BR112016024352A2 - ?cepa de listeria recombinante, listeria recombinante, composição farmacêutica, e, métodos de induzir uma resposta imune contra um tumor ou um câncer em um indivíduo humano e de listeria? - Google Patents
?cepa de listeria recombinante, listeria recombinante, composição farmacêutica, e, métodos de induzir uma resposta imune contra um tumor ou um câncer em um indivíduo humano e de listeria?Info
- Publication number
- BR112016024352A2 BR112016024352A2 BR112016024352-8A BR112016024352A BR112016024352A2 BR 112016024352 A2 BR112016024352 A2 BR 112016024352A2 BR 112016024352 A BR112016024352 A BR 112016024352A BR 112016024352 A2 BR112016024352 A2 BR 112016024352A2
- Authority
- BR
- Brazil
- Prior art keywords
- listeria
- recombinant listeria
- tumor
- inducing
- cancer
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
- A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20051—Methods of production or purification of viral material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461983732P | 2014-04-24 | 2014-04-24 | |
| US61/983732 | 2014-04-24 | ||
| PCT/US2015/025690 WO2015164121A1 (en) | 2014-04-24 | 2015-04-14 | Recombinant listeria vaccine strains and methods of producing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016024352A2 true BR112016024352A2 (pt) | 2018-01-23 |
Family
ID=54333010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016024352-8A BR112016024352A2 (pt) | 2014-04-24 | 2015-04-14 | ?cepa de listeria recombinante, listeria recombinante, composição farmacêutica, e, métodos de induzir uma resposta imune contra um tumor ou um câncer em um indivíduo humano e de listeria? |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US10258679B2 (https=) |
| EP (1) | EP3134510B1 (https=) |
| JP (3) | JP7009061B2 (https=) |
| KR (2) | KR102359691B1 (https=) |
| CN (1) | CN106459887A (https=) |
| AU (1) | AU2015250111A1 (https=) |
| BR (1) | BR112016024352A2 (https=) |
| CA (1) | CA2946716A1 (https=) |
| IL (1) | IL248483A0 (https=) |
| MA (1) | MA39849A (https=) |
| MX (1) | MX2016013985A (https=) |
| RU (1) | RU2016145464A (https=) |
| SG (2) | SG11201608820WA (https=) |
| TW (2) | TWI692525B (https=) |
| WO (1) | WO2015164121A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| CA2829960A1 (en) | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| WO2013138337A1 (en) | 2012-03-12 | 2013-09-19 | Advaxis | Suppressor cell function inhibition following listeria vaccine treatment |
| JP2017511796A (ja) | 2014-02-18 | 2017-04-27 | アドバクシス, インコーポレイテッド | 多標的免疫療法を目的とするバイオマーカー |
| EP3134510B1 (en) | 2014-04-24 | 2023-11-01 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of producing the same |
| CN107429289A (zh) * | 2014-10-14 | 2017-12-01 | 宾夕法尼亚大学理事会 | 用于癌症治疗的联合疗法 |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| CA3035591A1 (en) | 2016-11-30 | 2018-06-07 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| CN106978381A (zh) * | 2017-03-23 | 2017-07-25 | 上海理工大学 | prfA基因缺失单核细胞增生李斯特氏菌及制备方法 |
| AU2018336988B2 (en) | 2017-09-19 | 2023-06-22 | Advaxis, Inc. | Compositions and methods for lyophilization of bacteria or Listeria strains |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| CN111511392A (zh) | 2017-10-31 | 2020-08-07 | 潘塔希生物科学股份有限公司 | 用于治疗和/或预防肺癌的免疫治疗方法 |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| AU2019231783B2 (en) * | 2018-03-09 | 2023-11-16 | Advaxis, Inc. | Compositions and methods for evaluating attenuation and infectivity of Listeria strains |
| CN110408634B (zh) * | 2018-04-27 | 2021-08-03 | 苏州若泰医药科技有限公司 | 一种非整合李斯特菌疫苗及抗肿瘤免疫应答方法 |
| US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
| WO2021259963A1 (en) | 2020-06-23 | 2021-12-30 | Pandora Endocrine Innovation B.V. | Immunization against wnt4 for treatment and prophylaxis of breast cancer |
| US12537071B1 (en) | 2020-07-22 | 2026-01-27 | David Gordon Bermudes | Bacteria having boolean control pathways expressing therapeutic proteins including immunotherapeutic cytotoxins |
| US20250026818A1 (en) | 2021-10-19 | 2025-01-23 | Sciencemed Spóka z ograniczon odpowiedzialnoci | Male contraception |
| CN116218754B (zh) * | 2023-04-10 | 2025-06-03 | 四川大学 | 一种提高绵羊李斯特菌膜囊泡产量的方法及应用 |
| CN119060155B (zh) * | 2024-11-07 | 2025-03-07 | 山东大学 | 一种蛋白在调节肠道稳态及抵抗致病菌感染中的应用 |
Family Cites Families (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5830702A (en) | 1990-10-31 | 1998-11-03 | The Trustees Of The University Of Pennsylvania | Live, recombinant listeria monocytogenes and production of cytotoxic T-cell response |
| US7662396B2 (en) | 2001-03-26 | 2010-02-16 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US8956621B2 (en) | 1994-11-08 | 2015-02-17 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical dysplasia |
| US6051237A (en) | 1994-11-08 | 2000-04-18 | The Trustees Of The University Of Pennsylvania | Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector |
| US7820180B2 (en) | 2004-09-24 | 2010-10-26 | The Trustees Of The University Of Pennsylvania | Listeria-based and LLO-based vaccines |
| US8791237B2 (en) | 1994-11-08 | 2014-07-29 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of non-hodgkins lymphoma |
| US8114414B2 (en) | 1994-11-08 | 2012-02-14 | The Trustees Of The University Of Pennsylvania | Compositions and methods for treatment of cervical cancer |
| US20070264279A1 (en) * | 1994-11-08 | 2007-11-15 | Claudia Gravekamp | Compositions and methods comprising a MAGE-b antigen |
| US6099848A (en) | 1997-11-18 | 2000-08-08 | The Trustees Of The University Of Pennsylvania | Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use |
| US9012141B2 (en) | 2000-03-27 | 2015-04-21 | Advaxis, Inc. | Compositions and methods comprising KLK3 of FOLH1 antigen |
| AU2001255196A1 (en) | 2000-03-29 | 2001-10-08 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing immunogenicity of antigens |
| US6855320B2 (en) | 2000-03-29 | 2005-02-15 | The Trustees Of The University Of Pennsylvania | Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| US7700344B2 (en) | 2001-03-26 | 2010-04-20 | The Trustees Of The University Of Pennsylvania | Compositions and methods for enhancing the immunogenicity of antigens |
| US7794728B2 (en) | 2002-05-29 | 2010-09-14 | The Regents Of The University Of California | Attenuated Listeria spp. and methods for using the same |
| US8337861B2 (en) | 2003-01-09 | 2012-12-25 | The Trustees Of The University Of Pennsylvania | Compositions, methods and kits for enhancing the immunogenicity of a bacterial vaccine vector |
| US7855064B2 (en) | 2004-08-13 | 2010-12-21 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free vaccines and methods for constructing and using same |
| PT2942391T (pt) | 2004-08-13 | 2018-10-09 | Univ Pennsylvania | Métodos de produção de vacinas não resistentes aos antibióticos |
| US7858097B2 (en) * | 2004-08-13 | 2010-12-28 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free Listeria strains and methods for constructing and using same |
| CA2584130A1 (en) * | 2004-10-18 | 2006-04-27 | Medimmune, Inc. | High cell density process for growth of listeria |
| US7935804B2 (en) | 2006-03-01 | 2011-05-03 | Aduro Biotech | Engineered Listeria and methods of use thereof |
| EP3284478A1 (en) | 2006-08-15 | 2018-02-21 | The Trustees of the University of Pennsylvania | Compositions comprising hmw-maa and fragments thereof for treating cancer |
| US8268326B2 (en) | 2006-08-15 | 2012-09-18 | The Trustees Of The University Of Pennsylvania | Compositions comprising HMW-MAA and fragments thereof, and methods of use thereof |
| WO2008130551A2 (en) | 2007-04-16 | 2008-10-30 | The Trustees Of The University Of Pennsylvania | Antibiotic resistance free listeria strains and methods for constructing and using same |
| US9017660B2 (en) | 2009-11-11 | 2015-04-28 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of Her2/neu over-expressing tumors |
| US20150366955A9 (en) | 2009-11-11 | 2015-12-24 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
| US20110129499A1 (en) | 2008-05-19 | 2011-06-02 | Paulo Maciag | Dual delivery system for heterologous antigens |
| US20140234370A1 (en) | 2009-11-11 | 2014-08-21 | Advaxis, Inc. | Compositions and methods for prevention of escape mutation in the treatment of her2/neu over-expressing tumors |
| US9650639B2 (en) | 2008-05-19 | 2017-05-16 | Advaxis, Inc. | Dual delivery system for heterologous antigens |
| EP2283112B1 (en) * | 2008-05-19 | 2016-10-12 | Aduro Biotech | Compositions comprising prfa*mutant listeria and methods of use thereof |
| US20120135033A1 (en) | 2008-05-19 | 2012-05-31 | Anu Wallecha | Multiple delivery system for heterologous antigens |
| WO2010011870A2 (en) * | 2008-07-24 | 2010-01-28 | Anza Therapeutics, Inc. | Compositions and methods for the treatment of hepatitis c |
| WO2010102140A1 (en) | 2009-03-04 | 2010-09-10 | The Trustees Of The University Of Pennsylvania | Compositions comprising angiogenic factors and methods of use thereof |
| US10016617B2 (en) | 2009-11-11 | 2018-07-10 | The Trustees Of The University Of Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of Her-2-positive cancers |
| JP5985397B2 (ja) | 2009-11-11 | 2016-09-06 | アドバクシス インコーポレイテッド | 組換えリステリア株およびそれを含む免疫原性組成物 |
| WO2011100754A1 (en) | 2010-02-15 | 2011-08-18 | The Trustees Of The University Of Pennsylvania | Live listeria-based vaccines for central nervous system therapy |
| US20110305724A1 (en) | 2010-04-19 | 2011-12-15 | Yvonne Paterson | Immunotherapeutic, anti-tumorigenic compositions and methods of use thereof |
| WO2012138377A2 (en) | 2010-10-01 | 2012-10-11 | Trustees Of The University Of Pennsylvania | The use of listeria vaccine vectors to reverse vaccine unresponsiveness in parasitically infected individuals |
| SMT201800444T1 (it) * | 2010-11-17 | 2018-09-13 | Aduro Biotech Inc | Metodi e composizioni per indurre una risposta immunitaria contro egfrviii |
