BR112016015629A2 - produção de vetores virais adenoassociados de alto título - Google Patents

produção de vetores virais adenoassociados de alto título

Info

Publication number
BR112016015629A2
BR112016015629A2 BR112016015629A BR112016015629A BR112016015629A2 BR 112016015629 A2 BR112016015629 A2 BR 112016015629A2 BR 112016015629 A BR112016015629 A BR 112016015629A BR 112016015629 A BR112016015629 A BR 112016015629A BR 112016015629 A2 BR112016015629 A2 BR 112016015629A2
Authority
BR
Brazil
Prior art keywords
production
viral vectors
vectors
adenoassociated viral
cell lines
Prior art date
Application number
BR112016015629A
Other languages
English (en)
Inventor
Satkunanathan Stifani
Zhao Yuan
Original Assignee
The Sec Dep For Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Sec Dep For Health filed Critical The Sec Dep For Health
Publication of BR112016015629A2 publication Critical patent/BR112016015629A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14151—Methods of production or purification of viral material
    • C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

a presente invenção refere-se a vetores virais adenoassociado (avv), a linhagens de células produtoras para a produção de vetores aav e a métodos de produção desses vetores. mais especificamente, a invenção refere-se a linhagens de células produtoras adaptadas para aumentar o título dos referidos vetores e a métodos de produção de vetores aav usando essas linhagens de células produtoras.
BR112016015629A 2014-01-31 2015-01-30 produção de vetores virais adenoassociados de alto título BR112016015629A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201401707A GB201401707D0 (en) 2014-01-31 2014-01-31 Adeno-associated viral vectors
PCT/GB2015/050240 WO2015114365A1 (en) 2014-01-31 2015-01-30 High titer production of adeno-associated viral vectors

Publications (1)

Publication Number Publication Date
BR112016015629A2 true BR112016015629A2 (pt) 2017-10-24

Family

ID=50344213

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016015629A BR112016015629A2 (pt) 2014-01-31 2015-01-30 produção de vetores virais adenoassociados de alto título

Country Status (13)

Country Link
US (1) US10035985B2 (pt)
EP (1) EP3099788A1 (pt)
JP (1) JP2017506885A (pt)
KR (1) KR20160137985A (pt)
CN (1) CN105980551A (pt)
AU (1) AU2015212563A1 (pt)
BR (1) BR112016015629A2 (pt)
CA (1) CA2934774A1 (pt)
GB (1) GB201401707D0 (pt)
IL (1) IL246588A0 (pt)
MX (1) MX2016009965A (pt)
SG (1) SG11201605848TA (pt)
WO (1) WO2015114365A1 (pt)

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Also Published As

Publication number Publication date
US20170029785A1 (en) 2017-02-02
CN105980551A (zh) 2016-09-28
CA2934774A1 (en) 2015-08-06
JP2017506885A (ja) 2017-03-16
GB201401707D0 (en) 2014-03-19
SG11201605848TA (en) 2016-08-30
MX2016009965A (es) 2017-06-14
EP3099788A1 (en) 2016-12-07
KR20160137985A (ko) 2016-12-02
WO2015114365A1 (en) 2015-08-06
IL246588A0 (en) 2016-08-31
AU2015212563A1 (en) 2016-07-14
US10035985B2 (en) 2018-07-31

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Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2616 DE 23-02-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.