BR112017005533A2 - compostos e métodos - Google Patents
compostos e métodosInfo
- Publication number
- BR112017005533A2 BR112017005533A2 BR112017005533A BR112017005533A BR112017005533A2 BR 112017005533 A2 BR112017005533 A2 BR 112017005533A2 BR 112017005533 A BR112017005533 A BR 112017005533A BR 112017005533 A BR112017005533 A BR 112017005533A BR 112017005533 A2 BR112017005533 A2 BR 112017005533A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- methods
- agents
- refers
- pde1
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D347/00—Heterocyclic compounds containing rings having halogen atoms as ring hetero atoms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
Abstract
resumo ?compostos e métodos? a presente invenção refere-se, de modo geral, a compostos e métodos de tratamento e/ou profilaxia de doenças, distúrbios e/ou lesões do cns. em um aspecto, o campo se refere a inibidores de fosfodiesterase 1 (pde1) como agentes neuroprotetores e/ou agentes regenerativos neurais. em um outro aspecto, o assunto refere-se a indivíduos que estão em risco de desenvolvimento de doença ou distúrbio do cns.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462051735P | 2014-09-17 | 2014-09-17 | |
US62/051,735 | 2014-09-17 | ||
US201462052283P | 2014-09-18 | 2014-09-18 | |
US62/052,283 | 2014-09-18 | ||
PCT/US2015/050814 WO2016044667A1 (en) | 2014-09-17 | 2015-09-17 | Compounds and methods |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017005533A2 true BR112017005533A2 (pt) | 2017-12-05 |
BR112017005533B1 BR112017005533B1 (pt) | 2023-10-10 |
Family
ID=55533880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017005533-3A BR112017005533B1 (pt) | 2014-09-17 | 2015-09-17 | Compostos inibidores de fosfodiesterase 1 (pde1), composição farmacêutica que compreende os ditos compostos e usos dos mesmos no tratamento de uma doença, distúrbio, e/ou lesão do snc e no tratamento e/ou na profilaxia de uma doença, distúrbio e/ou lesão do snp |
Country Status (14)
Country | Link |
---|---|
US (2) | US10150774B2 (pt) |
EP (2) | EP3725789B1 (pt) |
JP (1) | JP6596080B2 (pt) |
KR (1) | KR102332957B1 (pt) |
CN (1) | CN107106563B (pt) |
AU (1) | AU2015317527B2 (pt) |
BR (1) | BR112017005533B1 (pt) |
CA (1) | CA2961212C (pt) |
ES (2) | ES2857567T3 (pt) |
HK (1) | HK1243342A1 (pt) |
IL (2) | IL292225A (pt) |
MX (1) | MX2017003646A (pt) |
RU (1) | RU2711442C2 (pt) |
WO (1) | WO2016044667A1 (pt) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3725789B1 (en) | 2014-09-17 | 2022-03-09 | Intra-Cellular Therapies, Inc. | 7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-one derivatives as phosphodiesterase 1 (pde1) inhibitors for treating diseases, disorders or injuries of the central nervous system (cns) |
WO2019152697A1 (en) | 2018-01-31 | 2019-08-08 | Intra-Cellular Therapies, Inc. | Novel uses |
CN112189013A (zh) * | 2018-05-25 | 2021-01-05 | 细胞内治疗公司 | 有机化合物 |
BR112021007571A2 (pt) * | 2018-10-21 | 2021-07-27 | Intra-Cellular Therapies, Inc. | novos usos |
US20220184240A1 (en) * | 2019-04-12 | 2022-06-16 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (77)
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AR091507A1 (es) | 2012-06-21 | 2015-02-11 | Intra Cellular Therapies Inc | SALES DE (6aR,9aS)-5,6a,7,8,9,9a-HEXAHIDRO-5-METIL-3-(FENILAMINO)-2-((4-(6-FLUOROPIRIDIN-2-IL)FENIL)METIL)-CICLOPENT[4,5]IMIDAZO[1,2-a]PIRAZOLO[4,3-e]PIRIMIDIN-4(2H)-ONA |
US9073936B2 (en) | 2013-03-15 | 2015-07-07 | Intra-Cellular Therapies, Inc. | Organic compounds |
DK3177627T3 (da) | 2014-08-07 | 2019-10-21 | Intra Cellular Therapies Inc | Imidazo[1,2-a]-pyrazolo[4,3-e]-pyrimidin-4-on-derivater med pde1-hæmmende aktivitet |
EP3725789B1 (en) | 2014-09-17 | 2022-03-09 | Intra-Cellular Therapies, Inc. | 7,8-dihydro-[2h]-imidazo-[1,2-a]pyrazolo[4,3-e]pyrimidin-4(5h)-one derivatives as phosphodiesterase 1 (pde1) inhibitors for treating diseases, disorders or injuries of the central nervous system (cns) |
CN104570148B (zh) * | 2014-12-29 | 2015-09-02 | 河海大学 | 涉水结构物渗漏无热源光纤定位定向系统及监测方法 |
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2015
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- 2015-09-17 IL IL292225A patent/IL292225A/en unknown
- 2015-09-17 JP JP2017514842A patent/JP6596080B2/ja active Active
- 2015-09-17 ES ES15841777T patent/ES2857567T3/es active Active
- 2015-09-17 US US15/512,005 patent/US10150774B2/en active Active
- 2015-09-17 WO PCT/US2015/050814 patent/WO2016044667A1/en active Application Filing
- 2015-09-17 BR BR112017005533-3A patent/BR112017005533B1/pt active IP Right Grant
- 2015-09-17 AU AU2015317527A patent/AU2015317527B2/en active Active
- 2015-09-17 MX MX2017003646A patent/MX2017003646A/es unknown
- 2015-09-17 KR KR1020177010409A patent/KR102332957B1/ko active IP Right Grant
- 2015-09-17 ES ES20178873T patent/ES2915200T3/es active Active
- 2015-09-17 CA CA2961212A patent/CA2961212C/en active Active
- 2015-09-17 EP EP15841777.4A patent/EP3193878B1/en active Active
- 2015-09-17 CN CN201580062061.3A patent/CN107106563B/zh active Active
- 2015-09-17 RU RU2017112989A patent/RU2711442C2/ru active
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2018
- 2018-02-28 HK HK18102919.4A patent/HK1243342A1/zh unknown
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KR102332957B1 (ko) | 2021-11-29 |
EP3725789B1 (en) | 2022-03-09 |
JP6596080B2 (ja) | 2019-10-23 |
CA2961212C (en) | 2024-02-06 |
WO2016044667A1 (en) | 2016-03-24 |
AU2015317527B2 (en) | 2020-08-20 |
KR20170058406A (ko) | 2017-05-26 |
EP3193878A4 (en) | 2018-03-21 |
US10150774B2 (en) | 2018-12-11 |
MX2017003646A (es) | 2017-07-13 |
RU2711442C2 (ru) | 2020-01-17 |
RU2017112989A (ru) | 2018-10-17 |
BR112017005533B1 (pt) | 2023-10-10 |
US20170291904A1 (en) | 2017-10-12 |
CN107106563A (zh) | 2017-08-29 |
AU2015317527A1 (en) | 2017-04-13 |
CN107106563B (zh) | 2021-05-25 |
HK1243342A1 (zh) | 2018-07-13 |
IL251107A0 (en) | 2017-04-30 |
CA2961212A1 (en) | 2016-03-24 |
ES2857567T3 (es) | 2021-09-29 |
EP3725789A1 (en) | 2020-10-21 |
IL251107B (en) | 2022-05-01 |
RU2017112989A3 (pt) | 2019-04-23 |
ES2915200T3 (es) | 2022-06-21 |
EP3193878A1 (en) | 2017-07-26 |
US20190144460A1 (en) | 2019-05-16 |
JP2017527598A (ja) | 2017-09-21 |
IL292225A (en) | 2022-06-01 |
EP3193878B1 (en) | 2021-01-06 |
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