BR112018070463A2 - método e aparelho para prover um regime farmacocinético de dosagem de fármaco - Google Patents

método e aparelho para prover um regime farmacocinético de dosagem de fármaco

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Publication number
BR112018070463A2
BR112018070463A2 BR112018070463A BR112018070463A BR112018070463A2 BR 112018070463 A2 BR112018070463 A2 BR 112018070463A2 BR 112018070463 A BR112018070463 A BR 112018070463A BR 112018070463 A BR112018070463 A BR 112018070463A BR 112018070463 A2 BR112018070463 A2 BR 112018070463A2
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BR
Brazil
Prior art keywords
patient
weight
cfviii
providing
life
Prior art date
Application number
BR112018070463A
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English (en)
Other versions
BR112018070463A8 (pt
Inventor
Loew-Baselli Alexandra
Spotts Gerald
Rao Kuchimanchi Kameswara
Wolfsegger Martin
Don Hale Michael
Oh Myungshin
Original Assignee
Baxalta GmbH
Baxalta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH, Baxalta Inc filed Critical Baxalta GmbH
Publication of BR112018070463A2 publication Critical patent/BR112018070463A2/pt
Publication of BR112018070463A8 publication Critical patent/BR112018070463A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medical Informatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Data Mining & Analysis (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Primary Health Care (AREA)
  • Biomedical Technology (AREA)
  • Theoretical Computer Science (AREA)
  • Databases & Information Systems (AREA)
  • Pathology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computing Systems (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Evolutionary Computation (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Pure & Applied Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Mathematical Analysis (AREA)
  • Mathematical Optimization (AREA)
  • Computational Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mathematical Physics (AREA)
  • Algebra (AREA)
  • Diabetes (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)

Abstract

a presente invenção refere-se a sistemas e métodos para prover um regime de dosagem de fator de coagulação viii (cfviii) que incluem: coletar duas amostras de sangue a partir de um paciente depois de uma infusão de cfviii e determinar a depuração de cfviii depuração com base nas duas amostras de sangue, e determinar se um paciente possui uma meia-vida maior que um limite predeterminado. o perfil farmacocinético (pk) do paciente é determinado usando o modelo bayesiano de perfis farmacocinéticos de pacientes analisados com peso corporal ou idade similar à do paciente. um primeiro peso é aplicado ao modelo bayesiano de perfis farmacocinéticos de pacientes analisados se a meia-vida do paciente for maior que o limite predeterminado, e um segundo peso, menor que o primeiro peso, é aplicado ao modelo bayesiano de perfis farmacocinéticos de pacientes analisados se a meia-vida do paciente for menor que o limite predeterminado. um regime de dosagem é determinado para o paciente com base no perfil pk.
BR112018070463A 2016-04-15 2017-04-13 Método e aparelho para prover um regime farmacocinético de dosagem de fármaco BR112018070463A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323015P 2016-04-15 2016-04-15
PCT/US2017/027309 WO2017180807A1 (en) 2016-04-15 2017-04-13 Method and apparatus for providing a pharmacokinetic drug dosing regiment

Publications (2)

Publication Number Publication Date
BR112018070463A2 true BR112018070463A2 (pt) 2019-02-05
BR112018070463A8 BR112018070463A8 (pt) 2022-08-30

Family

ID=60041975

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018070463A BR112018070463A8 (pt) 2016-04-15 2017-04-13 Método e aparelho para prover um regime farmacocinético de dosagem de fármaco

Country Status (25)

Country Link
US (3) US11670409B2 (pt)
EP (2) EP4343774A3 (pt)
JP (2) JP6942721B2 (pt)
KR (2) KR102415992B1 (pt)
CN (1) CN109804432B (pt)
AR (1) AR108212A1 (pt)
AU (1) AU2017250570A1 (pt)
BR (1) BR112018070463A8 (pt)
CA (1) CA3020346A1 (pt)
CL (1) CL2018002870A1 (pt)
CO (1) CO2018012293A2 (pt)
EA (1) EA201892347A1 (pt)
ES (1) ES2973210T3 (pt)
HU (1) HUE065455T2 (pt)
IL (3) IL288790B2 (pt)
MA (1) MA43617A1 (pt)
MX (1) MX2018012612A (pt)
MY (1) MY197302A (pt)
PH (1) PH12018502178A1 (pt)
PL (1) PL3442656T3 (pt)
SG (1) SG11201808475XA (pt)
TW (1) TWI672602B (pt)
UA (1) UA126379C2 (pt)
WO (1) WO2017180807A1 (pt)
ZA (1) ZA201807214B (pt)

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US10925565B2 (en) * 2018-04-11 2021-02-23 Siemens Healthcare Gmbh Machine-learning based contrast agent administration
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