BR112015030582A2 - Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão - Google Patents
Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressãoInfo
- Publication number
- BR112015030582A2 BR112015030582A2 BR112015030582A BR112015030582A BR112015030582A2 BR 112015030582 A2 BR112015030582 A2 BR 112015030582A2 BR 112015030582 A BR112015030582 A BR 112015030582A BR 112015030582 A BR112015030582 A BR 112015030582A BR 112015030582 A2 BR112015030582 A2 BR 112015030582A2
- Authority
- BR
- Brazil
- Prior art keywords
- chimeric
- preparing
- arrangement
- influenza virus
- influenza
- Prior art date
Links
- 101710154606 Hemagglutinin Proteins 0.000 title abstract 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 title abstract 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 title abstract 4
- 101710176177 Protein A56 Proteins 0.000 title abstract 4
- 241000712461 unidentified influenza virus Species 0.000 title abstract 4
- 206010022000 influenza Diseases 0.000 title abstract 3
- 230000008707 rearrangement Effects 0.000 title abstract 3
- 102000005348 Neuraminidase Human genes 0.000 title abstract 2
- 108010006232 Neuraminidase Proteins 0.000 title abstract 2
- 239000000185 hemagglutinin Substances 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16151—Methods of production or purification of viral material
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832091P | 2013-06-06 | 2013-06-06 | |
| EP13179013 | 2013-08-01 | ||
| PCT/IB2014/062030 WO2014195920A2 (en) | 2013-06-06 | 2014-06-06 | Influenza virus reassortment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015030582A2 true BR112015030582A2 (pt) | 2017-08-29 |
Family
ID=48900885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015030582A BR112015030582A2 (pt) | 2013-06-06 | 2014-06-06 | Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10329537B2 (https=) |
| EP (1) | EP3004332A2 (https=) |
| JP (1) | JP2016521553A (https=) |
| KR (1) | KR20160014657A (https=) |
| CN (1) | CN105722976A (https=) |
| AU (1) | AU2014276418A1 (https=) |
| BR (1) | BR112015030582A2 (https=) |
| CA (1) | CA2914604A1 (https=) |
| HK (1) | HK1222882A1 (https=) |
| MX (1) | MX2015016755A (https=) |
| SG (1) | SG11201509985XA (https=) |
| WO (1) | WO2014195920A2 (https=) |
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| EP2493912B1 (en) | 2009-10-26 | 2020-07-29 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in vero cells |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| WO2015009743A1 (en) | 2013-07-15 | 2015-01-22 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| US11013795B2 (en) | 2015-06-26 | 2021-05-25 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| US9890363B2 (en) | 2015-07-06 | 2018-02-13 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| CN109312310B (zh) * | 2016-07-15 | 2022-08-02 | 一般财团法人阪大微生物病研究会 | 重配流感病毒的制备方法 |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| ES2991988T3 (es) | 2017-10-30 | 2024-12-05 | Takeda Pharmaceuticals Co | Detergentes compatibles con el medio ambiente para la inactivación de virus con envoltura lipídica |
| CN108048476B (zh) * | 2017-11-21 | 2020-09-08 | 浙江迪福润丝生物科技有限公司 | 一种制备区分免疫和感染动物h9亚型禽流感疫苗株的方法及应用 |
| CN108018300B (zh) * | 2017-11-21 | 2020-08-28 | 浙江迪福润丝生物科技有限公司 | 区分免疫和感染动物h7亚型禽流感疫苗株及其制备方法和应用 |
| DK3768846T5 (da) * | 2018-03-21 | 2024-08-19 | Aldevron L L C | Virale og ikke-virale nanoplasmidvektorer med forbedret produktion |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| CN114929269A (zh) | 2019-05-01 | 2022-08-19 | 威斯康星校友研究基金会(Warf) | 用于疫苗开发的改进的流感病毒复制 |
| US11807872B2 (en) | 2019-08-27 | 2023-11-07 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN113527443B (zh) * | 2020-04-16 | 2023-03-07 | 中国科学院微生物研究所 | 甲型流感病毒pb1蛋白t细胞表位多肽片段及其应用 |
| KR20230171446A (ko) * | 2021-04-15 | 2023-12-20 | 주식회사 바이오오케스트라 | 단백질 발현을 증진시킬 수 있는 폴리뉴클레오티드 및 이의 용도 |
| CN114058742B (zh) * | 2022-01-18 | 2022-04-22 | 广州科方生物技术股份有限公司 | 一种引物探针组合物、包含其的试剂盒及其检测方法 |
| CN119452088A (zh) * | 2022-05-31 | 2025-02-14 | Vlp治疗日本公司 | 修饰疫苗设计开发 |
| CN116144612B (zh) * | 2022-12-08 | 2023-11-10 | 广州医科大学附属第一医院（广州呼吸中心） | 重组乙型流感病毒及其制备方法与应用 |
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-
2014
- 2014-06-06 CN CN201480044797.3A patent/CN105722976A/zh active Pending
- 2014-06-06 US US14/896,348 patent/US10329537B2/en active Active
- 2014-06-06 MX MX2015016755A patent/MX2015016755A/es unknown
- 2014-06-06 HK HK16110972.3A patent/HK1222882A1/zh unknown
- 2014-06-06 WO PCT/IB2014/062030 patent/WO2014195920A2/en not_active Ceased
- 2014-06-06 CA CA2914604A patent/CA2914604A1/en not_active Abandoned
- 2014-06-06 EP EP14733369.4A patent/EP3004332A2/en not_active Withdrawn
- 2014-06-06 BR BR112015030582A patent/BR112015030582A2/pt not_active Application Discontinuation
- 2014-06-06 KR KR1020157035931A patent/KR20160014657A/ko not_active Withdrawn
- 2014-06-06 AU AU2014276418A patent/AU2014276418A1/en not_active Abandoned
- 2014-06-06 JP JP2016517733A patent/JP2016521553A/ja not_active Ceased
- 2014-06-06 SG SG11201509985XA patent/SG11201509985XA/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2016521553A (ja) | 2016-07-25 |
| HK1222882A1 (zh) | 2017-07-14 |
| MX2015016755A (es) | 2016-04-13 |
| SG11201509985XA (en) | 2016-01-28 |
| AU2014276418A1 (en) | 2016-01-21 |
| CN105722976A (zh) | 2016-06-29 |
| CA2914604A1 (en) | 2014-12-11 |
| US20160122726A1 (en) | 2016-05-05 |
| EP3004332A2 (en) | 2016-04-13 |
| KR20160014657A (ko) | 2016-02-11 |
| US10329537B2 (en) | 2019-06-25 |
| WO2014195920A3 (en) | 2015-05-28 |
| WO2014195920A2 (en) | 2014-12-11 |
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