BR112016012968A2 - Métodos e composições para o tratamento de condições associadas com o envelhecimento - Google Patents

Métodos e composições para o tratamento de condições associadas com o envelhecimento

Info

Publication number
BR112016012968A2
BR112016012968A2 BR112016012968A BR112016012968A BR112016012968A2 BR 112016012968 A2 BR112016012968 A2 BR 112016012968A2 BR 112016012968 A BR112016012968 A BR 112016012968A BR 112016012968 A BR112016012968 A BR 112016012968A BR 112016012968 A2 BR112016012968 A2 BR 112016012968A2
Authority
BR
Brazil
Prior art keywords
aging
methods
compositions
conditions associated
treatment
Prior art date
Application number
BR112016012968A
Other languages
English (en)
Portuguese (pt)
Inventor
Wyss-Coray Anton
M Castellano Joseph
MIDDELDORP Jinte
A Villeda Saul
S Angst Martin
Luo Jian
Original Assignee
Univ Leland Stanford Junior
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leland Stanford Junior filed Critical Univ Leland Stanford Junior
Publication of BR112016012968A2 publication Critical patent/BR112016012968A2/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14Blood; Artificial blood
    • A61K35/16Blood plasma; Blood serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48Reproductive organs
    • A61K35/51Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
BR112016012968A 2013-12-09 2014-12-05 Métodos e composições para o tratamento de condições associadas com o envelhecimento BR112016012968A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361913812P 2013-12-09 2013-12-09
US201462069044P 2014-10-27 2014-10-27
PCT/US2014/068897 WO2015088915A1 (en) 2013-12-09 2014-12-05 Methods and compositions for treating aging-associated conditions

Publications (1)

Publication Number Publication Date
BR112016012968A2 true BR112016012968A2 (pt) 2017-08-08

Family

ID=53270052

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016012968A BR112016012968A2 (pt) 2013-12-09 2014-12-05 Métodos e composições para o tratamento de condições associadas com o envelhecimento

Country Status (13)

Country Link
US (2) US10688130B2 (ja)
EP (1) EP3079708A4 (ja)
JP (2) JP6667438B2 (ja)
KR (2) KR102155857B1 (ja)
CN (1) CN106163530A (ja)
AU (1) AU2014364182B2 (ja)
BR (1) BR112016012968A2 (ja)
CA (1) CA2933440A1 (ja)
EA (1) EA035336B1 (ja)
IL (1) IL246023B (ja)
MX (1) MX2016007492A (ja)
NZ (1) NZ720949A (ja)
WO (1) WO2015088915A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
CN106163530A (zh) 2013-12-09 2016-11-23 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物
CN113855804A (zh) 2015-06-15 2021-12-31 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物
US11628190B2 (en) * 2015-08-28 2023-04-18 University Of South Florida Plasma derived from human umbilical cord blood for the treatment of neurodegenerative disorders
US11007230B1 (en) * 2015-08-28 2021-05-18 University Of South Florida Plasma derived from human umbilical cord blood for the treatment of neurodegenerative disorders
EP3995141B1 (en) 2016-04-28 2024-01-03 Alkahest, Inc. Plasma fractions as therapy for thymic cancer
EP3252452A1 (en) * 2016-05-25 2017-12-06 The Board of Trustees of the Leland Stanford Junior University Method for imaging and analysis of a biological specimen
US20210290835A1 (en) * 2016-08-05 2021-09-23 Jay Yadav Plasma banking to mitigate aging
HRP20211628T1 (hr) * 2016-08-18 2022-02-04 Alkahest, Inc. Frakcije krvne plazme kao tretman za kongitivne poremećaje povezane sa starenjem
WO2018071869A1 (en) * 2016-10-14 2018-04-19 The Regents Of The University Of California Heterochronic blood exchange as a modality to influence myogenesis, neurogenesis, and liver regeneration
EA039316B1 (ru) * 2016-10-24 2022-01-12 Алкахест, Инк. Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением
CN106581063B (zh) * 2016-12-29 2018-11-06 北京豪思生物科技有限公司 一种用于增强记忆力的血浆分离物及其制备方法和应用
CN106581062B (zh) * 2016-12-29 2020-09-18 江苏豪思睦可生物科技有限公司 一种用于改善记忆力的混合物及其制备方法和应用
US11040068B2 (en) 2017-04-26 2021-06-22 Alkahest, Inc. Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
EP4299129A3 (en) 2017-04-26 2024-03-20 Alkahest, Inc. Dosing regimen for treatment of cognitive impairments with blood plasma products
ES2690178A1 (es) * 2017-05-18 2018-11-19 Apc Europe Slu Plasma de animal o fracciones del mismo para su utilización en el tratamiento de trastornos de deterioro cognitivo en seres humanos y animales de compañia
EP3765010A2 (en) * 2018-03-13 2021-01-20 Nuchido Limited Treatment of diseases involving nad
JP2022505915A (ja) 2018-10-26 2022-01-14 アルカヘスト,インコーポレイテッド 疼痛、創傷治癒及び術後回復の改善のための血漿及び血漿画分の使用
WO2021062007A1 (en) * 2019-09-25 2021-04-01 Cytegen Corp. Treatment of mitochondrial deficits and age-related diseases using blood products
CA3151943A1 (en) 2019-11-04 2021-05-14 Viktoria Kheifets Blood plasma fractions for use in muscle regeneration
CN114746100A (zh) 2019-11-20 2022-07-12 万能溶剂有限公司 用于肝再生的血浆级分
US11484551B2 (en) 2019-11-20 2022-11-01 Alkahest, Inc. Method of treating liver failure with plasma fraction IV-4
WO2022150818A1 (en) * 2021-01-06 2022-07-14 Yuvan Research, Inc. Anti-aging compositions and uses thereof
CN113081079B (zh) * 2021-03-30 2022-04-22 中国科学院生态环境研究中心 血桥限位器
WO2024011127A1 (en) * 2022-07-06 2024-01-11 Yuvan Research, Inc. Rna-enriched anti-aging compositions and uses thereof

Family Cites Families (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708713A (en) 1984-11-16 1987-11-24 Anisa Medical, Inc. Method and system for removing immunosuppressive components from the blood of mammals
EP0319862B1 (de) 1987-12-11 1994-01-12 Akzo Nobel N.V. Biocompatible Dialysemembran aus Cellulose mit erhöhter Beta-2-Microglobulinadsorption
DE69033982T2 (de) 1989-03-21 2002-10-24 Us Health Matrizenmetalloproteinase-inhibitor-peptide
US5240614A (en) 1992-01-10 1993-08-31 Baxter International Inc. Process for removing unwanted materials from fluids and for producing biological products
US6544761B2 (en) 1994-12-13 2003-04-08 Human Genome Sciences, Inc. Human tissue inhibitor of metalloproteinase-4
GB9607287D0 (en) 1996-04-09 1996-06-12 British Biotech Pharm Diagnosis method
US5916202A (en) 1996-08-30 1999-06-29 Haswell; John N. Umbilical cord blood collection
US6416487B1 (en) 1997-07-30 2002-07-09 Renal Tech International Llc Method of removing beta-2 microglobulin from blood
US5904663A (en) 1997-07-30 1999-05-18 Braverman; Andrew Method of removing beta-2 microglobulin from blood
US20020159995A1 (en) 1997-07-30 2002-10-31 Renal Tech International Devices, systems, and methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood, generated as a result of extracorporeal blood processing
AUPR748501A0 (en) 2001-09-04 2001-09-27 Life Therapeutics Limited Renal dialysis
AUPP790898A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Renal dialysis
WO2000040749A2 (en) 1999-01-06 2000-07-13 Genenews Inc. Method for the detection of gene transcripts in blood and uses thereof
DE69942282D1 (de) 1999-01-22 2010-06-02 Dow Global Technologies Inc Oberflächenverändertes divinylbenzenharz mit hämokompatibler beschichtung
UA35656C2 (uk) 1999-12-27 2001-04-16 Олександр Миколайович Макаренко Спосіб лікування безперервно прогредієнтних ослабоумлюючих психічних захворювань
US7582292B2 (en) 2000-02-26 2009-09-01 Artecel, Inc. Adipose tissue derived stromal cells for the treatment of neurological disorders
US6946546B2 (en) 2000-03-06 2005-09-20 Cambridge Antibody Technology Limited Human antibodies against eotaxin
GB0015761D0 (en) 2000-06-27 2000-08-16 Univ Bristol Polypeptide
US6632174B1 (en) 2000-07-06 2003-10-14 Cognifit Ltd (Naiot) Method and apparatus for testing and training cognitive ability
US20020151064A1 (en) 2001-02-07 2002-10-17 Children's Hospital Medical Center Regulation of CCR3 expression
WO2003006006A1 (en) 2001-07-09 2003-01-23 The Regents Of The University Of California Use of matrix metalloproteinase inhibitors to mitigate nerve damage
US20050071088A1 (en) 2001-08-13 2005-03-31 Landfield Philip W Gene expression profile biomarkers and therapeutic targets for brain aging and age-related cognitive impairment
US6906036B2 (en) 2001-08-16 2005-06-14 Kimberly-Clark Worldwide, Inc. Anti-aging and wound healing compounds
US7608406B2 (en) 2001-08-20 2009-10-27 Biosite, Inc. Diagnostic markers of stroke and cerebral injury and methods of use thereof
US8105580B2 (en) 2001-12-07 2012-01-31 Cytori Therapeutics, Inc. Methods of using adipose derived stem cells to promote wound healing
EP1394549A1 (en) 2002-08-23 2004-03-03 Bayer HealthCare AG Biomarkers for diagnosing Alzheimer's disease
ATE475888T1 (de) 2002-08-23 2010-08-15 Bayer Schering Pharma Ag Biomarker zur diagnose von alzheimer
US20040127445A1 (en) 2002-08-28 2004-07-01 Chondrogene Limited Beta-2 microglobulin (B2M) and B2M related gene products for the regulation of osteoarthritis pathogenesis and chondrocyte proliferation
US20050244448A1 (en) 2002-10-14 2005-11-03 The Board Of Trustees Of The Leland Stanford Jr. University Diagnosis and treatment of disorders of collagen and elastin metabolism
