-26
SG10201912678QA (en) 2020-02-27
WO2018015433A2 (en) 2018-01-25
JP2019524106A (ja) 2019-09-05
MX2023009370A (es) 2023-08-16
CY1124551T1 (el) 2022-07-22
BR112018077122A8 (pt) 2023-01-31
EP3488443B8 (en) 2021-09-29
LT3488443T (lt) 2021-10-25
IL264203B1 (en) 2024-04-01
RS62390B1 (sr) 2021-10-29
KR20230019223A (ko) 2023-02-07
IL311369A (en) 2024-05-01
SG11201900132QA (en) 2019-02-27
EP3967324A1 (en) 2022-03-16
CA3031003A1 (en) 2018-01-25

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Free format text: AS CLASSIFICACOES ANTERIORES ERAM: G06F 19/00 , C12Q 1/68 , A61K 39/00

Ipc: C12N 15/10 (2006.01), C12Q 1/68 (2018.01), C12Q 1/

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