BR112017011936A8 - Receptores quiméricos de antígenos que alvejam molécula semelhante a receptor fc 5 e uso dos mesmos - Google Patents

Receptores quiméricos de antígenos que alvejam molécula semelhante a receptor fc 5 e uso dos mesmos

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Publication number
BR112017011936A8
BR112017011936A8 BR112017011936A BR112017011936A BR112017011936A8 BR 112017011936 A8 BR112017011936 A8 BR 112017011936A8 BR 112017011936 A BR112017011936 A BR 112017011936A BR 112017011936 A BR112017011936 A BR 112017011936A BR 112017011936 A8 BR112017011936 A8 BR 112017011936A8
Authority
BR
Brazil
Prior art keywords
receptor
chimeric antigen
antigen receptors
fcrl5
target
Prior art date
Application number
BR112017011936A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112017011936A2 (pt
Inventor
Chen Liu
L Smith Eric
J Brentjens Renier
Original Assignee
Eureka Therapeutics Inc
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eureka Therapeutics Inc, Memorial Sloan Kettering Cancer Center filed Critical Eureka Therapeutics Inc
Publication of BR112017011936A2 publication Critical patent/BR112017011936A2/pt
Publication of BR112017011936A8 publication Critical patent/BR112017011936A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
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    • C—CHEMISTRY; METALLURGY
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/7056—Lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3061—Blood cells
    • C—CHEMISTRY; METALLURGY
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C—CHEMISTRY; METALLURGY
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    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
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BR112017011936A 2014-12-05 2015-12-04 Receptores quiméricos de antígenos que alvejam molécula semelhante a receptor fc 5 e uso dos mesmos BR112017011936A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462088164P 2014-12-05 2014-12-05
US62/088,164 2014-12-05
PCT/US2015/064134 WO2016090337A1 (en) 2014-12-05 2015-12-04 Chimeric antigen receptors targeting fc receptor-like 5 and uses thereof

Publications (2)

Publication Number Publication Date
BR112017011936A2 BR112017011936A2 (pt) 2018-01-16
BR112017011936A8 true BR112017011936A8 (pt) 2021-11-09

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US (3) US11059891B2 (enExample)
EP (2) EP4506036A3 (enExample)
JP (3) JP7174522B2 (enExample)
KR (1) KR20170108946A (enExample)
CN (2) CN109072199B (enExample)
AU (2) AU2015357543B2 (enExample)
BR (1) BR112017011936A8 (enExample)
CA (1) CA2974434A1 (enExample)
IL (2) IL252655B (enExample)
MX (1) MX395028B (enExample)
MY (1) MY192062A (enExample)
NZ (1) NZ732570A (enExample)
PH (1) PH12017501041A1 (enExample)
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WO (1) WO2016090337A1 (enExample)

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