BR112017016895A2 - processo de produção de gonadotrofina - Google Patents

processo de produção de gonadotrofina

Info

Publication number
BR112017016895A2
BR112017016895A2 BR112017016895A BR112017016895A BR112017016895A2 BR 112017016895 A2 BR112017016895 A2 BR 112017016895A2 BR 112017016895 A BR112017016895 A BR 112017016895A BR 112017016895 A BR112017016895 A BR 112017016895A BR 112017016895 A2 BR112017016895 A2 BR 112017016895A2
Authority
BR
Brazil
Prior art keywords
production process
gonadotropin production
host cell
gonadotropin
hcg
Prior art date
Application number
BR112017016895A
Other languages
English (en)
Inventor
Grinhut Ayelet
Plaksin Daniel
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of BR112017016895A2 publication Critical patent/BR112017016895A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C12Y204/99004—Beta-galactoside alpha-2,3-sialyltransferase (2.4.99.4)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

a presente invenção refere-se a uma célula hospedeira caracterizada em que ela compreende integrada em seu genoma uma sequência codificando a cadeia alfa de hcg, e uso da célula hospedeira para produção de hcg recombinante.
BR112017016895A 2015-04-24 2016-04-22 processo de produção de gonadotrofina BR112017016895A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15164965 2015-04-24
PCT/EP2016/059006 WO2016170113A1 (en) 2015-04-24 2016-04-22 Method of production of gonadotrophin

Publications (1)

Publication Number Publication Date
BR112017016895A2 true BR112017016895A2 (pt) 2018-03-27

Family

ID=53002568

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017016895A BR112017016895A2 (pt) 2015-04-24 2016-04-22 processo de produção de gonadotrofina

Country Status (32)

Country Link
US (1) US10464984B2 (pt)
EP (1) EP3286209B1 (pt)
JP (1) JP6964519B2 (pt)
KR (1) KR102658666B1 (pt)
CN (2) CN107532172A (pt)
AU (1) AU2016251314B2 (pt)
BR (1) BR112017016895A2 (pt)
CA (1) CA2975449A1 (pt)
CL (1) CL2017002661A1 (pt)
CO (1) CO2017011964A2 (pt)
DK (1) DK3286209T3 (pt)
EA (1) EA034022B1 (pt)
ES (1) ES2837111T3 (pt)
HK (1) HK1246325A1 (pt)
HR (1) HRP20201945T1 (pt)
HU (1) HUE051879T2 (pt)
IL (1) IL253694B (pt)
LT (1) LT3286209T (pt)
MA (1) MA41949B1 (pt)
MD (1) MD3286209T2 (pt)
MX (1) MX2017010884A (pt)
MY (1) MY185823A (pt)
PH (1) PH12017501585A1 (pt)
PT (1) PT3286209T (pt)
RS (1) RS61163B1 (pt)
SA (1) SA517390029B1 (pt)
SG (1) SG11201706832PA (pt)
SI (1) SI3286209T1 (pt)
TN (1) TN2017000328A1 (pt)
UA (1) UA124187C2 (pt)
WO (1) WO2016170113A1 (pt)
ZA (1) ZA201707136B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD3675894T2 (ro) 2017-09-01 2022-03-31 Ferring Bv Compoziție pentru stimularea ovariană controlată
CN108264549A (zh) * 2018-03-29 2018-07-10 北京伟杰信生物科技有限公司 重组绒促性素rhCG的制备方法及应用
JP2021522268A (ja) 2018-04-30 2021-08-30 フェリング ベスローテン フェンノートシャップ 制御された卵巣刺激のための組成物
CN110812366B (zh) * 2019-11-18 2023-11-17 珠海丽凡达生物技术有限公司 一种可用于激素补充的mRNA药物及其制备方法
CN113337562B (zh) * 2021-05-24 2022-06-03 宁波人健药业集团股份有限公司 使用CHO细胞高效发酵生产rhCG的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855544B1 (en) 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
WO2001058493A1 (en) * 2000-02-11 2001-08-16 Maxygen Aps Conjugates of follicle stimulating hormones
US20030036181A1 (en) 2000-06-30 2003-02-20 Okkels Jens Sigurd Peptide extended glycosylated polypeptides
CN1194016C (zh) * 2000-12-29 2005-03-23 申庆祥 新的人绒毛膜促性腺激素－促黄体素融合蛋白及其制法和用途
CN101250531B (zh) * 2006-11-27 2013-04-24 株式会社Lg生命科学 一核苷酸序列、包含该序列的表达载体、该载体转化的动物细胞及利用该细胞生产人fsh的方法
TWI604850B (zh) 2009-10-05 2017-11-11 菲瑞茵國際中心股份有限公司 藥學製劑
US8326547B2 (en) * 2009-10-07 2012-12-04 Nanjingjinsirui Science & Technology Biology Corp. Method of sequence optimization for improved recombinant protein expression using a particle swarm optimization algorithm
WO2011084145A2 (en) 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
EP2833923A4 (en) 2012-04-02 2016-02-24 Moderna Therapeutics Inc MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS
CA2868391A1 (en) * 2012-04-02 2013-10-10 Stephane Bancel Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
CN103539862B (zh) * 2013-11-01 2015-04-01 广州联康生物科技有限公司 一种长效重组促卵泡激素及其应用

Also Published As

Publication number Publication date
SA517390029B1 (ar) 2021-04-04
UA124187C2 (uk) 2021-08-04
AU2016251314A1 (en) 2017-08-17
WO2016170113A1 (en) 2016-10-27
US20180127477A1 (en) 2018-05-10
AU2016251314B2 (en) 2019-12-05
MY185823A (en) 2021-06-11
PT3286209T (pt) 2020-12-04
ES2837111T3 (es) 2021-06-29
RS61163B1 (sr) 2021-01-29
CN114107315A (zh) 2022-03-01
HRP20201945T1 (hr) 2021-02-05
EP3286209A1 (en) 2018-02-28
CA2975449A1 (en) 2016-10-27
MX2017010884A (es) 2017-12-07
PH12017501585A1 (en) 2018-02-05
CO2017011964A2 (es) 2018-03-09
EA201791724A1 (ru) 2018-04-30
HK1246325A1 (zh) 2018-09-07
ZA201707136B (en) 2022-03-30
IL253694A0 (en) 2017-09-28
MA41949A (fr) 2018-02-28
JP6964519B2 (ja) 2021-11-10
TN2017000328A1 (en) 2019-01-16
MD3286209T2 (ro) 2021-04-30
EA034022B1 (ru) 2019-12-19
CN107532172A (zh) 2018-01-02
IL253694B (en) 2021-09-30
DK3286209T3 (da) 2020-12-21
EP3286209B1 (en) 2020-11-25
MA41949B1 (fr) 2020-12-31
SG11201706832PA (en) 2017-09-28
HUE051879T2 (hu) 2021-03-29
KR20170138390A (ko) 2017-12-15
SI3286209T1 (sl) 2021-01-29
LT3286209T (lt) 2021-02-25
KR102658666B1 (ko) 2024-04-17
US10464984B2 (en) 2019-11-05
JP2018512885A (ja) 2018-05-24
CL2017002661A1 (es) 2018-03-23

Similar Documents

Publication Publication Date Title
BR112017016895A2 (pt) processo de produção de gonadotrofina
AR118777A2 (es) Neurotoxinas catiónicas
BR112018007017A2 (pt) polipeptídeos
BR112019000718A2 (pt) processo para a produção de geopolímero ou compósito de geopolímero
GT201600187A (es) Codificación de transformación inversa de espacio de color universal
CR20150466A (es) Péptidos y composiciones para el tratamiento de daño articular
BR112017011217A2 (pt) impurezas de dna em uma composição compreendendo um vírion parvoviral
BR112018011787A2 (pt) processo de envase a quente com fechos feitos de composições de polietileno bimodal
CL2013002044A1 (es) Anticuerpo que une il-17a humano e il-17f humano; secuencia de adn que lo codifica; vector; celula huesped; proceso de produccion; composicion farmaceutica que lo comprende; y su uso para el tratamiento profilaxis de un trastorno patologico mediado por il-17a y/o il-17f.
EA201590994A1 (ru) Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина
BR112017013394A2 (pt) fabricação de proteína
CL2014000291A1 (es) Vacuna que comprende al menos 30 aminoacidos de un polipeptido de p62/sqstm1 o un acido nucleico que lo codifica; y su uso para el tratamiento y profilaxis del cancer.
BR112017000293A2 (pt) processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina
BR112015018599A2 (pt) Micro-organismos com produtividade de putrescina e processo para produzir putrescina que utiliza os mesmos
AR079821A1 (es) Cepas y metodo para la produccion de metionina
BR112018010387A2 (pt) levedura geneticamente modificada e processo para fabricar etanol
BR112017004233A2 (pt) polipeptídeos tendo atividade de xilanase com uma alta taxa de conversão de polissacarídeos contendo xilose
BR112017005109A2 (pt) produto refratário com base em al2o3, composição de matérias-primas para a fabricação do produto, método para a fabricação de um produto refratário, produto refratário, e emprego do produto refratário
BR112018013180A2 (pt) partículas zeolíticas com dimensões nanométricas e processo para produção das mesmas
BR112017028065A2 (pt) sistema de bioacabamento
CO2019003429A2 (es) Salsa de tomate con estabilidad de almacenamiento mejorada
BR112018003778A2 (pt) animal transgênico para produção de anticorpos que apresenta uma cadeia leve comum
CL2017001383A1 (es) Proceso para la fabricación de anhídrido carboxílico
BR112016017281A2 (pt) microrganismos produtores de l-aminoácidos e processo para produção de l-aminoácidos usando os mesmos
BR112018069435A2 (pt) composição de polímero de etileno, artigo, e, processo para produzir um artigo.

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]