| CA2829960A1 (en) * | 2011-03-11 | 2012-09-20 | John Rothman | Listeria-based adjuvants |
| WO2013138337A1 (en) | 2012-03-12 | 2013-09-19 | Advaxis | Suppressor cell function inhibition following listeria vaccine treatment |
| JP2017511796A (ja) | 2014-02-18 | 2017-04-27 | アドバクシス, インコーポレイテッド | 多標的免疫療法を目的とするバイオマーカー |
| EP3110942A4 (en) | 2014-02-25 | 2017-08-30 | Advaxis, Inc. | Compositions and methods for the treatment of her2/neu over-expressing tumors |
| AU2015227163A1 (en) | 2014-03-05 | 2016-10-20 | Advaxis, Inc. | Methods and compositions for increasing a T-effector cell to regulatory T cell ratio |
| EP3134510B1 (en) | 2014-04-24 | 2023-11-01 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of producing the same |
| SG11201609135VA (en) | 2014-05-02 | 2016-11-29 | Univ Pennsylvania | Combination immuno therapy and radiotherapy for the treatment of her-2-positive cancers |
| SG11201700092XA (en) | 2014-07-18 | 2017-02-27 | Advaxis Inc | Recombinant listeria strain expressing heterologous antigen fusion proteins and methods of use thereof |
| CA2955612C (en) | 2014-07-18 | 2022-05-17 | Advaxis, Inc. | Combination of a pd-1 antagonist and a listeria-based vaccine for treating prostate cancer |
| EP3169355A4 (en) | 2014-07-18 | 2018-07-25 | Advaxis, Inc. | Listeria-based immunogenic compositions for eliciting anti-tumor responses |
| WO2016011320A1 (en) | 2014-07-18 | 2016-01-21 | Advaxis, Inc. | Bivalent listeria-based delivery system of heterologous antigens |
| CN107429289A (zh) | 2014-10-14 | 2017-12-01 | 宾夕法尼亚大学理事会 | 用于癌症治疗的联合疗法 |
| MA41218A (fr) | 2014-12-19 | 2017-10-24 | Advaxis Inc | Combinaison de vaccin à base de listeria comportant des anticorps anti-ox40 ou anti-gitr |
| WO2016126878A2 (en) | 2015-02-03 | 2016-08-11 | The Trustees Of The University Of Pennsylvania | Listeria-based immunomodulation |
| WO2016126876A2 (en) | 2015-02-03 | 2016-08-11 | Advaxis, Inc. | Listeria-based adjuvants |
| US20160220652A1 (en) | 2015-02-03 | 2016-08-04 | Advaxis, Inc. | Methods of using recombinant listeria vaccine strains in disease immunotherapy |
| MA41644A (fr) | 2015-03-03 | 2018-01-09 | Advaxis Inc | Compositions à base de listeria comprenant un système d'expression de minigènes codant pour des peptides, et leurs procédés d'utilisation |
| WO2016154412A2 (en) | 2015-03-26 | 2016-09-29 | The Trustees Of The University Of Pennsylvania | Combination of a pd-1 antagonist and a listeria based vaccine for treating pancreatic cancer |
| US20180104284A1 (en) | 2015-05-13 | 2018-04-19 | Advaxis, Inc. | Immunogenic Listeria-Based Compositions Comprising Truncated Acta-Antigen Fusions And Methods Of Use Thereof |
| MX2017015149A (es) | 2015-05-26 | 2018-03-28 | Advaxis Inc | Inmunoterapia personalizada basada en vectores de suministro y usos de esta. |
| WO2016207859A1 (en) | 2015-06-24 | 2016-12-29 | Advaxis, Inc. | Manufacturing device and process for personalized delivery vector-based immunotherapy |
| EP3350337A4 (en) | 2015-09-15 | 2019-04-03 | Advaxis, Inc. | METHOD FOR PRODUCING IMMUNOTHERAPEUTIC FORMULATION WITH A RECOMBINANT LISTERIA STRAIN |
| US20180305702A1 (en) | 2015-09-15 | 2018-10-25 | Advaxis, Inc. | Listeria-Based Immunogenic Compositions And Methods Of Use Thereof in Cancer Prevention And Treatment |
| MA42845A (fr) | 2015-09-17 | 2018-07-25 | Advaxis Inc | Souches vaccinales de listeria de recombinaison et méthodes d'utilisation desdites souches dans l'immunothérapie anticancéreuse |
| CA3001702A1 (en) | 2015-10-14 | 2017-04-20 | Advaxis, Inc. | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy |
| US20180325964A1 (en) | 2015-11-20 | 2018-11-15 | Advaxis, Inc. | Manufacturing device and method of an immunotherapeutic formulation comprising a recombinant listeria strain |
| EP3389705A4 (en) | 2015-12-16 | 2019-08-07 | Advaxis, Inc. | LIST-BASED IMMUNOTHERAPY AND METHOD OF USE THEREOF |
| CN108884468A (zh) | 2016-01-27 | 2018-11-23 | 阿德瓦希斯公司 | 基于个性化递送载体的免疫疗法及其用途 |
| CA3029235A1 (en) | 2016-07-05 | 2018-01-11 | Advaxis, Inc. | Listeria-based immunogenic compositions comprising wilms tumor protein antigens and methods of use thereof |
| US20200061167A1 (en) | 2016-11-07 | 2020-02-27 | Advaxis, Inc. | Combination of listeria-based vaccine with anti-ctla-4 or anti-cd137 antibodies |
| CA3035591A1 (en) | 2016-11-30 | 2018-06-07 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| WO2018102585A1 (en) | 2016-11-30 | 2018-06-07 | Advaxis, Inc. | Personalized immunotherapy in combination with immunotherapy targeting recurrent cancer mutations |
| AR110730A1 (es) | 2017-01-05 | 2019-04-24 | Advaxis Inc | Vacunas de cepas recombinantes de listeria y método para usarlas en inmunoterapia de cáncer |
-
2015
- 2015-04-14 EP EP15782800.5A patent/EP3134510B1/en active Active
- 2015-04-14 MX MX2016013985A patent/MX2016013985A/es unknown
- 2015-04-14 AU AU2015250111A patent/AU2015250111A1/en not_active Abandoned
- 2015-04-14 RU RU2016145464A patent/RU2016145464A/ru not_active Application Discontinuation
- 2015-04-14 SG SG11201608820WA patent/SG11201608820WA/en unknown
- 2015-04-14 MA MA039849A patent/MA39849A/fr unknown
- 2015-04-14 US US15/306,289 patent/US10258679B2/en active Active
- 2015-04-14 CA CA2946716A patent/CA2946716A1/en not_active Abandoned
- 2015-04-14 CN CN201580021074.6A patent/CN106459887A/zh active Pending
- 2015-04-14 KR KR1020167029990A patent/KR102359691B1/ko not_active Expired - Fee Related
- 2015-04-14 JP JP2016564032A patent/JP7009061B2/ja not_active Expired - Fee Related
- 2015-04-14 WO PCT/US2015/025690 patent/WO2015164121A1/en not_active Ceased
- 2015-04-14 BR BR112016024352-8A patent/BR112016024352A2/pt not_active Application Discontinuation
- 2015-04-14 KR KR1020227003655A patent/KR102491332B1/ko active Active
- 2015-04-14 SG SG10202011841WA patent/SG10202011841WA/en unknown
- 2015-04-21 TW TW104112751A patent/TWI692525B/zh not_active IP Right Cessation
- 2015-04-21 TW TW109111533A patent/TWI722858B/zh not_active IP Right Cessation
-
2016
- 2016-10-25 IL IL248483A patent/IL248483A0/en unknown
-
2019
- 2019-02-14 US US16/276,520 patent/US20190240303A1/en not_active Abandoned
-
2020
- 2020-03-18 JP JP2020047632A patent/JP2020099352A/ja not_active Withdrawn
-
2022
- 2022-05-30 JP JP2022087587A patent/JP7300041B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201546276A (zh) | 2015-12-16 |
| KR102359691B1 (ko) | 2022-02-10 |
| US20190240303A1 (en) | 2019-08-08 |
| US10258679B2 (en) | 2019-04-16 |
| SG11201608820WA (en) | 2016-11-29 |
| AU2015250111A1 (en) | 2016-12-08 |
| JP2020099352A (ja) | 2020-07-02 |
| JP2017513502A (ja) | 2017-06-01 |
| TW202041671A (zh) | 2020-11-16 |
| US20170042996A1 (en) | 2017-02-16 |
| TWI722858B (zh) | 2021-03-21 |
| IL248483A0 (en) | 2016-12-29 |
| KR20160145627A (ko) | 2016-12-20 |
| EP3134510A1 (en) | 2017-03-01 |
| CN106459887A (zh) | 2017-02-22 |
| TWI692525B (zh) | 2020-05-01 |
| JP7009061B2 (ja) | 2022-01-25 |
| EP3134510B1 (en) | 2023-11-01 |
| JP7300041B2 (ja) | 2023-06-28 |
| MA39849A (fr) | 2017-03-01 |
| SG10202011841WA (en) | 2021-01-28 |
| MX2016013985A (es) | 2017-01-11 |
| CA2946716A1 (en) | 2015-10-29 |
| JP2022105768A (ja) | 2022-07-14 |
| EP3134510A4 (en) | 2018-04-25 |
| KR102491332B1 (ko) | 2023-01-27 |
| RU2016145464A (ru) | 2018-05-24 |
| WO2015164121A1 (en) | 2015-10-29 |
| KR20220021021A (ko) | 2022-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112016024352A2 (pt) | ?cepa de listeria recombinante, listeria recombinante, composição farmacêutica, e, métodos de induzir uma resposta imune contra um tumor ou um câncer em um indivíduo humano e de listeria? | |
| SG10201903349YA (en) | Recombinant listeria vaccine strains and methods of using the same in cancer immunotherapy | |
| MX2018004598A (es) | Cepas vacunales recombinantes de listeria y métodos para usar las mismas en la inmunoterapia contra el cáncer. | |
| EP4421094A3 (en) | Targeted therapeutic agents and uses thereof | |
| BR112016020364A2 (pt) | métodos para suscitar uma resposta de uma célula t antitumoral em um indivíduo tendo um tumor ou câncer e para aumentar a razão de células t efetoras sobre células t reguladoras no baço de um indivíduo | |
| PH12019501414A1 (en) | Amino acid compositions and methods for the treatment of liver diseases | |
| CO2018004564A2 (es) | Genes de ataxia de friedreich modificados y vectores para terapia génica | |
| MX2022005291A (es) | Vacunas para el tratamiento y prevencion del cancer. | |
| PH12019501010A1 (en) | Arginase inhibitor combination therapies | |
| MD4733B1 (ro) | Anticorpi anti-TIGIT | |
| MX2017004838A (es) | Composiciones de interleucina-15 y usos de estas. | |
| IN2014CN04187A (https=) | ||
| GEAP202115055A (en) | Anti-cd27 antibodies | |
| MX382908B (es) | Polipéptidos de folistatina y sus usos. | |
| MX2015009963A (es) | Metodos y composición farmacéutica para el tratamiento y la prevención de cardiomiopatía debido a falta de energía. | |
| MX390894B (es) | Polipéptido de fusión anti-cáncer. | |
| MY173162A (en) | Immune balance regulator | |
| MX386613B (es) | El uso de un péptido timosina alfa y un inhibidor de pd-1 para el tratamiento de cáncer o una metástasis de este en un sujeto. | |
| ZA202204223B (en) | Vaccination with mica/b alpha 3 domain for the treatment of cancer | |
| MY193807A (en) | T-cell receptor and uses thereof | |
| MX2018015110A (es) | Arn modificado que codifica polipeptidos de vegf-a. formulaciones y usos relacionados con los mismos. | |
| MY190102A (en) | Tolerogenic dna vaccine | |
| MX2020002585A (es) | Inhibidor de hdac combinado con un modulador del punto de control inmunitario para la terapia contra el cancer. | |
| MX2019003970A (es) | Péptidos de arginasa inmunogénicos. | |
| EP4342544A3 (en) | Enhancing the therapeutic activity of an immune checkpoint inhibitor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS. |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |