MA43617A1 - Méthode et appareil générant un schéma posologique pharmacocinétique - Google Patents

Méthode et appareil générant un schéma posologique pharmacocinétique

Info

Publication number
MA43617A1
MA43617A1 MA43617A MA43617A MA43617A1 MA 43617 A1 MA43617 A1 MA 43617A1 MA 43617 A MA43617 A MA 43617A MA 43617 A MA43617 A MA 43617A MA 43617 A1 MA43617 A1 MA 43617A1
Authority
MA
Morocco
Prior art keywords
patient
product
pharmacokinetic
cfviii
dosage regimen
Prior art date
Application number
MA43617A
Other languages
English (en)
Inventor
Alexandra Loew-Baselli
Kameswara Kuchimanchi
Gerald Spotts
Myungshin Oh
Michael Hale
Martin Wolfsegger
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of MA43617A1 publication Critical patent/MA43617A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/30—Prediction of properties of chemical compounds, compositions or mixtures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06N—COMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N7/00—Computing arrangements based on specific mathematical models
    • G06N7/01—Probabilistic graphical models, e.g. probabilistic networks
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/70—Machine learning, data mining or chemometrics

Abstract

L'invention concerne des systèmes et des méthodes permettant de générer un schéma d'administration du facteur de coagulation viii (cfviii) consistant à prélever deux échantillons de sang chez un patient après une perfusion de cfviii, à déterminer le profil d'élimination du cfviii d'après ces deux échantillons de sang, et à déterminer si la demi-vie du produit chez ledit patient est supérieure à un seuil prédéterminé. Le profil pharmacocinétique (pk) du produit chez le patient est déterminé en utilisant un modèle bayésien de profils pharmacocinétiques chez des patients sélectionnés ayant un poids corporel ou un âge similaire à celui du patient en question. Un premier poids est appliqué au modèle bayésien des profils pharmacocinétiques chez les patients sélectionnés si la demi-vie du produit chez le patient est supérieure au seuil prédéterminé, et un second poids, inférieur au premier, est appliqué au modèle bayésien des profils pharmacocinétiques chez les patients sélectionnés si la demi-vie du produit chez le patient est inférieure au seuil prédéterminé. Un schéma posologique est déterminé pour le patient en fonction du profil pk.
MA43617A 2016-04-15 2017-04-13 Méthode et appareil générant un schéma posologique pharmacocinétique MA43617A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323015P 2016-04-15 2016-04-15
PCT/US2017/027309 WO2017180807A1 (fr) 2016-04-15 2017-04-13 Méthode et appareil générant un schéma posologique pharmacocinétique

Publications (1)

Publication Number Publication Date
MA43617A1 true MA43617A1 (fr) 2019-06-28

Family

ID=60041975

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43617A MA43617A1 (fr) 2016-04-15 2017-04-13 Méthode et appareil générant un schéma posologique pharmacocinétique

Country Status (22)

Country Link
US (3) US11670409B2 (fr)
EP (2) EP4343774A2 (fr)
JP (2) JP6942721B2 (fr)
KR (2) KR102415992B1 (fr)
CN (1) CN109804432B (fr)
AR (1) AR108212A1 (fr)
AU (1) AU2017250570A1 (fr)
BR (1) BR112018070463A8 (fr)
CA (1) CA3020346A1 (fr)
CL (1) CL2018002870A1 (fr)
CO (1) CO2018012293A2 (fr)
EA (1) EA201892347A1 (fr)
IL (3) IL288790B2 (fr)
MA (1) MA43617A1 (fr)
MX (1) MX2018012612A (fr)
MY (1) MY197302A (fr)
PH (1) PH12018502178A1 (fr)
SG (1) SG11201808475XA (fr)
TW (1) TWI672602B (fr)
UA (1) UA126379C2 (fr)
WO (1) WO2017180807A1 (fr)
ZA (1) ZA201807214B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment
US10896749B2 (en) 2017-01-27 2021-01-19 Shire Human Genetic Therapies, Inc. Drug monitoring tool
EP3726532A1 (fr) * 2019-04-15 2020-10-21 Agilent Technologies, Inc. Traçage par isotope d'étiquettes stable pour données non ciblées
EP3748553A1 (fr) 2019-06-06 2020-12-09 Assistance Publique, Hopitaux De Paris Procédé de détermination d'un régime de dosage de médicaments optimal
USD953348S1 (en) * 2020-10-27 2022-05-31 Takeda Pharmaceutical Company Limited Display screen with a transitional graphical user interface
USD1018556S1 (en) * 2021-03-31 2024-03-19 Takeda Pharmaceutical Company Limited Display screen of a mobile phone with graphical user interface
WO2023170680A1 (fr) 2022-03-08 2023-09-14 Equashield Medical Ltd Station de transfert de fluide dans un système de préparation pharmaceutique robotique

Family Cites Families (159)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073321A (en) 1976-03-15 1978-02-14 George Moskowitz Adjustable blocking means for dosage regulation
US4709331A (en) 1984-05-01 1987-11-24 Barkett Patricia A Calculator-computer for calculating infusion rates over varying time intervals
US4810243A (en) 1985-01-18 1989-03-07 Intelligent Medicine, Inc. Device and method for effecting application of a therapeutic agent
US4807170A (en) 1986-03-25 1989-02-21 John Kulli Drug dose rate calculator
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
US5104374A (en) 1990-01-16 1992-04-14 Bishko Jay R Electronic fluid flow rate controller for controlling the infusion of intravenous drugs into a patient
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
JP3224607B2 (ja) 1992-09-11 2001-11-05 株式会社アズウェル 血液凝固第ｘｉｉｉ因子活性測定方法および該測定用試薬キット
CA2125693C (fr) 1992-10-15 2005-05-03 Alan D. Ford Pompe a perfusion avec pharmacopee individualisee chargee electroniquement
US5318544A (en) 1992-10-20 1994-06-07 Kerr Manufacturing Company Metering syringe
US6101478A (en) 1997-04-30 2000-08-08 Health Hero Network Multi-user remote health monitoring system
US6330426B2 (en) 1994-05-23 2001-12-11 Stephen J. Brown System and method for remote education using a memory card
US5897493A (en) 1997-03-28 1999-04-27 Health Hero Network, Inc. Monitoring system for remotely querying individuals
US5678571A (en) 1994-05-23 1997-10-21 Raya Systems, Inc. Method for treating medical conditions using a microprocessor-based video game
US5833599A (en) 1993-12-13 1998-11-10 Multum Information Services Providing patient-specific drug information
US5609575A (en) 1994-04-11 1997-03-11 Graseby Medical Limited Infusion pump and method with dose-rate calculation
US5462222A (en) 1994-07-15 1995-10-31 Boeck, Ii; Edgar L. Sealing closure clip for gable top container
US5526853A (en) 1994-08-17 1996-06-18 Mcgaw, Inc. Pressure-activated medication transfer system
US5522798A (en) 1994-10-17 1996-06-04 Abbott Laboratories Control of a multi-channel drug infusion pump using a pharmacokinetic model
US5792833A (en) 1994-12-22 1998-08-11 New England Medical Center Hospitals, Inc. E2 binding proteins
EP0737926A1 (fr) 1995-04-11 1996-10-16 Hoechst Marion Roussel, Inc. Méthode pour la détermination de paramètres pharmacodynamiques et l'élaboration d'un régime de dosage d'un médicament
US6321164B1 (en) 1995-06-07 2001-11-20 Akzo Nobel N.V. Method and apparatus for predicting the presence of an abnormal level of one or more proteins in the clotting cascade
US5630664A (en) 1995-12-20 1997-05-20 Farrelly; Patricia A. Hand held apparatus for performing medical calculations
HUP9700603A3 (en) 1996-03-20 2001-08-28 Baxter Ag Pharmaceutical preparation for the treatment of blood coagulation disorders
US5915971A (en) 1996-07-29 1999-06-29 Chemical Concepts Corporation Tutorial device and method for determining drug dosages
JP4289687B2 (ja) 1997-03-14 2009-07-01 ザ チルドレンズ ホスピタル オブ フィラデルフィア 血友病の治療のための遺伝子治療で使用する方法と組成物
US6025984A (en) 1997-09-22 2000-02-15 Borkowski; Brian Portable drug information computer
US5951526A (en) 1997-09-24 1999-09-14 Korisch; Marina Syringe holder with integral dose divider
DE19755682A1 (de) 1997-12-15 1999-06-17 Knoll Ag Verfahren zur Ermittlung eines Dosierungschemas für Thrombininhibitoren
US20020010595A1 (en) 1998-02-27 2002-01-24 Kapp Thomas L. Web-based medication management system
AU2673599A (en) 1998-02-27 1999-09-15 Thomas L. Kapp Pharmacy drug management system providing patient specific drug dosing, drug interaction analysis, order generation, and patient data matching
US6421650B1 (en) 1998-03-04 2002-07-16 Goetech Llc Medication monitoring system and apparatus
US7820796B2 (en) 1998-03-12 2010-10-26 Genetics Institute, Llc. Methods for producing Factor VIII proteins
US6167412A (en) 1998-07-14 2000-12-26 Agilent Technologies, Inc. Handheld medical calculator and medical reference device
US20020010550A1 (en) 1998-09-14 2002-01-24 George M. Grass Pharmacokinetic-based drug design tool and method
BR9804648A (pt) 1998-11-23 2000-05-30 Fundacao Oswaldo Cruz Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos.
US6358703B1 (en) 1998-12-10 2002-03-19 Bayer Corporation Expression system for factor VIII
KR200166416Y1 (ko) 1999-04-10 2000-02-15 최해영 피스톤 고정장치가 설치된 주사기
JP2003523940A (ja) 1999-05-11 2003-08-12 オーソ−マクネイル ファーマシューティカル インコーポレイテッド エリスロポエチン投与の薬物速度論的および薬力学的モデリング
US8326649B2 (en) 1999-11-18 2012-12-04 Koninklijke Philips Electronics N.V. System for providing expert care to outpatients from a remote location
US6658396B1 (en) 1999-11-29 2003-12-02 Tang Sharon S Neural network drug dosage estimation
US7860583B2 (en) 2004-08-25 2010-12-28 Carefusion 303, Inc. System and method for dynamically adjusting patient therapy
AU1227302A (en) 2000-09-15 2002-03-26 Virco Nv System and method for optimizing drug therapy for the treatment of diseases
WO2002032036A2 (fr) 2000-10-10 2002-04-18 University Of Utah Research Foundation Procede et appareil pour surveiller les effets, les concentrations et les dosages de medicaments anesthesiques, a l'aide de representations a n dimensions de fonctions critiques
US20050054942A1 (en) 2002-01-22 2005-03-10 Melker Richard J. System and method for therapeutic drug monitoring
US7043415B1 (en) 2001-01-31 2006-05-09 Pharsight Corporation Interactive graphical environment for drug model generation
US20020130779A1 (en) 2001-03-13 2002-09-19 Herbert Ford Intensive care calculator
CA2440799A1 (fr) 2001-03-14 2002-09-19 Baxter International Inc. Systeme et procede de gestion d'un traitement fondee sur internet
US7015193B2 (en) 2001-04-20 2006-03-21 University Of Vermont Compositions and methods to control bleeding
US6844149B2 (en) 2001-06-29 2005-01-18 International Business Machines Corporation Method, system, and apparatus for measurement and recording of blood chemistry and other physiological measurements
GB0116142D0 (en) 2001-07-02 2001-08-22 Astrazeneca Ab Method
JP4495962B2 (ja) 2001-07-31 2010-07-07 スコット・ラボラトリーズ・インコーポレイテッド ドラッグデリバリを滴定する装置および方法
CA2459328C (fr) 2001-08-27 2008-03-11 Informmed Calculateur de posologie portatif
CA2496143A1 (fr) 2001-10-12 2003-04-17 University Of Utah Research Foundation Appareil de surveillance pour medicament anesthesiant
US20030078760A1 (en) 2001-10-19 2003-04-24 Globomax Holdings, Llc Population pharmacokinetic modeling and analysis (PDx-POP™)
US6944638B1 (en) 2001-11-14 2005-09-13 Katharine T. Putnam Medication dosage calculator
US7204823B2 (en) 2001-12-19 2007-04-17 Medtronic Minimed, Inc. Medication delivery system and monitor
US20070167853A1 (en) 2002-01-22 2007-07-19 Melker Richard J System and method for monitoring health using exhaled breath
AU2003213821A1 (en) 2002-03-11 2003-09-29 The University Of Vermont And State Agriculture College Blood clotting predictor
US20100205001A1 (en) 2002-05-15 2010-08-12 Novo Nordisk A/S System and method for assisting in the home treatment of a medical condition
US20060129357A1 (en) 2002-08-27 2006-06-15 Francis Mathis, Inc., D/B/A Informmed Medication dose calculator
US20080052317A1 (en) 2002-08-27 2008-02-28 Francis Katharine R Medication dose calculator and associated methods
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
EP1593080A2 (fr) 2003-02-01 2005-11-09 Baxter International Inc. Systeme et procede de communication de donnees medicales sans fil
US9342657B2 (en) 2003-03-24 2016-05-17 Nien-Chih Wei Methods for predicting an individual's clinical treatment outcome from sampling a group of patient's biological profiles
WO2004091487A2 (fr) 2003-04-09 2004-10-28 Wyeth Traitement de l'hemophilie par inhalation de facteurs de coagulation
WO2004101740A2 (fr) 2003-05-06 2004-11-25 Syntonix Pharmaceuticals, Inc. Proteines chimeriques a facteur de coagulation-region constante (fc) destinees au traitement de l'hemophilie
AU2004311577A1 (en) 2003-07-11 2005-07-21 Myriad Genetics, Inc. Pharmaceutical methods, dosing regimes and dosage forms for the treatment of Alzheimer's disease
US8200775B2 (en) 2005-02-01 2012-06-12 Newsilike Media Group, Inc Enhanced syndication
WO2005038049A2 (fr) 2003-10-06 2005-04-28 Heinrich Guenther Systeme et methode pour optimiser une pharmacotherapie
SE0302815D0 (sv) 2003-10-24 2003-10-24 Mathcore Engineering Ab Computer system for determining a drug dosage
US8774886B2 (en) 2006-10-04 2014-07-08 Dexcom, Inc. Analyte sensor
DE102004010516A1 (de) 2004-03-04 2005-09-22 Bayer Technology Services Gmbh Verbessertes Verfahren zur zeitlichen Dosierung von Arzneistoffen
US7813880B2 (en) 2004-03-25 2010-10-12 University Of Maryland, Baltimore Apparatus and method for providing optimal concentrations for medication infusions
US20050215957A1 (en) 2004-03-26 2005-09-29 Mallinckrodt Inc. Calibrated pushrod for injection volume control in prefilled syringes
EP1642607A1 (fr) 2004-10-04 2006-04-05 Sanofi-Aventis Deutschland GmbH Mécanisme d'affichage de dose destiné à un dispositif d'administration de médicament
US20060078897A1 (en) 2004-10-13 2006-04-13 Wedinger Robert S Method of providing customized drug delivery correlating to a patient's metabolic profile
JP2006155071A (ja) 2004-11-26 2006-06-15 Toshiba Sumiden Medical Information Systems Corp 電子カルテ薬物療法指示実施システム
US20080040151A1 (en) 2005-02-01 2008-02-14 Moore James F Uses of managed health care data
US20060271405A1 (en) 2005-05-27 2006-11-30 Regents Of The University Of Minnesota Pharmaceutical care of patients and documentation system therefor
CA2630604C (fr) 2005-11-29 2016-01-19 Children's Hospital Medical Center Optimisation et personnalisation de selection et de dosage de medicaments
