EA201791703A1 - Композиция для повышения эффективности приживления гемопоэтических стволовых клеток после трансплантации - Google Patents

Композиция для повышения эффективности приживления гемопоэтических стволовых клеток после трансплантации

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EA201791703A1
EA201791703A1 EA201791703A EA201791703A EA201791703A1 EA 201791703 A1 EA201791703 A1 EA 201791703A1 EA 201791703 A EA201791703 A EA 201791703A EA 201791703 A EA201791703 A EA 201791703A EA 201791703 A1 EA201791703 A1 EA 201791703A1
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Prior art keywords
stem cells
composition
transplantation
ammission
efficiency
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EA201791703A
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English (en)
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EA039149B1 (ru
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Михаель Фрайсмут
Ева-Мария Цебедин-Брандль
Захра Каземи
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Сифарм Сарл
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Publication of EA201791703A1 publication Critical patent/EA201791703A1/ru
Publication of EA039149B1 publication Critical patent/EA039149B1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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Abstract

Настоящее изобретение обеспечивает новое применение композиции, включающей по меньшей мере один ингибитор дипептидилпептидазы IV для усиления миграции и хоуминга гемопоэтических клеток-предшественников у реципиентов, которым были трансплантированы стволовые клетки, в которой указанные гемопоэтические стволовые клетки и/или клетки-предшественники перед трансплантацией обрабатывают in vitro соединением, усиливающим приживление, более конкретно, аналогом простациклина и средством, повышающим уровень сАМР.
EA201791703A 2015-01-27 2016-01-27 Применение композиции, содержащей вилдаглиптин, для повышения эффективности приживления гемопоэтических стволовых клеток после трансплантации и способ для повышения способности гемопоэтических стволовых клеток к приживлению EA039149B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15152664 2015-01-27
PCT/EP2016/051672 WO2016120310A1 (en) 2015-01-27 2016-01-27 Composition for use in increasing engraftment efficacy of haematopoetic stem cells after transplantation

Publications (2)

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EA201791703A1 true EA201791703A1 (ru) 2017-11-30
EA039149B1 EA039149B1 (ru) 2021-12-10

Family

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EA201791703A EA039149B1 (ru) 2015-01-27 2016-01-27 Применение композиции, содержащей вилдаглиптин, для повышения эффективности приживления гемопоэтических стволовых клеток после трансплантации и способ для повышения способности гемопоэтических стволовых клеток к приживлению

Country Status (24)

Country Link
US (1) US10226465B2 (ru)
EP (1) EP3250202B1 (ru)
JP (1) JP6669762B2 (ru)
KR (1) KR102577669B1 (ru)
CN (1) CN107548305A (ru)
AU (1) AU2016212090B2 (ru)
BR (1) BR112017016077A2 (ru)
CA (1) CA2973146C (ru)
CL (1) CL2017001903A1 (ru)
CY (1) CY1124317T1 (ru)
DK (1) DK3250202T3 (ru)
EA (1) EA039149B1 (ru)
ES (1) ES2872698T3 (ru)
HR (1) HRP20210930T1 (ru)
HU (1) HUE054615T2 (ru)
IL (1) IL253389B (ru)
LT (1) LT3250202T (ru)
PL (1) PL3250202T3 (ru)
PT (1) PT3250202T (ru)
RS (1) RS61945B1 (ru)
SG (1) SG11201705812SA (ru)
SI (1) SI3250202T1 (ru)
UA (1) UA122488C2 (ru)
WO (1) WO2016120310A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160048029A (ko) 2013-03-15 2016-05-03 마르쿠스 카레 토를레이프 라르손 제대혈 수집 및 세포의 분리를 위한 세포, 방법 및 장치
US11542473B2 (en) 2016-10-21 2023-01-03 Amniotics Ab Methods and compositions for generating hematopoietic cells
US11213546B2 (en) 2017-09-07 2022-01-04 Emory University Methods to mobilize tissue resident cells for adoptive t cell therapy
US20210189344A1 (en) * 2018-08-30 2021-06-24 The Regents Of The University Of California Mobilization and collection of peripheral blood hematopoietic stem cells from deceased donors
EP3647413A1 (en) * 2018-10-31 2020-05-06 Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT) Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation
US20220372444A1 (en) 2019-10-18 2022-11-24 Amniotics Ab Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof
WO2022036306A1 (en) * 2020-08-14 2022-02-17 Navan Technologies, Inc. Methods and apparatuses for biomolecule delivery to primary human hematopoietic stem cells using nanostraws
CN112961827B (zh) * 2021-04-25 2024-04-26 河南省肿瘤医院 佛司可林在t细胞培养中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040247574A1 (en) 2003-05-27 2004-12-09 Christopherson Kent W. Methods for enhancing stem cell engraftment during transplantation
AU2006297130B2 (en) * 2005-09-30 2009-12-24 Novartis Ag DPP IV inhibitor for use in the treatment of autoimmune diseases and graft rejection
WO2008094689A2 (en) * 2007-02-01 2008-08-07 Nephrogen, Llc Potentiation of stem cell homing and treatment of organ dysfunction or organ failure
WO2009152186A1 (en) * 2008-06-09 2009-12-17 American Stem Cell, Inc. Methods for enhancing cell therapy efficacy including treatment with cd26 peptidase inhibitors
WO2012074676A2 (en) 2010-11-09 2012-06-07 Emory University Glp-1 agonists, dpp-4 inhibitors, compositions, and uses related thereto
BR112013017878B1 (pt) * 2011-01-13 2021-08-31 Scipharm Sàrl Método para melhorar o enxerto de células-tronco hematopoéticas e composições derivadas
US20140288010A1 (en) * 2013-02-22 2014-09-25 Georgia Regents Research Institute, Inc. Compositions and Methods for Increasing Stem Cell Survival

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KR102577669B1 (ko) 2023-09-12
HRP20210930T1 (hr) 2021-09-03
KR20170106980A (ko) 2017-09-22
DK3250202T3 (da) 2021-05-31
LT3250202T (lt) 2021-06-25
AU2016212090B2 (en) 2021-05-20
CA2973146A1 (en) 2016-08-04
CA2973146C (en) 2024-01-09
EP3250202A1 (en) 2017-12-06
JP6669762B2 (ja) 2020-03-18
IL253389A0 (en) 2017-09-28
US10226465B2 (en) 2019-03-12
SI3250202T1 (sl) 2021-07-30
PT3250202T (pt) 2021-06-17
JP2018505171A (ja) 2018-02-22
EA039149B1 (ru) 2021-12-10
ES2872698T3 (es) 2021-11-02
BR112017016077A2 (pt) 2018-04-03
CY1124317T1 (el) 2022-07-22
CN107548305A (zh) 2018-01-05
EP3250202B1 (en) 2021-03-10
US20180008606A1 (en) 2018-01-11
PL3250202T3 (pl) 2021-08-30
AU2016212090A1 (en) 2017-08-03
UA122488C2 (uk) 2020-11-25
RS61945B1 (sr) 2021-07-30
SG11201705812SA (en) 2017-08-30
IL253389B (en) 2021-02-28
HUE054615T2 (hu) 2021-09-28
CL2017001903A1 (es) 2018-03-23
WO2016120310A1 (en) 2016-08-04

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