US20040120937A1 (en) * 2002-12-19 2004-06-24 Therapy Patent Corporation Blood therapy process
BR0317715A (pt) 2002-12-27 2005-11-22 Angiotech Int Ag Composições e processos de uso de collajolie
US7785601B2 (en) 2002-12-31 2010-08-31 Sygnis Bioscience Gmbh & Co. Kg Methods of treating neurological conditions with hematopoietic growth factors
GB0305133D0 (en) * 2003-03-06 2003-04-09 Sinvent As Product
CA2520225C (en) 2003-03-24 2014-08-12 Bayer Healthcare Ag Benzenesulfonamide derivatives
US20040254152A1 (en) 2003-04-17 2004-12-16 Monje Michelle L. Prevention of deficits in neurogenesis with anti-inflammatory agents
US7368542B2 (en) 2003-06-09 2008-05-06 Redox-Reactive Reagents Llc Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions
US20060094064A1 (en) 2003-11-19 2006-05-04 Sandip Ray Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids
EP1692520A2 (en) 2003-11-19 2006-08-23 Satoris, Inc. Method for diagnosis, stratification and monitoring of alzheimer's disease
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
WO2005106492A2 (en) 2004-04-30 2005-11-10 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with c-c chemokine receptor 3 (ccr3)
KR101236046B1 (ko) 2004-07-23 2013-02-21 카네카 코포레이션 수불용성 미립자를 제거한 흡착재를 충전시킨 직접 혈액관류용 흡착기, 및 수불용성 미립자를 제거한 직접 혈액관류용 흡착재를 얻는 방법
US20090209615A1 (en) 2004-09-27 2009-08-20 Stuart Lipton Inhibitors of matrix metalloproteinases to treat neurological disorders
PE20061329A1 (es) * 2004-12-15 2006-12-08 Neuralab Ltd Anticuerpos ab humanizados para mejorar la cognicion
CA2638892A1 (en) 2005-03-18 2006-09-28 Oregon Health & Science University Recombinant mhc molecules useful for manipulation of antigen-specific t cells
DK1929297T3 (da) 2005-09-29 2013-03-04 Caprion Proteomics Usa Llc Biomarkører for dissemineret sklerose og fremgangsmåder til anvendelse heraf
WO2007059135A2 (en) 2005-11-10 2007-05-24 Satoris, Inc. Methods of treating alzheimer's disease
US20080125354A1 (en) 2005-11-21 2008-05-29 Florida Atlantic University Selective inhibition of matrix metalloproteinases
US7908090B2 (en) 2005-11-30 2011-03-15 The Board Of Trustees Of The Leland Stanford Junior University Signatures for human aging
WO2007098099A2 (en) 2006-02-16 2007-08-30 Discogen, Llc Method of treating a subject suffering from degenerative disc disease using a matrix metalloprotease inhibitor
US10344095B2 (en) 2006-02-16 2019-07-09 University Of Kentucky Research Foundation CCR3 inhibition for ocular angiogenesis and macular degeneration
JP2009149524A (ja) 2006-03-16 2009-07-09 Kyushu Univ アルツハイマー病の予防・治療剤
EP2008100A4 (en) 2006-04-18 2009-12-16 Univ Leland Stanford Junior ESTABLISHING ANTIBODY PROFILES FOR DETERMINING PATIENT SENSITIVITY TO TREATMENT
EP2924440A3 (en) 2006-06-07 2016-03-09 Health Diagnostic Laboratory, Inc. Markers associated with arteriovascular events and methods of use thereof
US7851172B2 (en) 2006-07-25 2010-12-14 University Of Kentucky Research Foundation Biomarkers of mild cognitive impairment and alzheimer's disease
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US8211310B2 (en) 2006-11-20 2012-07-03 Cytosorbents, Inc. Size-selective polymer system
WO2009008928A2 (en) 2007-04-13 2009-01-15 Stemnion, Inc. Methods for treating nervous system injury and disease
GB0710522D0 (en) 2007-06-01 2007-07-11 Royal Veterinary College The Drug delivery system comprising matrix metalloproteinase inhibitors
BRPI0815551A2 (pt) * 2007-08-15 2015-02-18 Univ South Florida Tratamento através de hucbc de doença beta-amiloide
