ATE475888T1 - Biomarker zur diagnose von alzheimer - Google Patents

Biomarker zur diagnose von alzheimer

Info

Publication number
ATE475888T1
ATE475888T1 AT08002793T AT08002793T ATE475888T1 AT E475888 T1 ATE475888 T1 AT E475888T1 AT 08002793 T AT08002793 T AT 08002793T AT 08002793 T AT08002793 T AT 08002793T AT E475888 T1 ATE475888 T1 AT E475888T1
Authority
AT
Austria
Prior art keywords
alzheimer
human
patients
disease
disclosed
Prior art date
Application number
AT08002793T
Other languages
English (en)
Inventor
Oezkan A Yalkinoglu
Gerhard Koenig
Denis Francois Hochstrasser
Jean-Charles Sanchez
Odile Carrette
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP02018283A external-priority patent/EP1394549A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of ATE475888T1 publication Critical patent/ATE475888T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT08002793T 2002-08-23 2003-08-11 Biomarker zur diagnose von alzheimer ATE475888T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02018283A EP1394549A1 (de) 2002-08-23 2002-08-23 Biomarker zur Diagnose von Alzheimer Erkrankung
EP02026643 2002-11-29

Publications (1)

Publication Number Publication Date
ATE475888T1 true ATE475888T1 (de) 2010-08-15

Family

ID=31947886

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08002793T ATE475888T1 (de) 2002-08-23 2003-08-11 Biomarker zur diagnose von alzheimer
AT03792291T ATE403875T1 (de) 2002-08-23 2003-08-11 Polypeptid-biomarker zur diagnose von morbus alzheimer

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT03792291T ATE403875T1 (de) 2002-08-23 2003-08-11 Polypeptid-biomarker zur diagnose von morbus alzheimer

Country Status (10)

Country Link
EP (3) EP1953556B1 (de)
JP (1) JP4405919B2 (de)
AT (2) ATE475888T1 (de)
AU (3) AU2003251702B2 (de)
CA (6) CA2745724C (de)
DE (2) DE60333608D1 (de)
DK (3) DK1953556T3 (de)
ES (3) ES2347924T3 (de)
PT (1) PT1535076E (de)
WO (1) WO2004019043A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469312A1 (de) * 2003-04-18 2004-10-20 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnose der Alzheimer Krankheit
WO2005001483A2 (en) * 2003-06-27 2005-01-06 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Methods for diagnisis and differential diagnosis of dementia disorders
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
GB0502068D0 (en) 2005-02-01 2005-03-09 King S College London Screening method
EP1869473A2 (de) * 2005-04-06 2007-12-26 mosaiques diagnostics and therapeutics AG Polypeptidmarker zur diagnose von alzheimer
ATE511643T1 (de) * 2005-06-16 2011-06-15 Vermillion Inc Fragment des neurosekretorischen proteins vgf als biomarker für morbus alzheimer
CA2689848A1 (en) * 2006-02-28 2007-09-07 Phenomenome Discoveries Inc. Methods for the diagnosis of dementia and other neurological disorders
WO2007106466A2 (en) * 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
GB0616230D0 (en) * 2006-08-16 2006-09-27 Univ Cambridge Tech Biomarkers and uses thereof
EP2117527B1 (de) 2007-02-08 2020-06-17 Med-Life Discoveries LP Verbindungen zur verwendung bei der behandlung von altersdemenz vom alzheimer-typ
CA2718955C (en) 2008-03-21 2015-10-13 Manuela G. Neuman Methods and kits for the differential diagnosis of alzheimer's disease versus frontotemporal dementia and for the diagnosis of frontotemporal dementia comprising fas-l and ck 18 as biomarkers
AU2009295357A1 (en) * 2008-09-26 2010-04-01 The University Of Melbourne Alzheimer's disease biomarkers
JP2010271078A (ja) 2009-05-19 2010-12-02 Mcbi:Kk 認知機能障害疾患を含む精神疾患のバイオマーカーおよび該バイオマーカーを用いた認知機能障害疾患を含む精神疾患の検出方法
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
US10688130B2 (en) 2013-12-09 2020-06-23 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated conditions
GB201322094D0 (en) * 2013-12-13 2014-01-29 Electrophoretics Ltd Methods and compositions relating to alzheimers disease
CA2989138C (en) 2015-06-15 2022-11-22 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating cognitive impairment or decline comprising tissue inhibitor of mettaloproteinase-2 (timp-2)
KR102572009B1 (ko) * 2020-10-21 2023-08-29 순천향대학교 산학협력단 시스타틴 c를 포함하는 퇴행성 신경 질환 진단용 바이오마커 조성물 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
EP1123509B1 (de) * 1998-10-23 2004-12-29 EVOTEC Neurosciences GmbH Methoden zur diagnose oder prognose der alzheimerschen krankheit
EP1259539A1 (de) * 2000-02-24 2002-11-27 Oxford GlycoSciences (UK) Limited Diagnose und behandlung von bipolarer affektiver störung
EP1266225A2 (de) * 2000-03-20 2002-12-18 Oxford GlycoSciences (UK) Limited Diagnose und behandlung von brustkrebs
EP1325338A2 (de) * 2000-04-03 2003-07-09 Oxford GlycoSciences (UK) Limited Diagnose und behandlung der alzheimerschen krankheit
CA2446886A1 (en) * 2001-04-06 2002-10-17 Biovision Ag Method for detecting chronic dementia diseases, and corresponding peptides and detection reagents
EP1408333A3 (de) * 2001-10-03 2006-10-25 Pfizer Products Inc. Diagnose und behandlung von alzheimer's krankheit

Also Published As

Publication number Publication date
CA2745569C (en) 2015-07-14
CA2745998A1 (en) 2004-03-04
AU2010212316B2 (en) 2012-05-24
DK1953556T3 (da) 2010-10-25
ATE403875T1 (de) 2008-08-15
CA2496321C (en) 2013-05-21
CA2745731A1 (en) 2004-03-04
CA2746000A1 (en) 2004-03-04
WO2004019043A2 (en) 2004-03-04
JP4405919B2 (ja) 2010-01-27
EP1535076B1 (de) 2008-08-06
AU2010212316A1 (en) 2010-09-09
CA2745998C (en) 2013-11-26
DE60322719D1 (de) 2008-09-18
DK2221620T3 (da) 2014-01-06
EP1953556B1 (de) 2010-07-28
AU2003251702B2 (en) 2010-06-03
PT1535076E (pt) 2008-11-03
EP1953556A2 (de) 2008-08-06
CA2745724A1 (en) 2004-03-04
CA2745724C (en) 2015-06-02
WO2004019043A3 (en) 2004-06-24
CA2745569A1 (en) 2004-03-04
AU2010212317A1 (en) 2010-09-09
CA2496321E (en) 2004-03-04
EP2221620A3 (de) 2010-11-24
EP2221620A2 (de) 2010-08-25
EP1535076A2 (de) 2005-06-01
DE60333608D1 (de) 2010-09-09
AU2003251702A1 (en) 2004-03-11
EP1953556A3 (de) 2008-11-26
DK1535076T3 (da) 2008-11-24
ES2311751T3 (es) 2009-02-16
CA2496321A1 (en) 2004-03-04
ES2436318T3 (es) 2013-12-30
EP2221620B1 (de) 2013-10-02
JP2005536729A (ja) 2005-12-02
CA2745731C (en) 2015-05-12
CA2746000C (en) 2014-10-21
ES2347924T3 (es) 2010-11-25
AU2010212317B2 (en) 2013-01-10

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