BR112018003745B1 - Composições que compreendem um composto de urolitina e uso da referida composição - Google Patents

Composições que compreendem um composto de urolitina e uso da referida composição Download PDF

Info

Publication number
BR112018003745B1
BR112018003745B1 BR112018003745-1A BR112018003745A BR112018003745B1 BR 112018003745 B1 BR112018003745 B1 BR 112018003745B1 BR 112018003745 A BR112018003745 A BR 112018003745A BR 112018003745 B1 BR112018003745 B1 BR 112018003745B1
Authority
BR
Brazil
Prior art keywords
composition
urolithin
compound
size
formula
Prior art date
Application number
BR112018003745-1A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112018003745A2 (pt
Inventor
Penelope Andreux
Christopher Rinsch
William Blanco-Bose
Original Assignee
Amazentis Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amazentis Sa filed Critical Amazentis Sa
Publication of BR112018003745A2 publication Critical patent/BR112018003745A2/pt
Publication of BR112018003745B1 publication Critical patent/BR112018003745B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/366Lactones having six-membered rings, e.g. delta-lactones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/80Dibenzopyrans; Hydrogenated dibenzopyrans

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR112018003745-1A 2015-08-28 2016-08-26 Composições que compreendem um composto de urolitina e uso da referida composição BR112018003745B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1515387.7 2015-08-28
GBGB1515387.7A GB201515387D0 (en) 2015-08-28 2015-08-28 Compositions
PCT/EP2016/070255 WO2017036992A1 (en) 2015-08-28 2016-08-26 Compositions comprising urolithin compounds

Publications (2)

Publication Number Publication Date
BR112018003745A2 BR112018003745A2 (pt) 2018-09-25
BR112018003745B1 true BR112018003745B1 (pt) 2023-11-07

Family

ID=54326542

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018003745-1A BR112018003745B1 (pt) 2015-08-28 2016-08-26 Composições que compreendem um composto de urolitina e uso da referida composição

Country Status (15)

Country Link
US (4) US10695320B2 (https=)
EP (1) EP3340977B1 (https=)
JP (3) JP7227003B2 (https=)
KR (2) KR102822365B1 (https=)
CN (1) CN108289879A (https=)
AU (1) AU2016314987B2 (https=)
BR (1) BR112018003745B1 (https=)
CA (1) CA2996724C (https=)
ES (1) ES2936723T3 (https=)
GB (1) GB201515387D0 (https=)
MX (1) MX2018002543A (https=)
PT (1) PT3340977T (https=)
RU (1) RU2754761C2 (https=)
SG (1) SG10202001793PA (https=)
WO (1) WO2017036992A1 (https=)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6054301B2 (ja) * 2010-12-23 2017-01-11 アマゼンティス エスアーAmazentis Sa ミトコンドリア機能向上と、神経変性疾患および認知障害治療とのための組成物および方法
DK4233858T3 (da) 2012-06-27 2025-05-12 Amazentis Sa Forbedring af autofagi eller forøgelse af levetiden ved indgivelse af urolithiner eller forstadier til disse
GB201515387D0 (en) 2015-08-28 2015-10-14 Amazentis Sa Compositions
US20180256538A1 (en) * 2017-03-08 2018-09-13 Amazentis Sa Method for improving mitophagy in subjects
CA3100335A1 (en) 2018-05-15 2019-11-21 University Of Louisville Research Foundation, Inc. Urolithin a and derivatives thereof for use in therapy
GB201916046D0 (en) * 2019-11-04 2019-12-18 Amazentis Sa Diagnostic method
CA3188397A1 (en) 2020-09-25 2022-03-31 Anupama Dattatreya Compositions and methods using xanthan gum to stabilize at least one urolithin in an aqueous matrix
WO2022113693A1 (ja) * 2020-11-30 2022-06-02 国立研究開発法人産業技術総合研究所 筋ジストロフィー治療剤、中心静脈栄養用組成物、筋組織の炎症抑制剤および筋ジストロフィーの抗炎症用食品組成物
KR102623664B1 (ko) 2020-12-10 2024-01-12 서울대학교산학협력단 유로리틴 a를 이용한 당뇨성 알츠하이머병의 치료 조성물 및 치료 방법
CA3206062A1 (en) 2021-01-27 2022-08-04 Said Oumouch Urolithin derivatives and methods of use thereof
EP4085906A1 (en) * 2021-05-06 2022-11-09 Universite De Bordeaux Composition comprising ppar-modulator and an urolithin derivative and uses thereof
CN113813255B (zh) * 2021-10-20 2023-09-01 山东大学 尿石素a及其衍生物在肿瘤免疫治疗的应用
WO2023199908A1 (ja) * 2022-04-11 2023-10-19 株式会社ダイセル 乳化組成物の製造方法
GB202219317D0 (en) * 2022-12-20 2023-02-01 Amazentis Sa Methods for improving mitophagy in subjects
EP4642448A1 (en) * 2022-12-27 2025-11-05 Indian Institute of Science A method for the treatment of epilepsy
GB202308224D0 (en) 2023-06-01 2023-07-19 Amazentis Sa Formulation
GB202316295D0 (en) 2023-10-24 2023-12-06 Amazentis Sa Composition
EP4555997A1 (en) * 2023-11-15 2025-05-21 Science4Beauty Sp. z o.o. Water-soluble composition comprising urolithin
GB202319994D0 (en) 2023-12-22 2024-02-07 Amazentis Sa Compositions for use
KR20250158913A (ko) 2024-04-30 2025-11-07 주식회사 파이안바이오테크놀로지 유로리틴을 함유하는 탈모완화제와 모발성장촉진제
WO2025252771A1 (en) 2024-06-03 2025-12-11 Amazentis Sa Urolithin combinations

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3786447B2 (ja) * 1995-03-31 2006-06-14 エーザイ株式会社 C型肝炎の予防・治療剤
BR9708248A (pt) 1996-03-26 1999-07-27 Lilly Co Eli Benzotiofenos formulações contendo os mesmos e metódos
WO1999053941A1 (fr) * 1998-04-15 1999-10-28 Shionogi & Co., Ltd. Preparations orales contenant des derives de trh
CA2363123C (en) 1999-02-22 2011-09-06 Kenneth Iain Cumming Solid oral dosage form containing an enhancer
US6623734B2 (en) * 2000-06-22 2003-09-23 Soft Gel Technologies, Inc. Super absorption coenzyme Q10
US20050282781A1 (en) 2004-06-18 2005-12-22 Shibnath Ghosal Compositions of stable bioactive metabolites of docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids
WO2006035900A1 (ja) 2004-09-29 2006-04-06 San-Ei Gen F.F.I., Inc. コエンザイムq10含有乳化組成物
US20060257337A1 (en) * 2005-04-28 2006-11-16 David Sherris Compositions and methods to treat skin diseases characterized by cellular proliferation and angiogenesis
US8894993B2 (en) * 2006-08-04 2014-11-25 Natreon Inc. Mitochondria-targeted antioxidants
EP2145904A1 (de) 2008-07-18 2010-01-20 Basf Se Verfahren zur enzymkatalysierten Hydrolyse von Polyacrylsäureestern sowie dafür zu verwendende Esterasen
CN102176900B (zh) 2008-09-17 2017-09-26 克艾思马有限公司 药物组合物和相关的给药方法
US20110182985A1 (en) 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
PT2547205T (pt) 2010-03-19 2024-05-27 1Globe Biomedical Co Ltd Novos métodos para atingir células estaminais cancerígenas
EP2550092B1 (de) 2010-03-22 2018-08-15 Instillo GmbH Verfahren zur herstellung von mikro- oder nanopartikeln
WO2011131943A2 (en) 2010-04-20 2011-10-27 Cipla Limited Pharmaceutical compositions
US20140107100A1 (en) 2010-11-24 2014-04-17 Exelixis, Inc. Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of Their Use and Manufacture
JP2012111712A (ja) 2010-11-25 2012-06-14 Toyo Capsule Kk 油性ビタミンc経口投与用組成物
JP6054301B2 (ja) * 2010-12-23 2017-01-11 アマゼンティス エスアーAmazentis Sa ミトコンドリア機能向上と、神経変性疾患および認知障害治療とのための組成物および方法
EP2661273A4 (en) 2011-01-07 2014-06-04 Merrion Res Iii Ltd IRON PHARMACEUTICAL COMPOSITIONS FOR ORAL ADMINISTRATION
CA2826884A1 (en) * 2012-09-14 2014-03-14 Natreon, Inc. Method for improving endothelial function and decreasing cardiovascular morbidity using shilajit
GB201323008D0 (en) * 2013-12-24 2014-02-12 Amazentis As Compounds and uses thereof
GB201515387D0 (en) 2015-08-28 2015-10-14 Amazentis Sa Compositions
GB201515391D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions

Also Published As

Publication number Publication date
BR112018003745A2 (pt) 2018-09-25
KR102660005B1 (ko) 2024-04-22
JP7227003B2 (ja) 2023-02-21
PT3340977T (pt) 2023-01-31
US10695320B2 (en) 2020-06-30
AU2016314987A1 (en) 2018-03-29
CN108289879A (zh) 2018-07-17
JP2022177130A (ja) 2022-11-30
RU2018108136A3 (https=) 2020-01-31
SG10202001793PA (en) 2020-04-29
WO2017036992A1 (en) 2017-03-09
HK1257500A1 (en) 2019-10-25
US11925616B2 (en) 2024-03-12
MX2018002543A (es) 2018-06-15
US20200323818A1 (en) 2020-10-15
US20220323407A1 (en) 2022-10-13
KR102822365B1 (ko) 2025-06-17
RU2754761C2 (ru) 2021-09-07
KR20180037052A (ko) 2018-04-10
ES2936723T3 (es) 2023-03-21
US11337957B2 (en) 2022-05-24
AU2016314987B2 (en) 2021-07-08
JP2018533618A (ja) 2018-11-15
RU2018108136A (ru) 2019-09-30
GB201515387D0 (en) 2015-10-14
US20240148690A1 (en) 2024-05-09
EP3340977A1 (en) 2018-07-04
US20180243261A1 (en) 2018-08-30
KR20240060826A (ko) 2024-05-08
JP2025004129A (ja) 2025-01-14
CA2996724A1 (en) 2017-03-09
EP3340977B1 (en) 2022-11-02
CA2996724C (en) 2024-05-21

Similar Documents

Publication Publication Date Title
US11925616B2 (en) Compositions comprising urolithin compounds
US12297182B2 (en) Compositions comprising an urolithin compound
EP3592425A1 (en) Methods for improving mitophagy in subjects
JP6775419B2 (ja) 末梢神経障害の予防又は改善用組成物
HK1257500B (en) Compositions comprising urolithin compounds
KR20250133322A (ko) 우롤리틴과 케톤체의 조합물
HK40129047A (zh) 包含尿石素化合物的组合物

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/08/2016, OBSERVADAS AS CONDICOES LEGAIS