US8097645B2 (en) 2007-10-12 2012-01-17 The Board Of Trustees Of The Leland Stanford Junior University Compounds for activating TGF-β signaling
US20100015235A1 (en) 2008-04-28 2010-01-21 Revalesio Corporation Compositions and methods for treating multiple sclerosis
US20100310609A1 (en) 2007-10-25 2010-12-09 Revalesio Corporation Compositions and methods for treatment of neurodegenerative diseases
US20090227018A1 (en) 2007-10-25 2009-09-10 Revalesio Corporation Compositions and methods for modulating cellular membrane-mediated intracellular signal transduction
CA2707685C (en) 2007-12-06 2014-05-27 Asahi Kasei Kuraray Medical Co., Ltd. Porous hollow fiber membrane for treating blood
EP2307052A4 (en) 2008-08-07 2012-08-01 Da Zen Group Llc ANTI-BETA-2-MICROGLOBULIN AGENTS AND THEIR USE
JP5651474B2 (ja) 2008-10-09 2015-01-14 オリエンタル酵母工業株式会社 β−アミロイド前駆体蛋白質由来マトリックスメタロプロテアーゼ−2インヒビターペプチドと組織メタロプロテアーゼ阻害物質との融合タンパク質
US20100124756A1 (en) 2008-10-10 2010-05-20 Sandip Ray Collection of biomarkers for diagnosis and monitoring of alzheimer's disease in body fluids
US20110117100A1 (en) 2008-11-03 2011-05-19 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosis, stratification and treatment of amyloidogenic diseases
US8778616B2 (en) 2009-05-26 2014-07-15 University Of Kentucky Research Foundation Method of using CCR3 binding agents to detect choroidal neovascularization
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
WO2011094535A2 (en) 2010-01-28 2011-08-04 The Board Of Trustees Of The Leland Stanford Junior University Biomarkers of aging for detection and treatment of disorders
WO2016187217A2 (en) 2015-05-18 2016-11-24 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US20110202284A1 (en) 2010-02-10 2011-08-18 Mcreynolds Cristopher Novel groups of biomarkers for diagnosing alzheimer's disease
RU2428997C1 (ru) 2010-03-01 2011-09-20 Федеральное государственное образовательное учреждение высшего профессионального образования Волгоградская государственная сельскохозяйственная академия Способ получения лечебных препаратов из пуповины плода
AR080698A1 (es) 2010-04-01 2012-05-02 Imclone Llc Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
SI2566517T1 (sl) 2010-05-04 2019-01-31 Five Prime Therapeutics, Inc. Protitelesa, ki vežejo CSF1R
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
US9782457B2 (en) 2011-10-07 2017-10-10 Tissue Repair Company Flowable formulations for tissue repair and regeneration
RU2470677C1 (ru) 2011-10-19 2012-12-27 Надежда Михайловна Цулая Способ стимуляции репаративных и трофических процессов в коже
WO2013063086A1 (en) 2011-10-24 2013-05-02 Intellect Neurosciences, Inc. Compositions and methods for treatment of proteinopathies
WO2013122950A1 (en) 2012-02-13 2013-08-22 Wuyi Kong Nprcps, pfdncs and uses thereof
WO2013142135A1 (en) * 2012-03-20 2013-09-26 Albert Einstein College Of Medicine Of Yeshiva University Method of enhancing efficacy of blood transfusions
US20130302322A1 (en) 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
US9512052B2 (en) 2012-10-29 2016-12-06 China Petroleum & Chemical Corporation Adsorption desulfurization process for hydrocarbons and a reaction apparatus therefor
JP6364488B2 (ja) 2013-11-26 2018-07-25 ユニバーシティー オブ ノース テキサス ヘルス サイエンス センター アット フォートワースUniversity Of North Texas Health Science Center At Fort Worth 認知欠損を治療するための個別化医療的手法
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
CN106163530A (zh) 2013-12-09 2016-11-23 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物
EP3131923A1 (en) 2014-04-16 2017-02-22 Blood Systems Research Institute Method and composition for conferring neuroprotection
CN113855804A (zh) 2015-06-15 2021-12-31 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物

Also Published As

Publication number Publication date
NZ720949A (en) 2019-03-29
JP2019194249A (ja) 2019-11-07
WO2015088915A1 (en) 2015-06-18
IL246023A0 (en) 2016-07-31
JP6667438B2 (ja) 2020-03-18
US20150157664A1 (en) 2015-06-11
EA035336B1 (ru) 2020-05-29
JP6931678B2 (ja) 2021-09-08
KR102155857B1 (ko) 2020-09-15
KR20160086965A (ko) 2016-07-20
KR102351604B1 (ko) 2022-01-18
EP3079708A1 (en) 2016-10-19
AU2014364182B2 (en) 2019-03-07
EP3079708A4 (en) 2017-08-30
MX2016007492A (es) 2017-03-06
KR20200108372A (ko) 2020-09-17
CA2933440A1 (en) 2015-06-18
EA201690969A1 (ru) 2016-09-30
AU2014364182A1 (en) 2016-06-30
CN106163530A (zh) 2016-11-23
US20200352994A1 (en) 2020-11-12
IL246023B (en) 2019-11-28
JP2016539992A (ja) 2016-12-22
US10688130B2 (en) 2020-06-23

Similar Documents

Publication Publication Date Title
BR112016012968A2 (pt) Métodos e composições para o tratamento de condições associadas com o envelhecimento
CL2018000542A1 (es) Nuevos derivados de fenoximetilo.
CL2015002855A1 (es) Derivados de oxopiridina sustituida.
EA201590388A1 (ru) Способы лечения таупатии
CL2018000596A1 (es) Nuevos compuestos bicíclicos como inhibidores de la atx
BR112016016916A8 (pt) uso de um anticorpo que se liga à calicreína plasmática ativa para tratamento de angiodema hereditário (hae)
BR112017005517A2 (pt) anticorpos antiage para o tratamento de inflama-ção e de transtornos autoimunes
BR112016026993A2 (pt) combinação de um anticorpo anti-ccr4 e um agonista 4-1bb para tratar câncer
EA201691134A1 (ru) Новые ингибиторы глутаминазы
CL2018000107A1 (es) Moléculas de anticuerpo que se unen a cd79
BR112014020826A2 (pt) moduladores e métodos de uso
CY1120535T1 (el) Δοτες νιτροξυλιου με βελτιωμενο θεραπευτικο δεικτη
CL2016001076A1 (es) (aza) piridopirazolopirimidinonas e indazolopirimidinonas como inhibidores de fibrinolosis.
CO2018002568A2 (es) Acetamida tienotriazolodiazepinas y usos de las mismas
BR112016022318A2 (pt) método, composição farmacêutica para uso no tratamento de doenças de retina e uso de um anticorpo
BR112015030356A2 (pt) métodos de tratamento de uma taupatia
BR112015030385A8 (pt) composto, composto para uso e composição farmacêutica
BR112015019873A2 (pt) inibidores macrocíclicos da lrrk2 cinase
BR112019005040A2 (pt) aplicação de pridopidina para tratamento de síndrome de rett
BR112017007025A2 (pt) sulfatos de colesterol oxigenados para terapia de distúrbios causados por pelo menos um de atividade de leptina atenuada e um distúrbio de armazenamento de lipídio
BR112018012927A2 (pt) reguladores cftr e métodos de uso dos mesmos
BR112016015997A2 (pt) ?composições farmacêuticas que compreendem 15- hepe e métodos para tratar asma e distúrbios pulmonares com o uso das mesmas?
BR112016022214A2 (pt) rnase para uso no tratamento ou prevenção de infecções virais
BR112016002317A8 (pt) Uso de benralizumab ou de um seu fragmento de ligação ao antígeno para aumentar o volume expiratório forçado em asmáticos e benralizumab ou de um seu fragmento de ligação ao antígeno para uso para aumentar o volume expiratório forçado em asmáticos
BR112015024625A2 (pt) composição de galacto-oligossacarídeo para o uso na prevenção ou tratamento de disfunção cognitiva e transtornos emocionais em doenças neuropsiquiátricas ou envelhecimento

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements