BR112015023129A2 - compostos aromáticos substituídos para o tratamento de fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca - Google Patents

compostos aromáticos substituídos para o tratamento de fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca

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Publication number
BR112015023129A2
BR112015023129A2 BR112015023129A BR112015023129A BR112015023129A2 BR 112015023129 A2 BR112015023129 A2 BR 112015023129A2 BR 112015023129 A BR112015023129 A BR 112015023129A BR 112015023129 A BR112015023129 A BR 112015023129A BR 112015023129 A2 BR112015023129 A2 BR 112015023129A2
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BR
Brazil
Prior art keywords
fibrosis
treatment
aromatic compounds
substituted aromatic
skin
Prior art date
Application number
BR112015023129A
Other languages
English (en)
Inventor
Zacharie Boulos
Grouix Brigitte
Sarra-Bournet François
Bienvenu Jean-Francois
Geerts Lilianne
Gagnon Lyne
leduc Martin
Laurin Pierre
Abbott Shaun
Perron Valérie
Original Assignee
Prometic Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prometic Biosciences Inc filed Critical Prometic Biosciences Inc
Publication of BR112015023129A2 publication Critical patent/BR112015023129A2/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4418—Non condensed pyridines; Hydrogenated derivatives thereof having a carbocyclic group directly attached to the heterocyclic ring, e.g. cyproheptadine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
    • C07C57/42—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C07C57/60—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings having unsaturation outside the rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/52—Unsaturated compounds containing hydroxy or O-metal groups a hydroxy or O-metal group being bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

resumo compostos aromáticos substituídos para o tratamento de fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca a presente invenção se refere aos compostos aromáticos substituídos para utilização na prevenção ou tratamento de diversas doenças fibróticas e condições em sujeitos, incluindo fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca, onde o composto tem a seguinte fórmula: ou um sal farmaceuticamente aceitável do mesmo, em que: a é um c5 alquil, c6 alquil, c5 alquenil, c6 alquenil, c(o)-(ch2)n-ch3 ou ch(oh)-(ch2)n-ch3 em que n é 3 ou 4; r1 é h, oh ou f; r2 é h, oh, f ou ch2-oh; r3 é h, oh, f ou ch2ph; r4 é h, oh ou f; q é 1) (ch2)mc(o)oh, em que m é 1 ou 2, 2) ch(ch3)c(o)oh, 3) c(ch3)2c(o)oh, 4) ch(f)-c(o)oh, 5) cf2-c(o)oh, ou 6) c(o)-c(o)oh.
BR112015023129A 2013-03-15 2014-03-14 compostos aromáticos substituídos para o tratamento de fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca BR112015023129A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361798427P 2013-03-15 2013-03-15
PCT/CA2014/000237 WO2014138907A1 (en) 2013-03-15 2014-03-14 Substituted aromatic compounds for the treatment of pulmonary fibrosis, liver fibrosis, skin fibrosis and cardiac fibrosis

Publications (1)

Publication Number Publication Date
BR112015023129A2 true BR112015023129A2 (pt) 2017-07-18

Family

ID=51535670

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BR112015023129A BR112015023129A2 (pt) 2013-03-15 2014-03-14 compostos aromáticos substituídos para o tratamento de fibrose pulmonar, fibrose hepática, fibrose da pele e fibrose cardíaca

Country Status (26)

Country Link
US (3) US9884802B2 (pt)
EP (1) EP2970088B1 (pt)
JP (1) JP6381557B2 (pt)
KR (1) KR102303493B1 (pt)
CN (1) CN105143170B (pt)
AR (1) AR095427A1 (pt)
AU (1) AU2014231649C1 (pt)
BR (1) BR112015023129A2 (pt)
CA (1) CA2905633C (pt)
CL (1) CL2015002725A1 (pt)
DK (1) DK2970088T3 (pt)
EA (1) EA031511B1 (pt)
ES (1) ES2780825T3 (pt)
HK (1) HK1220439A1 (pt)
IL (1) IL241164B (pt)
MX (1) MX2015012886A (pt)
MY (1) MY194727A (pt)
NZ (1) NZ712745A (pt)
PH (1) PH12015502012A1 (pt)
PL (1) PL2970088T3 (pt)
PT (1) PT2970088T (pt)
SG (1) SG11201507274PA (pt)
TW (2) TWI689489B (pt)
UY (1) UY35401A (pt)
WO (1) WO2014138907A1 (pt)
ZA (1) ZA201507062B (pt)

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JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
NZ710079A (en) 2013-01-15 2020-01-31 Incyte Holdings Corp Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
TWI689489B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
AR097431A1 (es) 2013-08-23 2016-03-16 Incyte Corp Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de quinasas pim
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
MX2017004733A (es) * 2014-10-10 2017-07-17 Prometic Pharma Smt Ltd Compuestos aromaticos sustituidos y composiciones farmaceuticas para la prevencion y tratamiento de osteoporosis.
CA2967499C (en) 2014-11-12 2023-01-17 Prometic Biosciences Inc. Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration
MA41120A (fr) * 2014-12-02 2017-10-10 Afimmune Ltd Compositions comprenant le 15-hepe et méthodes de traitement ou de prévention de la fibrose à l'aide de celles-ci
CN107847477A (zh) 2015-05-13 2018-03-27 Ds生物制药有限公司 包含15‑氧代‑epa或15‑氧代‑dgla的组合物及其制备和使用方法
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
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TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
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WO2019231281A1 (ko) * 2018-05-31 2019-12-05 재단법인 아산사회복지재단 폐섬유증의 예방 또는 치료를 위한 스테아르산의 용도
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WO2020181163A1 (en) * 2019-03-06 2020-09-10 Tobira Therapeutics, Inc. Lipid-based formulation of cenicriviroc
WO2021015218A1 (ja) * 2019-07-24 2021-01-28 国立大学法人九州大学 転写関連因子を標的とする線維化疾患の予防または治療
CN112441916A (zh) * 2019-08-29 2021-03-05 广东药科大学 新型苯乙酸衍生物、其制备方法及其作为药物的用途
US20220193073A1 (en) * 2020-12-18 2022-06-23 NovMeta Pharma Co., Ltd. Method of treating fibrosis

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ITMI20012434A1 (it) 2001-11-20 2003-05-20 Dompe Spa Acidi 2-aril-propionici e composizioni farmaceutiche che li contengono
PL2427417T3 (pl) 2009-05-04 2014-03-31 Prometic Pharma Smt Ltd Sole kwasu 3-pentylofenylooctowego i ich farmaceutyczne zastosowania
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CN102070433B (zh) * 2010-12-27 2013-03-27 桂林师范高等专科学校 芳香基乙酸类衍生物的制备方法
TWI689490B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療纖維化之經取代之芳族化合物及相關方法
TWI689489B (zh) * 2013-03-15 2020-04-01 英商邊緣生物科技有限公司 用於治療肺纖維化、肝纖維化、皮膚纖維化及心臟纖維化之經取代之芳族化合物
CA2967499C (en) * 2014-11-12 2023-01-17 Prometic Biosciences Inc. Substituted aromatic compounds and pharmaceutical compositions for tissue self-repair and regeneration

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Publication number Publication date
SG11201507274PA (en) 2015-10-29
DK2970088T3 (da) 2020-03-30
US9884802B2 (en) 2018-02-06
ZA201507062B (en) 2017-04-26
PL2970088T3 (pl) 2020-11-02
UY35401A (es) 2014-10-31
MX2015012886A (es) 2016-04-04
TWI689489B (zh) 2020-04-01
AU2014231649A1 (en) 2015-10-22
MY194727A (en) 2022-12-15
JP2016510769A (ja) 2016-04-11
AR095427A1 (es) 2015-10-14
EP2970088A4 (en) 2016-10-19
CA2905633A1 (en) 2014-09-18
EA031511B1 (ru) 2019-01-31
CN105143170B (zh) 2019-11-08
WO2014138907A1 (en) 2014-09-18
US11267779B2 (en) 2022-03-08
AU2014231649B2 (en) 2018-01-04
TW201441185A (zh) 2014-11-01
TW202045469A (zh) 2020-12-16
US20180134649A1 (en) 2018-05-17
CN105143170A (zh) 2015-12-09
NZ712745A (en) 2020-06-26
EP2970088B1 (en) 2020-01-01
TWI742541B (zh) 2021-10-11
EA201591774A1 (ru) 2015-12-30
US20160023983A1 (en) 2016-01-28
KR20160040452A (ko) 2016-04-14
AU2014231649C1 (en) 2018-08-23
PH12015502012A1 (en) 2016-01-11
IL241164B (en) 2020-11-30
US20200017432A1 (en) 2020-01-16
IL241164A0 (en) 2015-11-30
CL2015002725A1 (es) 2016-04-15
EP2970088A1 (en) 2016-01-20
ES2780825T3 (es) 2020-08-27
HK1220439A1 (zh) 2017-05-05
JP6381557B2 (ja) 2018-08-29
PT2970088T (pt) 2020-03-27
CA2905633C (en) 2021-12-28
US10450258B2 (en) 2019-10-22
KR102303493B1 (ko) 2021-09-16

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Owner name: PROMETIC PHARMA SMT LIMITED (CA)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements