BR112017016077A2 - ?composição e método para uso no aumento da eficácia do enxerto de células-tronco hematopoiéticas após transplante? - Google Patents

?composição e método para uso no aumento da eficácia do enxerto de células-tronco hematopoiéticas após transplante?

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Publication number
BR112017016077A2
BR112017016077A2 BR112017016077A BR112017016077A BR112017016077A2 BR 112017016077 A2 BR112017016077 A2 BR 112017016077A2 BR 112017016077 A BR112017016077 A BR 112017016077A BR 112017016077 A BR112017016077 A BR 112017016077A BR 112017016077 A2 BR112017016077 A2 BR 112017016077A2
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BR
Brazil
Prior art keywords
transplantation
composition
stem cell
efficacy
hematopoietic stem
Prior art date
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BR112017016077A
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English (en)
Inventor
Michael Freissmuth
Zahra Kazemi
Eva-Maria Zebedin-Brandl
Original Assignee
Scipharm Sarl
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Publication date
Application filed by Scipharm Sarl filed Critical Scipharm Sarl
Publication of BR112017016077A2 publication Critical patent/BR112017016077A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
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    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5578—Eicosanoids, e.g. leukotrienes or prostaglandins having a pentalene ring system, e.g. carbacyclin, iloprost
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    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0669—Bone marrow stromal cells; Whole bone marrow
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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Abstract

?composição e método para uso no aumento da eficácia do enxerto de células-tronco hematopoiéticas após transplante?. a presente invenção se refere ao novo uso de uma composição que compreende pelo menos um inibidor da dipeptidil peptidase iv (dpp-iv) para aumentar a migração e o alojamento de células progenitoras hematopoiéticas em receptores transplantados com células-tronco, onde as ditas células-tronco e/ou progenitoras hematopoiéticas tinham sido tratadas in vitro com um composto melhorador do enxerto, especificamente com um análogo da prostaciclina e um melhorador de camp antes do transplante.
BR112017016077A 2015-01-27 2016-01-27 ?composição e método para uso no aumento da eficácia do enxerto de células-tronco hematopoiéticas após transplante? BR112017016077A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15152664 2015-01-27
PCT/EP2016/051672 WO2016120310A1 (en) 2015-01-27 2016-01-27 Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation

Publications (1)

Publication Number Publication Date
BR112017016077A2 true BR112017016077A2 (pt) 2018-04-03

Family

ID=52449965

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BR112017016077A BR112017016077A2 (pt) 2015-01-27 2016-01-27 ?composição e método para uso no aumento da eficácia do enxerto de células-tronco hematopoiéticas após transplante?

Country Status (24)

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US (1) US10226465B2 (pt)
EP (1) EP3250202B1 (pt)
JP (1) JP6669762B2 (pt)
KR (1) KR102577669B1 (pt)
CN (1) CN107548305A (pt)
AU (1) AU2016212090B2 (pt)
BR (1) BR112017016077A2 (pt)
CA (1) CA2973146C (pt)
CL (1) CL2017001903A1 (pt)
CY (1) CY1124317T1 (pt)
DK (1) DK3250202T3 (pt)
EA (1) EA039149B1 (pt)
ES (1) ES2872698T3 (pt)
HR (1) HRP20210930T1 (pt)
HU (1) HUE054615T2 (pt)
IL (1) IL253389B (pt)
LT (1) LT3250202T (pt)
PL (1) PL3250202T3 (pt)
PT (1) PT3250202T (pt)
RS (1) RS61945B1 (pt)
SG (1) SG11201705812SA (pt)
SI (1) SI3250202T1 (pt)
UA (1) UA122488C2 (pt)
WO (1) WO2016120310A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014140921A2 (en) 2013-03-15 2014-09-18 Larsson Marcus Kare Torleif Cells, methods and apparatuses for umbilical cord blood collection and isolation of cells
US11542473B2 (en) 2016-10-21 2023-01-03 Amniotics Ab Methods and compositions for generating hematopoietic cells
US11213546B2 (en) 2017-09-07 2022-01-04 Emory University Methods to mobilize tissue resident cells for adoptive t cell therapy
WO2020047236A1 (en) * 2018-08-30 2020-03-05 The Regents Of The University Of California Mobilization and collection of peripheral blood hematopoietic stem cells from deceased donors
EP3647413A1 (en) * 2018-10-31 2020-05-06 Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT) Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation
CN114765957A (zh) 2019-10-18 2022-07-19 Amniotics公司 从羊水中获得羊膜间充质干细胞的方法和设备及其来源的细胞
WO2022036306A1 (en) * 2020-08-14 2022-02-17 Navan Technologies, Inc. Methods and apparatuses for biomolecule delivery to primary human hematopoietic stem cells using nanostraws
CN112961827B (zh) * 2021-04-25 2024-04-26 河南省肿瘤医院 佛司可林在t细胞培养中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040247574A1 (en) 2003-05-27 2004-12-09 Christopherson Kent W. Methods for enhancing stem cell engraftment during transplantation
KR20080064961A (ko) * 2005-09-30 2008-07-10 노파르티스 아게 자가면역 질환 및 이식편 거부반응의 치료에 사용하기 위한ｄｐｐ ｉｖ 억제제
US20100247491A1 (en) * 2007-02-01 2010-09-30 Christof Westenfelder Potentiation of Stem Cell Homing and Treatment of Organ Dysfunction or Organ Failure
WO2009152186A1 (en) * 2008-06-09 2009-12-17 American Stem Cell, Inc. Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors
WO2012074676A2 (en) 2010-11-09 2012-06-07 Emory University Glp-1 agonists, dpp-4 inhibitors, compositions, and uses related thereto
ES2693622T3 (es) * 2011-01-13 2018-12-13 SciPharm S.à r.l. Método para mejorar el injerto de células madre hematopoyéticas
US20140288010A1 (en) * 2013-02-22 2014-09-25 Georgia Regents Research Institute, Inc. Compositions and Methods for Increasing Stem Cell Survival

Also Published As

Publication number Publication date
HUE054615T2 (hu) 2021-09-28
CA2973146C (en) 2024-01-09
KR20170106980A (ko) 2017-09-22
PL3250202T3 (pl) 2021-08-30
HRP20210930T1 (hr) 2021-09-03
US10226465B2 (en) 2019-03-12
CA2973146A1 (en) 2016-08-04
UA122488C2 (uk) 2020-11-25
AU2016212090B2 (en) 2021-05-20
IL253389B (en) 2021-02-28
JP6669762B2 (ja) 2020-03-18
DK3250202T3 (da) 2021-05-31
SI3250202T1 (sl) 2021-07-30
PT3250202T (pt) 2021-06-17
LT3250202T (lt) 2021-06-25
JP2018505171A (ja) 2018-02-22
EP3250202A1 (en) 2017-12-06
WO2016120310A1 (en) 2016-08-04
AU2016212090A1 (en) 2017-08-03
US20180008606A1 (en) 2018-01-11
CN107548305A (zh) 2018-01-05
SG11201705812SA (en) 2017-08-30
EA201791703A1 (ru) 2017-11-30
CL2017001903A1 (es) 2018-03-23
IL253389A0 (en) 2017-09-28
CY1124317T1 (el) 2022-07-22
EA039149B1 (ru) 2021-12-10
EP3250202B1 (en) 2021-03-10
ES2872698T3 (es) 2021-11-02
RS61945B1 (sr) 2021-07-30
KR102577669B1 (ko) 2023-09-12

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]