BR112018010391A2 - agonista de receptor de adenosina a3ar, ligante de a3ar, uso de um agonista de a3ar para a preparação de uma composição farmacêutica, composição farmacêutica, método para reduzir acúmulo de lipídeo em um tecido hepático de um indivíduo, e kit - Google Patents
agonista de receptor de adenosina a3ar, ligante de a3ar, uso de um agonista de a3ar para a preparação de uma composição farmacêutica, composição farmacêutica, método para reduzir acúmulo de lipídeo em um tecido hepático de um indivíduo, e kitInfo
- Publication number
- BR112018010391A2 BR112018010391A2 BR112018010391-8A BR112018010391A BR112018010391A2 BR 112018010391 A2 BR112018010391 A2 BR 112018010391A2 BR 112018010391 A BR112018010391 A BR 112018010391A BR 112018010391 A2 BR112018010391 A2 BR 112018010391A2
- Authority
- BR
- Brazil
- Prior art keywords
- a3ar
- pharmaceutical composition
- agonist
- preparation
- kit
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 4
- 239000000556 agonist Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 229940122614 Adenosine receptor agonist Drugs 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 230000006372 lipid accumulation Effects 0.000 title 1
- 210000005228 liver tissue Anatomy 0.000 title 1
- 239000003379 purinergic P1 receptor agonist Substances 0.000 title 1
- 238000009825 accumulation Methods 0.000 abstract 4
- 239000011230 binding agent Substances 0.000 abstract 4
- 208000004930 Fatty Liver Diseases 0.000 abstract 2
- 206010019708 Hepatic steatosis Diseases 0.000 abstract 2
- 208000010706 fatty liver disease Diseases 0.000 abstract 2
- 231100000240 steatosis hepatitis Toxicity 0.000 abstract 2
- IPSYPUKKXMNCNQ-PFHKOEEOSA-N (2s,3s,4r,5r)-5-[2-chloro-6-[(3-iodophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-n-methyloxolane-2-carboxamide Chemical compound O[C@@H]1[C@H](O)[C@@H](C(=O)NC)O[C@H]1N1C2=NC(Cl)=NC(NCC=3C=C(I)C=CC=3)=C2N=C1 IPSYPUKKXMNCNQ-PFHKOEEOSA-N 0.000 abstract 1
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
a presente revelação se refere ao ligante de a3ar para reduzir acúmulo ectópico de gordura, particularmente, em fígado gorduroso. também provido pela presente revelação é o uso de ligante de a3ar para a preparação de uma composição farmacêutica para reduzir esse acúmulo de gordura, método de tratamento de uma condição associada ao acúmulo de gordura fazendo uso do ligante e kits compreendendo composições farmacêuticas compreendendo o ligante, e instruções para uso dele, para tratar uma condição associada ao acúmulo ectópico de gordura. em uma realização, a presente revelação provê o uso de um agonista de a3ar, como 2-cloro-n6-(3-iodobenzil)-adenosina-5?-n-metiluronamida (cl-ib-meca, cf102) para tratar fígado gorduroso, especificamente, doença hepática gordurosa não alcoólica (dhgna).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IL242723A IL242723B (en) | 2015-11-23 | 2015-11-23 | A3 adenosine receptor ligand for the treatment of ectopic fat accumulation |
| IL242723 | 2015-11-23 | ||
| PCT/IL2016/051258 WO2017090036A1 (en) | 2015-11-23 | 2016-11-22 | An a3 adenosine receptor ligand for use in treating ectopic fat accumulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112018010391A2 true BR112018010391A2 (pt) | 2018-11-21 |
| BR112018010391A8 BR112018010391A8 (pt) | 2019-02-26 |
Family
ID=57485841
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018010391A BR112018010391A8 (pt) | 2015-11-23 | 2016-11-22 | agonista de receptor de adenosina a3ar, ligante de a3ar, uso de um agonista de a3ar para a preparação de uma composição farmacêutica, composição farmacêutica, método para reduzir acúmulo de lipídeo em um tecido hepático de um indivíduo, e kit |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10780106B2 (pt) |
| EP (1) | EP3380104B1 (pt) |
| JP (2) | JP6980655B2 (pt) |
| KR (1) | KR102103657B1 (pt) |
| CN (1) | CN108367016B (pt) |
| BR (1) | BR112018010391A8 (pt) |
| CA (1) | CA3005961C (pt) |
| DK (1) | DK3380104T3 (pt) |
| ES (1) | ES2848150T3 (pt) |
| HR (1) | HRP20210020T1 (pt) |
| HU (1) | HUE053558T2 (pt) |
| IL (3) | IL242723B (pt) |
| LT (1) | LT3380104T (pt) |
| MX (1) | MX2018006026A (pt) |
| PL (1) | PL3380104T3 (pt) |
| PT (1) | PT3380104T (pt) |
| RS (1) | RS61372B1 (pt) |
| SI (1) | SI3380104T1 (pt) |
| WO (1) | WO2017090036A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL254535A0 (en) * | 2017-09-17 | 2017-11-30 | Can Fite Biopharma Ltd | Adenosine a3 receptor ligand for use in the management of cytokine release syndrome |
| IL264112A (en) * | 2019-01-06 | 2020-07-30 | Fishman Pnina | Adenosine a3 receptor ligand for use in lowering adipocyte levels |
| IL272078A (en) | 2020-01-16 | 2021-07-29 | Can Fite Biopharma Ltd | Cannabinoids for use in therapy |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5443836A (en) | 1993-03-15 | 1995-08-22 | Gensia, Inc. | Methods for protecting tissues and organs from ischemic damage |
| US5688774A (en) | 1993-07-13 | 1997-11-18 | The United States Of America As Represented By The Department Of Health And Human Services | A3 adenosine receptor agonists |
| EP0708781B1 (en) | 1993-07-13 | 2001-10-04 | THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services | A 3 adenosine receptor agonists |
| WO1997027173A2 (en) | 1996-01-24 | 1997-07-31 | Sumitomo Chemical Company, Limited | Dihalopropene compounds, their use as insecticides/acaricides and intermediates for their production |
| US6048865A (en) | 1997-07-29 | 2000-04-11 | Medco Research, Inc. | N6 -substituted-adenosine-5'-uronamides as adenosine receptor modulator |
| EP1019427A4 (en) | 1997-07-29 | 2000-07-19 | Medco Res Inc | N? 6 -SUBSTITUES-ADENOSINE-5'-URONAMIDES USEFUL AS MODULATORS OF ADENOSINE RECEPTORS |
| WO1999020284A1 (en) | 1997-10-23 | 1999-04-29 | Trustees Of The University Of Pennsylvania | Methods for reducing ischemic injury of the heart via the sequential administration of monophosphoryl lipid a and adenosine receptor agents |
| IL133680A0 (en) | 1999-09-10 | 2001-04-30 | Can Fite Technologies Ltd | Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist |
| CA2434906C (en) * | 2001-01-16 | 2008-08-19 | Can-Fite Biopharma Ltd. | Use of an adenosine a3 receptor agonist for inhibition of viral replication |
| EP1983990B1 (en) | 2006-01-26 | 2011-03-23 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | A3 adenosine receptor allosteric modulators |
| DK2227234T3 (da) * | 2007-10-15 | 2014-08-11 | Can Fite Biopharma Ltd | Fremgangsmåde til induktion af hepatocytproliferering og anvendelserderaf |
| US20150018299A1 (en) | 2012-01-23 | 2015-01-15 | Can-Fite Biopharma Ltd. | Treatment of liver conditions |
-
2015
- 2015-11-23 IL IL242723A patent/IL242723B/en active IP Right Grant
-
2016
- 2016-11-22 CA CA3005961A patent/CA3005961C/en active Active
- 2016-11-22 PL PL16806299T patent/PL3380104T3/pl unknown
- 2016-11-22 JP JP2018526535A patent/JP6980655B2/ja active Active
- 2016-11-22 HU HUE16806299A patent/HUE053558T2/hu unknown
- 2016-11-22 LT LTEP16806299.0T patent/LT3380104T/lt unknown
- 2016-11-22 PT PT168062990T patent/PT3380104T/pt unknown
- 2016-11-22 SI SI201631045T patent/SI3380104T1/sl unknown
- 2016-11-22 KR KR1020187016840A patent/KR102103657B1/ko active IP Right Grant
- 2016-11-22 DK DK16806299.0T patent/DK3380104T3/da active
- 2016-11-22 BR BR112018010391A patent/BR112018010391A8/pt not_active Application Discontinuation
- 2016-11-22 RS RS20210079A patent/RS61372B1/sr unknown
- 2016-11-22 ES ES16806299T patent/ES2848150T3/es active Active
- 2016-11-22 EP EP16806299.0A patent/EP3380104B1/en active Active
- 2016-11-22 CN CN201680068558.0A patent/CN108367016B/zh active Active
- 2016-11-22 IL IL289841A patent/IL289841B/en unknown
- 2016-11-22 MX MX2018006026A patent/MX2018006026A/es unknown
- 2016-11-22 WO PCT/IL2016/051258 patent/WO2017090036A1/en active Application Filing
-
2018
- 2018-05-16 IL IL259396A patent/IL259396B/en unknown
- 2018-05-22 US US15/986,332 patent/US10780106B2/en active Active
-
2020
- 2020-02-10 JP JP2020020917A patent/JP6990934B2/ja active Active
- 2020-08-26 US US17/003,191 patent/US11291681B2/en active Active
-
2021
- 2021-01-07 HR HRP20210020TT patent/HRP20210020T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
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| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |