BR112016017502B1 - Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal - Google Patents
Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal Download PDFInfo
- Publication number
- BR112016017502B1 BR112016017502B1 BR112016017502-6A BR112016017502A BR112016017502B1 BR 112016017502 B1 BR112016017502 B1 BR 112016017502B1 BR 112016017502 A BR112016017502 A BR 112016017502A BR 112016017502 B1 BR112016017502 B1 BR 112016017502B1
- Authority
- BR
- Brazil
- Prior art keywords
- chymosin
- polypeptide
- variant
- seq
- amino acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6478—Aspartic endopeptidases (3.4.23)
- C12N9/6483—Chymosin (3.4.23.4), i.e. rennin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C19/00—Cheese; Cheese preparations; Making thereof
- A23C19/02—Making cheese curd
- A23C19/04—Making cheese curd characterised by the use of specific enzymes of vegetable or animal origin
- A23C19/041—Proteolytic or milk clotting enzymes from plants or vegetables, e.g. papain, ficin, bromelain
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; PREPARATION THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/12—Fermented milk preparations; Treatment using microorganisms or enzymes
- A23C9/1203—Addition of, or treatment with, enzymes or microorganisms other than lactobacteriaceae
- A23C9/1209—Proteolytic or milk coagulating enzymes, e.g. trypsine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/23—Aspartic endopeptidases (3.4.23)
- C12Y304/23004—Chymosin (3.4.23.4), i.e. rennin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Husbandry (AREA)
- Botany (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Enzymes And Modification Thereof (AREA)
- Fodder In General (AREA)
- Beans For Foods Or Fodder (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14156707 | 2014-02-26 | ||
| EP14156707.3 | 2014-02-26 | ||
| EP14176664.2 | 2014-07-11 | ||
| EP14176664 | 2014-07-11 | ||
| PCT/EP2015/054020 WO2015128417A1 (en) | 2014-02-26 | 2015-02-26 | Variants of chymosin with improved milk-clotting properties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112016017502A2 BR112016017502A2 (https=) | 2017-08-08 |
| BR112016017502B1 true BR112016017502B1 (pt) | 2023-10-24 |
Family
ID=52596486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016017502-6A BR112016017502B1 (pt) | 2014-02-26 | 2015-02-26 | Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10982204B2 (https=) |
| EP (2) | EP3110948B1 (https=) |
| JP (3) | JP7098270B2 (https=) |
| KR (2) | KR102494645B1 (https=) |
| CN (2) | CN106062187B (https=) |
| AU (2) | AU2015222149B2 (https=) |
| BR (1) | BR112016017502B1 (https=) |
| CA (1) | CA2938015A1 (https=) |
| DK (1) | DK3110948T3 (https=) |
| MX (2) | MX2016009937A (https=) |
| NZ (1) | NZ722003A (https=) |
| RU (2) | RU2717770C2 (https=) |
| UA (1) | UA121380C2 (https=) |
| WO (1) | WO2015128417A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ702030A (en) | 2012-05-25 | 2016-11-25 | Chr Hansen As | Variants of chymosin with improved milk-clotting properties |
| RU2717770C2 (ru) | 2014-02-26 | 2020-03-25 | Кхр. Хансен А/С | Варианты химозина с улучшенными молокосвертывающими свойствами |
| RU2740317C2 (ru) * | 2015-06-22 | 2021-01-13 | Кхр. Хансен А/С | Варианты химозина с улучшенными свойствами |
| EP3344049A1 (en) * | 2015-08-31 | 2018-07-11 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| ES3023033T3 (en) * | 2015-09-18 | 2025-05-29 | Dsm Ip Assets Bv | Yogurt with reduced ripening |
| EP3457859A1 (en) * | 2016-05-19 | 2019-03-27 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| US10961524B2 (en) | 2016-05-19 | 2021-03-30 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| CN106754840B (zh) * | 2016-12-22 | 2019-06-21 | 江南大学 | 一种酶活及热稳定性改善的凝乳酶突变体 |
| US20200345022A1 (en) | 2018-01-15 | 2020-11-05 | Chr. Hansen A/S | Fermented milk product and preparation thereof using phospholipase |
| CN113801867B (zh) * | 2021-11-18 | 2022-03-18 | 中国农业科学院生物技术研究所 | 骆驼凝乳酶原突变蛋白及其编码基因和应用 |
| US20260000087A1 (en) | 2022-04-06 | 2026-01-01 | Chr. Hansen A/S | Aspartic Protease, Methods and Uses Thereof |
| WO2024189187A1 (en) | 2023-03-15 | 2024-09-19 | Dsm Ip Assets B.V. | Novel process for producing a fermented milk product and new fermented milk product so produced |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0123928A3 (en) | 1983-03-31 | 1986-02-05 | Codon Genetic Engineering Laboratories | Recombinant dna coding for a polypeptide displaying milk clotting activity |
| US5217891A (en) * | 1987-07-28 | 1993-06-08 | Chiron Corporation | DNA constructs containing a kluyveromyces α factor leader sequence for directing secretion of heterologous polypeptides |
| US7390936B1 (en) * | 1999-08-23 | 2008-06-24 | Sembiosys Genetics Inc. | Commercial production of chymosin in plants |
| RU2192137C2 (ru) | 2000-08-07 | 2002-11-10 | Открытое акционерное общество "Уфамолагропром" | Способ производства сыра |
| DK1334182T4 (da) * | 2000-11-06 | 2021-04-26 | Eidgenoessische Technische Hochschule Eth | Fremgangsmåde til fremstilling af ikke-bovint chymosin og anvendelse heraf |
| AU2003282724B2 (en) | 2002-10-02 | 2010-03-04 | Catalyst Biosciences, Inc. | Methods of generating and screening for proteases with altered specificity |
| WO2004072225A2 (en) | 2003-02-12 | 2004-08-26 | Ramot At Tel Aviv University Ltd. | Transgenic fungi expressing bcl-2 and methods of using bcl-2 or portions thereof for improving biomass production, survival, longevity, stress resistance and pathogenicity of fungi |
| BRPI0412007A (pt) | 2003-06-27 | 2006-08-15 | Bioren Inc | mutagênese look-through |
| EP1745068A4 (en) * | 2004-03-30 | 2009-11-04 | Sudershan Biotech Ltd | RECOMBINANT CALM CHYMOSIN AND PROCESS FOR PRODUCING THE SAME |
| EP3763220A1 (en) | 2007-02-13 | 2021-01-13 | Chr. Hansen A/S | Coagulation of milk |
| JP2010046034A (ja) | 2008-08-22 | 2010-03-04 | Toyota Central R&D Labs Inc | 変異体のスクリーニング方法 |
| EP2411512B1 (en) * | 2009-03-24 | 2013-11-20 | Meito Sangyo Co., Ltd. | Improved type milk-clotting protease derived from a microorganism |
| DK2602317T3 (da) * | 2009-11-20 | 2017-11-13 | Danisco Us Inc | Beta-glucosidasevarianter med forbedrede egenskaber |
| KR20130102534A (ko) * | 2010-07-12 | 2013-09-17 | 에이티와이알 파마, 인코포레이티드 | 히스티딜trna 합성효소의 단백질 단편에 관련된 치료적, 진단적, 및 항체 조성물의 혁신적 발견 |
| EA035275B1 (ru) * | 2012-05-03 | 2020-05-22 | ДСМ АйПи АССЕТС Б.В. | Варианты химозина с повышенной специфичностью и их применение в получении сыра |
| NZ702030A (en) | 2012-05-25 | 2016-11-25 | Chr Hansen As | Variants of chymosin with improved milk-clotting properties |
| CN103484488B (zh) * | 2013-09-16 | 2015-07-15 | 中国农业科学院生物技术研究所 | 优化的牛凝乳酶原基因及其分泌表达方法和应用 |
| RU2717770C2 (ru) | 2014-02-26 | 2020-03-25 | Кхр. Хансен А/С | Варианты химозина с улучшенными молокосвертывающими свойствами |
| US20180110234A1 (en) | 2015-02-10 | 2018-04-26 | Chr. Hansen A/S | Blends of chymosins with improved milk-clotting properties |
| RU2740317C2 (ru) | 2015-06-22 | 2021-01-13 | Кхр. Хансен А/С | Варианты химозина с улучшенными свойствами |
| EP3344049A1 (en) | 2015-08-31 | 2018-07-11 | Chr. Hansen A/S | Variants of chymosin with improved properties |
| EP3457859A1 (en) | 2016-05-19 | 2019-03-27 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
| US10961524B2 (en) | 2016-05-19 | 2021-03-30 | Chr. Hansen A/S | Variants of chymosin with improved milk-clotting properties |
-
2015
- 2015-02-26 RU RU2016132974A patent/RU2717770C2/ru active
- 2015-02-26 EP EP15707110.1A patent/EP3110948B1/en active Active
- 2015-02-26 AU AU2015222149A patent/AU2015222149B2/en active Active
- 2015-02-26 CN CN201580009539.6A patent/CN106062187B/zh active Active
- 2015-02-26 KR KR1020217042407A patent/KR102494645B1/ko active Active
- 2015-02-26 BR BR112016017502-6A patent/BR112016017502B1/pt active IP Right Grant
- 2015-02-26 KR KR1020167026056A patent/KR102344861B1/ko active Active
- 2015-02-26 UA UAA201607691A patent/UA121380C2/uk unknown
- 2015-02-26 CN CN202010904707.0A patent/CN111944791A/zh active Pending
- 2015-02-26 EP EP25169128.3A patent/EP4627930A3/en active Pending
- 2015-02-26 WO PCT/EP2015/054020 patent/WO2015128417A1/en not_active Ceased
- 2015-02-26 RU RU2020107148A patent/RU2739004C1/ru active
- 2015-02-26 US US15/121,286 patent/US10982204B2/en active Active
- 2015-02-26 DK DK15707110.1T patent/DK3110948T3/da active
- 2015-02-26 JP JP2016553838A patent/JP7098270B2/ja active Active
- 2015-02-26 CA CA2938015A patent/CA2938015A1/en active Pending
- 2015-02-26 NZ NZ722003A patent/NZ722003A/en unknown
- 2015-02-26 MX MX2016009937A patent/MX2016009937A/es unknown
-
2016
- 2016-07-29 MX MX2022006692A patent/MX2022006692A/es unknown
-
2020
- 2020-03-05 JP JP2020038155A patent/JP7144470B2/ja active Active
-
2021
- 2021-04-15 US US17/231,956 patent/US11629343B2/en active Active
- 2021-12-17 AU AU2021286442A patent/AU2021286442B2/en active Active
-
2022
- 2022-01-07 US US17/571,413 patent/US11827913B2/en active Active
- 2022-05-25 JP JP2022085229A patent/JP2022122926A/ja active Pending
-
2023
- 2023-10-30 US US18/497,758 patent/US20240084281A1/en not_active Abandoned
Also Published As
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| BR112016017502B1 (pt) | Variantes de polipeptídeo de quimosina isoladas método para a produção das mesmas e método para a fabricação de um produto de alimentação humana ou animal | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 26/02/2015, OBSERVADAS AS CONDICOES LEGAIS |