BR112015028075A2 - derivado de glicinamida alfa-substituída - Google Patents
derivado de glicinamida alfa-substituídaInfo
- Publication number
- BR112015028075A2 BR112015028075A2 BR112015028075A BR112015028075A BR112015028075A2 BR 112015028075 A2 BR112015028075 A2 BR 112015028075A2 BR 112015028075 A BR112015028075 A BR 112015028075A BR 112015028075 A BR112015028075 A BR 112015028075A BR 112015028075 A2 BR112015028075 A2 BR 112015028075A2
- Authority
- BR
- Brazil
- Prior art keywords
- alpha
- amide derivative
- glycine amide
- compound
- substituted glycine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
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- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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- A61K31/415—1,2-Diazoles
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07C2601/14—The ring being saturated
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- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
Abstract
resumo "derivado de glicinamida alfa-substituída" trata-se de um novo derivado de gliciamida a-substituída, ou um sal farma-ceuticamente aceitável do mesmo, uma composição farmacêutica que compreende o mesmo, e um uso farmacêutico do mesmo. a presente invenção fornece um composto representado pela fórmula geral (i), que tem efeitos inibitórios de trpm8: composto (em que a1 representa uma c6-10 arila e similares, a2 representa uma c6-10 arila e similares, x representa ch e similares, y representa -cr1r2- e similares, r1 e r2 representam de maneira independente um átomo de hidrogênio e similares, r3 e r4 representam de maneira independente um átomo de halogênio e similares, n é 1 ou 2), ou um sal farmaceuticamente aceitável do mesmo. além disso, o composto (i) da presente invenção pode ser usado como um agente para tratar ou evitar doenças ou sintomas causados por hiperexcitabilidade ou distúrbio dos neurônios aferentes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2013098835 | 2013-05-08 | ||
PCT/JP2014/062218 WO2014181788A1 (ja) | 2013-05-08 | 2014-05-07 | α-置換グリシンアミド誘導体 |
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BR112015028075A2 true BR112015028075A2 (pt) | 2017-07-25 |
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BR112015028075A BR112015028075A2 (pt) | 2013-05-08 | 2014-05-07 | derivado de glicinamida alfa-substituída |
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US (1) | US9458092B2 (pt) |
EP (1) | EP2995611B1 (pt) |
JP (1) | JP6200495B2 (pt) |
KR (1) | KR102128376B1 (pt) |
CN (1) | CN105263901B (pt) |
AU (1) | AU2014263615B2 (pt) |
BR (1) | BR112015028075A2 (pt) |
CA (1) | CA2911037A1 (pt) |
ES (1) | ES2645847T3 (pt) |
IL (1) | IL242491B (pt) |
MX (1) | MX362192B (pt) |
NZ (1) | NZ714111A (pt) |
RU (1) | RU2670982C2 (pt) |
SG (1) | SG11201509244XA (pt) |
TW (1) | TWI641584B (pt) |
WO (1) | WO2014181788A1 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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MY195177A (en) | 2015-06-23 | 2023-01-11 | Kissei Pharmaceutical | Pyrazole Derivative or Pharmaceutically Acceptable Salt Thereof |
EP3184524A1 (en) * | 2015-12-21 | 2017-06-28 | Dompé farmaceutici S.p.A. | 4-hydroxy-2-phenyl-1,3-thiazol-5-yl methanone derivatives as trpm8 antagonists |
JP6654614B2 (ja) * | 2016-12-21 | 2020-02-26 | キッセイ薬品工業株式会社 | Trpm8阻害薬 |
WO2022105986A1 (de) * | 2020-11-17 | 2022-05-27 | Symrise Ag | Neue kühlstoffe und zubereitungen, die diese enthalten |
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US5296591A (en) | 1990-12-31 | 1994-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Trifluoromethylketone derivatives, processes for preparation thereof and use thereof |
US5618792A (en) | 1994-11-21 | 1997-04-08 | Cortech, Inc. | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase |
CN1247542A (zh) * | 1996-12-06 | 2000-03-15 | 康泰驰公司 | 丝氨酸蛋白酶抑制剂 |
CN1678314A (zh) * | 2002-08-27 | 2005-10-05 | 默克专利有限公司 | 作为raf-激酶抑制剂的甘氨酸酰胺衍生物 |
GB0219961D0 (en) | 2002-08-28 | 2002-10-02 | Pfizer Ltd | Oxytocin inhibitors |
KR100496183B1 (ko) | 2002-08-30 | 2005-06-20 | 주식회사 오엔텍 | 침 자동제조기 |
CN100459842C (zh) | 2003-08-27 | 2009-02-11 | 洋马株式会社 | 联合收割机 |
EP1740553A1 (en) * | 2004-04-14 | 2007-01-10 | AstraZeneca AB | Aryl glycinamide derivatives and their use as nk1 antagonists and serotonin reuptake inhibithors |
WO2007017093A1 (en) | 2005-08-04 | 2007-02-15 | Bayer Healthcare Ag | Substituted 2-benzyloxy-benzoic acid amide derivatives |
JP2013544894A (ja) | 2010-12-09 | 2013-12-19 | ヤンセン ファーマシューティカ エヌ.ベー. | Trpm8モジュレータとしてのイミダゾ[1,2−a]ピリジンスルホンアミド |
EP2481727A1 (en) * | 2011-01-28 | 2012-08-01 | Dompe S.p.A. | TRPM8 receptor antagonists |
AU2012229813B2 (en) | 2011-03-16 | 2015-09-03 | Mitsubishi Tanabe Pharma Corporation | Sulfonamide compounds having TRPM8 antagonistic activity |
EP2723718A1 (en) * | 2011-06-24 | 2014-04-30 | Amgen Inc. | Trpm8 antagonists and their use in treatments |
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2014
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- 2014-05-07 JP JP2015515880A patent/JP6200495B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
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JP6200495B2 (ja) | 2017-09-20 |
TW201522288A (zh) | 2015-06-16 |
IL242491A0 (en) | 2016-02-01 |
KR20160005347A (ko) | 2016-01-14 |
US20160115119A1 (en) | 2016-04-28 |
US9458092B2 (en) | 2016-10-04 |
CA2911037A1 (en) | 2014-11-13 |
WO2014181788A1 (ja) | 2014-11-13 |
IL242491B (en) | 2019-05-30 |
EP2995611B1 (en) | 2017-10-11 |
CN105263901A (zh) | 2016-01-20 |
JPWO2014181788A1 (ja) | 2017-02-23 |
AU2014263615B2 (en) | 2017-12-07 |
SG11201509244XA (en) | 2015-12-30 |
RU2670982C2 (ru) | 2018-10-29 |
AU2014263615A1 (en) | 2015-11-26 |
RU2015152201A (ru) | 2017-06-14 |
MX2015015485A (es) | 2016-06-14 |
TWI641584B (zh) | 2018-11-21 |
NZ714111A (en) | 2019-03-29 |
EP2995611A4 (en) | 2016-10-12 |
ES2645847T3 (es) | 2017-12-11 |
CN105263901B (zh) | 2017-06-23 |
EP2995611A1 (en) | 2016-03-16 |
MX362192B (es) | 2019-01-08 |
KR102128376B1 (ko) | 2020-06-30 |
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