BR112018072579A2 - composto fenólico, composição farmacêutica, combinação do composto de fórmula i, e, usos de composto de fórmula i e de combinação - Google Patents
composto fenólico, composição farmacêutica, combinação do composto de fórmula i, e, usos de composto de fórmula i e de combinaçãoInfo
- Publication number
- BR112018072579A2 BR112018072579A2 BR112018072579-0A BR112018072579A BR112018072579A2 BR 112018072579 A2 BR112018072579 A2 BR 112018072579A2 BR 112018072579 A BR112018072579 A BR 112018072579A BR 112018072579 A2 BR112018072579 A2 BR 112018072579A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- formula
- combination
- derivatives
- phenolic
- Prior art date
Links
- 150000002989 phenols Chemical class 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 2
- 150000008442 polyphenolic compounds Chemical class 0.000 abstract 2
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 abstract 1
- 108090000312 Calcium Channels Proteins 0.000 abstract 1
- 102000003922 Calcium Channels Human genes 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 230000002424 anti-apoptotic effect Effects 0.000 abstract 1
- 230000001910 anti-glutamatergic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 150000001557 benzodiazepines Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000003371 gabaergic effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 230000000626 neurodegenerative effect Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Psychology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CU2016-0059 | 2016-05-04 | ||
CU2016000059A CU24576B1 (es) | 2016-05-04 | 2016-05-04 | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
PCT/CU2017/050003 WO2017190714A1 (es) | 2016-05-04 | 2017-05-03 | Compuesto fenólico y combinación del mismo con una benzodiazepina fusionada a 1,4-dihidropiridina para el tratamiento de afecciones del sistema nervioso central y vascular |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112018072579A2 true BR112018072579A2 (pt) | 2019-02-19 |
BR112018072579B1 BR112018072579B1 (pt) | 2024-02-20 |
Family
ID=60202803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018072579-0A BR112018072579B1 (pt) | 2016-05-04 | 2017-05-03 | Composto fenólico, composição farmacêutica, combinação do composto de fórmula i, e, usos de composto de fórmula i e de combinação |
Country Status (19)
Country | Link |
---|---|
US (1) | US10722491B2 (pt) |
EP (1) | EP3453704B1 (pt) |
JP (1) | JP6997995B2 (pt) |
KR (1) | KR102416478B1 (pt) |
CN (1) | CN109476627B (pt) |
AR (1) | AR108370A1 (pt) |
AU (1) | AU2017259749C1 (pt) |
BR (1) | BR112018072579B1 (pt) |
CA (1) | CA3023073C (pt) |
CL (1) | CL2018003114A1 (pt) |
CO (1) | CO2018011927A2 (pt) |
CU (1) | CU24576B1 (pt) |
EA (1) | EA037951B1 (pt) |
ES (1) | ES2878579T3 (pt) |
MX (1) | MX2018013422A (pt) |
PH (1) | PH12018502327A1 (pt) |
SG (1) | SG11201809843SA (pt) |
WO (1) | WO2017190714A1 (pt) |
ZA (1) | ZA201808161B (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU20160058A7 (es) | 2016-05-04 | 2017-12-08 | Centro De Investigación Y Desarrollo De Medicamentos (Cidem) Organizacion Superior De Desarrollo Emp | Derivado de benzodiazepina con actividad sobre el sistema nervioso central y vascular |
MX2022008001A (es) * | 2019-12-26 | 2022-07-21 | Centro De Investig Y Desarrollo De Medicamentos Cidem | Uso de un derivado benzodiacepinico y metodo de tratamiento de la lesion traumatica cerebral. |
