PL408649A1 - Białko hemaglutyniny wirusów grypy jako antygen szczepionkowy - Google Patents

Białko hemaglutyniny wirusów grypy jako antygen szczepionkowy

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Publication number
PL408649A1
PL408649A1 PL408649A PL40864914A PL408649A1 PL 408649 A1 PL408649 A1 PL 408649A1 PL 408649 A PL408649 A PL 408649A PL 40864914 A PL40864914 A PL 40864914A PL 408649 A1 PL408649 A1 PL 408649A1
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PL
Poland
Prior art keywords
protein
influenza viruses
vaccine antigen
vaccine
haemagglutinin protein
Prior art date
Application number
PL408649A
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English (en)
Other versions
PL235555B1 (pl
Inventor
Violetta Sączyńska
Agnieszka Romanik
Katarzyna Florys
Violetta Cecuda-Adamczewska
Małgorzata Kęsik-Brodacka
Grażyna Płucienniczak
Andrzej Płucienniczak
Piotr Borowicz
Natalia Łukasiewicz
Iwona Sokołowska
Diana Mikiewicz
Agnieszka Sobolewska
Piotr Baran
Józef Kapusta
Michał Odrowąż-Sypniewski
Anna Bierczyńska-Krzysik
Zenon Minta
Krzysztof Śmietanka
Monika Olszewska
Bogusław Szewczyk
Original Assignee
Instytut Biotechnologii i Antybiotyków
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Instytut Biotechnologii i Antybiotyków filed Critical Instytut Biotechnologii i Antybiotyków
Priority to PL408649A priority Critical patent/PL235555B1/pl
Priority to US15/320,484 priority patent/US10398770B2/en
Priority to PCT/PL2015/050025 priority patent/WO2015199564A1/en
Priority to EP15744381.3A priority patent/EP3160501B1/en
Publication of PL408649A1 publication Critical patent/PL408649A1/pl
Publication of PL235555B1 publication Critical patent/PL235555B1/pl

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/108—Orthomyxoviridae (F), e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • C—CHEMISTRY; METALLURGY
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16171—Demonstrated in vivo effect

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Wynalazek dotyczy białka hemaglutyniny wirusów grypy jako antygenu szczepionkowego przeciwko wirusom grypy, w szczególności białka będącego fragmentem hemaglutyniny H5 wysoko-patogennego szczepu wirusa ptasiej grypy (HPAIV) H5N1 ekspresjonowanego w bakteryjnym systemie ekspresyjnym. Białko według wynalazku jest potencjalnym składnikiem szczepionki przeciwko HPAIV H5N1, podawanej kurczętom parenteralnie lub przez błony śluzowe w obecności adiuwantów. Przedmiotem wynalazku jest również sposób otrzymywania białka szczepionkowego.
PL408649A 2014-06-24 2014-06-24 Wyizolowany i oczyszczony polipeptyd hemaglutyniny (HA ) wirusa grypy H5N1, kompozycja zawierająca polipeptyd i jej zastosowanie, przeciwciało wiążące się specyficznie z polipeptydem oraz sposób otrzymywania tego polipeptydu PL235555B1 (pl)

Priority Applications (4)

Application Number Priority Date Filing Date Title
PL408649A PL235555B1 (pl) 2014-06-24 2014-06-24 Wyizolowany i oczyszczony polipeptyd hemaglutyniny (HA ) wirusa grypy H5N1, kompozycja zawierająca polipeptyd i jej zastosowanie, przeciwciało wiążące się specyficznie z polipeptydem oraz sposób otrzymywania tego polipeptydu
US15/320,484 US10398770B2 (en) 2014-06-24 2015-06-24 Influenza virus hemagglutinin protein as a vaccine antigen
PCT/PL2015/050025 WO2015199564A1 (en) 2014-06-24 2015-06-24 Influenza virus hemagglutinin protein as a vaccine antigen
EP15744381.3A EP3160501B1 (en) 2014-06-24 2015-06-24 Influenza virus hemagglutinin protein as a vaccine antigen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL408649A PL235555B1 (pl) 2014-06-24 2014-06-24 Wyizolowany i oczyszczony polipeptyd hemaglutyniny (HA ) wirusa grypy H5N1, kompozycja zawierająca polipeptyd i jej zastosowanie, przeciwciało wiążące się specyficznie z polipeptydem oraz sposób otrzymywania tego polipeptydu

