BR112016028581A2 - método para a determinação in vitro da presença de um tumor, método para a determinação in vitro do estado de transformação de tumor, vesículas extracelulares tm9sf4-positivas e kit para uso na determinação in vitro da presença de um tumor ou um estado de transformação de tumor - Google Patents
método para a determinação in vitro da presença de um tumor, método para a determinação in vitro do estado de transformação de tumor, vesículas extracelulares tm9sf4-positivas e kit para uso na determinação in vitro da presença de um tumor ou um estado de transformação de tumorInfo
- Publication number
- BR112016028581A2 BR112016028581A2 BR112016028581A BR112016028581A BR112016028581A2 BR 112016028581 A2 BR112016028581 A2 BR 112016028581A2 BR 112016028581 A BR112016028581 A BR 112016028581A BR 112016028581 A BR112016028581 A BR 112016028581A BR 112016028581 A2 BR112016028581 A2 BR 112016028581A2
- Authority
- BR
- Brazil
- Prior art keywords
- tumor
- determining
- state
- transformation
- tm9sf4
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- 230000009466 transformation Effects 0.000 title abstract 3
- 238000000338 in vitro Methods 0.000 title 1
- 239000000090 biomarker Substances 0.000 abstract 4
- 238000001514 detection method Methods 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 108091062762 miR-21 stem-loop Proteins 0.000 abstract 1
- 108091041631 miR-21-1 stem-loop Proteins 0.000 abstract 1
- 108091044442 miR-21-2 stem-loop Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57488—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/56—Staging of a disease; Further complications associated with the disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
a presente invenção refere-se a biomarcadores de microvesículas extracelulares para a determinação do estado de transformação de tumor ou a presença de um tumor em um indivíduo, e aos usos de tais biomarcadores e a métodos de diagnóstico que utilizam tais biomarcadores. em particular, os métodos e usos da presente invenção envolvem o isolamento de vesículas extracelulares tm9sf4-positivas e a detecção da expressão de um segundo biomarcador, preferencialmente selecionado a partir do grupo que consiste em proteína cd9, mir-21 e rnu6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14171464.2 | 2014-06-06 | ||
| EP14171464 | 2014-06-06 | ||
| PCT/EP2015/062594 WO2015185730A2 (en) | 2014-06-06 | 2015-06-05 | Exosomal biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016028581A2 true BR112016028581A2 (pt) | 2018-01-30 |
| BR112016028581B1 BR112016028581B1 (pt) | 2024-05-21 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| ES2700404T3 (es) | 2019-02-15 |
| RU2712223C2 (ru) | 2020-01-27 |
| JP6650929B2 (ja) | 2020-02-19 |
| AU2015270450B2 (en) | 2021-04-01 |
| US20170146543A1 (en) | 2017-05-25 |
| CA2950977C (en) | 2023-10-10 |
| CN113092764A (zh) | 2021-07-09 |
| RU2016152346A (ru) | 2018-07-09 |
| MX2016016122A (es) | 2017-04-27 |
| WO2015185730A3 (en) | 2016-02-18 |
| AU2015270450A1 (en) | 2017-01-05 |
| EP3152576B1 (en) | 2018-09-12 |
| PL3152576T3 (pl) | 2019-01-31 |
| EP3152576A2 (en) | 2017-04-12 |
| US20220349892A1 (en) | 2022-11-03 |
| JP2017518517A (ja) | 2017-07-06 |
| RU2016152346A3 (pt) | 2019-03-18 |
| WO2015185730A2 (en) | 2015-12-10 |
| CN106574928A (zh) | 2017-04-19 |
| CA2950977A1 (en) | 2015-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B25D | Requested change of name of applicant approved |
Owner name: EXOSOMICS S.P.A. (IT) |
|
| B25G | Requested change of headquarter approved |
Owner name: EXOSOMICS S.P.A. (IT) |
|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 05/06/2015, OBSERVADAS AS CONDICOES LEGAIS |