BR112018009774A8 - método para a produção de isobuteno, organismo ou micro-organismo recombinante e seu uso, uso de uma enzima e composição? - Google Patents
método para a produção de isobuteno, organismo ou micro-organismo recombinante e seu uso, uso de uma enzima e composição?Info
- Publication number
- BR112018009774A8 BR112018009774A8 BR112018009774A BR112018009774A BR112018009774A8 BR 112018009774 A8 BR112018009774 A8 BR 112018009774A8 BR 112018009774 A BR112018009774 A BR 112018009774A BR 112018009774 A BR112018009774 A BR 112018009774A BR 112018009774 A8 BR112018009774 A8 BR 112018009774A8
- Authority
- BR
- Brazil
- Prior art keywords
- isobutene
- methylcrotonic acid
- production
- microorganism
- enzyme
- Prior art date
Links
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 2
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- YYPNJNDODFVZLE-UHFFFAOYSA-N 3-methylbut-2-enoic acid Chemical compound CC(C)=CC(O)=O YYPNJNDODFVZLE-UHFFFAOYSA-N 0.000 abstract 14
- 238000006243 chemical reaction Methods 0.000 abstract 4
- 230000002255 enzymatic effect Effects 0.000 abstract 4
- 108090000489 Carboxy-Lyases Proteins 0.000 abstract 2
- PMWATMXOQQZNBX-DKBZLLMOSA-N 2-methylcrotonoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C(/C)=C/C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 PMWATMXOQQZNBX-DKBZLLMOSA-N 0.000 abstract 1
- AXFYFNCPONWUHW-UHFFFAOYSA-N 3-hydroxyisovaleric acid Chemical compound CC(C)(O)CC(O)=O AXFYFNCPONWUHW-UHFFFAOYSA-N 0.000 abstract 1
- BXIPALATIYNHJN-ZMHDXICWSA-N 3-methylbut-2-enoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C=C(C)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 BXIPALATIYNHJN-ZMHDXICWSA-N 0.000 abstract 1
- 102100038248 Cis-aconitate decarboxylase Human genes 0.000 abstract 1
- 102000005454 Dimethylallyltranstransferase Human genes 0.000 abstract 1
- 108010006731 Dimethylallyltranstransferase Proteins 0.000 abstract 1
- 108010030713 Geranoyl-CoA carboxylase Proteins 0.000 abstract 1
- 108010048430 aconitate decarboxylase Proteins 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
- C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
- C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/13—Transferases (2.) transferring sulfur containing groups (2.8)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
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- C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
- C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02007—Butyrate kinase (2.7.2.7)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02014—Branched-chain-fatty-acid kinase (2.7.2.14)
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- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
- C12Y207/02015—Propionate kinase (2.7.2.15)
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- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/03—CoA-transferases (2.8.3)
- C12Y208/03001—Propionate CoA-transferase (2.8.3.1)
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- C12Y—ENZYMES
- C12Y208/00—Transferases transferring sulfur-containing groups (2.8)
- C12Y208/03—CoA-transferases (2.8.3)
- C12Y208/03008—Acetate CoA-transferase (2.8.3.8)
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/02001—Acetyl-CoA hydrolase (3.1.2.1)
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/02018—ADP-dependent short-chain-acyl-CoA hydrolase (3.1.2.18)
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- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/02—Thioester hydrolases (3.1.2)
- C12Y301/0202—Acyl-CoA hydrolase (3.1.2.20)
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- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01006—Aconitate decarboxylase (4.1.1.6)
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- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/01—Carboxy-lyases (4.1.1)
- C12Y401/01063—Protocatechuate decarboxylase (4.1.1.63)
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- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01004—Methylcrotonoyl-CoA carboxylase (6.4.1.4)
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- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01005—Geranoyl-CoA carboxylase (6.4.1.5)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
trata-se de métodos para a produção de isobuteno que compreende a conversão enzimática de ácido 3-metilcrotônico em isobuteno, em que o dito ácido 3- metilcrotônico é obtido pela conversão enzimática de 3-metilcrotonil-coa em ácido 3- metilcrotônico ou em que o dito ácido 3-metilcrotônico é obtido pela conversão enzimática de 3-hidroxiisovalerato (hiv) em ácido 3-metilcrotônico. é descrito que a conversão enzimática de ácido 3-metilcrotônico em isobuteno pode ser, por exemplo, alcançada fazendo-se uso de uma ácido 3-metilcrotônico decarboxilase, preferencialmente uma decarboxilase dependente de fmn associada a uma prenil transferase de fmn, uma aconitato decarboxilase (ec 4.1.1.6), uma metilcrotonil-coa carboxilase (ec 6.4.1.4) ou uma geranoil-coa carboxilase (ec 6.4.1.5).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15194984.9 | 2015-11-17 | ||
| EP15194984 | 2015-11-17 | ||
| PCT/EP2016/077956 WO2017085167A2 (en) | 2015-11-17 | 2016-11-17 | Methods for producing isobutene from 3-methylcrotonic acid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112018009774A2 BR112018009774A2 (pt) | 2018-11-06 |
| BR112018009774A8 true BR112018009774A8 (pt) | 2019-02-26 |
| BR112018009774B1 BR112018009774B1 (pt) | 2024-04-16 |
Family
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Also Published As
| Publication number | Publication date |
|---|---|
| EP3377639A2 (en) | 2018-09-26 |
| JP6971231B2 (ja) | 2021-11-24 |
| CA3002609C (en) | 2023-09-05 |
| US20180371503A1 (en) | 2018-12-27 |
| AU2016357456B2 (en) | 2023-02-09 |
| AU2016357456A1 (en) | 2018-05-10 |
| US11124806B2 (en) | 2021-09-21 |
| US20210403956A1 (en) | 2021-12-30 |
| CA3002609A1 (en) | 2017-05-26 |
| BR112018009774A2 (pt) | 2018-11-06 |
| WO2017085167A3 (en) | 2017-06-29 |
| CN108350469A (zh) | 2018-07-31 |
| JP2019500022A (ja) | 2019-01-10 |
| HK1258308A1 (zh) | 2019-11-08 |
| WO2017085167A2 (en) | 2017-05-26 |
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Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 17/11/2016, OBSERVADAS AS CONDICOES LEGAIS |