Publications (2)

Publication Number Publication Date
PL408649A1 true PL408649A1 (pl) 2016-01-04
PL235555B1 PL235555B1 (pl) 2020-09-07

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PL408649A PL235555B1 (pl) 2014-06-24 2014-06-24 Wyizolowany i oczyszczony polipeptyd hemaglutyniny (HA ) wirusa grypy H5N1, kompozycja zawierająca polipeptyd i jej zastosowanie, przeciwciało wiążące się specyficznie z polipeptydem oraz sposób otrzymywania tego polipeptydu

Country Status (4)

Country Link
US (1) US10398770B2 (pl)
EP (1) EP3160501B1 (pl)
PL (1) PL235555B1 (pl)
WO (1) WO2015199564A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102939103A (zh) 2010-03-30 2013-02-20 西奈山医学院 流感病毒疫苗及其应用
KR20140068205A (ko) 2011-09-20 2014-06-05 마운트 시나이 스쿨 오브 메디슨 인플루엔자 바이러스 백신 및 이의 용도
KR20150104117A (ko) 2012-12-18 2015-09-14 이칸 스쿨 오브 메디슨 엣 마운트 시나이 인플루엔자 바이러스 백신 및 그의 용도
WO2014159960A1 (en) 2013-03-14 2014-10-02 Icahn School Of Medicine At Mount Sinai Antibodies against influenza virus hemagglutinin and uses thereof
US10736956B2 (en) 2015-01-23 2020-08-11 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
US20190125859A1 (en) * 2016-06-03 2019-05-02 Icahn School Of Medicine At Mount Sinai Influenza virus vaccination regimens
WO2017218624A1 (en) 2016-06-15 2017-12-21 Icahn School Of Medicine At Mount Sinai Influenza virus hemagglutinin proteins and uses thereof
WO2018187706A2 (en) 2017-04-07 2018-10-11 Icahn School Of Medicine At Mount Sinai Anti-influenza b virus neuraminidase antibodies and uses thereof
EP3810634A4 (en) 2018-06-21 2022-07-27 Icahn School of Medicine at Mount Sinai Mosaic influenza virus hemagglutinin polypeptides and uses thereof
EP3959216A4 (en) 2019-04-24 2023-01-11 Icahn School of Medicine at Mount Sinai ANTI-INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF
WO2025194003A1 (en) * 2024-03-13 2025-09-18 Vst Llc Dba Medgene Avian influenza virus vaccines
US20260056207A1 (en) * 2024-05-17 2026-02-26 Vst Llc Dba Medgene Method of determining neutralizing antibodies using modified hemagglutination assays

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101605558A (zh) * 2005-08-16 2009-12-16 夏威夷生物技术公司 流感重组亚单位疫苗
EP3011969A1 (en) 2006-03-07 2016-04-27 Vaxinnate Corporation Compositions that include hemagglutinin, methods of making and methods of use thereof
PL216037B1 (pl) 2006-06-09 2014-02-28 Inst Biotechnologii I Antybiotykow Kaseta ekspresyjna, zastosowanie kasety ekspresyjnej, wektor, komórka gospodarza oraz sposób otrzymywania polipeptydu
WO2009128952A2 (en) 2008-04-18 2009-10-22 Vaxinnate Corporation Compositions of papillomavirus proteins and methods of use
EP2595653B1 (en) * 2010-07-23 2017-06-28 Novavax AB Influenza vaccine
GB201116416D0 (en) * 2011-09-23 2011-11-02 Isis Innovation Composition
PL220281B1 (pl) * 2011-09-23 2015-09-30 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA
US8932598B2 (en) 2012-08-28 2015-01-13 Vaxinnate Corporation Fusion proteins and methods of use
PL238555B1 (pl) * 2013-12-20 2021-09-06 Inst Biochemii I Biofizyki Polskiej Akademii Nauk Sposób wytwarzania hydrofilowej domeny hemaglutyniny wirusa H5

Also Published As

Publication number Publication date
US10398770B2 (en) 2019-09-03
PL235555B1 (pl) 2020-09-07
US20170165352A1 (en) 2017-06-15
EP3160501B1 (en) 2021-08-04
EP3160501A1 (en) 2017-05-03
WO2015199564A1 (en) 2015-12-30

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