BR112018068381A2 - replicon de rna, sistema, dna, métodos para produção de uma proteína de interesse e célula - Google Patents
replicon de rna, sistema, dna, métodos para produção de uma proteína de interesse e célulaInfo
- Publication number
- BR112018068381A2 BR112018068381A2 BR112018068381A BR112018068381A BR112018068381A2 BR 112018068381 A2 BR112018068381 A2 BR 112018068381A2 BR 112018068381 A BR112018068381 A BR 112018068381A BR 112018068381 A BR112018068381 A BR 112018068381A BR 112018068381 A2 BR112018068381 A2 BR 112018068381A2
- Authority
- BR
- Brazil
- Prior art keywords
- protein
- rna replicon
- replicase
- replication
- present
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 5
- 102000004169 proteins and genes Human genes 0.000 title abstract 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 6
- 230000010076 replication Effects 0.000 abstract 5
- 241000710929 Alphavirus Species 0.000 abstract 4
- 108010026228 mRNA guanylyltransferase Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 3
- 108700026244 Open Reading Frames Proteins 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 108020004705 Codon Proteins 0.000 abstract 1
- 108020004414 DNA Proteins 0.000 abstract 1
- 108091081024 Start codon Proteins 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000014616 translation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/36011—Togaviridae
- C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
- C12N2770/36141—Use of virus, viral particle or viral elements as a vector
- C12N2770/36143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
a presente invenção abrange um replicon de rna que pode ser replicado por uma replicase de origem alfaviral. o replicon de rna compreende elementos de sequência necessários para replicação pela replicase, mas estes elementos de sequência não codificam nenhuma proteína ou fragmento desta, tal como uma proteína não estrutural de alfavírus ou fragmento da mesma. assim, no replicon de rna de acordo com a invenção, os elementos de sequência necessários para a replicação pela replicase e região(ões) codificante(s) de proteína estão desacoplados. de acordo com a presente invenção, o desacoplamento é conseguido pela remoção de pelo menos um códon de iniciação em comparação com um rna genômico de alfavírus nativo. em particular, o replicon de rna compreende uma sequência de reconhecimento de replicação 5?, em que a sequência de reconhecimento de replicação 5? é caracterizada por compreender a remoção de pelo menos um códon de iniciação em comparação com uma sequência de reconhecimento de replicação 5? de um alfavírus nativo. a replicase da origem alfaviral pode ser codificada por um quadro de leitura aberto no replicon de rna ou molécula de rna separada. a presente invenção permite a expressão eficiente e segura de uma proteína de interesse em uma célula ou organismo, mas não está associada à produção indesejada de fragmentos de proteína não estrutural de alfavírus. a presente invenção provê métodos de produção de proteína in vitro e in vivo, bem como a utilização médica.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2016/056165 WO2017162266A1 (en) | 2016-03-21 | 2016-03-21 | Rna replicon for versatile and efficient gene expression |
| PCT/EP2017/055808 WO2017162460A1 (en) | 2016-03-21 | 2017-03-13 | Rna replicon for versatile and efficient gene expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018068381A2 true BR112018068381A2 (pt) | 2019-01-15 |
Family
ID=55587284
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018068381A BR112018068381A2 (pt) | 2016-03-21 | 2017-03-13 | replicon de rna, sistema, dna, métodos para produção de uma proteína de interesse e célula |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US11168337B2 (pt) |
| EP (2) | EP3433369B1 (pt) |
| JP (2) | JP7121443B2 (pt) |
| KR (1) | KR102161607B1 (pt) |
| CN (2) | CN115927467A (pt) |
| AU (1) | AU2017236239B2 (pt) |
| BR (1) | BR112018068381A2 (pt) |
| CA (1) | CA3017272A1 (pt) |
| CY (1) | CY1125086T1 (pt) |
| DK (2) | DK3433369T3 (pt) |
| ES (2) | ES2784711T3 (pt) |
| HK (1) | HK1259449A1 (pt) |
| HR (1) | HRP20220044T1 (pt) |
| HU (2) | HUE059139T2 (pt) |
| IL (2) | IL261379B (pt) |
| LT (1) | LT3701959T (pt) |
| MX (1) | MX2018011383A (pt) |
| PL (2) | PL3433369T3 (pt) |
| PT (2) | PT3433369T (pt) |
| RS (1) | RS62864B1 (pt) |
| RU (1) | RU2748892C2 (pt) |
| SG (1) | SG11201807374WA (pt) |
| SI (2) | SI3701959T1 (pt) |
| WO (2) | WO2017162266A1 (pt) |
| ZA (1) | ZA201805519B (pt) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| JP7389741B2 (ja) * | 2017-09-13 | 2023-11-30 | バイオエヌテック セル アンド ジーン セラピーズ ゲーエムベーハー | Ｔ細胞受容体または人工ｔ細胞受容体を発現するためのｒｎａレプリコン |
| CN111094549B (zh) * | 2017-09-13 | 2024-11-01 | 生物技术公司 | 用于将体细胞重编程的rna复制子 |
| AU2020207641A1 (en) | 2019-01-10 | 2021-07-22 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| CN114341361A (zh) * | 2019-06-10 | 2022-04-12 | 传染病研究所 | 星状病毒复制子的方法和组合物 |
| TW202128775A (zh) | 2019-10-16 | 2021-08-01 | 英商阿法克塔生命科學有限公司 | PD-L1抑制劑-TGFβ抑制劑雙特異性藥物部分 |
| PE20221182A1 (es) | 2019-11-18 | 2022-08-05 | Janssen Biotech Inc | Vacunas basadas en calr y jak2 mutantes y sus usos |
| CN110890127B (zh) * | 2019-11-27 | 2024-02-23 | 山东大学 | 酿酒酵母dna复制起始区域识别方法 |
| CN116196405A (zh) | 2019-12-31 | 2023-06-02 | 伊利克斯根治疗公司 | 核酸和蛋白质向细胞和组织的基于温度的瞬时递送 |
| EP4103228A1 (en) | 2020-02-13 | 2022-12-21 | Institut Pasteur | Nucleic acid vaccine against the sars-cov-2 coronavirus |
| EP4117720A4 (en) | 2020-03-09 | 2024-04-24 | Arcturus Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR INDUCING IMMUNE RESPONSES |
| GB2594364A (en) * | 2020-04-22 | 2021-10-27 | Biontech Rna Pharmaceuticals Gmbh | Coronavirus vaccine |
| CN116096409A (zh) * | 2020-05-11 | 2023-05-09 | 杨森制药公司 | 编码稳定化的冠状病毒刺突蛋白的rna复制子 |
| JP2023527910A (ja) * | 2020-06-04 | 2023-06-30 | バイオエヌテック エスエー | 多用途かつ効率的な遺伝子発現のためのｒｎａレプリコン |
| GB202101299D0 (en) | 2020-06-09 | 2021-03-17 | Avacta Life Sciences Ltd | Diagnostic polypetides and methods |
| EP4308136A1 (en) | 2021-03-19 | 2024-01-24 | Tiba Biotech LLC | Artificial alphavirus-derived rna replicon expression systems |
| KR20240006575A (ko) | 2021-04-26 | 2024-01-15 | 앵스띠뛰 파스퇴르 | SARS-CoV-2에 대한 사람 중화 모노클로날 항체 및 이의 용도 |
| WO2022234003A1 (en) | 2021-05-07 | 2022-11-10 | Avacta Life Sciences Limited | Cd33 binding polypeptides with stefin a protein |
| WO2023057567A1 (en) | 2021-10-07 | 2023-04-13 | Avacta Life Sciences Limited | Pd-l1 binding affimers |
| TW202332694A (zh) | 2021-10-07 | 2023-08-16 | 英商阿凡克塔生命科學公司 | 血清半衰期延長之ｐｄ－ｌ１結合多肽 |
| JP2024539087A (ja) | 2021-10-18 | 2024-10-28 | バイオエヌテック エスエー | 修飾複製可能ｒｎａおよび関連組成物ならびにそれらの使用 |
| CN118451194A (zh) | 2021-10-18 | 2024-08-06 | 生物技术公司 | 用于确定用于提高经修饰可复制rna功能的突变的方法以及相关组合物及其用途 |
| EP4285932A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4401788A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4186528A1 (en) | 2021-11-30 | 2023-05-31 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4169534A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide complexes and uses |
| AU2022369405A1 (en) | 2021-10-22 | 2024-05-09 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4286394A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4169578A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4286003A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4402149A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| EP4169579A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| EP4401789A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4402150A1 (en) | 2021-10-22 | 2024-07-24 | BioNTech SE | Oligosaccharide compounds and complexes |
| EP4285933A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Oligosaccharide complexes and uses |
| EP4286004A1 (en) | 2022-05-30 | 2023-12-06 | BioNTech SE | Disulfide oligosaccharide compounds and complexes |
| EP4169580A1 (en) | 2021-10-22 | 2023-04-26 | BioNTech SE | Oligosaccharide compounds and complexes |
| WO2023153876A1 (ko) | 2022-02-10 | 2023-08-17 | 주식회사 아피셀테라퓨틱스 | Cd40l에 특이적으로 결합하는 스테핀 a 단백질 변이체 및 이의 용도 |
| CN114639442B (zh) * | 2022-03-30 | 2024-01-30 | 中国农业科学院农业基因组研究所 | 一种基于单核苷酸多态性预测开放阅读框的方法及系统 |
| WO2023213378A1 (en) | 2022-05-02 | 2023-11-09 | BioNTech SE | Replicon compositions and methods of using same for the treatment of diseases |
| WO2023218243A1 (en) | 2022-05-12 | 2023-11-16 | Avacta Life Sciences Limited | Lag-3/pd-l1 binding fusion proteins |
| WO2023232747A1 (en) | 2022-05-30 | 2023-12-07 | BioNTech SE | Complexes for delivery of nucleic acids |
| WO2024056856A1 (en) | 2022-09-15 | 2024-03-21 | BioNTech SE | Systems and compositions comprising trans-amplifying rna vectors with mirna |
| WO2024068674A1 (en) | 2022-09-26 | 2024-04-04 | BioNTech SE | Nucleic acid complexes and uses thereof |
| WO2024084462A1 (en) | 2022-10-21 | 2024-04-25 | BioNTech SE | Nucleic acid complexes and uses thereof |
| WO2024176192A1 (en) | 2023-02-24 | 2024-08-29 | BioNTech SE | Immunogenic compositions |
| EP4442276A1 (en) | 2023-04-07 | 2024-10-09 | Institut Pasteur | Combined antibodies against sarbecoviruses and uses thereof |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002537842A (ja) | 1999-03-09 | 2002-11-12 | ラージ スケール バイオロジー コーポレイション | 外来の配列を発現するための多成分ｒｎａベクター系 |
| US7045335B2 (en) * | 2001-09-06 | 2006-05-16 | Alphavax, Inc. | Alphavirus replicon vector systems |
| WO2004085660A2 (en) * | 2003-03-20 | 2004-10-07 | Alphavax, Inc. | Improved alphavirus replicons and helper constructs |
| WO2008119827A1 (en) * | 2007-04-02 | 2008-10-09 | Fit Biotech Oy | Transreplicase constructs |
| EP2167523B1 (en) | 2007-06-19 | 2014-07-23 | Board of Supervisors of Louisiana State University and Agricultural and Mechanical College | Synthesis and use of anti-reverse phosphorothioate analogs of the messenger rna cap |
| CA2689588C (en) * | 2007-06-21 | 2016-08-23 | Alphavax, Inc. | Promoterless cassettes for expression of alphavirus structural proteins |
| CA2695484C (en) | 2007-08-20 | 2018-05-01 | Glaxo Group Limited | Production method of therapeutic proteins based on codon adaptation |
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| DE102008061522A1 (de) | 2008-12-10 | 2010-06-17 | Biontech Ag | Verwendung von Flt3-Ligand zur Verstärkung von Immunreaktionen bei RNA-Immunisierung |
| EP2281579A1 (en) | 2009-08-05 | 2011-02-09 | BioNTech AG | Vaccine composition comprising 5'-Cap modified RNA |
| ES2557382T3 (es) | 2010-07-06 | 2016-01-25 | Glaxosmithkline Biologicals Sa | Liposomas con lípidos que tienen un valor de pKa ventajoso para el suministro de ARN |
| RU2625546C2 (ru) | 2010-07-06 | 2017-07-14 | Новартис Аг | Катионные эмульсии "масло-в-воде" |
| CN103384515B (zh) | 2010-08-31 | 2017-02-15 | 诺华有限公司 | 适用于脂质体递送编码蛋白质的rna的脂质 |
| CN103179984A (zh) | 2010-08-31 | 2013-06-26 | 诺华有限公司 | 用于递送免疫原编码rna的peg化脂质体 |
| SI2611467T1 (sl) | 2010-08-31 | 2022-10-28 | Glaxosmithkline Biologicals Sa | Majhni liposomi za dostavo RNA, ki kodira imunogen |
| CN103269713B (zh) * | 2010-10-11 | 2016-01-20 | 诺华有限公司 | 抗原递送平台 |
| CN103796639B (zh) | 2011-07-06 | 2017-05-31 | 诺华股份有限公司 | 阳离子水包油乳液 |
| MX350764B (es) | 2011-07-06 | 2017-09-18 | Novartis Ag | Liposomas con relacion nitrogeno:fosfato (n:p) util para el suministro de moleculas de arn. |
| JP6059220B2 (ja) | 2011-07-06 | 2017-01-18 | ノバルティス アーゲー | 核酸を含む水中油型エマルジョン |
| TR201900264T4 (tr) | 2011-08-31 | 2019-02-21 | Glaxosmithkline Biologicals Sa | İmmünojen şifreleyici rna'nın verilmesi için pegile edilmiş lipozomlar. |
| WO2013143555A1 (en) | 2012-03-26 | 2013-10-03 | Biontech Ag | Rna formulation for immunotherapy |
| WO2014071963A1 (en) | 2012-11-09 | 2014-05-15 | Biontech Ag | Method for cellular rna expression |
| WO2016005004A1 (en) | 2014-07-11 | 2016-01-14 | Biontech Rna Pharmaceuticals Gmbh | Stabilization of poly(a) sequence encoding dna sequences |
-
2016
- 2016-03-21 WO PCT/EP2016/056165 patent/WO2017162266A1/en active Application Filing
-
2017
- 2017-03-13 EP EP17710528.5A patent/EP3433369B1/en active Active
- 2017-03-13 EP EP20156693.2A patent/EP3701959B1/en active Active
- 2017-03-13 MX MX2018011383A patent/MX2018011383A/es unknown
- 2017-03-13 US US16/086,157 patent/US11168337B2/en active Active
- 2017-03-13 SI SI201731043T patent/SI3701959T1/sl unknown
- 2017-03-13 KR KR1020187027294A patent/KR102161607B1/ko active IP Right Grant
- 2017-03-13 HU HUE20156693A patent/HUE059139T2/hu unknown
- 2017-03-13 AU AU2017236239A patent/AU2017236239B2/en active Active
- 2017-03-13 WO PCT/EP2017/055808 patent/WO2017162460A1/en active Application Filing
- 2017-03-13 CN CN202210935299.4A patent/CN115927467A/zh active Pending
- 2017-03-13 PL PL17710528T patent/PL3433369T3/pl unknown
- 2017-03-13 DK DK17710528.5T patent/DK3433369T3/da active
- 2017-03-13 LT LTEP20156693.2T patent/LT3701959T/lt unknown
- 2017-03-13 PT PT177105285T patent/PT3433369T/pt unknown
- 2017-03-13 PT PT201566932T patent/PT3701959T/pt unknown
- 2017-03-13 RU RU2018131966A patent/RU2748892C2/ru active
- 2017-03-13 JP JP2018549313A patent/JP7121443B2/ja active Active
- 2017-03-13 CA CA3017272A patent/CA3017272A1/en active Pending
- 2017-03-13 HU HUE17710528A patent/HUE050350T2/hu unknown
- 2017-03-13 SG SG11201807374WA patent/SG11201807374WA/en unknown
- 2017-03-13 BR BR112018068381A patent/BR112018068381A2/pt active Search and Examination
- 2017-03-13 PL PL20156693T patent/PL3701959T3/pl unknown
- 2017-03-13 CN CN201780019155.1A patent/CN108884473B/zh active Active
- 2017-03-13 ES ES17710528T patent/ES2784711T3/es active Active
- 2017-03-13 DK DK20156693.2T patent/DK3701959T3/da active
- 2017-03-13 HR HRP20220044TT patent/HRP20220044T1/hr unknown
- 2017-03-13 RS RS20220067A patent/RS62864B1/sr unknown
- 2017-03-13 SI SI201730212T patent/SI3433369T1/sl unknown
- 2017-03-13 ES ES20156693T patent/ES2906807T3/es active Active
-
2018
- 2018-08-17 ZA ZA201805519A patent/ZA201805519B/en unknown
- 2018-08-26 IL IL261379A patent/IL261379B/en unknown
-
2019
- 2019-02-01 HK HK19101854.2A patent/HK1259449A1/zh unknown
-
2021
- 2021-10-05 US US17/494,601 patent/US20220033852A1/en active Pending
-
2022
- 2022-01-26 CY CY20221100063T patent/CY1125086T1/el unknown
- 2022-03-03 IL IL291100A patent/IL291100B2/en unknown
- 2022-08-02 JP JP2022123058A patent/JP7465310B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112018068381A2 (pt) | replicon de rna, sistema, dna, métodos para produção de uma proteína de interesse e célula | |
| BR112018068391A2 (pt) | sistema e métodos para produzir uma proteína, célula inoculada, construção de rna para expressar a replicase de alfavírus e dna | |
| BR112017015906A2 (pt) | complexo compreendendo um peptídeo de penetração celular, uma carga e um agonista de peptídeo tlr | |
| BR112017020445A2 (pt) | polipeptídeo de fusão, molécula de ácido nucleico, célula hospedeira, método de produção de um polipeptídeo de fusão, uso do polipeptídeo de fusão, método para ativar as vias de sinalização, método para coestimular células, método para induzir a proliferação de linfócitos e método para direcionar o agrupamento de cd137 | |
| BR112014019627A2 (pt) | ácido nucleico compreendendo ou codificando uma haste-alça de histona e sequência poli(a) ou sinal de poliadenilação para aumento da expressão de uma proteína terapêutica codificada | |
| BR112018011002A2 (pt) | variantes de fgf21 | |
| BR112016030462A2 (pt) | moléculas de ligação, um ou mais polinucleotídeos isolados, um ou mais vetores, célula hospedeira, método de produção de uma molécula de ligação, composição farmacêutica, uso da molécula de ligação, método de tratamento de doenças e de indução da lise de células alvo | |
| BR112014017384A2 (pt) | ácido nucleico que compreende ou codifica para uma estrutura em haste laçada de histona e uma sequência poli (a) ou um sinal de poliadenilação para aumentar a expressão de um antigênio de tumor codificado | |
| BR112017017293A2 (pt) | método para predizer modificações de aminoácidos, para selecionar e/ou classificar modificações de aminoácidos e para fornecer uma vacina e vacina | |
| BR112017015773A2 (pt) | muteína de lipocalina, muteína de hngal, molécula de ácido nucleico, célula hospedeira, método para produzir a muteína de hngal, composição farmacêutica, kit, uso da muteína de hngal, uso da muteína de hngal, método para ligar ang-2 em um indivíduo, método para inibir angiogênese em um indivíduo, método para tratar, prevenir ou melhorar uma doença e método para inibir ou reduzir angiogênese em um indivíduo | |
| BR112017009177A2 (pt) | vacinas terapêuticas contra hpv16 | |
| BR112014019459A8 (pt) | Proteínas de ligação à cdim e usos das mesmas | |
| GT201600084A (es) | (aza) piridopirazolopirimidinonas e indazolopirimidinonas y su uso | |
| MX2017000378A (es) | ANTICUERPOS DE UNION A PROTOFIBRILLAS BETA AMILOIDE (Aß) MEJORADOS. | |
| BR112017027048A2 (pt) | processo para extração de pectina e uso da pectina | |
| BR112015018591B8 (pt) | Processo para a produção de um concentrado de café líquido, e, concentrado de café líquido | |
| BR112018017077A2 (pt) | terapias de combinação para tratamento de atrofia muscular espinhal | |
| BR112016030728A2 (pt) | método para tratar ou prevenir uma inflamação induzida por bactérias em um indivíduo, composição imunogênica, composição farmacêutica, uso da composição imunogênica, método para produzir uma composição imunogênica, e, método para tratar ou prevenir uma doença | |
| Fornai et al. | Virtual reconstruction of the pelvic remains of KNM-WT 15000 Homo erectus from Nariokotome, Kenya | |
| Wang et al. | Study on the improvement of hemorheology and prognosis of cervical spondylosis of vertebral artery by combination of strong dingxuan tablet | |
| BR112016027915A2 (pt) | endoprotease específica de prolina e uso da mesma | |
| Huynh | Molecular Simulations of Membrane Proteins Related to Human Diseases | |
| Min et al. | Screening for the Interaction of Diabetes Mellitus and Other Factors in Tuberculosis | |
| Wang et al. | Curative effect of inhalation of hypertonic saline combined with epinephrine in the treatment of acute moderate and severe bronchiolitis | |
| Can et al. | The effect of smokeless tobacco |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ GEMEINNUETZIGE GMBH (DE) ; BIONTECH SE (DE) |
|
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] |