CU20190114A7 (es) | 2019-12-26 | 2021-08-06 | Centro De Investig Y Desarrollo De Medicamentos Cidem | Combinación para simultáneamente incrementar la eficacia analgésica de la morfina y reducir su dependencia física |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5281714A (en) | 1990-08-16 | 1994-01-25 | American Home Products Corporation | N,N',N'-trisubstituted-5-bisaminomethylene-1,3-dioxane-4,6-dione inhibitors of acyl-CoA: cholesterol-acyl transferase |
MX9204939A (es) | 1991-09-06 | 1993-03-01 | American Home Prod | Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n',n'-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa. |
ES2074770T3 (es) | 1992-07-17 | 1995-09-16 | Biogal Gyogyszergyar | Procedimiento de preparacion de derivados de 1,3-dioxano-4,6-diona. |
JPH11180975A (ja) | 1997-10-13 | 1999-07-06 | Chemiprokasei Kaisha Ltd | アミノメチレンジオキサン誘導体、その製造方法および用途 |
EA011010B1 (ru) | 2004-02-27 | 2008-12-30 | Эмджен, Инк. | Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина |
JP2007063444A (ja) * | 2005-08-31 | 2007-03-15 | Tdk Corp | 錯化合物及びこれを用いた光記録媒体 |
-
2016
- 2016-05-04 CU CU2016000059A patent/CU24576B1/es unknown
-
2017
- 2017-05-03 MX MX2018013422A patent/MX2018013422A/es unknown
- 2017-05-03 SG SG11201809843SA patent/SG11201809843SA/en unknown
- 2017-05-03 KR KR1020187035042A patent/KR102416478B1/ko active IP Right Grant
- 2017-05-03 EP EP17732730.1A patent/EP3453704B1/en active Active
- 2017-05-03 CA CA3023073A patent/CA3023073C/en active Active
- 2017-05-03 BR BR112018072579-0A patent/BR112018072579B1/pt active IP Right Grant
- 2017-05-03 ES ES17732730T patent/ES2878579T3/es active Active
- 2017-05-03 US US16/098,683 patent/US10722491B2/en active Active
- 2017-05-03 JP JP2019510749A patent/JP6997995B2/ja active Active
- 2017-05-03 EA EA201892462A patent/EA037951B1/ru unknown
- 2017-05-03 WO PCT/CU2017/050003 patent/WO2017190714A1/es unknown
- 2017-05-03 AU AU2017259749A patent/AU2017259749C1/en not_active Ceased
- 2017-05-03 CN CN201780040492.9A patent/CN109476627B/zh active Active
- 2017-05-04 AR ARP170101153A patent/AR108370A1/es unknown
-
2018
- 2018-10-31 CL CL2018003114A patent/CL2018003114A1/es unknown
- 2018-11-02 CO CONC2018/0011927A patent/CO2018011927A2/es unknown
- 2018-11-05 PH PH12018502327A patent/PH12018502327A1/en unknown
- 2018-12-03 ZA ZA2018/08161A patent/ZA201808161B/en unknown
Also Published As
Publication number | Publication date |
---|---|
AR108370A1 (es) | 2018-08-15 |
KR20210025138A (ko) | 2021-03-09 |
PH12018502327A1 (en) | 2019-09-02 |
CL2018003114A1 (es) | 2019-06-14 |
US10722491B2 (en) | 2020-07-28 |
CU20160059A7 (es) | 2017-12-08 |
AU2017259749B2 (en) | 2021-08-19 |
ZA201808161B (en) | 2021-10-27 |
ES2878579T3 (es) | 2021-11-19 |
EP3453704B1 (en) | 2021-06-16 |
EA037951B1 (ru) | 2021-06-11 |
AU2017259749C1 (en) | 2021-12-02 |
MX2018013422A (es) | 2019-08-16 |
CA3023073C (en) | 2022-08-30 |
EA201892462A1 (ru) | 2019-07-31 |
CN109476627A (zh) | 2019-03-15 |
JP2019516791A (ja) | 2019-06-20 |
US20190133996A1 (en) | 2019-05-09 |
CU24576B1 (es) | 2022-02-04 |
AU2017259749A1 (en) | 2018-12-20 |
SG11201809843SA (en) | 2018-12-28 |
KR102416478B1 (ko) | 2022-07-04 |
BR112018072579B1 (pt) | 2024-02-20 |
WO2017190714A1 (es) | 2017-11-09 |
JP6997995B2 (ja) | 2022-02-04 |
CN109476627B (zh) | 2021-06-15 |
CA3023073A1 (en) | 2017-11-09 |
CO2018011927A2 (es) | 2019-02-08 |
EP3453704A1 (en) | 2019-03-13 |
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 03/05/2017, OBSERVADAS AS CONDICOES LEGAIS |
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