BR112017004739A2 - ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica - Google Patents

ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica

Info

Publication number
BR112017004739A2
BR112017004739A2 BR112017004739A BR112017004739A BR112017004739A2 BR 112017004739 A2 BR112017004739 A2 BR 112017004739A2 BR 112017004739 A BR112017004739 A BR 112017004739A BR 112017004739 A BR112017004739 A BR 112017004739A BR 112017004739 A2 BR112017004739 A2 BR 112017004739A2
Authority
BR
Brazil
Prior art keywords
ligand
binder
stimulating hormone
pharmaceutical composition
follicle stimulating
Prior art date
Application number
BR112017004739A
Other languages
English (en)
Other versions
BR112017004739B1 (pt
Inventor
Kara Elodie
Decourtye Jérémye
Maurel Marie-Christine
Casteret Sophie
Original Assignee
Repropharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Repropharm filed Critical Repropharm
Publication of BR112017004739A2 publication Critical patent/BR112017004739A2/pt
Publication of BR112017004739B1 publication Critical patent/BR112017004739B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/624—Disulfide-stabilized antibody (dsFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

a presente invenção se refere a anticorpos direcionados contra o hormônio folículo estimulante (fsh) e capazes de potencializar a bioatividade de gonadotrofinas.
BR112017004739-0A 2014-09-10 2015-09-10 Ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica BR112017004739B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
FR1458469A FR3025517B1 (fr) 2014-09-10 2014-09-10 Ligands potentialisants de la bioactivite des gonadotrophines
FR1458469 2014-09-10
FR1558078A FR3025518B1 (fr) 2014-09-10 2015-08-31 Ligands potentialisants de la bioactivite des gonadotrophines
FR1558078 2015-08-31
PCT/FR2015/052414 WO2016038309A1 (fr) 2014-09-10 2015-09-10 Ligands potentialisants de la bioactivite des gonadotrophines

Publications (2)

Publication Number Publication Date
BR112017004739A2 true BR112017004739A2 (pt) 2017-12-05
BR112017004739B1 BR112017004739B1 (pt) 2024-01-16

Family

ID=52589468

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112017004620-2A BR112017004620A2 (pt) 2014-09-10 2015-09-10 ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica
BR112017004739-0A BR112017004739B1 (pt) 2014-09-10 2015-09-10 Ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR112017004620-2A BR112017004620A2 (pt) 2014-09-10 2015-09-10 ligantes de hormônio folículo estimulante, complexo de ligante e gonadotrofina, uso de um ligante, e composição farmacêutica

Country Status (21)

Country Link
US (2) US10584166B2 (pt)
EP (2) EP3191515B1 (pt)
JP (2) JP6705608B2 (pt)
KR (1) KR102072650B1 (pt)
CN (2) CN107108732B (pt)
AU (1) AU2015314029C1 (pt)
BR (2) BR112017004620A2 (pt)
CA (2) CA2960132C (pt)
CY (2) CY1123168T1 (pt)
DK (2) DK3191514T3 (pt)
ES (2) ES2797752T3 (pt)
FR (2) FR3025517B1 (pt)
HR (2) HRP20200969T1 (pt)
HU (2) HUE049357T2 (pt)
IL (1) IL250978B2 (pt)
LT (2) LT3191515T (pt)
PL (2) PL3191515T3 (pt)
PT (2) PT3191514T (pt)
RS (2) RS60501B1 (pt)
SI (2) SI3191515T1 (pt)
WO (2) WO2016038309A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3025517B1 (fr) 2014-09-10 2016-12-23 Repropharm Ligands potentialisants de la bioactivite des gonadotrophines
WO2017192847A1 (en) * 2016-05-04 2017-11-09 University Of Cincinnati Female fertility therapies
JP6952219B1 (ja) * 2019-11-18 2021-10-20 住友化学株式会社 哺乳動物の発情迅速検査薬
WO2023091148A1 (en) * 2021-11-22 2023-05-25 National Health Research Institutes ANTI-HSP90α ANTIBODY AND USES THEREOF
CN114213534B (zh) * 2022-02-21 2022-06-03 南京佰抗生物科技有限公司 抗人PlGF鼠源单克隆抗体及应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA936260B (en) * 1992-09-09 1994-03-18 Smithkline Beecham Corp Novel antibodies for conferring passive immunity against infection by a pathogen in man
GB9519511D0 (en) 1995-09-25 1995-11-29 Babraham The Inst Peptides
JPH1189569A (ja) * 1997-09-25 1999-04-06 Matsushita Electric Ind Co Ltd モノクローナル抗体産生細胞ライン及びその作製方法、並びにモノクローナル抗体
US20020102613A1 (en) * 1999-05-18 2002-08-01 Hoogenboom Hendricus Renerus Jacobus Mattheus Novel Fab fragment libraries and methods for their use
ATE491726T1 (de) 2003-09-26 2011-01-15 Agronomique Inst Nat Rech Antikörper modulierende die biologische aktivität von pferd-choriongonadotropin
DK1937815T3 (en) 2005-09-13 2015-08-03 Nat Res Council Canada Methods and compositions for the modulation of tumor cell activity
FR2967676B1 (fr) * 2010-11-19 2014-09-19 Agronomique Inst Nat Rech Ligand d'hormone luteinisante et complexe ligand-gonadotrophine
US9199234B2 (en) 2011-05-27 2015-12-01 Abbott Point Of Care Inc. TSH antibodies for point-of-care immunoassay formats
SG10201710574UA (en) * 2012-03-15 2018-02-27 Janssen Biotech Inc Human anti-cd27 antibodies, methods and uses
FR3025517B1 (fr) 2014-09-10 2016-12-23 Repropharm Ligands potentialisants de la bioactivite des gonadotrophines

Also Published As

Publication number Publication date
JP2017533257A (ja) 2017-11-09
AU2015314029C1 (en) 2021-01-07
CY1123738T1 (el) 2022-05-27
DK3191515T3 (da) 2021-02-15
JP6649385B2 (ja) 2020-02-19
US10584166B2 (en) 2020-03-10
CA2960132A1 (fr) 2016-03-17
FR3025518B1 (fr) 2019-06-14
US20170190774A1 (en) 2017-07-06
CY1123168T1 (el) 2021-10-29
KR102072650B1 (ko) 2020-02-03
CA2960132C (fr) 2023-03-21
FR3025517A1 (fr) 2016-03-11
CA2960120A1 (fr) 2016-03-17
CA2960120C (fr) 2023-03-21
PT3191515T (pt) 2021-01-26
HUE049357T2 (hu) 2020-09-28
EP3191514A1 (fr) 2017-07-19
LT3191515T (lt) 2021-04-26
HRP20210141T1 (hr) 2021-04-30
SI3191515T1 (sl) 2021-03-31
IL250978A0 (en) 2017-04-30
IL250978B (en) 2022-10-01
EP3191514B1 (fr) 2020-04-08
WO2016038309A1 (fr) 2016-03-17
PL3191514T3 (pl) 2020-09-21
AU2015314029A1 (en) 2017-04-13
IL250978B2 (en) 2023-02-01
BR112017004620A2 (pt) 2018-01-30
EP3191515A1 (fr) 2017-07-19
CN107108732A (zh) 2017-08-29
CN107108731B (zh) 2021-11-23
JP2017537971A (ja) 2017-12-21
SI3191514T1 (sl) 2020-08-31
LT3191514T (lt) 2020-07-10
WO2016038308A1 (fr) 2016-03-17
DK3191514T3 (da) 2020-06-22
PT3191514T (pt) 2020-06-25
RS60501B1 (sr) 2020-08-31
HRP20200969T1 (hr) 2020-10-16
CN107108732B (zh) 2021-11-23
RS61358B1 (sr) 2021-02-26
US10703815B2 (en) 2020-07-07
JP6705608B2 (ja) 2020-06-03
FR3025517B1 (fr) 2016-12-23
PL3191515T3 (pl) 2021-05-17
EP3191515B1 (fr) 2020-12-30
KR20170052658A (ko) 2017-05-12
AU2015314029B2 (en) 2020-09-17
CN107108731A (zh) 2017-08-29
BR112017004739B1 (pt) 2024-01-16
US20170190773A1 (en) 2017-07-06
HUE053100T2 (hu) 2021-06-28
FR3025518A1 (fr) 2016-03-11
ES2845674T3 (es) 2021-07-27
ES2797752T3 (es) 2020-12-03

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: REPROPHARM VET (FR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 10/09/2015, OBSERVADAS AS CONDICOES LEGAIS