BR112015026736A2 - método, aparelho, mídia de armazenamento não transitório, programa de computador, e, sinal - Google Patents

método, aparelho, mídia de armazenamento não transitório, programa de computador, e, sinal

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Publication number
BR112015026736A2
BR112015026736A2 BR112015026736A BR112015026736A BR112015026736A2 BR 112015026736 A2 BR112015026736 A2 BR 112015026736A2 BR 112015026736 A BR112015026736 A BR 112015026736A BR 112015026736 A BR112015026736 A BR 112015026736A BR 112015026736 A2 BR112015026736 A2 BR 112015026736A2
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Brazil
Prior art keywords
pathway
risk
computer program
storage media
signal
Prior art date
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BR112015026736A
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English (en)
Inventor
Van De Stolpe Anja
Jan Van Ooijen Hendrik
Alves De Inda Márcia
Franciscus Johannes Verhaegh Wilhelmus
Original Assignee
Koninklijke Philips Nv
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Application filed by Koninklijke Philips Nv filed Critical Koninklijke Philips Nv
Publication of BR112015026736A2 publication Critical patent/BR112015026736A2/pt

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    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/30—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for calculating health indices; for individual health risk assessment
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

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Abstract

resumo método, aparelho, mídia de armazenamento não transitório, programa de computador, e, sinal o presente pedido se refere a um método para determinar um escore de risco que indica um risco de que um evento clínico ocorrerá dentro de um certo período de tempo. o escore de risco tem por base, ao menos em parte, uma combinação das atividades inferidas de duas ou mais vias de sinalização celular em um tecido e/ou em células e/ou em fluido corpóreo de um indivíduo. dessa forma, de acordo com uma modalidade preferencial, as vias de sinalização celular compreendem uma via wnt, uma via er, uma via ar ou uma via hh. o escore de risco é definido de modo que o risco indicado de que o evento clínico ocorrerá dentro de um certo período de tempo diminui com um per crescente e aumenta com um max(pwnt, phh) crescente, em que per, pwnt e phh denotam a atividade inferida da via er, da via wnt e da via hh, respectivamente. 1/1
BR112015026736A 2013-04-26 2014-04-24 método, aparelho, mídia de armazenamento não transitório, programa de computador, e, sinal BR112015026736A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13165471 2013-04-26
PCT/EP2014/058326 WO2014174003A1 (en) 2013-04-26 2014-04-24 Medical prognosis and prediction of treatment response using multiple cellular signalling pathway activities

Publications (1)

Publication Number Publication Date
BR112015026736A2 true BR112015026736A2 (pt) 2017-07-25

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BR112015026736A BR112015026736A2 (pt) 2013-04-26 2014-04-24 método, aparelho, mídia de armazenamento não transitório, programa de computador, e, sinal

Country Status (11)

Country Link
US (1) US11309059B2 (pt)
EP (2) EP2989211B1 (pt)
JP (1) JP6603208B2 (pt)
KR (1) KR102256141B1 (pt)
CN (1) CN105121665B (pt)
AU (1) AU2014259459B2 (pt)
BR (1) BR112015026736A2 (pt)
CA (1) CA2909991A1 (pt)
MX (1) MX366204B (pt)
RU (1) RU2718647C2 (pt)
WO (1) WO2014174003A1 (pt)

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WO2014174003A1 (en) 2013-04-26 2014-10-30 Koninklijke Philips N.V. Medical prognosis and prediction of treatment response using multiple cellular signalling pathway activities
CA2923092C (en) 2014-01-03 2019-12-17 Koninklijke Philips N.V. Assessment of the pi3k cellular signaling pathway activity using mathematical modelling of target gene expression
CA2965442A1 (en) 2014-10-24 2016-04-28 Koninklijke Philips N.V. Assessment of tgf-b cellular signaling pathway activity using mathematical modelling of target gene expression
ES2838923T3 (es) 2014-10-24 2021-07-02 Koninklijke Philips Nv Pronóstico médico y predicción de la respuesta a tratamiento usando múltiples actividades de la ruta de señalización celular
JP7065609B6 (ja) 2014-10-24 2022-06-06 コーニンクレッカ フィリップス エヌ ヴェ 複数の細胞シグナル伝達経路活性を用いる治療応答の医学的予後及び予測
ES2861400T3 (es) 2015-08-14 2021-10-06 Koninklijke Philips Nv Evaluación de la actividad de la ruta de señalización celular de NFkB usando modelos matemáticos de la expresión de genes diana
US20190128899A1 (en) * 2016-06-13 2019-05-02 Koninklijke Philips N.V. Method for inferring activity of a transcription factor of a signal transduction pathway in a subject
US20190385697A1 (en) * 2017-02-14 2019-12-19 The Regents Of The University Of Colorado, A Body Corporate Methods for predicting transcription factor activity
EP3431582A1 (en) 2017-07-18 2019-01-23 Koninklijke Philips N.V. Cell culturing materials
EP3692170A1 (en) 2017-10-02 2020-08-12 Koninklijke Philips N.V. Determining functional status of immune cells types and immune response
EP3461915A1 (en) 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of jak-stat1/2 cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression
US11462325B2 (en) * 2018-09-29 2022-10-04 Roche Molecular Systems, Inc. Multimodal machine learning based clinical predictor
EP3963108A1 (en) * 2019-05-03 2022-03-09 Koninklijke Philips N.V. Methods of prognosis in high-grade serous ovarian cancer
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EP3882363A1 (en) 2020-03-17 2021-09-22 Koninklijke Philips N.V. Prognostic pathways for high risk sepsis patients
KR102565378B1 (ko) * 2020-03-23 2023-08-10 단국대학교 산학협력단 유방암 호르몬 수용체의 상태 예측을 위한 바이오 마커
US20230223108A1 (en) 2020-04-16 2023-07-13 Innosign B.V. Prognostic pathways for viral infections
EP3978628A1 (en) 2020-10-01 2022-04-06 Koninklijke Philips N.V. Prognostic pathways for viral infections
EP3940704A1 (en) 2020-07-14 2022-01-19 Koninklijke Philips N.V. Method for determining the differentiation state of a stem cell
EP3960875A1 (en) * 2020-08-28 2022-03-02 Koninklijke Philips N.V. Pcr method and kit for determining pathway activity
EP3965119A1 (en) 2020-09-04 2022-03-09 Koninklijke Philips N.V. Methods for estimating heterogeneity of a tumour based on values for two or more genome mutation and/or gene expression related parameter, as well as corresponding devices
EP3974540A1 (en) 2020-09-25 2022-03-30 Koninklijke Philips N.V. Method for predicting immunotherapy resistance
KR102189142B1 (ko) * 2020-10-15 2020-12-09 서울대학교병원 만성신장질환의 악화 예측 마커로서의 snp 및 이의 이용
EP4015651A1 (en) 2020-12-17 2022-06-22 Koninklijke Philips N.V. Treatment prediction and effectiveness of anti-tnf alpha treatment in ibd patients
EP4039825A1 (en) 2021-02-09 2022-08-10 Koninklijke Philips N.V. Comparison and standardization of cell and tissue culture
WO2022189530A1 (en) 2021-03-11 2022-09-15 Koninklijke Philips N.V. Prognostic pathways for high risk sepsis patients
CN114410667B (zh) * 2021-12-31 2022-10-11 广东省科学院动物研究所 一种鞍带石斑鱼znrf3基因及其编码的蛋白和应用
KR102508252B1 (ko) * 2022-01-11 2023-03-09 주식회사 볼츠만바이오 생체신호전달 네트워크 모델의 학습방법 및 이를 위한 장치
CN114524872A (zh) * 2022-03-09 2022-05-24 广州诺诚生物技术研发有限公司 一种用于乳腺癌检测的单克隆抗体及其试剂盒

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Also Published As

Publication number Publication date
EP2989211B1 (en) 2018-06-13
EP3372695A1 (en) 2018-09-12
WO2014174003A1 (en) 2014-10-30
CN105121665A (zh) 2015-12-02
JP6603208B2 (ja) 2019-11-06
US20160110494A1 (en) 2016-04-21
AU2014259459B2 (en) 2020-03-26
EP3372695B1 (en) 2020-09-09
MX366204B (es) 2019-07-02
EP2989211A1 (en) 2016-03-02
RU2015150464A (ru) 2017-06-02
RU2718647C2 (ru) 2020-04-10
CA2909991A1 (en) 2014-10-30
JP2016519926A (ja) 2016-07-11
CN105121665B (zh) 2019-11-26
US11309059B2 (en) 2022-04-19
MX2015014847A (es) 2016-03-11
AU2014259459A1 (en) 2015-12-17
KR20160003124A (ko) 2016-01-08
KR102256141B1 (ko) 2021-05-27

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