US7875288B2 (en) 2006-03-30 2011-01-25 The Research Foundation Of State University Of New York Method for treating blood coagulation disorders
US7990251B1 (en) 2006-05-17 2011-08-02 Ford Jr Herbert Drug management systems
DE102006028232A1 (de) 2006-06-20 2007-12-27 Bayer Technology Services Gmbh Vorrichtung und Verfahren zur Berechnung und Bereitstellung einer Medikamentendosis
WO2008009459A1 (fr) 2006-07-21 2008-01-24 Novartis Ag Modèle pharmacocinétique de l'acide mycophénolique
US20080091084A1 (en) 2006-10-12 2008-04-17 Yudkovitch Laurence M User interface for a pk/pd anesthetic drug model display
US20080091083A1 (en) 2006-10-12 2008-04-17 Yudkovitch Laurence M Anesthetic drug model user interface
US7997269B2 (en) 2006-10-18 2011-08-16 General Electric Company System and method of safely displaying PK/PD anesthetic drug models
US8326545B2 (en) 2006-10-18 2012-12-04 General Electric Company System and method for displaying a pharmacokinetic and pharmacodynamic drug model
JP5558106B2 (ja) 2007-01-03 2014-07-23 ノボ ノルディスク ヘルス ケア アーゲー 凝固第ｖｉｉ因子関連ポリペプチドの皮下投与
US9398863B2 (en) 2007-06-20 2016-07-26 General Electric Company Detection of anomalies in measurement of level of hypnosis
KR101423807B1 (ko) 2007-06-27 2014-07-30 에프. 호프만-라 로슈 아게 환자 생리학의 모델링에 기초하여 환자 맞춤형 치료를 개발하는 시스템 및 방법
WO2009002622A2 (fr) 2007-06-27 2008-12-31 F. Hoffman-La Roche Ag Interface d'entrée d'informations de patient pour un système de thérapie
US8156158B2 (en) 2007-07-18 2012-04-10 Famillion Ltd. Method and system for use of a database of personal data records
EP2210226A4 (fr) 2007-10-12 2013-11-06 Patientslikeme Inc Procédé auto-amélioré d'utilisation de communautés en ligne pour prédire des résultats cliniques
US20090144082A1 (en) 2007-11-30 2009-06-04 Steven Selbst Physician practice management software for maximizing reimbursement rates from payer contracts
CN104622879A (zh) 2008-02-12 2015-05-20 托斯克公司 减少毒性的多柔比星助剂及其使用方法
WO2009111465A2 (fr) 2008-03-03 2009-09-11 Virginia Commonwealth University Modélisation détaillée du système immunitaire-inflammatoire de coagulation-fibrinolyse fortement réticulé
EP2286359A2 (fr) 2008-03-27 2011-02-23 Medtronic, Inc. Outils pharmacocinétiques et pharmacodynamiques destinés à définir des régimes thérapeutiques spécifiques à un patient
US8682687B2 (en) 2008-04-24 2014-03-25 The Invention Science Fund I, Llc Methods and systems for presenting a combination treatment
US9649469B2 (en) 2008-04-24 2017-05-16 The Invention Science Fund I Llc Methods and systems for presenting a combination treatment
US20100036676A1 (en) 2008-08-07 2010-02-11 E-Merge Health Solutions, Ltd. Computer implemented medical treatment management system
US8546096B2 (en) 2008-08-22 2013-10-01 Baxter International Inc. Method for identifying a non-anticoagulant sulfated polysaccharide which enhances blood coagulation dependence on FXI
US8591454B2 (en) 2008-11-10 2013-11-26 The Invention Science Fund I, Llc Administering a therapeutic agent with more than one taggant
US20100152620A1 (en) 2008-12-12 2010-06-17 Immersion Corporation Method and Apparatus for Providing A Haptic Monitoring System Using Multiple Sensors
US9727139B2 (en) 2008-12-12 2017-08-08 Immersion Corporation Method and apparatus for providing a haptic monitoring system using multiple sensors
US20100169063A1 (en) 2008-12-31 2010-07-01 The General Electric Company System and Method of Modeling the Pharmacodynamic Effect to Drugs Delivered to a Patient
US8512309B2 (en) 2009-01-15 2013-08-20 Teva Medical Ltd. Vial adapter element
EP2403401B1 (fr) 2009-03-04 2017-05-10 Sensible Medical Innovations Ltd. Système de surveillance de tissus intracorporels
WO2010111403A2 (fr) 2009-03-25 2010-09-30 Proteus Biomedical, Inc. Pharmacocinétique probabiliste et modélisation pharmacodynamique
US20100273738A1 (en) 2009-04-23 2010-10-28 Valcke Christian P Integrated patient management and control system for medication delivery
US8412538B2 (en) 2009-06-09 2013-04-02 Wellpartner Incorporated System and method for prepurchased replenishment of pharmaceuticals
EP2443620B1 (fr) 2009-06-16 2018-09-05 SimQuest LLC Simulateur de contrôle d'hémorragie
US8838694B2 (en) * 2009-06-19 2014-09-16 Futurewei Technologies, Inc. System and method for shared multimedia experiences across multiple subscriptions
US20110015939A1 (en) 2009-07-17 2011-01-20 Marcos Lara Gonzalez Systems and methods to create log entries and share a patient log using open-ended electronic messaging and artificial intelligence
WO2011014721A2 (fr) 2009-07-30 2011-02-03 Transposagen Biopharmaceuticals, Inc. Modèles de rat génétiquement modifiés pour pharmacocinétique
US8370056B2 (en) 2009-08-12 2013-02-05 Ford Global Technologies, Llc False event suppression for collision avoidance systems
EA201200543A1 (ru) 2009-09-28 2012-11-30 Иллюминэр Холдингз Лтд. Устройство внутривлагалищного наблюдения и сеть
HUE036233T2 (hu) 2009-12-06 2018-06-28 Bioverativ Therapeutics Inc VIII-FC Faktor kimérás és hibrid polipeptidek, és ezek használati módszerei
US8318641B2 (en) 2010-02-10 2012-11-27 Selinfreund Richard H Systems and methods for the detection of biomarkers
EP2371284A1 (fr) 2010-03-24 2011-10-05 C A Casyso AG Procédé et appareil pour définir au moins un paramètre d'évaluation d'un échantillon sanguin
TWI479152B (zh) * 2010-04-15 2015-04-01 Univ Ming Chi Technology Methods of detecting allergic asthma by immunization with chitin
CN107325979B (zh) 2010-06-18 2023-01-24 北卡罗莱纳州立大学 减少炎性反应的具有减少的脂磷壁酸的重组乳杆菌
UA126265C2 (uk) 2010-07-09 2022-09-14 Байовератів Терапьютікс Інк. Поліпептид фактора іх і спосіб його застосування
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012024401A2 (fr) 2010-08-17 2012-02-23 University Of Florida Research Foundation, Inc. Système intelligent d'administration de médicament et/ou de fluide, destiné à optimiser un traitement médical ou une thérapie au moyen de données pharmacodynamiques et/ou pharmacocinétiques
SG189914A1 (en) 2010-10-27 2013-06-28 Baxter Int Fviii peptides for immune tolerance induction and immunodiagnostics
US8589186B1 (en) 2010-11-01 2013-11-19 Walgreen Co. Systems and methods for determining pharmaceutical consultation compliance
DK2652655T3 (da) 2010-12-16 2019-08-05 Region Nordjylland Fremgangsmåder og modeller til forudberegning af dosis af et lægemiddel og/eller respons i et individ
JP5625895B2 (ja) 2010-12-27 2014-11-19 株式会社ジェイ・エム・エス オス部材カバー及びカバー付きオス部材
WO2012126800A1 (fr) 2011-03-18 2012-09-27 Sanofi-Aventis Deutschland Gmbh Calcul d'une dose de médicament
CN103688332A (zh) 2011-05-25 2014-03-26 赛诺菲-安万特德国有限公司 具有剂量按钮的手持给药装置
CN104160274A (zh) 2011-05-30 2014-11-19 奥德特里克公司 通过照护点药物动力学曲线分析进行治疗药物监测和投配的方法与组合物
KR101969515B1 (ko) 2011-06-10 2019-04-16 박스알타 인코퍼레이티드 재조합 vwf의 투여에 의한 응고 질환의 치료
WO2013049624A1 (fr) 2011-09-30 2013-04-04 University Of Louisville Research Foundation, Inc. Système et procédé de dosage personnalisé d'agents pharmacologiques
US20130085712A1 (en) 2011-09-30 2013-04-04 Industrial Technology Research Institute Inertial sensing input apparatus and method thereof
US10289953B2 (en) * 2011-12-13 2019-05-14 Koninklijke Philips N.V. Dose optimization based on outcome quality
CA2877466C (fr) 2012-06-27 2020-07-28 Carmel Pharma Ab Dispositif de raccordement medical
US9500639B2 (en) 2012-07-18 2016-11-22 Theranos, Inc. Low-volume coagulation assay
WO2014018777A2 (fr) 2012-07-25 2014-01-30 Biogen Idec Ma Inc. Essai de surveillance de facteur sanguin et utilisations de celui-ci
US8744828B2 (en) 2012-07-26 2014-06-03 Rimidi Diabetes, Inc. Computer-implemented system and method for improving glucose management through modeling of circadian profiles
JP5868555B2 (ja) 2012-09-13 2016-02-24 メディモップ・メディカル・プロジェクツ・リミテッド 入れ子式雌薬瓶アダプタ
JP6412499B2 (ja) 2012-10-05 2018-10-24 ダイアン モールド 数学モデルの関数として患者特有の投与を提供するためのシステムおよび方法
AU2013331000B2 (en) 2012-10-18 2018-04-19 Bioverativ Therapeutics Inc. Methods of using a fixed dose of a clotting factor
US20140114676A1 (en) 2012-10-23 2014-04-24 Theranos, Inc. Drug Monitoring and Regulation Systems and Methods
EP3943102A1 (fr) 2012-10-30 2022-01-26 Bioverativ Therapeutics Inc. Procédé d'utilisation de polypeptide du facteur viii
US20150356252A1 (en) 2013-01-16 2015-12-10 Medaware Ltd. Medical database and system
AU2014217831A1 (en) 2013-02-16 2015-07-16 Albumedix Ltd. Pharmacokinetic animal model
US9345642B2 (en) 2013-03-14 2016-05-24 Pharmajet, Inc. Vial adapter for a needle-free syringe
US8961479B2 (en) 2013-03-19 2015-02-24 Biolife, L.L.C. Hemostatic device and method
US20140303901A1 (en) 2013-04-08 2014-10-09 Ilan Sadeh Method and system for predicting a disease
US9849241B2 (en) * 2013-04-24 2017-12-26 Fresenius Kabi Deutschland Gmbh Method of operating a control device for controlling an infusion device
CA2915472C (fr) * 2013-06-20 2023-09-19 Baxalta GmbH Appareil de regime de dosage de medicament pharmacocinetique et methode
WO2015026837A1 (fr) 2013-08-20 2015-02-26 Baxter International Inc. Dispositif pour encourager l'adhésion à un programme de médication et technique d'administration appropriée
WO2015085276A1 (fr) * 2013-12-06 2015-06-11 Biogen Idec Ma Inc. Outils pharmacocinétiques de population et leurs utilisations
FR3016461B1 (fr) 2014-01-10 2017-06-23 Imabiotech Procede de traitement de donnees d'imagerie moleculaire et serveur de donnees correspondant
US10534895B2 (en) 2015-01-20 2020-01-14 Icpd Technologies, Llc System and method for ranking options for medical treatments
AU2016245862A1 (en) 2015-04-09 2018-02-22 Diane R. Mould Systems and methods for patient-specific dosing
SG11201808475XA (en) 2016-04-15 2018-10-30 Baxalta Inc Method and apparatus for providing a pharmacokinetic drug dosing regiment

Also Published As

Publication number Publication date
CL2018002870A1 (es) 2019-08-09
UA126379C2 (uk) 2022-09-28
KR20190003568A (ko) 2019-01-09
US11670409B2 (en) 2023-06-06
MX2018012612A (es) 2019-02-21
IL284083B (en) 2022-01-01
EP3442656A4 (fr) 2020-07-08
JP2019514114A (ja) 2019-05-30
JP6942721B2 (ja) 2021-09-29
BR112018070463A2 (pt) 2019-02-05
IL284083A (en) 2021-07-29
MY197302A (en) 2023-06-12
EA201892347A1 (ru) 2019-04-30
CA3020346A1 (fr) 2017-10-19
BR112018070463A8 (pt) 2022-08-30
CN109804432B (zh) 2023-07-14
IL288790A (en) 2022-02-01
CN109804432A (zh) 2019-05-24
AR108212A1 (es) 2018-07-25
IL288790B2 (en) 2024-01-01
KR20220098398A (ko) 2022-07-12
US11081211B2 (en) 2021-08-03
TWI672602B (zh) 2019-09-21
US20210343375A1 (en) 2021-11-04
IL288790B1 (en) 2023-09-01
TW201741914A (zh) 2017-12-01
KR102468699B1 (ko) 2022-11-21
JP7287697B2 (ja) 2023-06-06
EP4343774A2 (fr) 2024-03-27
US11749394B2 (en) 2023-09-05
EP3442656A1 (fr) 2019-02-20
SG11201808475XA (en) 2018-10-30
KR102415992B1 (ko) 2022-07-04
AU2017250570A1 (en) 2018-11-15
IL262226A (en) 2018-11-29
CO2018012293A2 (es) 2019-02-08
ZA201807214B (en) 2023-10-25
WO2017180807A1 (fr) 2017-10-19
IL262226B (en) 2021-07-29
US20210027876A1 (en) 2021-01-28
US20200312436A1 (en) 2020-10-01
JP2022003540A (ja) 2022-01-11
PH12018502178A1 (en) 2019-10-21
EP3442656B1 (fr) 2023-12-13

Similar Documents

Publication Publication Date Title
MA43617A1 (fr) Méthode et appareil générant un schéma posologique pharmacocinétique
EP4279135A3 (fr) Utilisation d'un antagoniste du vegf pour le traitement de la rétinopathie diabétique
MX2022011167A (es) Metodos para mejorar las respuestas inmune innata y/o deteccion de patogenos de la mucosa mediante oligosacaridos de la leche humana.
WO2013109279A3 (fr) Stabilisation de l'anticorps anti-cd20 rituximab
MX2018008849A (es) Diagnostico diferencial de sindrome de cushing ectopico.
EA201690537A1 (ru) Способы и средства для введения контрастной среды
WO2017140416A3 (fr) Dispositif pour réaliser un traitement extra-corporel du sang
MA34381B1 (fr) Procédé de prédiction de réponse thérapeutique chez des patients atteints de sclérose en plaques
Inan Greater occipital nerve blockade for the treatment of chronic migraine
Rai Blood pressure and heart rate dropped in an elderly patient: case report
TH160649B (th) เครื่องและวิธีการสำหรับข้อกำหนดการให้ขนาดยาทางเภสัชจลนศาสตร์
Rad Drug induced-angioedema: case report
Dutta Delirium: case report
Dohmen Biliary pseudolithiasis: case report
Zhou Dasatinib/interferon alpha
TH179028A (th) วิธีการและเครื่องมือที่เกี่ยวข้องกับการจ่ายสารเพิ่มความชัดภาพ
Aoufi Rabih Retinopathy: case report
Chamorro-de-Vega Ombitasvir/paritaprevir/ritonavir/dasabuvir
Honda Stevens Johnson Syndrome: case report
Tufan Macular hole: case report
Narayanaswamy et al. Investigating the interaction between KNDy peptides on gonadotrophin release in humans-novel findings with therapeutic importance
Kimura et al. Treatment persistence with antidepressants in Japan: Assessment of the first 60 days of treatment based on pharmacy claims data from reimbursement database
Garcia-Catalan Charles Bonnet syndrome in an elderly patient: case report
Gharib Immune-globulin
Tang et al. Treatment recommendations for invasive fungal disease in pediatric patients with cancer or blood disease