BR112015022558A2 - sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesse - Google Patents
sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesseInfo
- Publication number
- BR112015022558A2 BR112015022558A2 BR112015022558A BR112015022558A BR112015022558A2 BR 112015022558 A2 BR112015022558 A2 BR 112015022558A2 BR 112015022558 A BR112015022558 A BR 112015022558A BR 112015022558 A BR112015022558 A BR 112015022558A BR 112015022558 A2 BR112015022558 A2 BR 112015022558A2
- Authority
- BR
- Brazil
- Prior art keywords
- promoter
- nucleic acid
- acid sequence
- protein
- interest
- Prior art date
Links
- 150000007523 nucleic acids Chemical group 0.000 title abstract 9
- 108091028043 Nucleic acid sequence Proteins 0.000 title abstract 7
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 5
- 101100028900 Caenorhabditis elegans pcs-1 gene Proteins 0.000 title abstract 3
- 238000004113 cell culture Methods 0.000 title abstract 2
- 108020004707 nucleic acids Proteins 0.000 title abstract 2
- 102000039446 nucleic acids Human genes 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 4
- 241000235058 Komagataella pastoris Species 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
- C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13159527 | 2013-03-15 | ||
| US13/835,589 US9150870B2 (en) | 2013-03-15 | 2013-03-15 | Constitutive promoter |
| PCT/EP2013/077144 WO2014139608A1 (en) | 2013-03-15 | 2013-12-18 | Constitutive promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015022558A2 true BR112015022558A2 (pt) | 2017-10-24 |
Family
ID=49841670
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015022558A BR112015022558A2 (pt) | 2013-03-15 | 2013-12-18 | sequência isolada de ácidos nucleicos do promotor pcs1, construção de expressão ou célula hospedeira recombinante compreendendo a sequência de ácidos nucleicos, cultura celular estável de uma pluralidade das referidas células hospedeiras, método para a produção de uma proteína de interesse e utilização de uma sequência isolada de ácidos nucleicos compreendendo um promotor em um método para a produção de uma proteína de interesse |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11168117B2 (https=) |
| EP (2) | EP3584322B1 (https=) |
| JP (2) | JP6698352B2 (https=) |
| KR (1) | KR102128959B1 (https=) |
| CN (1) | CN105229154B (https=) |
| AU (1) | AU2013382370B2 (https=) |
| BR (1) | BR112015022558A2 (https=) |
| CA (1) | CA2903568C (https=) |
| DK (1) | DK2970994T3 (https=) |
| ES (2) | ES2751336T3 (https=) |
| HK (1) | HK1213292A1 (https=) |
| IL (1) | IL241340B (https=) |
| PL (1) | PL2970994T3 (https=) |
| SG (2) | SG11201507557UA (https=) |
| WO (1) | WO2014139608A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2970994T3 (da) * | 2013-03-15 | 2019-10-28 | Lonza Ag | Konstitutiv promotor |
| EP3423588A1 (en) | 2016-03-02 | 2019-01-09 | Lonza Ltd | Improved fermentation process |
| JP7717459B2 (ja) | 2018-02-12 | 2025-08-04 | ロンザ リミテッド | 目的タンパク質を産生するための宿主細胞 |
| EP3536784A1 (en) | 2018-03-05 | 2019-09-11 | ACIB GmbH | Host cell engineered for improved metabolite production |
| EP3802820B1 (en) * | 2018-06-07 | 2022-09-07 | Basf Se | Methods for identifying promoters for protein production in yeast |
| JP2020146307A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146304A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146317A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146316A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146300A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146312A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146301A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146313A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146315A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146305A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146303A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146299A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146314A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146306A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146311A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146297A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146318A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146309A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146298A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146302A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| JP2020146308A (ja) * | 2019-03-14 | 2020-09-17 | 株式会社三洋物産 | 遊技機 |
| WO2020200414A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Protein production in mut-methylotrophic yeast |
| JP7570346B2 (ja) | 2019-04-01 | 2024-10-21 | ウニヴェルズィテート・フューア・ボーデンクルトゥーア・ウィーン | Ｍｕｔ－メチロトローフ酵母 |
| WO2020200415A1 (en) | 2019-04-01 | 2020-10-08 | Lonza Ltd | Mut- methylotrophic yeast |
| WO2021014470A1 (en) * | 2019-07-25 | 2021-01-28 | Council Of Scientific And Industrial Research | Recombinant vector for high-expression of proteins in yeasts |
| ES3034258T3 (en) | 2020-04-01 | 2025-08-14 | Lonza Ag | Helper factors for expressing proteins in yeast |
| EP4217383A1 (en) | 2020-09-22 | 2023-08-02 | Bristol-Myers Squibb Company | Methods for producing therapeutic proteins |
| CN116490517A (zh) | 2020-09-30 | 2023-07-25 | 龙沙有限公司 | 过表达翻译因子的宿主细胞 |
| WO2022130163A1 (en) * | 2020-12-14 | 2022-06-23 | Indian Institute Of Science | Nucleotide sequence, expression vectors, recombinant yeast cells and applications thereof |
| US20240141363A1 (en) | 2021-02-12 | 2024-05-02 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Signal peptides for increased protein secretion |
| WO2024133538A1 (en) | 2022-12-20 | 2024-06-27 | Lonza Ltd | Host cells with pat1 knockout for increased specific protein productivity |
| CN118308361B (zh) * | 2024-06-07 | 2024-09-17 | 中国人民解放军军事科学院军事医学研究院 | 表达人血清白蛋白的重组序列、生物材料及其应用与方法 |
| WO2026027251A1 (en) | 2024-08-01 | 2026-02-05 | Boehringer Ingelheim Rcv Gmbh & Co Kg | Signal peptides for increased protein secretion |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU577259B2 (en) | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
| US4808537A (en) | 1984-10-30 | 1989-02-28 | Phillips Petroleum Company | Methanol inducible genes obtained from pichia and methods of use |
| US4855231A (en) | 1984-10-30 | 1989-08-08 | Phillips Petroleum Company | Regulatory region for heterologous gene expression in yeast |
| WO1997044470A1 (en) | 1996-05-21 | 1997-11-27 | Novo Nordisk A/S | Novel yeast promoters suitable for expression cloning in yeast and heterologous expression of proteins in yeast |
| US6730499B1 (en) | 1998-07-03 | 2004-05-04 | Research Corporation Technologies, Inc. | Promoter for the Pichia pastoris formaldehyde dehydrogenase gene FLD1 |
| US7259255B2 (en) | 2003-06-25 | 2007-08-21 | E. I. Du Pont De Nemours And Company | Glyceraldehyde-3-phosphate dehydrogenase and phosphoglycerate mutase promoters for gene expression in oleaginous yeast |
| AT501955B1 (de) | 2005-02-23 | 2007-08-15 | Univ Graz Tech | Mutierte aox1-promotoren |
| KR20070009269A (ko) | 2005-07-15 | 2007-01-18 | 한국생명공학연구원 | 재조합단백질 생산용 단백질융합인자 라이브러리 및이로부터 획득된 단백질융합인자 |
| US7816509B2 (en) | 2005-11-16 | 2010-10-19 | Korean Research Institute Of Bioscience & Biotechnology | Translational elongation factor promoter from Pichia pastoris and method for producing recombinant protein using the same |
| US8440456B2 (en) | 2009-05-22 | 2013-05-14 | Vib, Vzw | Nucleic acids of Pichia pastoris and use thereof for recombinant production of proteins |
| CN102180954B (zh) * | 2011-03-01 | 2013-04-17 | 华南理工大学 | 一种毕赤酵母壁蛋白及其构建的表面展示系统和构建方法 |
| CN102994501B (zh) | 2012-10-15 | 2018-04-27 | 华南理工大学 | 具有组成型启动子活性的dna及其应用和巴斯德毕赤酵母表达载体 |
| US20150293076A1 (en) * | 2012-10-22 | 2015-10-15 | Bolt Threads, Inc. | Cellular Reprogramming for Product Optimization |
| BR112015021753B1 (pt) * | 2013-03-08 | 2023-02-23 | Keck Graduate Institute Of Applied Life Sciences | Ácidos nucleicos isolados de pichia pastoris, vetor de expressão, células hospedeiras de levedura e construto de dna, bem como método para produzir uma proteína |
| DK2970994T3 (da) * | 2013-03-15 | 2019-10-28 | Lonza Ag | Konstitutiv promotor |
-
2013
- 2013-12-18 DK DK13811203T patent/DK2970994T3/da active
- 2013-12-18 AU AU2013382370A patent/AU2013382370B2/en not_active Ceased
- 2013-12-18 ES ES13811203T patent/ES2751336T3/es active Active
- 2013-12-18 CA CA2903568A patent/CA2903568C/en active Active
- 2013-12-18 SG SG11201507557UA patent/SG11201507557UA/en unknown
- 2013-12-18 PL PL13811203T patent/PL2970994T3/pl unknown
- 2013-12-18 HK HK16101211.3A patent/HK1213292A1/zh unknown
- 2013-12-18 SG SG10201804002PA patent/SG10201804002PA/en unknown
- 2013-12-18 EP EP19186013.9A patent/EP3584322B1/en active Active
- 2013-12-18 EP EP13811203.2A patent/EP2970994B1/en active Active
- 2013-12-18 ES ES19186013T patent/ES3013464T3/es active Active
- 2013-12-18 BR BR112015022558A patent/BR112015022558A2/pt not_active Application Discontinuation
- 2013-12-18 CN CN201380076047.XA patent/CN105229154B/zh active Active
- 2013-12-18 WO PCT/EP2013/077144 patent/WO2014139608A1/en not_active Ceased
- 2013-12-18 JP JP2015561962A patent/JP6698352B2/ja active Active
- 2013-12-18 KR KR1020157028747A patent/KR102128959B1/ko active Active
-
2015
- 2015-09-08 IL IL241340A patent/IL241340B/en unknown
-
2018
- 2018-11-05 JP JP2018208031A patent/JP2019047804A/ja not_active Withdrawn
-
2019
- 2019-07-16 US US16/513,022 patent/US11168117B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013382370B2 (en) | 2020-01-23 |
| KR102128959B1 (ko) | 2020-07-02 |
| DK2970994T3 (da) | 2019-10-28 |
| PL2970994T3 (pl) | 2020-03-31 |
| EP3584322A1 (en) | 2019-12-25 |
| CN105229154A (zh) | 2016-01-06 |
| ES2751336T3 (es) | 2020-03-31 |
| AU2013382370A1 (en) | 2015-09-24 |
| CA2903568C (en) | 2022-07-12 |
| IL241340B (en) | 2022-02-01 |
| ES3013464T3 (en) | 2025-04-14 |
| CA2903568A1 (en) | 2014-09-18 |
| CN105229154B (zh) | 2026-03-03 |
| EP3584322B1 (en) | 2024-12-04 |
| EP3584322C0 (en) | 2024-12-04 |
| JP2016508742A (ja) | 2016-03-24 |
| HK1213292A1 (zh) | 2016-06-30 |
| IL241340A0 (en) | 2015-11-30 |
| JP6698352B2 (ja) | 2020-05-27 |
| US11168117B2 (en) | 2021-11-09 |
| JP2019047804A (ja) | 2019-03-28 |
| SG11201507557UA (en) | 2015-10-29 |
| WO2014139608A1 (en) | 2014-09-18 |
| EP2970994A1 (en) | 2016-01-20 |
| KR20160002763A (ko) | 2016-01-08 |
| US20190337998A1 (en) | 2019-11-07 |
| EP2970994B1 (en) | 2019-07-17 |
| SG10201804002PA (en) | 2018-07-30 |
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Legal Events
| Date | Code | Title | Description |
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| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06I | Publication of requirement cancelled [chapter 6.9 patent gazette] |
Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA. |
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| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |