DK1535076T3 - Polypeptid-biomarkörer til diagnose af Alzheimers sygdom - Google Patents

Polypeptid-biomarkörer til diagnose af Alzheimers sygdom

Info

Publication number
DK1535076T3
DK1535076T3 DK03792291T DK03792291T DK1535076T3 DK 1535076 T3 DK1535076 T3 DK 1535076T3 DK 03792291 T DK03792291 T DK 03792291T DK 03792291 T DK03792291 T DK 03792291T DK 1535076 T3 DK1535076 T3 DK 1535076T3
Authority
DK
Denmark
Prior art keywords
alzheimer
disease
diagnosis
human
patients
Prior art date
Application number
DK03792291T
Other languages
English (en)
Inventor
Denis Francois Hochstrasser
Jean-Charles Sanchez
Odile Carrette
Oezkan Yalkinoglu
Gerhard Koenig
Original Assignee
Bayer Healthcare Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP02018283A external-priority patent/EP1394549A1/en
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Application granted granted Critical
Publication of DK1535076T3 publication Critical patent/DK1535076T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70539—MHC-molecules, e.g. HLA-molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK03792291T 2002-08-23 2003-08-11 Polypeptid-biomarkörer til diagnose af Alzheimers sygdom DK1535076T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02018283A EP1394549A1 (en) 2002-08-23 2002-08-23 Biomarkers for diagnosing Alzheimer's disease
EP02026643 2002-11-29
PCT/EP2003/008879 WO2004019043A2 (en) 2002-08-23 2003-08-11 Polypeptide biomarkers for diagnosing alzheimer's disease

Publications (1)

Publication Number Publication Date
DK1535076T3 true DK1535076T3 (da) 2008-11-24

Family

ID=31947886

Family Applications (3)

Application Number Title Priority Date Filing Date
DK08002793.1T DK1953556T3 (da) 2002-08-23 2003-08-11 Polypeptidbiomarkører til diagnose af Alzheimer's sygdom
DK03792291T DK1535076T3 (da) 2002-08-23 2003-08-11 Polypeptid-biomarkörer til diagnose af Alzheimers sygdom
DK10164475.5T DK2221620T3 (da) 2002-08-23 2003-08-11 Polypeptidbiomarkører til diagnosticering af Alzheimers sygdom

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK08002793.1T DK1953556T3 (da) 2002-08-23 2003-08-11 Polypeptidbiomarkører til diagnose af Alzheimer's sygdom

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK10164475.5T DK2221620T3 (da) 2002-08-23 2003-08-11 Polypeptidbiomarkører til diagnosticering af Alzheimers sygdom

Country Status (10)

Country Link
EP (3) EP1953556B1 (da)
JP (1) JP4405919B2 (da)
AT (2) ATE403875T1 (da)
AU (3) AU2003251702B2 (da)
CA (6) CA2745731C (da)
DE (2) DE60333608D1 (da)
DK (3) DK1953556T3 (da)
ES (3) ES2347924T3 (da)
PT (1) PT1535076E (da)
WO (1) WO2004019043A2 (da)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1469312A1 (en) * 2003-04-18 2004-10-20 Friedrich-Alexander-Universität Erlangen-Nürnberg Diagnosis of Alzheimer's disease
WO2005001483A2 (en) * 2003-06-27 2005-01-06 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts Methods for diagnisis and differential diagnosis of dementia disorders
US7794948B2 (en) 2003-11-07 2010-09-14 Vermilllion, Inc. Biomarkers for alzheimer's disease
US7749716B2 (en) * 2004-05-18 2010-07-06 Vermilllion, Inc. Methods of detecting a fragment of neurosecretory protein VGF for diagnosing alzheimer's disease
GB0502068D0 (en) * 2005-02-01 2005-03-09 King S College London Screening method
AU2006231597B2 (en) * 2005-04-06 2011-11-17 Mosaiques Diagnostics And Therapeutics Ag Polypeptide marker for diagnosing Alzheimer's disease
EP1907838B1 (en) * 2005-06-16 2011-06-01 Vermillion, Inc. Fragment of neurosecretory protein vgf as a biomarker for alzheimer's disease
WO2007098585A1 (en) 2006-02-28 2007-09-07 Phenomenome Discoveries Inc. Methods for the diagnosis of dementia and other neurological disorders
WO2007106466A2 (en) * 2006-03-11 2007-09-20 The Board Of Trustees Of The Leland Stanford Junior University Beta-2 microglobulin as a biomarker for peripheral artery disease
GB0616230D0 (en) * 2006-08-16 2006-09-27 Univ Cambridge Tech Biomarkers and uses thereof
EP2117527B1 (en) 2007-02-08 2020-06-17 Med-Life Discoveries LP Compounds for use in the treatment of senile dementia of the alzheimer's type
WO2009114945A1 (en) 2008-03-21 2009-09-24 Neuman Manuela G Methods and kits for the differential diagnosis of alzheimer's disease versus frontotemporal dementia, and for the diagnosis of frontotemporal dementia, comprising fas-l and ckl 18 as biomarkers
WO2010034072A1 (en) * 2008-09-26 2010-04-01 The University Of Melbourne Alzheimer's disease biomarkers
JP2010271078A (ja) * 2009-05-19 2010-12-02 Mcbi:Kk 認知機能障害疾患を含む精神疾患のバイオマーカーおよび該バイオマーカーを用いた認知機能障害疾患を含む精神疾患の検出方法
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
WO2017120461A1 (en) 2016-01-08 2017-07-13 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
WO2015088915A1 (en) 2013-12-09 2015-06-18 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated conditions
GB201322094D0 (en) * 2013-12-13 2014-01-29 Electrophoretics Ltd Methods and compositions relating to alzheimers disease
PT3307296T (pt) 2015-06-15 2022-01-07 Univ Leland Stanford Junior Timp2 para uso no tratamento de condições associadas ao envelhecimento
KR102572009B1 (ko) * 2020-10-21 2023-08-29 순천향대학교 산학협력단 시스타틴 c를 포함하는 퇴행성 신경 질환 진단용 바이오마커 조성물 및 이의 용도

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
AU1153300A (en) * 1998-10-23 2000-05-15 Roger Nitsch Methods of diagnosing or prognosing alzheimer's disease
EP1259819A2 (en) * 2000-02-24 2002-11-27 Oxford GlycoSciences (UK) Limited Diagnosis of bipolar affective disorder (bad) and unipolar depression
WO2001071357A2 (en) * 2000-03-20 2001-09-27 Oxford Glycosciences (Uk) Limited Diagnosis and treatment of breast cancer
US20020164668A1 (en) * 2000-04-03 2002-11-07 Durham L. Kathryn Nucleic acid molecules, polypeptides and uses therefor, including diagnosis and treatment of alzheimer's disease
WO2002082075A2 (de) * 2001-04-06 2002-10-17 Biovision Ag Verfahren zum nachweis chronisch-demenzieller erkrankungen, zugehörige peptide und nachweisreagenzien
EP1408333A3 (en) * 2001-10-03 2006-10-25 Pfizer Products Inc. Diagnosis and treatment of Alzheimer's disease

Also Published As

Publication number Publication date
CA2496321E (en) 2004-03-04
EP2221620A3 (en) 2010-11-24
JP4405919B2 (ja) 2010-01-27
DE60322719D1 (de) 2008-09-18
CA2745731C (en) 2015-05-12
EP1535076A2 (en) 2005-06-01
AU2003251702A1 (en) 2004-03-11
EP1953556A3 (en) 2008-11-26
CA2745569A1 (en) 2004-03-04
ATE475888T1 (de) 2010-08-15
AU2010212317B2 (en) 2013-01-10
CA2746000A1 (en) 2004-03-04
JP2005536729A (ja) 2005-12-02
EP2221620B1 (en) 2013-10-02
ES2311751T3 (es) 2009-02-16
CA2745569C (en) 2015-07-14
CA2745724A1 (en) 2004-03-04
EP1953556B1 (en) 2010-07-28
WO2004019043A3 (en) 2004-06-24
CA2745724C (en) 2015-06-02
CA2496321C (en) 2013-05-21
AU2003251702B2 (en) 2010-06-03
ES2347924T3 (es) 2010-11-25
EP1953556A2 (en) 2008-08-06
PT1535076E (pt) 2008-11-03
AU2010212317A1 (en) 2010-09-09
CA2745731A1 (en) 2004-03-04
AU2010212316A1 (en) 2010-09-09
CA2745998C (en) 2013-11-26
ES2436318T3 (es) 2013-12-30
AU2010212316B2 (en) 2012-05-24
DK1953556T3 (da) 2010-10-25
CA2746000C (en) 2014-10-21
EP1535076B1 (en) 2008-08-06
DE60333608D1 (de) 2010-09-09
EP2221620A2 (en) 2010-08-25
DK2221620T3 (da) 2014-01-06
ATE403875T1 (de) 2008-08-15
WO2004019043A2 (en) 2004-03-04
CA2496321A1 (en) 2004-03-04
CA2745998A1 (en) 2004-03-04

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