BR112018009931A2 - 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação - Google Patents

4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação

Info

Publication number
BR112018009931A2
BR112018009931A2 BR112018009931A BR112018009931A BR112018009931A2 BR 112018009931 A2 BR112018009931 A2 BR 112018009931A2 BR 112018009931 A BR112018009931 A BR 112018009931A BR 112018009931 A BR112018009931 A BR 112018009931A BR 112018009931 A2 BR112018009931 A2 BR 112018009931A2
Authority
BR
Brazil
Prior art keywords
difluorphenyl
triazol
benzonitrile
difluoro
pyridin
Prior art date
Application number
BR112018009931A
Other languages
English (en)
Other versions
BR112018009931A8 (pt
Inventor
Whiteker Gregory
Yang Qiang
Ryan Sarah
Hao Yan
Original Assignee
Dow Agrosciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Agrosciences Llc filed Critical Dow Agrosciences Llc
Publication of BR112018009931A2 publication Critical patent/BR112018009931A2/pt
Publication of BR112018009931A8 publication Critical patent/BR112018009931A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a presente invenção refere-se a um processo para a preparação de 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila.
BR112018009931A 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação BR112018009931A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562256531P 2015-11-17 2015-11-17
PCT/US2016/062485 WO2017087643A1 (en) 2015-11-17 2016-11-17 4-((6-2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation

Publications (2)

Publication Number Publication Date
BR112018009931A2 true BR112018009931A2 (pt) 2018-11-06
BR112018009931A8 BR112018009931A8 (pt) 2019-02-26

Family

ID=58717854

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018009931A BR112018009931A8 (pt) 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação

Country Status (12)

Country Link
US (2) US20180370946A1 (pt)
EP (1) EP3377475A4 (pt)
JP (1) JP6898340B2 (pt)
KR (1) KR20180101342A (pt)
CN (1) CN108473443A (pt)
AR (1) AR106728A1 (pt)
BR (1) BR112018009931A8 (pt)
CA (1) CA3005862A1 (pt)
IL (1) IL259440B (pt)
TW (1) TWI636049B (pt)
WO (1) WO2017087643A1 (pt)
ZA (1) ZA201803747B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102151082B1 (ko) 2014-03-19 2020-09-03 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 시크리터리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비시스 항진균 화합물 제조방법
JP2017507991A (ja) 2014-03-19 2017-03-23 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
WO2015143188A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation
JP6518683B2 (ja) 2014-03-19 2019-05-22 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
BR112016021260B1 (pt) 2014-03-19 2020-05-26 Viamet Pharmaceuticals 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-substituída-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-ois e processos para a sua preparação
EP3119764B1 (en) 2014-03-19 2019-04-17 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
CA2942231A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA2942930A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
US10464921B2 (en) 2015-09-18 2019-11-05 Mycovia Pharmaceuticals, Inc. Antifungal compound process
CA3005743A1 (en) * 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
BR112018009920A2 (pt) * 2015-11-17 2018-11-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
WO2020180832A1 (en) * 2019-03-06 2020-09-10 Dow Agrosciences Llc A difluoro-(2-hydroxypropyl)pyridine compound as a fungicide for black sigatoka

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839170A1 (de) * 1988-11-19 1990-05-31 Bayer Ag Cyclopropyl-substituierte azolylmethylcarbinole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4987144A (en) * 1989-05-02 1991-01-22 Ss Pharmaceutical Co., Ltd. 1,3-bis(1,2,4-triazol-1-yl)2-(4-trifluoromethylphenyl)propan-2-ol useful for the prevention and/or treatment of deep-seated mycosis
JP2630877B2 (ja) * 1990-08-24 1997-07-16 持田製薬株式会社 光学活性なトリアゾール誘導体および組成物
TW211006B (pt) * 1990-08-24 1993-08-11 Mochida Pharm Co Ltd
US5710280A (en) * 1996-07-09 1998-01-20 Development Center For Biotechnology Preparation of fluconazole and pharmaceutically acceptable salts thereof
JP3622882B2 (ja) * 1996-10-04 2005-02-23 三共株式会社 トリアゾール誘導体を含有する医薬
KR100194945B1 (ko) * 1997-01-29 1999-06-15 서치영 플루코나졸의 제조방법
KR20030029878A (ko) * 2000-08-30 2003-04-16 다우 아그로사이언시즈 엘엘씨 살충제로서 유용한 화합물, 살비제로서 유용한 화합물 및,이들의 사용방법 및 제조방법
CZ20022642A3 (cs) * 2001-08-27 2003-09-17 Pfizer Products Inc. Způsob výroby dialkylpyridylboranů
US6884892B2 (en) * 2002-06-20 2005-04-26 Sumitomo Chemical Company, Limited Production methods of epoxytriazole derivative and intermediate therefor
WO2006049304A1 (ja) * 2004-11-02 2006-05-11 Banyu Pharmaceutical Co., Ltd アリールオキシ置換ベンズイミダゾール誘導体
EP1905769B1 (en) * 2005-07-13 2017-03-29 Msd K.K. Heterocycle-substituted benzimidazole derivative
AU2006295645B2 (en) * 2005-09-30 2011-09-29 Msd K.K. 2-heteroaryl-substituted indole derivative
EA024385B1 (ru) 2011-06-19 2016-09-30 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
CN105884743B (zh) * 2011-06-19 2019-08-06 威尔金制药(Nc)有限公司 金属酶抑制剂化合物
KR101964195B1 (ko) 2011-06-23 2019-04-01 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
US9447073B2 (en) * 2013-05-28 2016-09-20 Viamet Pharmaceuticals, Inc. Fungicidal compositions
WO2015143188A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and proceses for their preparation
BR112016021260B1 (pt) * 2014-03-19 2020-05-26 Viamet Pharmaceuticals 2-(2,4-difluorofenil)-1,1-difluoro-1-(5-substituída-piridin-2-il)-3-(1h-tetrazol-1-il)propan-2-ois e processos para a sua preparação
WO2015150947A1 (en) * 2014-03-29 2015-10-08 Wockhardt Limited A process for the preparation of isavuconazole and its intermediates
US9719857B2 (en) * 2014-12-31 2017-08-01 Thermo Scientific Portable Analytical Instruments Inc. Laser induced breakdown spectroscopy sample chamber
US11051514B2 (en) * 2015-05-18 2021-07-06 Mycovia Pharmaceuticals, Inc. Antifungal compounds
BR112018009920A2 (pt) * 2015-11-17 2018-11-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
CA3005743A1 (en) * 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
WO2018094140A1 (en) * 2016-11-18 2018-05-24 Vps-3, Inc. 4-(6-(2-(2,4-difluorophenyl)-1.1-difluoro-2-hydroxy-3-(5-mercapto-1h-1,2,4-triazol-1-yl) propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
ES2890228T3 (es) * 2016-11-18 2022-01-18 Corteva Agriscience Llc 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-hidroxi-3-(5-mercapto-1H-1,2,4-triazol-1-il)propil)piridin-3-il)oxi)benzonitrilo y procesos de preparación

Also Published As

Publication number Publication date
IL259440A (en) 2018-07-31
AR106728A1 (es) 2018-02-14
TW201726649A (zh) 2017-08-01
CN108473443A (zh) 2018-08-31
EP3377475A1 (en) 2018-09-26
JP6898340B2 (ja) 2021-07-07
EP3377475A4 (en) 2019-04-10
IL259440B (en) 2021-07-29
ZA201803747B (en) 2019-03-27
WO2017087643A1 (en) 2017-05-26
TWI636049B (zh) 2018-09-21
CA3005862A1 (en) 2017-05-26
US20180370946A1 (en) 2018-12-27
KR20180101342A (ko) 2018-09-12
JP2018538366A (ja) 2018-12-27
US20190382369A1 (en) 2019-12-19
BR112018009931A8 (pt) 2019-02-26

Similar Documents

Publication Publication Date Title
BR112018009920A2 (pt) 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
BR112018009931A2 (pt) 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
BR112018009915A2 (pt) 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
BR112018009924A2 (pt) 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-oxoetil)piridin-3-il)óxi)benzonitrila e processos de preparação
IL257282B (en) Compounds 2-(4-aminocyclohexylamino)-4-(pyrazol-4-yl)pyrimidine
ZA201801534B (en) New uses of 2-(2,4-dichlorophenyl)methyl-4,4-dimethyl-3-isoxazolidone as foliar herbicide
EP3500392A4 (en) LASER FINISHING OF CLOTHING
MA53150A (fr) Composés de benzimidazole en tant qu'inhibiteurs de c-kit
MA52063A (fr) Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique
MA40774A (fr) Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
MA43169A (fr) Composés hétérocycliques utilisés en tant qu'inhibiteurs de pi3k-gamma
DK3497081T3 (da) Fremgangsmåde til fremstilling af 4-ammonium-2,2,6,6-tetraalkylpiperidinylsalte
MA47460A (fr) Aminotriazolopyridines utilisées en tant qu'inhibiteurs de kinase
SV2017005586A (es) Procesos e intermediarios para la preparacion de {1- (etilsulfonil) -3- [4 -(7h -pirrolo [2, 3-d] pirimidin -4- il) -1h -pirazol -1- il] azetidin -3- il} acetonitrilo
MA53110A (fr) Composés polycycliques en tant qu'inhibiteurs de la tyrosine-kinase de bruton
EP3541794A4 (en) 4 - ((6- (2- (2,4-DIFLUOROPHENYL) -1,1-DIFLUOR-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE AND METHOD FOR THE PRODUCTION THEREOF
EP3541799A4 (en) PROCESSES FOR THE PREPARATION OF 4 - ((6- (2- (2,4-DIFLUOROPHENYL) -1,1-DIFLUORO-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1- YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE
IT201600130642A1 (it) Processo per la produzione di 2(3 alchilmorfolino)-etan-1-olo
EP3541798A4 (en) 4 - ((6- (2- (2,4-DIFLUORPHENYL) -1,1-DIFLUOR-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE AND METHOD FOR PRODUCING THE SAME
EP3541800A4 (en) PROCESSES FOR THE PREPARATION OF 4 - ((6- (2,4-DIFLUOROPHENYL) -1,1-DIFLUORO-2-HYDROXY-3- (5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL) PROPYL ) PYRIDIN-3-YL) OXY) BENZONITRILE
EP3541797A4 (en) 4 - ((6- (2- (2,4-DIFLUORPHENYL) -1,1-DIFLUOR-2-HYDROXY-3- (5-MERCAPTO-1H
EP3419627C0 (en) PROCESS FOR MANUFACTURING ANTIVIRAL COMPOUNDS, SUCH AS TRIAZAVIRINE
EP3541795A4 (en) PROCESSES FOR THE PREPARATION OF 4 - ((6- (2,4-DIFLUOROPHENYL) -1,1-DIFLUORO-2-HYDROXY-3 (5-MERCAPTO-1H-1,2,4-TRIAZOL-1-YL) PROPYL) PYRIDIN-3-YL) OXY) BENZONITRILE
ZA201800792B (en) 5¿bromo¿2,6¿di¿(lh¿pyrazol¿l¿yl)pyrimidin¿4¿amine for use in the treatment of cancer
AU2016904469A0 (en) Process for preparing 2-substituted 3’,4’-polyhydroxystilbene compounds

Legal Events

Date Code Title Description
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements